{"id":"https://openalex.org/W4413338656","doi":"https://doi.org/10.1038/s41598-025-14580-1","title":"Unsupervised clustering of biochemical markers reveals health profiles associated with function and survival in active aging","display_name":"Unsupervised clustering of biochemical markers reveals health profiles associated with function and survival in active aging","publication_year":2025,"publication_date":"2025-08-20","ids":{"openalex":"https://openalex.org/W4413338656","doi":"https://doi.org/10.1038/s41598-025-14580-1","pmid":"https://pubmed.ncbi.nlm.nih.gov/40835865","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12368133"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-025-14580-1","doi":"https://doi.org/10.1038/s41598-025-14580-1","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-025-14580-1","pdf_url":"https://www.nature.com/articles/s41598-025-14580-1.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-025-14580-1.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081371948","display_name":"Raquel Gonz\u00e1lez\u2010Martos","orcid":"https://orcid.org/0000-0003-3340-1794","observed_orcids":["https://orcid.org/0000-0003-3340-1794"]},"institutions":[{"id":"https://openalex.org/I79189158","display_name":"University of Castilla-La Mancha","ror":"https://ror.org/05r78ng12","country_code":"ES","type":"education","lineage":["https://openalex.org/I79189158"]},{"id":"https://openalex.org/I88060688","display_name":"Universidad Polit\u00e9cnica de Madrid","ror":"https://ror.org/03n6nwv02","country_code":"ES","type":"education","lineage":["https://openalex.org/I88060688"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Raquel Gonz\u00e1lez-Martos","raw_affiliation_strings":["Centro de Tecnolog\u00eda Biom\u00e9dica (CTB), Escuela T\u00e9cnica Superior de Ingenier\u00eda Agron\u00f3mica, Alimentaria y de Biosistemas (ETSIAAB), Universidad Polit\u00e9cnica de Madrid, 28040, Madrid, Spain","GENUD Toledo Research Group, Faculty of Sport Sciences, University of Castilla-La Mancha, Avda. Calos III S/N, 45071, Toledo, Spain","Nageru S.L, 28045, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Tecnolog\u00eda Biom\u00e9dica (CTB), Escuela T\u00e9cnica Superior de Ingenier\u00eda Agron\u00f3mica, Alimentaria y de Biosistemas (ETSIAAB), Universidad Polit\u00e9cnica de Madrid, 28040, Madrid, Spain","institution_ids":["https://openalex.org/I88060688"]},{"raw_affiliation_string":"GENUD Toledo Research Group, Faculty of Sport Sciences, University of Castilla-La Mancha, Avda. Calos III S/N, 45071, Toledo, Spain","institution_ids":["https://openalex.org/I79189158"]},{"raw_affiliation_string":"Nageru S.L, 28045, Madrid, Spain","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026267991","display_name":"Javier Galeano","orcid":"https://orcid.org/0000-0003-0706-4317","observed_orcids":["https://orcid.org/0000-0003-0706-4317"]},"institutions":[{"id":"https://openalex.org/I88060688","display_name":"Universidad Polit\u00e9cnica de Madrid","ror":"https://ror.org/03n6nwv02","country_code":"ES","type":"education","lineage":["https://openalex.org/I88060688"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Javier Galeano","raw_affiliation_strings":["Complex Systems Group, ETSIAAB, Universidad Polit\u00e9cnica de Madrid, 28040, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Complex Systems Group, ETSIAAB, Universidad Polit\u00e9cnica de Madrid, 28040, Madrid, Spain","institution_ids":["https://openalex.org/I88060688"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055303856","display_name":"Carmen Ram\u00edrez\u2010Castillejo","orcid":"https://orcid.org/0000-0002-1877-3381","observed_orcids":["https://orcid.org/0000-0002-1877-3381"]},"institutions":[{"id":"https://openalex.org/I4210097846","display_name":"Instituto de Investigaci\u00f3n Sanitaria del Hospital Cl\u00ednico San Carlos","ror":"https://ror.org/014v12a39","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210097846"]},{"id":"https://openalex.org/I88060688","display_name":"Universidad Polit\u00e9cnica de Madrid","ror":"https://ror.org/03n6nwv02","country_code":"ES","type":"education","lineage":["https://openalex.org/I88060688"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Carmen Ramirez-Castillejo","raw_affiliation_strings":["Centro de Tecnolog\u00eda Biom\u00e9dica (CTB), Escuela T\u00e9cnica Superior de Ingenier\u00eda Agron\u00f3mica, Alimentaria y de Biosistemas (ETSIAAB), Universidad Polit\u00e9cnica de Madrid, 28040, Madrid, Spain","Departamento de Oncolog\u00eda, Instituto de Investigaci\u00f3n Sanitaria San Carlos, (IdISSC), 28040, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Tecnolog\u00eda Biom\u00e9dica (CTB), Escuela T\u00e9cnica Superior de Ingenier\u00eda Agron\u00f3mica, Alimentaria y de Biosistemas (ETSIAAB), Universidad Polit\u00e9cnica de Madrid, 28040, Madrid, Spain","institution_ids":["https://openalex.org/I88060688"]},{"raw_affiliation_string":"Departamento de Oncolog\u00eda, Instituto de Investigaci\u00f3n Sanitaria San Carlos, (IdISSC), 28040, Madrid, Spain","institution_ids":["https://openalex.org/I4210097846"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042480120","display_name":"Narc\u00eds Gusi","orcid":"https://orcid.org/0000-0002-1001-8883","observed_orcids":["https://orcid.org/0000-0002-1001-8883"]},"institutions":[{"id":"https://openalex.org/I2801357902","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4210115082","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red","ror":"https://ror.org/02g87qh62","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4210115082","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4210149569","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Fragilidad y Envejecimiento Saludable","ror":"https://ror.org/04j0sev46","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4210115082","https://openalex.org/I4210149569","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I80606768","display_name":"Universidad de Extremadura","ror":"https://ror.org/0174shg90","country_code":"ES","type":"education","lineage":["https://openalex.org/I80606768"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Narcis Gusi","raw_affiliation_strings":["Centro de Investigaci\u00f3n Biom\u00e9dica en Red Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III, Madrid, Spain","Grupo Actividad F\u00edsica, Calidad de Vida y Salud (AFYCAV), Facultad Ciencias del Deporte, Universidad de Extremadura, C\u00e1ceres, Spain","Instituto Universitario de Investigaci\u00f3n e Innovaci\u00f3n en el Deporte, Universidad de Extremadura, C\u00e1ceres, Spain","Spanish Network for Exercise and Health (EXERNET), 50009, Zaragoza, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III, Madrid, Spain","institution_ids":["https://openalex.org/I2801357902","https://openalex.org/I4210115082","https://openalex.org/I4210149569"]},{"raw_affiliation_string":"Grupo Actividad F\u00edsica, Calidad de Vida y Salud (AFYCAV), Facultad Ciencias del Deporte, Universidad de Extremadura, C\u00e1ceres, Spain","institution_ids":["https://openalex.org/I80606768"]},{"raw_affiliation_string":"Instituto Universitario de Investigaci\u00f3n e Innovaci\u00f3n en el Deporte, Universidad de Extremadura, C\u00e1ceres, Spain","institution_ids":["https://openalex.org/I80606768"]},{"raw_affiliation_string":"Spanish Network for Exercise and Health (EXERNET), 50009, Zaragoza, Spain","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040031998","display_name":"Eva Gesteiro","orcid":"https://orcid.org/0000-0002-9498-4228","observed_orcids":["https://orcid.org/0000-0002-9498-4228"]},"institutions":[{"id":"https://openalex.org/I88060688","display_name":"Universidad Polit\u00e9cnica de Madrid","ror":"https://ror.org/03n6nwv02","country_code":"ES","type":"education","lineage":["https://openalex.org/I88060688"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Eva Gesteiro","raw_affiliation_strings":["ImFINE Research Group, Department of Health and Human Performance, Universidad Polit\u00e9cnica de Madrid, 28040, Madrid, Spain","Spanish Network for Exercise and Health (EXERNET), 50009, Zaragoza, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ImFINE Research Group, Department of Health and Human Performance, Universidad Polit\u00e9cnica de Madrid, 28040, Madrid, Spain","institution_ids":["https://openalex.org/I88060688"]},{"raw_affiliation_string":"Spanish Network for Exercise and Health (EXERNET), 50009, Zaragoza, Spain","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028158419","display_name":"Germ\u00e1n