{"id":"https://openalex.org/W4413334530","doi":"https://doi.org/10.1101/2025.08.13.670029","title":"PHA-4/FoxA controls the function of pharyngeal and extrapharyngeal enteric neurons of C. elegans","display_name":"PHA-4/FoxA controls the function of pharyngeal and extrapharyngeal enteric neurons of C. elegans","publication_year":2025,"publication_date":"2025-08-15","ids":{"openalex":"https://openalex.org/W4413334530","doi":"https://doi.org/10.1101/2025.08.13.670029","pmid":"https://pubmed.ncbi.nlm.nih.gov/41292769","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12642682"},"language":"en","primary_location":{"id":"doi:10.1101/2025.08.13.670029","doi":"https://doi.org/10.1101/2025.08.13.670029","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.08.13.670029","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2025/08/15/2025.08.13.670029.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2025/08/15/2025.08.13.670029.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5115789428","display_name":"Zion Walker","orcid":"https://orcid.org/0000-0001-5331-8467","observed_orcids":["https://orcid.org/0000-0001-5331-8467"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zion Walker","raw_affiliation_strings":["Department of Biological Sciences","Howard Hughes Medical Institute, Columbia University, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences","institution_ids":[]},{"raw_affiliation_string":"Howard Hughes Medical Institute, Columbia University, New York, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062139237","display_name":"Wen Xi Cao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wen Xi Cao","raw_affiliation_strings":["Department of Biological Sciences","Howard Hughes Medical Institute, Columbia University, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences","institution_ids":[]},{"raw_affiliation_string":"Howard Hughes Medical Institute, Columbia University, New York, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069126079","display_name":"Eduardo Leyva\u2010D\u00edaz","orcid":"https://orcid.org/0000-0001-6750-9168","observed_orcids":["https://orcid.org/0000-0001-6750-9168"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210087099","display_name":"Instituto de Neurociencias","ror":"https://ror.org/000nhpy59","country_code":"ES","type":"facility","lineage":["https://openalex.org/I111262870","https://openalex.org/I134820265","https://openalex.org/I4210087099"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["ES","US"],"is_corresponding":false,"raw_author_name":"Eduardo Leyva-Diaz","raw_affiliation_strings":["Department of Biological Sciences","Howard Hughes Medical Institute, Columbia University, New York, USA","Present address: Department of Developmental Neurobiology, Instituto de Neurociencias (CSIC-UMH), Sant Joan d'Alacant, Spain"],"raw_orcid":"https://orcid.org/0000-0001-6750-9168","affiliations":[{"raw_affiliation_string":"Department of Biological Sciences","institution_ids":[]},{"raw_affiliation_string":"Howard Hughes Medical Institute, Columbia University, New York, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I78577930"]},{"raw_affiliation_string":"Present address: Department of Developmental Neurobiology, Instituto de Neurociencias (CSIC-UMH), Sant Joan d'Alacant, Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210087099"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Mayeesa Rahman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mayeesa Rahman","raw_affiliation_strings":["Department of Biological Sciences","Howard Hughes Medical Institute, Columbia University, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences","institution_ids":[]},{"raw_affiliation_string":"Howard Hughes Medical Institute, Columbia University, New York, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081188656","display_name":"Surojit Sural","orcid":"https://orcid.org/0000-0002-0422-9799","observed_orcids":["https://orcid.org/0000-0002-0422-9799"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Surojit Sural","raw_affiliation_strings":["Department of Biological Sciences","Howard Hughes Medical Institute, Columbia University, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences","institution_ids":[]},{"raw_affiliation_string":"Howard Hughes Medical Institute, Columbia University, New York, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000413012","display_name":"Michelle A. Attner","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michelle A. Attner","raw_affiliation_strings":["Department of Biological Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041472770","display_name":"Oliver