{"id":"https://openalex.org/W4413258043","doi":"https://doi.org/10.1073/pnas.2507571122","title":"TRIM24 as a therapeutic target in endocrine treatment\u2013resistant breast cancer","display_name":"TRIM24 as a therapeutic target in endocrine treatment\u2013resistant breast cancer","publication_year":2025,"publication_date":"2025-08-15","ids":{"openalex":"https://openalex.org/W4413258043","doi":"https://doi.org/10.1073/pnas.2507571122","pmid":"https://pubmed.ncbi.nlm.nih.gov/40815626","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12377727"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.2507571122","doi":"https://doi.org/10.1073/pnas.2507571122","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.2507571122","pdf_url":"https://www.pnas.org/doi/pdf/10.1073/pnas.2507571122","source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.pnas.org/doi/pdf/10.1073/pnas.2507571122","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067987805","display_name":"Nuno Padr\u00e3o","orcid":"https://orcid.org/0000-0002-8368-2806","observed_orcids":["https://orcid.org/0000-0002-8368-2806"]},"institutions":[{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]},{"id":"https://openalex.org/I4210111138","display_name":"Oncode Institute","ror":"https://ror.org/01n92vv28","country_code":"NL","type":"education","lineage":["https://openalex.org/I4210111138"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Nuno Padr\u00e3o","raw_affiliation_strings":["Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute","Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute, Amsterdam 1066 CX, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0002-8368-2806","affiliations":[{"raw_affiliation_string":"Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute","institution_ids":["https://openalex.org/I2898336195","https://openalex.org/I4210111138"]},{"raw_affiliation_string":"Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute, Amsterdam 1066 CX, The Netherlands","institution_ids":["https://openalex.org/I2898336195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010181844","display_name":"Sebastian Gregoricchio","orcid":"https://orcid.org/0000-0001-9209-5403","observed_orcids":["https://orcid.org/0000-0001-9209-5403"]},"institutions":[{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]},{"id":"https://openalex.org/I4210111138","display_name":"Oncode Institute","ror":"https://ror.org/01n92vv28","country_code":"NL","type":"education","lineage":["https://openalex.org/I4210111138"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Sebastian Gregoricchio","raw_affiliation_strings":["Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute","Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute, Amsterdam 1066 CX, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute","institution_ids":["https://openalex.org/I2898336195","https://openalex.org/I4210111138"]},{"raw_affiliation_string":"Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute, Amsterdam 1066 CX, The Netherlands","institution_ids":["https://openalex.org/I2898336195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085704728","display_name":"Nils Eickhoff","orcid":"https://orcid.org/0000-0003-4461-1607","observed_orcids":["https://orcid.org/0000-0003-4461-1607"]},"institutions":[{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]},{"id":"https://openalex.org/I4210111138","display_name":"Oncode Institute","ror":"https://ror.org/01n92vv28","country_code":"NL","type":"education","lineage":["https://openalex.org/I4210111138"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Nils Eickhoff","raw_affiliation_strings":["Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute","Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute, Amsterdam 1066 CX, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute","institution_ids":["https://openalex.org/I2898336195","https://openalex.org/I4210111138"]},{"raw_affiliation_string":"Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute, Amsterdam 1066 CX, The Netherlands","institution_ids":["https://openalex.org/I2898336195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005828023","display_name":"Jing Dong","orcid":"https://orcid.org/0009-0000-9121-9849","observed_orcids":["https://orcid.org/0009-0000-9121-9849"]},"institutions":[{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]},{"id":"https://openalex.org/I4210111138","display_name":"Oncode Institute","ror":"https://ror.org/01n92vv28","country_code":"NL","type":"education","lineage":["https://openalex.org/I4210111138"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Jing Dong","raw_affiliation_strings":["Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute","Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute, Amsterdam 1066 CX, The