Vicente\u2010Rodr\u00edguez","orcid":"https://orcid.org/0000-0002-4303-4097","observed_orcids":["https://orcid.org/0000-0002-4303-4097"]},"institutions":[{"id":"https://openalex.org/I255234318","display_name":"Universidad de Zaragoza","ror":"https://ror.org/012a91z28","country_code":"ES","type":"education","lineage":["https://openalex.org/I255234318"]},{"id":"https://openalex.org/I2801724371","display_name":"Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition","ror":"https://ror.org/02s65tk16","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801724371"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"German Vicente-Rodriguez","raw_affiliation_strings":["Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (CIBERObn), Madrid, Spain","EXER-GENUD (Growth, Exercise, Nutrition and Development) Research Group, IA2, Faculty of Health and Sport Science, Department of Nursing and Fisiatry, University of Zaragoza, Zaragoza, Spain","Spanish Network for Exercise and Health (EXERNET), 50009, Zaragoza, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (CIBERObn), Madrid, Spain","institution_ids":["https://openalex.org/I2801724371"]},{"raw_affiliation_string":"EXER-GENUD (Growth, Exercise, Nutrition and Development) Research Group, IA2, Faculty of Health and Sport Science, Department of Nursing and Fisiatry, University of Zaragoza, Zaragoza, Spain","institution_ids":["https://openalex.org/I255234318"]},{"raw_affiliation_string":"Spanish Network for Exercise and Health (EXERNET), 50009, Zaragoza, Spain","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051392724","display_name":"Ignacio Ara","orcid":"https://orcid.org/0000-0002-2854-6684","observed_orcids":["https://orcid.org/0000-0002-2854-6684"]},"institutions":[{"id":"https://openalex.org/I2801357902","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4210115082","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red","ror":"https://ror.org/02g87qh62","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4210115082","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4210141158","display_name":"Servicio de Salud de Castilla La Mancha","ror":"https://ror.org/03k8zj440","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210141158"]},{"id":"https://openalex.org/I4210149569","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Fragilidad y Envejecimiento Saludable","ror":"https://ror.org/04j0sev46","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4210115082","https://openalex.org/I4210149569","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I79189158","display_name":"University of Castilla-La Mancha","ror":"https://ror.org/05r78ng12","country_code":"ES","type":"education","lineage":["https://openalex.org/I79189158"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Ignacio Ara","raw_affiliation_strings":["Centro de Investigaci\u00f3n Biom\u00e9dica en Red Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III, Madrid, Spain","GENUD Toledo Research Group, Faculty of Sport Sciences, University of Castilla-La Mancha, Avda. Calos III S/N, 45071, Toledo, Spain","Grupo Mixto de Fragilidad y Envejecimiento Exitoso UCLM-SESCAM, Universidad de Castilla-La Mancha-Servicio de Salud de Castilla-La Mancha, IDISCAM, Toledo, Spain","Spanish Network for Exercise and Health (EXERNET), 50009, Zaragoza, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III, Madrid, Spain","institution_ids":["https://openalex.org/I2801357902","https://openalex.org/I4210115082","https://openalex.org/I4210149569"]},{"raw_affiliation_string":"GENUD Toledo Research Group, Faculty of Sport Sciences, University of Castilla-La Mancha, Avda. Calos III S/N, 45071, Toledo, Spain","institution_ids":["https://openalex.org/I79189158"]},{"raw_affiliation_string":"Grupo Mixto de Fragilidad y Envejecimiento Exitoso UCLM-SESCAM, Universidad de Castilla-La Mancha-Servicio de Salud de Castilla-La Mancha, IDISCAM, Toledo, Spain","institution_ids":["https://openalex.org/I4210141158","https://openalex.org/I79189158"]},{"raw_affiliation_string":"Spanish Network for Exercise and Health (EXERNET), 50009, Zaragoza, Spain","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083448551","display_name":"Amelia