Hobert","orcid":"https://orcid.org/0000-0002-7634-2854","observed_orcids":["https://orcid.org/0000-0002-7634-2854","https://orcid.org/0000-0002-3068-068X"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Oliver Hobert","raw_affiliation_strings":["Department of Biological Sciences","Howard Hughes Medical Institute, Columbia University, New York, USA"],"raw_orcid":"https://orcid.org/0000-0002-7634-2854","affiliations":[{"raw_affiliation_string":"Department of Biological Sciences","institution_ids":[]},{"raw_affiliation_string":"Howard Hughes Medical Institute, Columbia University, New York, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I78577930"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5041472770"],"corresponding_institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I78577930"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.38769999146461487,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.38769999146461487,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10423","display_name":"Neurobiology and Insect Physiology Research","score":0.2809999883174896,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12237","display_name":"Congenital gastrointestinal and neural anomalies","score":0.147599995136261,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pha-4","display_name":"PHA-4","score":0.9269999861717224},{"id":"https://openalex.org/keywords/foxa-transcription-factors","display_name":"FoxA transcription factor","score":0.9120000004768372},{"id":"https://openalex.org/keywords/enteric-nervous-system","display_name":"enteric nervous system","score":0.9490000009536743},{"id":"https://openalex.org/keywords/gabaergic-interneurons","display_name":"GABAergic interneurons","score":0.7229999899864197},{"id":"https://openalex.org/keywords/peptidergic-neurons","display_name":"peptidergic neurons","score":0.9879999756813049},{"id":"https://openalex.org/keywords/defecation-behavior","display_name":"defecation behavior","score":0.9100000262260437},{"id":"https://openalex.org/keywords/sleep-regulation","display_name":"sleep regulation","score":0.5849999785423279},{"id":"https://openalex.org/keywords/caenorhabditis-elegans","display_name":"Caenorhabditis elegans","score":0.8270000219345093}],"concepts":[{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.5553919076919556},{"id":"https://openalex.org/C2777439022","wikidata":"https://www.wikidata.org/wiki/Q586582","display_name":"Enteric nervous system","level":2,"score":0.5458401441574097},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4523627460002899},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2761616110801697},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.19295603036880493}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1101/2025.08.13.670029","doi":"https://doi.org/10.1101/2025.08.13.670029","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.08.13.670029","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2025/08/15/2025.08.13.670029.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:41292769","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41292769","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:11449388","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12642682","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1101/2025.08.13.670029","doi":"https://doi.org/10.1101/2025.08.13.670029","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.08.13.670029","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2025/08/15/2025.08.13.670029.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000865705","display_name":"Caenorhabditis Genetics Center","funder_award_id":"P40OD010440","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000906376","display_name":"Homeobox Genes and Neuron Identity Control on a Brain-Wide Level","funder_award_id":"R01NS039996","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4413334530.pdf","grobid_xml":"https://content.openalex.org/works/W4413334530.grobid-xml"},"referenced_works_count":74,"referenced_works":["https://openalex.org/W1505732106","https://openalex.org/W1521011562","https://openalex.org/W1857876096","https://openalex.org/W1864026313","https://openalex.org/W1924615382","https://openalex.org/W1977999211","https://openalex.org/W1978664503","https://openalex.org/W1979415389","https://openalex.org/W1979826378","https://openalex.org/W1981367331","https://openalex.org/W1981557915","https://openalex.org/W1991355885","https://openalex.org/W1993272672","https://openalex.org/W1998060385","https://openalex.org/W2000646355","https://openalex.org/W2020493895","https://openalex.org/W2032502888","https://openalex.org/W2040703470","https://openalex.org/W2040805319","https://openalex.org/W2045924557","https://openalex.org/W2062492216","https://openalex