Netherlands"],"raw_orcid":"https://orcid.org/0009-0000-9121-9849","affiliations":[{"raw_affiliation_string":"Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute","institution_ids":["https://openalex.org/I2898336195","https://openalex.org/I4210111138"]},{"raw_affiliation_string":"Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute, Amsterdam 1066 CX, The Netherlands","institution_ids":["https://openalex.org/I2898336195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043745174","display_name":"Lara Luzietti","orcid":"https://orcid.org/0000-0002-5151-3979","observed_orcids":["https://orcid.org/0000-0002-5151-3979"]},"institutions":[{"id":"https://openalex.org/I142762351","display_name":"Royal College of Surgeons in Ireland","ror":"https://ror.org/01hxy9878","country_code":"IE","type":"education","lineage":["https://openalex.org/I142762351"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Lara Luzietti","raw_affiliation_strings":["School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, University of Medicine and Health Sciences","School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, University of Medicine and Health Sciences, Dublin D02 YN77, Ireland"],"raw_orcid":"https://orcid.org/0000-0002-5151-3979","affiliations":[{"raw_affiliation_string":"School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, University of Medicine and Health Sciences","institution_ids":["https://openalex.org/I142762351"]},{"raw_affiliation_string":"School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, University of Medicine and Health Sciences, Dublin D02 YN77, Ireland","institution_ids":["https://openalex.org/I142762351"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021103019","display_name":"Daniela Bossi","orcid":"https://orcid.org/0000-0002-8507-6754","observed_orcids":["https://orcid.org/0000-0002-8507-6754"]},"institutions":[{"id":"https://openalex.org/I4210101830","display_name":"Institute of Oncology Research","ror":"https://ror.org/01dpyn972","country_code":"CH","type":"facility","lineage":["https://openalex.org/I4210101830","https://openalex.org/I57201433"]},{"id":"https://openalex.org/I57201433","display_name":"Universit\u00e0 della Svizzera italiana","ror":"https://ror.org/03c4atk17","country_code":"CH","type":"education","lineage":["https://openalex.org/I57201433"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Daniela Bossi","raw_affiliation_strings":["Faculty of Biomedical Sciences, Universit\u00e0 della Svizzera Italiana","Institute of Oncology Research","Faculty of Biomedical Sciences, Universit\u00e0 della Svizzera Italiana, Lugano 6962, Switzerland","Institute of Oncology Research, Bellinzona 6500, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Biomedical Sciences, Universit\u00e0 della Svizzera Italiana","institution_ids":["https://openalex.org/I57201433"]},{"raw_affiliation_string":"Institute of Oncology Research","institution_ids":["https://openalex.org/I4210101830"]},{"raw_affiliation_string":"Faculty of Biomedical Sciences, Universit\u00e0 della Svizzera Italiana, Lugano 6962, Switzerland","institution_ids":["https://openalex.org/I57201433"]},{"raw_affiliation_string":"Institute of Oncology Research, Bellinzona 6500, Switzerland","institution_ids":["https://openalex.org/I4210101830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011590978","display_name":"Tesa Severson","orcid":"https://orcid.org/0000-0002-7568-4705","observed_orcids":["https://orcid.org/0000-0002-7568-4705"]},"institutions":[{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]},{"id":"https://openalex.org/I4210111138","display_name":"Oncode Institute","ror":"https://ror.org/01n92vv28","country_code":"NL","type":"education","lineage":["https://openalex.org/I4210111138"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Tesa M. Severson","raw_affiliation_strings":["Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute","Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute, Amsterdam 1066 CX, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute","institution_ids":["https://openalex.org/I2898336195","https://openalex.org/I4210111138"]},{"raw_affiliation_string":"Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute, Amsterdam 1066 CX, The Netherlands","institution_ids":["https://openalex.org/I2898336195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062641643","display_name":"Joseph C. Siefert","orcid":"https://orcid.org/0000-0001-5584-8672","observed_orcids":["https://orcid.org/0000-0001-5584-8672"]},"institutions":[{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]},{"id":"https://openalex.org/I4210111138","display_name":"Oncode Institute","ror":"https://ror.org/01n92vv28","country_code":"NL","type":"education","lineage":["https://openalex.org/I4210111138"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Joseph Siefert","raw_affiliation_strings":["Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute","Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute, Amsterdam 1066 