Guadalupe\u2010Grau","orcid":"https://orcid.org/0000-0003-2573-4572","observed_orcids":["https://orcid.org/0000-0003-2573-4572"]},"institutions":[{"id":"https://openalex.org/I2801357902","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4210115082","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red","ror":"https://ror.org/02g87qh62","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4210115082","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4210141158","display_name":"Servicio de Salud de Castilla La Mancha","ror":"https://ror.org/03k8zj440","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210141158"]},{"id":"https://openalex.org/I4210149569","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Fragilidad y Envejecimiento Saludable","ror":"https://ror.org/04j0sev46","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4210115082","https://openalex.org/I4210149569","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I79189158","display_name":"University of Castilla-La Mancha","ror":"https://ror.org/05r78ng12","country_code":"ES","type":"education","lineage":["https://openalex.org/I79189158"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Amelia Guadalupe-Grau","raw_affiliation_strings":["Centro de Investigaci\u00f3n Biom\u00e9dica en Red Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III, Madrid, Spain. amelia.guadalupe@uclm.es","GENUD Toledo Research Group, Faculty of Sport Sciences, University of Castilla-La Mancha, Avda. Calos III S/N, 45071, Toledo, Spain. amelia.guadalupe@uclm.es","Grupo Mixto de Fragilidad y Envejecimiento Exitoso UCLM-SESCAM, Universidad de Castilla-La Mancha-Servicio de Salud de Castilla-La Mancha, IDISCAM, Toledo, Spain. amelia.guadalupe@uclm.es","Spanish Network for Exercise and Health (EXERNET), 50009, Zaragoza, Spain. amelia.guadalupe@uclm.es","Centro de Investigaci\u00f3n Biom\u00e9dica en Red Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III, Madrid, Spain","GENUD Toledo Research Group, Faculty of Sport Sciences, University of Castilla-La Mancha, Avda. Calos III S/N, 45071, Toledo, Spain","Grupo Mixto de Fragilidad y Envejecimiento Exitoso UCLM-SESCAM, Universidad de Castilla-La Mancha-Servicio de Salud de Castilla-La Mancha, IDISCAM, Toledo, Spain","Spanish Network for Exercise and Health (EXERNET), 50009, Zaragoza, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III, Madrid, Spain. amelia.guadalupe@uclm.es","institution_ids":["https://openalex.org/I2801357902","https://openalex.org/I4210115082","https://openalex.org/I4210149569"]},{"raw_affiliation_string":"GENUD Toledo Research Group, Faculty of Sport Sciences, University of Castilla-La Mancha, Avda. Calos III S/N, 45071, Toledo, Spain. amelia.guadalupe@uclm.es","institution_ids":["https://openalex.org/I79189158"]},{"raw_affiliation_string":"Grupo Mixto de Fragilidad y Envejecimiento Exitoso UCLM-SESCAM, Universidad de Castilla-La Mancha-Servicio de Salud de Castilla-La Mancha, IDISCAM, Toledo, Spain. amelia.guadalupe@uclm.es","institution_ids":["https://openalex.org/I4210141158","https://openalex.org/I79189158"]},{"raw_affiliation_string":"Spanish Network for Exercise and Health (EXERNET), 50009, Zaragoza, Spain. amelia.guadalupe@uclm.es","institution_ids":[]},{"raw_affiliation_string":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III, Madrid, Spain","institution_ids":["https://openalex.org/I2801357902","https://openalex.org/I4210115082","https://openalex.org/I4210149569"]},{"raw_affiliation_string":"GENUD Toledo Research Group, Faculty of Sport Sciences, University of Castilla-La Mancha, Avda. Calos III S/N, 45071, Toledo, Spain","institution_ids":["https://openalex.org/I79189158"]},{"raw_affiliation_string":"Grupo Mixto de Fragilidad y Envejecimiento Exitoso UCLM-SESCAM, Universidad de Castilla-La Mancha-Servicio de Salud de Castilla-La Mancha, IDISCAM, Toledo, Spain","institution_ids":["https://openalex.org/I4210141158","https://openalex.org/I79189158"]},{"raw_affiliation_string":"Spanish Network for Exercise and Health (EXERNET), 50009, Zaragoza, Spain","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5083448551"],"corresponding_institution_ids":["https://openalex.org/I2801357902","https://openalex.org/I4210115082","https://openalex.org/I4210141158","https://openalex.org/I4210149569","https://openalex.org/I79189158"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":1.7957,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.83066331,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"15","issue":"1","first_page":"30546","last_page":"30546"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11011","display_name":"Frailty