.org/W2064145462","https://openalex.org/W2072419797","https://openalex.org/W2072449837","https://openalex.org/W2073732701","https://openalex.org/W2074182576","https://openalex.org/W2074821443","https://openalex.org/W2085239838","https://openalex.org/W2100279782","https://openalex.org/W2110359316","https://openalex.org/W2118509956","https://openalex.org/W2122097157","https://openalex.org/W2130995821","https://openalex.org/W2148463363","https://openalex.org/W2148581106","https://openalex.org/W2148966035","https://openalex.org/W2153476462","https://openalex.org/W2153539961","https://openalex.org/W2161658232","https://openalex.org/W2167279371","https://openalex.org/W2172886986","https://openalex.org/W2417162181","https://openalex.org/W2529831923","https://openalex.org/W2570429698","https://openalex.org/W2733392181","https://openalex.org/W2763254731","https://openalex.org/W2791185814","https://openalex.org/W2884568348","https://openalex.org/W2891018818","https://openalex.org/W2950667797","https://openalex.org/W2969998349","https://openalex.org/W2973155931","https://openalex.org/W3016926598","https://openalex.org/W3021530092","https://openalex.org/W3087651272","https://openalex.org/W3116063736","https://openalex.org/W3161339362","https://openalex.org/W3180956051","https://openalex.org/W3185784360","https://openalex.org/W3205279974","https://openalex.org/W4220661375","https://openalex.org/W4220732076","https://openalex.org/W4239478744","https://openalex.org/W4280627437","https://openalex.org/W4321367686","https://openalex.org/W4378781294","https://openalex.org/W4387164893","https://openalex.org/W4388424601","https://openalex.org/W4391945835","https://openalex.org/W4393863661","https://openalex.org/W4401378299","https://openalex.org/W4403542175","https://openalex.org/W4414532953","https://openalex.org/W7074076353"],"related_works":["https://openalex.org/W4417008904","https://openalex.org/W2032502888","https://openalex.org/W4220732076","https://openalex.org/W1977999211","https://openalex.org/W2040805319","https://openalex.org/W1994315589","https://openalex.org/W2153539961","https://openalex.org/W2013877266","https://openalex.org/W4416641421","https://openalex.org/W1968029921"],"abstract_inverted_index":{"ABSTRACT":[0],"FoxA":[1,54],"transcription":[2,198],"factors":[3],"pattern":[4],"gut":[5],"tissue":[6],"across":[7],"animal":[8],"phylogeny.":[9],"Beyond":[10],"their":[11,111],"early":[12],"patterning":[13,66],"function,":[14],"little":[15],"is":[16,93,168,182,195,204],"known":[17,200],"about":[18],"whether":[19],"they":[20],"control":[21,189],"the":[22,28,34,39,45,50,67,70,99,115,118,135,172,196,210],"terminal":[23,100],"differentiation":[24,101],"and/or":[25],"function":[26,48,146,212],"of":[27,38,49,72,103,117,125,127,175,213,217],"fully":[29],"mature":[30],"enteric":[31,105,131,190,218],"nervous":[32,36,222],"system,":[33],"intrinsic":[35],"system":[37],"gut.":[40],"We":[41,163],"show":[42,164],"here":[43,158],"that":[44,91,133,143,165,203],"expression":[46,126],"and":[47,80,138,150,179,207],"sole":[51],"C.":[52],"elegans":[53],"homolog,":[55],"PHA-4,":[56],"reaches":[57],"beyond":[58],"its":[59],"previously":[60],"described":[61],"pioneer":[62],"factor":[63,199],"roles":[64],"in":[65,86,129,159,206,220],"foregut.":[68],"Through":[69],"engineering":[71],"neuron-specific":[73],"cis":[74],"-regulatory":[75],"alleles,":[76],"Cre-mediated":[77],"cell-specific":[78],"knockouts":[79],"degron-mediated,":[81],"temporally":[82],"controlled":[83],"PHA-4/FoxA":[84,92,128,167],"removal":[85],"postmitotic":[87],"neurons,":[88,106],"we":[89,121,156],"found":[90],"required":[94,170,183,208],"not":[95,169],"only":[96,197],"to":[97,109,184,188,201],"initiate":[98],"program":[102],"foregut-associated":[104],"but":[107],"also":[108],"maintain":[110],"functional":[112],"properties":[113],"throughout":[114],"life":[116],"animal.":[119],"Moreover,":[120],"discovered":[122],"novel":[123],"sites":[124],"extrapharyngeal":[130],"neurons":[132,187,219],"innervate":[134],"hindgut":[136],"(AVL":[137],"DVB),":[139],"a":[140,151,221],"GABAergic":[141],"interneuron":[142],"controls":[144],"foregut":[145],"during":[147],"sleep":[148],"(RIS),":[149],"peptidergic":[152],"neuron,":[153],"PVT,":[154,180],"which":[155],"implicate":[157],"controlling":[160],"defecation":[161],"behavior.":[162],"while":[166],"for":[171,209],"developmental":[173],"specification":[174],"AVL,":[176],"DVB,":[177],"RIS,":[178],"it":[181],"enable":[185],"these":[186],"functions.":[191],"Taken":[192],"together,":[193],"pha-4":[194],"date":[202],"expressed":[205],"proper":[211],"all":[214],"distinct":[215],"types":[216],"system.":[223]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2025-10-10T00:00:00"}