CX, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute","institution_ids":["https://openalex.org/I2898336195","https://openalex.org/I4210111138"]},{"raw_affiliation_string":"Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute, Amsterdam 1066 CX, The Netherlands","institution_ids":["https://openalex.org/I2898336195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079690904","display_name":"Arianna Calcinotto","orcid":"https://orcid.org/0000-0003-1746-6424","observed_orcids":["https://orcid.org/0000-0003-1746-6424"]},"institutions":[{"id":"https://openalex.org/I4210101830","display_name":"Institute of Oncology Research","ror":"https://ror.org/01dpyn972","country_code":"CH","type":"facility","lineage":["https://openalex.org/I4210101830","https://openalex.org/I57201433"]},{"id":"https://openalex.org/I57201433","display_name":"Universit\u00e0 della Svizzera italiana","ror":"https://ror.org/03c4atk17","country_code":"CH","type":"education","lineage":["https://openalex.org/I57201433"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Arianna Calcinotto","raw_affiliation_strings":["Faculty of Biomedical Sciences, Universit\u00e0 della Svizzera Italiana","Institute of Oncology Research","Faculty of Biomedical Sciences, Universit\u00e0 della Svizzera Italiana, Lugano 6962, Switzerland","Institute of Oncology Research, Bellinzona 6500, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Biomedical Sciences, Universit\u00e0 della Svizzera Italiana","institution_ids":["https://openalex.org/I57201433"]},{"raw_affiliation_string":"Institute of Oncology Research","institution_ids":["https://openalex.org/I4210101830"]},{"raw_affiliation_string":"Faculty of Biomedical Sciences, Universit\u00e0 della Svizzera Italiana, Lugano 6962, Switzerland","institution_ids":["https://openalex.org/I57201433"]},{"raw_affiliation_string":"Institute of Oncology Research, Bellinzona 6500, Switzerland","institution_ids":["https://openalex.org/I4210101830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082921744","display_name":"Laki Buluwela","orcid":"https://orcid.org/0000-0001-6973-334X","observed_orcids":["https://orcid.org/0000-0001-6973-334X"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Laki Buluwela","raw_affiliation_strings":["Department of Surgery and Cancer, Imperial College London","Department of Surgery and Cancer, Imperial College London, London SW7 2BX, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0001-6973-334X","affiliations":[{"raw_affiliation_string":"Department of Surgery and Cancer, Imperial College London","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"Department of Surgery and Cancer, Imperial College London, London SW7 2BX, United Kingdom","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047242093","display_name":"Maria Donaldson Collier","orcid":"https://orcid.org/0000-0001-6403-6713","observed_orcids":["https://orcid.org/0000-0001-6403-6713"]},"institutions":[{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]},{"id":"https://openalex.org/I4210111138","display_name":"Oncode Institute","ror":"https://ror.org/01n92vv28","country_code":"NL","type":"education","lineage":["https://openalex.org/I4210111138"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Maria Donaldson Collier","raw_affiliation_strings":["Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute","Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute, Amsterdam 1066 CX, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute","institution_ids":["https://openalex.org/I2898336195","https://openalex.org/I4210111138"]},{"raw_affiliation_string":"Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute, Amsterdam 1066 CX, The Netherlands","institution_ids":["https://openalex.org/I2898336195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055145006","display_name":"Simak Ali","orcid":"https://orcid.org/0000-0002-1320-0816","observed_orcids":["https://orcid.org/0000-0002-1320-0816"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Simak Ali","raw_affiliation_strings":["Department of Surgery and Cancer, Imperial College London","Department of Surgery and Cancer, Imperial College London, London SW7 2BX, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery and Cancer, Imperial College London","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"Department of Surgery and Cancer, Imperial College London, London SW7 2BX, United Kingdom","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017933040","display_name":"Leonie S. Young","orcid":"https://orcid.org/0000-0002-4904-0367","observed_orcids":["https://orcid.org/0000-0002-4904-0367"]},"institutions":[{"id":"https://openalex.org/I142762351","display_name":"Royal College of Surgeons in Ireland","ror":"https://ror.org/01hxy9878","country_code":"IE","type":"education","lineage":["https://openalex.org/I142762351"]},{"id":"https://openalex.org/I2801846703","display_name":"Beaumont