in Older Adults","score":0.39089998602867126,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11011","display_name":"Frailty in Older Adults","score":0.39089998602867126,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10397","display_name":"Nutrition and Health in Aging","score":0.21639999747276306,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10352","display_name":"Physical Activity and Health","score":0.050599999725818634,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biochemical-markers","display_name":"biochemical markers","score":0.6539999842643738},{"id":"https://openalex.org/keywords/phenotypic-clusters","display_name":"phenotypic clusters","score":0.7239999771118164},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.8009999990463257},{"id":"https://openalex.org/keywords/active-aging","display_name":"active ageing","score":0.746999979019165},{"id":"https://openalex.org/keywords/mortality-risk","display_name":"mortality risk","score":0.7699999809265137},{"id":"https://openalex.org/keywords/body-composition","display_name":"body composition","score":0.890999972820282},{"id":"https://openalex.org/keywords/physical-functioning","display_name":"physical function","score":0.984000027179718},{"id":"https://openalex.org/keywords/metabolic-health","display_name":"metabolic health","score":0.5849999785423279},{"id":"https://openalex.org/keywords/liver-function","display_name":"liver function","score":0.6830000281333923},{"id":"https://openalex.org/keywords/exercise","display_name":"physical activity","score":0.8410000205039978},{"id":"https://openalex.org/keywords/adiposity","display_name":"adiposity","score":0.9810000061988831},{"id":"https://openalex.org/keywords/health-profile","display_name":"health profile","score":0.4169999957084656}],"concepts":[{"id":"https://openalex.org/C73555534","wikidata":"https://www.wikidata.org/wiki/Q622825","display_name":"Cluster analysis","level":2,"score":0.5955038070678711},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.46164101362228394},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.44596967101097107},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37813544273376465},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3610617518424988},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3052198588848114},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.2168285846710205},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.2031589150428772}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D001823","descriptor_name":"Body Composition","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015444","descriptor_name":"Exercise","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1038/s41598-025-14580-1","doi":"https://doi.org/10.1038/s41598-025-14580-1","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-025-14580-1","pdf_url":"https://www.nature.com/articles/s41598-025-14580-1.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12368133","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12368133","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmid:40835865","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40835865","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:hispana.mcu.es:62716990","doi":null,"is_oa":true,"landing_page_url":"https://oa.upm.es/96884/","pdf_url":null,"source":{"id":"https://openalex.org/S4377196108","display_name":"Hispana","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Scientific Reports, ISSN 20452322, 2025-08-20, Vol. 15, No. 1","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:oa.upm.es:96884","doi":null,"is_oa":true,"landing_page_url":"https://oa.upm.es/96884/","pdf_url":"https://oa.upm.es/96884/1/10390037.pdf","source":{"id":"https://openalex.org/S4377196323","display_name":"UPM Digital Archive (Technical University of Madrid)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I88060688","host_organization_name":"Universidad Polit\u00e9cnica de Madrid","host_organization_lineage":["https://openalex.org/I88060688"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, ISSN 20452322, 2025-08-20, Vol. 15, No. 