Hospital","ror":"https://ror.org/043mzjj67","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I2801846703"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Leonie Young","raw_affiliation_strings":["Beaumont Royal College of Surgeons in Ireland Cancer Centre, Beaumont Hospital","Endocrine Oncology Research Group, Department of Surgery, Royal College of Surgeons in Ireland, University of Medicine and Health Sciences","Beaumont Royal College of Surgeons in Ireland Cancer Centre, Beaumont Hospital, Dublin D09 V2N0, Ireland","Endocrine Oncology Research Group, Department of Surgery, Royal College of Surgeons in Ireland, University of Medicine and Health Sciences, Dublin D02 YN77, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beaumont Royal College of Surgeons in Ireland Cancer Centre, Beaumont Hospital","institution_ids":["https://openalex.org/I142762351","https://openalex.org/I2801846703"]},{"raw_affiliation_string":"Endocrine Oncology Research Group, Department of Surgery, Royal College of Surgeons in Ireland, University of Medicine and Health Sciences","institution_ids":["https://openalex.org/I142762351"]},{"raw_affiliation_string":"Beaumont Royal College of Surgeons in Ireland Cancer Centre, Beaumont Hospital, Dublin D09 V2N0, Ireland","institution_ids":["https://openalex.org/I142762351","https://openalex.org/I2801846703"]},{"raw_affiliation_string":"Endocrine Oncology Research Group, Department of Surgery, Royal College of Surgeons in Ireland, University of Medicine and Health Sciences, Dublin D02 YN77, Ireland","institution_ids":["https://openalex.org/I142762351"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010531211","display_name":"Jean-Philippe Paul. Theurillat","orcid":"https://orcid.org/0000-0003-0111-5937","observed_orcids":["https://orcid.org/0000-0003-0111-5937"]},"institutions":[{"id":"https://openalex.org/I4210101830","display_name":"Institute of Oncology Research","ror":"https://ror.org/01dpyn972","country_code":"CH","type":"facility","lineage":["https://openalex.org/I4210101830","https://openalex.org/I57201433"]},{"id":"https://openalex.org/I57201433","display_name":"Universit\u00e0 della Svizzera italiana","ror":"https://ror.org/03c4atk17","country_code":"CH","type":"education","lineage":["https://openalex.org/I57201433"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Jean-Philippe Theurillat","raw_affiliation_strings":["Faculty of Biomedical Sciences, Universit\u00e0 della Svizzera Italiana","Institute of Oncology Research","Faculty of Biomedical Sciences, Universit\u00e0 della Svizzera Italiana, Lugano 6962, Switzerland","Institute of Oncology Research, Bellinzona 6500, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Biomedical Sciences, Universit\u00e0 della Svizzera Italiana","institution_ids":["https://openalex.org/I57201433"]},{"raw_affiliation_string":"Institute of Oncology Research","institution_ids":["https://openalex.org/I4210101830"]},{"raw_affiliation_string":"Faculty of Biomedical Sciences, Universit\u00e0 della Svizzera Italiana, Lugano 6962, Switzerland","institution_ids":["https://openalex.org/I57201433"]},{"raw_affiliation_string":"Institute of Oncology Research, Bellinzona 6500, Switzerland","institution_ids":["https://openalex.org/I4210101830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089906606","display_name":"Damir Vare\u0161lija","orcid":"https://orcid.org/0000-0003-1000-0357","observed_orcids":["https://orcid.org/0000-0003-1000-0357"]},"institutions":[{"id":"https://openalex.org/I142762351","display_name":"Royal College of Surgeons in Ireland","ror":"https://ror.org/01hxy9878","country_code":"IE","type":"education","lineage":["https://openalex.org/I142762351"]},{"id":"https://openalex.org/I2801846703","display_name":"Beaumont Hospital","ror":"https://ror.org/043mzjj67","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I2801846703"]}],"countries":["IE"],"is_corresponding":true,"raw_author_name":"Damir Vare\u0161lija","raw_affiliation_strings":["Beaumont Royal College of Surgeons in Ireland Cancer Centre, Beaumont Hospital","School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, University of Medicine and Health Sciences","Beaumont Royal College of Surgeons in Ireland Cancer Centre, Beaumont Hospital, Dublin D09 V2N0, Ireland","School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, University of Medicine and Health Sciences, Dublin D02 YN77, Ireland"],"raw_orcid":"https://orcid.org/0000-0003-1000-0357","affiliations":[{"raw_affiliation_string":"Beaumont Royal College of Surgeons in Ireland Cancer Centre, Beaumont Hospital","institution_ids":["https://openalex.org/I142762351","https://openalex.org/I2801846703"]},{"raw_affiliation_string":"School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, University of Medicine and Health Sciences","institution_ids":["https://openalex.org/I142762351"]},{"raw_affiliation_string":"Beaumont Royal College