1","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:zaguan.unizar.es:162525","doi":null,"is_oa":true,"landing_page_url":"http://zaguan.unizar.es/record/162525","pdf_url":"https://zaguan.unizar.es/record/162525/files/texto_completo.pdf","source":{"id":"https://openalex.org/S4306402461","display_name":"Zaguan (Universidad de Zaragoza)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I255234318","host_organization_name":"Universidad de Zaragoza","host_organization_lineage":["https://openalex.org/I255234318"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:942b68078a1f4462b434fc5ac06471c7","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/942b68078a1f4462b434fc5ac06471c7","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 15, Iss 1, Pp 1-12 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41598-025-14580-1","doi":"https://doi.org/10.1038/s41598-025-14580-1","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-025-14580-1","pdf_url":"https://www.nature.com/articles/s41598-025-14580-1.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2443030001","display_name":null,"funder_award_id":"CB16/10/00456","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G2609813759","display_name":null,"funder_award_id":"CB16/10/00456)","funder_id":"https://openalex.org/F4320313680","funder_display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Fragilidad y Envejecimiento Saludable"},{"id":"https://openalex.org/G2673764007","display_name":null,"funder_award_id":"CB16/10/00477 and CB16/10/00456","funder_id":"https://openalex.org/F4320313680","funder_display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Fragilidad y Envejecimiento Saludable"},{"id":"https://openalex.org/G290725032","display_name":null,"funder_award_id":"(CB16/10/00477)","funder_id":"https://openalex.org/F4320313680","funder_display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Fragilidad y Envejecimiento Saludable"},{"id":"https://openalex.org/G3074049202","display_name":null,"funder_award_id":"2022-GRIN-34296","funder_id":"https://openalex.org/F4320324466","funder_display_name":"Universidad de Castilla-La Mancha"},{"id":"https://openalex.org/G3163992959","display_name":null,"funder_award_id":"RED2022-134800-T","funder_id":"https://openalex.org/F4320322930","funder_display_name":"Ministerio de Ciencia e Innovaci\u00f3n"},{"id":"https://openalex.org/G3207356259","display_name":null,"funder_award_id":"2007\u20132013","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G393177772","display_name":null,"funder_award_id":"FP7 2007-2013","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G5426386277","display_name":"Utility of omic-based biomarkers in characterizing older individuals at risk for frailty, its progression to disability and general consequences to health and well-being - The FRAILOMIC Initiative","funder_award_id":"305483","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G5702163051","display_name":null,"funder_award_id":"FP7/2007","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G6392622723","display_name":null,"funder_award_id":"2022-GRIN-34296","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G6683712414","display_name":null,"funder_award_id":"IND2022/BMD-23595","funder_id":"https://openalex.org/F4320313831","funder_display_name":"Comunidad de Madrid"},{"id":"https://openalex.org/G8506530257","display_name":null,"funder_award_id":"CB16/10/00477","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"}],"funders":[{"id":"https://openalex.org/F4320313680","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Fragilidad y Envejecimiento Saludable","ror":"https://ror.org/04j0sev46"},{"id":"https://openalex.org/F4320313831","display_name":"Comunidad de Madrid","ror":null},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320322930","display_name":"Ministerio de Ciencia e Innovaci\u00f3n","ror":null},{"id":"https://openalex.org/F4320324466","display_name":"Universidad de Castilla-La Mancha","ror":"https://ror.org/05r78ng12"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4413338656.pdf","grobid_xml":"https://content.openalex.org/works/W4413338656.