of Surgeons in Ireland Cancer Centre, Beaumont Hospital, Dublin D09 V2N0, Ireland","institution_ids":["https://openalex.org/I142762351","https://openalex.org/I2801846703"]},{"raw_affiliation_string":"School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, University of Medicine and Health Sciences, Dublin D02 YN77, Ireland","institution_ids":["https://openalex.org/I142762351"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006708192","display_name":"Wilbert T. Zwart","orcid":"https://orcid.org/0000-0002-9823-7289","observed_orcids":["https://orcid.org/0000-0002-9823-7289"]},"institutions":[{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]},{"id":"https://openalex.org/I4210111138","display_name":"Oncode Institute","ror":"https://ror.org/01n92vv28","country_code":"NL","type":"education","lineage":["https://openalex.org/I4210111138"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Wilbert Zwart","raw_affiliation_strings":["Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute","Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute, Amsterdam 1066 CX, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0002-9823-7289","affiliations":[{"raw_affiliation_string":"Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute","institution_ids":["https://openalex.org/I2898336195","https://openalex.org/I4210111138"]},{"raw_affiliation_string":"Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute, Amsterdam 1066 CX, The Netherlands","institution_ids":["https://openalex.org/I2898336195"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5006708192","https://openalex.org/A5010181844","https://openalex.org/A5085704728","https://openalex.org/A5089906606"],"corresponding_institution_ids":["https://openalex.org/I142762351","https://openalex.org/I2801846703","https://openalex.org/I2898336195","https://openalex.org/I4210111138"],"apc_list":null,"apc_paid":null,"fwci":5.0253,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.95875252,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"122","issue":"33","first_page":"e2507571122","last_page":"e2507571122"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9702000021934509,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9702000021934509,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12534","display_name":"Protein Degradation and Inhibitors","score":0.009700000286102295,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.004800000227987766,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trim24","display_name":"TRIM24","score":1.0},{"id":"https://openalex.org/keywords/endocrine-resistance","display_name":"endocrine therapy resistance","score":0.7549999952316284},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.7820000052452087},{"id":"https://openalex.org/keywords/estrogen-receptor-alpha","display_name":"estrogen receptor alpha","score":0.996999979019165},{"id":"https://openalex.org/keywords/protein-degraders","display_name":"protein degraders","score":0.6790000200271606},{"id":"https://openalex.org/keywords/esr1-mutations","display_name":"ESR1 mutations","score":0.746999979019165},{"id":"https://openalex.org/keywords/histone-acetylation","display_name":"histone acetylation","score":0.7929999828338623},{"id":"https://openalex.org/keywords/h3k27ac","display_name":"H3K27ac","score":0.996999979019165},{"id":"https://openalex.org/keywords/chromatin-interactions","display_name":"chromatin interactions","score":0.9120000004768372},{"id":"https://openalex.org/keywords/tumor-organoids","display_name":"tumor organoids","score":0.7950000166893005},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.6269999742507935}],"concepts":[{"id":"https://openalex.org/C172313692","wikidata":"https://www.wikidata.org/wiki/Q14902310","display_name":"Estrogen receptor alpha","level":5,"score":0.628337025642395},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5945165157318115},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.555526852607727},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.551559567451477},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.5442039370536804},{"id":"https://openalex.org/C46699223","wikidata":"https://www.wikidata.org/wiki/Q11078","display_name":"Endocrine system","level":3,"score":0.5149967670440674},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.4214106798171997},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.38303375244140625},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17829829454421997},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14588522911071777},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.12475147843360901},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.11618322134017944}],"mesh":[{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018931","descriptor_name":"Antineoplastic Agents, Hormonal","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047628","descriptor_name":"Estrogen Receptor alpha","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D047628","descriptor_name":"Estrogen Receptor alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D061986","descriptor_name":"MCF-7 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1073/pnas.2507571122","doi":"https://doi.org/10.1073/pnas.2507571122","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.2507571122","pdf_url":"https://www.pnas.org/doi/pdf/10.1073/pnas.2507571122","source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:11185860","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12377727","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:12377727","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12377727","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:40815626","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40815626","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"pmh:oai:lenus.ie:10147/646945","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/10147/646945","pdf_url":null,"source":{"id":"https://openalex.org/S4306401756","display_name":"Lenus, The Irish Health Repository (Dr Steevens Hospital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1073/pnas.2507571122","doi":"https://doi.org/10.1073/pnas.2507571122","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.2507571122","pdf_url":"https://www.pnas.org/doi/pdf/10.1073/pnas.2507571122","source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8999999761581421}],"study_designs":[],"awards":[{"id":"https://openalex.org/G251633868","display_name":null,"funder_award_id":"016.156.401","funder_id":"https://openalex.org/F4320321007","funder_display_name":"ZonMw"},{"id":"https://openalex.org/G2754367083","display_name":null,"funder_award_id":"C37/A18784","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G2804443655","display_name":null,"funder_award_id":"20/FFP-P/8597","funder_id":"https://openalex.org/F8766430056","funder_display_name":"Research Ireland"},{"id":"https://openalex.org/G3565105754","display_name":null,"funder_award_id":"2019AugSF1310","funder_id":"https://openalex.org/F4320311542","funder_display_name":"Breast Cancer Now"},{"id":"https://openalex.org/G3642646312","display_name":null,"funder_award_id":"813599","funder_id":"https://openalex.org/F4320338453","funder_display_name":"HORIZON EUROPE European Research Council"},{"id":"https://openalex.org/G5277255732","display_name":"Training network in drug discovery targeting TRIM Ubiquitin ligases in disease","funder_award_id":"813599","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G5571299875","display_name":null,"funder_award_id":"9171640","funder_id":"https://openalex.org/F4320322777","funder_display_name":"KWF Kankerbestrijding"},{"id":"https://openalex.org/G5589420786","display_name":null,"funder_award_id":"19/FFP/6443","funder_id":"https://openalex.org/F8766430056","funder_display_name":"Research Ireland"},{"id":"https://openalex.org/G5651567979","display_name":null,"funder_award_id":"2014MayPR234","funder_id":"https://openalex.org/F4320311542","funder_display_name":"Breast Cancer Now"},{"id":"https://openalex.org/G5942170794","display_name":null,"funder_award_id":"2021JulyPCC1460","funder_id":"https://openalex.org/F4320311542","funder_display_name":"Breast Cancer Now"},{"id":"https://openalex.org/G668351946","display_name":null,"funder_award_id":"18239A01","funder_id":"https://openalex.org/F4320331748","funder_display_name":"Breast Cancer Ireland"},{"id":"https://openalex.org/G8124784555","display_name":null,"funder_award_id":"23/SPP/11783","funder_id":"https://openalex.org/F8766430056","funder_display_name":"Research Ireland"}],"funders":[{"id":"https://openalex.org/F4320307770","display_name":"AstraZeneca","ror":"https://ror.org/04r9x1a08"},{"id":"https://openalex.org/F4320311542","display_name":"Breast Cancer Now","ror":"https://ror.org/02qa92s63"},{"id":"https://openalex.org/F4320319985","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320321007","display_name":"ZonMw","ror":"https://ror.org/01yaj9a77"},{"id":"https://openalex.org/F4320322777","display_name":"KWF Kankerbestrijding","ror":"https://ror.org/0368jnd28"},{"id":"https://openalex.org/F4320331748","display_name":"Breast Cancer Ireland","ror":"https://ror.org/034kj0g46"},{"id":"https://openalex.org/F4320338453","display_name":"HORIZON EUROPE European Research Council","ror":null},{"id":"https://openalex.org/F8766430056","display_name":"Research