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W2006948910","https://openalex.org/W2038429516","https://openalex.org/W2056088037","https://openalex.org/W2058499418","https://openalex.org/W2095869629","https://openalex.org/W2097345383","https://openalex.org/W2144383336","https://openalex.org/W2153552748","https://openalex.org/W2153836018","https://openalex.org/W2160684941","https://openalex.org/W2164059021","https://openalex.org/W2166001339","https://openalex.org/W2217853646","https://openalex.org/W2556710568","https://openalex.org/W2803346494","https://openalex.org/W3035395764","https://openalex.org/W3108106255","https://openalex.org/W3121102783","https://openalex.org/W3136137760","https://openalex.org/W3153254518","https://openalex.org/W3166630865","https://openalex.org/W3174810361","https://openalex.org/W3216366140","https://openalex.org/W4289853169","https://openalex.org/W4296375462","https://openalex.org/W4311585871","https://openalex.org/W4328048668","https://openalex.org/W4360610368","https://openalex.org/W4386102031","https://openalex.org/W4392861269","https://openalex.org/W4400380711","https://openalex.org/W4408921004","https://openalex.org/W4409378282","https://openalex.org/W6636413848"],"related_works":["https://openalex.org/W7162790199","https://openalex.org/W7123490022","https://openalex.org/W7148440494","https://openalex.org/W7166858057","https://openalex.org/W2792998237","https://openalex.org/W7162296293","https://openalex.org/W7154708482","https://openalex.org/W4390081028","https://openalex.org/W196456882","https://openalex.org/W4408069974"],"abstract_inverted_index":{"This":[0,200],"study":[1,201],"explores":[2],"the":[3,41,92,98,127,139,151,186,194,203],"relationships":[4],"between":[5,66,206],"biochemical":[6,63,89],"phenotypes":[7],"identified":[8],"using":[9,73],"machine":[10],"learning,":[11],"and":[12,21,53,55,68,77,95,107,146,153,177,183,189,191,213,234],"key":[13],"health":[14,69],"outcomes,":[15],"including":[16],"body":[17,144,211],"composition,":[18],"physical":[19,132,148,175,209],"function,":[20],"mortality":[22,48,159,215],"risk.":[23],"Data":[24],"were":[25,71,170],"collected":[26],"from":[27],"536":[28],"physically":[29],"active":[30],"Spanish":[31],"participants":[32],"aged":[33],"over":[34],"65":[35],"years":[36],"(76.5%":[37],"women)":[38],"enrolled":[39],"in":[40,217],"EXERNET":[42],"cohort":[43],"(2017-2018),":[44],"with":[45,179],"a":[46,157,228],"6-year":[47],"follow-up.":[49],"Principal":[50],"component":[51],"analysis,":[52],"hierarchical":[54],"k-means":[56],"clustering":[57],"was":[58],"used":[59,96],"to":[60,237],"identify":[61],"distinct":[62,83],"profiles.":[64],"Associations":[65],"clusters":[67,84,117,155,226],"outcomes":[70],"assessed":[72],"analysis":[74],"of":[75,121,130,181],"covariance":[76],"Cox":[78,164],"proportional":[79],"hazards":[80],"models.":[81],"Three":[82],"emerged:":[85],"'Healthy',":[86],"characterized":[87],"by":[88,103],"values":[90,180],"within":[91],"normal":[93],"range":[94],"as":[97,161],"reference":[99],"group;":[100],"'Metabolic',":[101],"marked":[102],"dysregulated":[104],"metabolic":[105,207],"parameters;":[106],"'Hepatic',":[108],"which":[109],"exhibited":[110],"impaired":[111],"liver":[112],"function":[113],"markers.":[114],"Notably,":[115],"all":[116],"showed":[118,142],"subclinical":[119],"levels":[120,129],"dysfunction.":[122],"The":[123],"'Healthy":[124],"Cluster'":[125,141,196],"demonstrated":[126,156],"highest":[128],"organized":[131],"activity":[133,176],"(90%,":[134],"p":[135],"<":[136,198],"0.001),":[137],"whereas":[138],"'Metabolic":[140,187],"poorer":[143],"composition":[145,212],"reduced":[147],"performance.":[149],"Both":[150],"'Metabolic'":[152],"'Hepatic'":[154],"higher":[158],"risk,":[160],"confirmed":[162],"through":[163],"regression":[165],"analyses.":[166],"Adjusted":[167],"hazard":[168],"ratios":[169],"significantly":[171],"elevated":[172],"when":[173],"considering":[174],"adiposity,":[178],"3.45":[182],"3.71":[184],"for":[185,193,223,231],"Cluster',":[188],"3.01":[190],"3.85":[192],"'Hepatic":[195],"(p":[197],"0.05).":[199],"underscores":[202],"strong":[204],"link":[205],"health,":[208],"activity,":[210],"6-years":[214],"risk":[216],"older":[218],"adults.":[219],"Machine":[220],"learning":[221],"techniques":[222],"identifying":[224],"phenotypic":[225],"offers":[227],"promising":[229],"tool":[230],"early":[232],"detection":[233],"targeted":[235],"interventions":[236],"improve":[238],"aging":[239],"outcomes.":[240]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2025-10-10T00:00:00"}