Ireland","ror":"https://ror.org/010t7sr36"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4413258043.pdf","grobid_xml":"https://content.openalex.org/works/W4413258043.grobid-xml"},"referenced_works_count":67,"referenced_works":["https://openalex.org/W1836603722","https://openalex.org/W1969490406","https://openalex.org/W1977295091","https://openalex.org/W1981030303","https://openalex.org/W1990153910","https://openalex.org/W2002262418","https://openalex.org/W2005895632","https://openalex.org/W2011810742","https://openalex.org/W2017297735","https://openalex.org/W2024180698","https://openalex.org/W2030631005","https://openalex.org/W2031211461","https://openalex.org/W2035618305","https://openalex.org/W2051360924","https://openalex.org/W2059979986","https://openalex.org/W2062364357","https://openalex.org/W2080374319","https://openalex.org/W2085615781","https://openalex.org/W2102904139","https://openalex.org/W2103441770","https://openalex.org/W2108234281","https://openalex.org/W2125362831","https://openalex.org/W2126773860","https://openalex.org/W2132776799","https://openalex.org/W2134526812","https://openalex.org/W2135060880","https://openalex.org/W2142780841","https://openalex.org/W2154402901","https://openalex.org/W2160402926","https://openalex.org/W2179438025","https://openalex.org/W2183407416","https://openalex.org/W2262681364","https://openalex.org/W2339784500","https://openalex.org/W2341539131","https://openalex.org/W2406478006","https://openalex.org/W2475032329","https://openalex.org/W2538138106","https://openalex.org/W2727352277","https://openalex.org/W2763006871","https://openalex.org/W2765643657","https://openalex.org/W2767600184","https://openalex.org/W2792397649","https://openalex.org/W2806700712","https://openalex.org/W2890343309","https://openalex.org/W2891700678","https://openalex.org/W2901027836","https://openalex.org/W2937299982","https://openalex.org/W2964849163","https://openalex.org/W2975561619","https://openalex.org/W3011706593","https://openalex.org/W3042260087","https://openalex.org/W3045747004","https://openalex.org/W3104389503","https://openalex.org/W3116128628","https://openalex.org/W3198683038","https://openalex.org/W3208691473","https://openalex.org/W3209656321","https://openalex.org/W4205379795","https://openalex.org/W4214507610","https://openalex.org/W4220930582","https://openalex.org/W4225539572","https://openalex.org/W4231356616","https://openalex.org/W4285799995","https://openalex.org/W4286797705","https://openalex.org/W4298856955","https://openalex.org/W4300690596","https://openalex.org/W4366237435"],"related_works":["https://openalex.org/W4285731927","https://openalex.org/W2913168907","https://openalex.org/W4226092132","https://openalex.org/W3046518781","https://openalex.org/W204695742","https://openalex.org/W4391972380","https://openalex.org/W2016820476","https://openalex.org/W2324836521","https://openalex.org/W7147583234","https://openalex.org/W2089001307"],"abstract_inverted_index":{"While":[0],"Estrogen":[1],"receptor":[2],"alpha":[3],"(ER\u03b1)+":[4],"breast":[5,198],"cancer":[6],"treatment":[7,192],"is":[8,15,19],"considered":[9],"effective,":[10],"resistance":[11,197],"to":[12,33,72],"endocrine":[13,49,196],"therapy":[14],"common.":[16],"Since":[17],"ER\u03b1":[18,35,60,66,70,74,177],"still":[20],"the":[21,59,150,156,171,176,191],"main":[22],"driver":[23],"in":[24,48,155,190],"most":[25],"therapy-resistant":[26],"tumors,":[27],"alternative":[28],"therapeutic":[29,46,188],"strategies":[30],"are":[31],"needed":[32],"disrupt":[34],"transcriptional":[36,61,96,112,178],"activity.":[37],"In":[38],"this":[39],"work,":[40],"we":[41,147],"position":[42],"TRIM24":[43,63,93,153,165,184],"as":[44,54,130,132,166,185],"a":[45,55,105,167,186],"target":[47],"resistance,":[50],"given":[51],"its":[52],"role":[53],"key":[56],"component":[57,169],"of":[58,81,92,152,175,183,193],"complex.":[62],"interacts":[64],"with":[65,180],"and":[67,77,87,98,114,158,173,195],"other":[68],"well-known":[69],"cofactors":[71],"facilitate":[73],"chromatin":[75],"interactions":[76],"allows":[78],"for":[79,170],"maintenance":[80],"active":[82],"histone":[83],"marks":[84],"including":[85],"H3K23ac":[86],"H3K27ac.":[88],"Consequently,":[89],"genetic":[90],"perturbation":[91,182],"abrogates":[94],"ER\u03b1-driven":[95,111],"programs":[97],"reduces":[99],"tumor":[100],"cell":[101,123,133],"proliferation":[102],"capacity.":[103],"Using":[104],"recently":[106],"developed":[107],"degrader":[108,154],"targeting":[109],"TRIM24,":[110],"output":[113],"growth":[115],"were":[116],"blocked,":[117],"effectively":[118],"treating":[119],"not":[120],"only":[121],"endocrine-responsive":[122,157],"lines":[124],"but":[125],"also":[126],"drug-resistant":[127],"derivatives":[128],"thereof":[129],"well":[131],"line":[134],"models":[135],"bearing":[136],"activating":[137],"ESR1":[138],"point":[139],"mutations.":[140],"Finally,":[141],"using":[142],"human":[143],"tumor-derived":[144],"organoid":[145],"models,":[146],"could":[148],"show":[149],"efficacy":[151],"-resistant":[159],"setting.":[160],"Overall,":[161],"our":[162],"study":[163],"positions":[164],"central":[168],"integrity":[172],"activity":[174],"complex,":[179],"degradation-mediated":[181],"promising":[187],"avenue":[189],"primary":[194],"cancer.":[199]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-10-10T00:00:00"}