{"id":"https://openalex.org/W4413242549","doi":"https://doi.org/10.21203/rs.3.rs-7314652/v1","title":"Anti-mitochondrial antibody-positive myositis: A systematic review of 123 cases","display_name":"Anti-mitochondrial antibody-positive myositis: A systematic review of 123 cases","publication_year":2025,"publication_date":"2025-08-08","ids":{"openalex":"https://openalex.org/W4413242549","doi":"https://doi.org/10.21203/rs.3.rs-7314652/v1"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-7314652/v1","doi":"https://doi.org/10.21203/rs.3.rs-7314652/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-7314652/v1","pdf_url":"https://www.researchsquare.com/article/rs-7314652/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-7314652/latest.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038371392","display_name":"Tomoyuki Mutoh","orcid":"https://orcid.org/0000-0001-5995-8609","observed_orcids":["https://orcid.org/0000-0001-5995-8609"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Tomoyuki Mutoh","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5995-8609","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080267891","display_name":"Mikihiro Takahashi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mikihiro Takahashi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5140012151","display_name":"Hiroshi Fujii","orcid":"https://orcid.org/0000-0002-6885-6492","observed_orcids":["https://orcid.org/0000-0002-6885-6492"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hiroshi Fujii","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6885-6492","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5038371392"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11724","display_name":"Inflammatory Myopathies and Dermatomyositis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11724","display_name":"Inflammatory Myopathies and Dermatomyositis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11271","display_name":"Myasthenia Gravis and Thymoma","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11576","display_name":"IgG4-Related and Inflammatory Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/idiopathic-inflammatory-myopathies","display_name":"idiopathic inflammatory myopathies","score":0.9909999966621399},{"id":"https://openalex.org/keywords/primary-biliary-cholangitis","display_name":"primary biliary cirrhosis","score":0.949999988079071},{"id":"https://openalex.org/keywords/cardiac-involvement","display_name":"cardiac involvement","score":0.9490000009536743},{"id":"https://openalex.org/keywords/cardiomyopathy","display_name":"cardiomyopathy","score":0.7129999995231628},{"id":"https://openalex.org/keywords/myocarditis","display_name":"myocarditis","score":0.7570000290870667},{"id":"https://openalex.org/keywords/pulmonary-hypertension","display_name":"pulmonary hypertension","score":0.9309999942779541},{"id":"https://openalex.org/keywords/muscle-pathology","display_name":"muscle pathology","score":0.8320000171661377},{"id":"https://openalex.org/keywords/necrotizing-autoimmune-myopathy","display_name":"necrotizing myopathy","score":0.8240000009536743},{"id":"https://openalex.org/keywords/glucocorticoids","display_name":"glucocorticoids","score":0.6579999923706055},{"id":"https://openalex.org/keywords/immunosuppressive-therapy","display_name":"immunosuppressive therapy","score":0.9229999780654907},{"id":"https://openalex.org/keywords/recurrence","display_name":"recurrence","score":0.7400000095367432},{"id":"https://openalex.org/keywords/prognosis","display_name":"prognosis","score":0.3970000147819519}],"concepts":[{"id":"https://openalex.org/C2781232998","wikidata":"https://www.wikidata.org/wiki/Q1433212","display_name":"Myositis","level":2,"score":0.7203838229179382},{"id":"https://openalex.org/C2778751314","wikidata":"https://www.wikidata.org/wiki/Q681160","display_name":"Dermatomyositis","level":2,"score":0.712605357170105},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7066115140914917},{"id":"https://openalex.org/C2780875844","wikidata":"https://www.wikidata.org/wiki/Q186235","display_name":"Myocarditis","level":2,"score":0.5334487557411194},{"id":"https://openalex.org/C2777327098","wikidata":"https://www.wikidata.org/wiki/Q1848471","display_name":"Inclusion body myositis","level":3,"score":0.5320326685905457},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5309150815010071},{"id":"https://openalex.org/C2776418732","wikidata":"https://www.wikidata.org/wiki/Q270421","display_name":"Muscle weakness","level":2,"score":0.46498745679855347},{"id":"https://openalex.org/C2781172350","wikidata":"https://www.wikidata.org/wiki/Q194520","display_name":"Atrophy","level":2,"score":0.44428128004074097},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.43494734168052673},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.42050105333328247},{"id":"https://openalex.org/C2778797674","wikidata":"https://www.wikidata.org/wiki/Q847583","display_name":"Cardiomyopathy","level":3,"score":0.41410568356513977},{"id":"https://openalex.org/C2777300911","wikidata":"https://www.wikidata.org/wiki/Q692536","display_name":"Myopathy","level":2,"score":0.4103606939315796},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.33500510454177856}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21203/rs.3.rs-7314652/v1","doi":"https://doi.org/10.21203/rs.3.rs-7314652/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-7314652/v1","pdf_url":"https://www.researchsquare.com/article/rs-7314652/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-7314652/v1","doi":"https://doi.org/10.21203/rs.3.rs-7314652/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-7314652/v1","pdf_url":"https://www.researchsquare.com/article/rs-7314652/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4413242549.pdf","grobid_xml":"https://content.openalex.org/works/W4413242549.grobid-xml"},"referenced_works_count":113,"referenced_works":["https://openalex.org/W93348877","https://openalex.org/W102470621","https://openalex.org/W116846885","https://openalex.org/W184510336","https://openalex.org/W1277162210","https://openalex.org/W1751141552","https://openalex.org/W1969242938","https://openalex.org/W1969661146","https://openalex.org/W1970292239","https://openalex.org/W1974551350","https://openalex.org/W1978970245","https://openalex.org/W2000164636","https://openalex.org/W2003831250","https://openalex.org/W2014182808","https://openalex.org/W2027904131","https://openalex.org/W2044034386","https://openalex.org/W2073400868","https://openalex.org/W2088165444","https://openalex.org/W2090268852","https://openalex.org/W2100230942","https://openalex.org/W2115404234","https://openalex.org/W2120215326","https://openalex.org/W2134758619","https://openalex.org/W2139954704","https://openalex.org/W2142895512","https://openalex.org/W2151179012","https://openalex.org/W2199442716","https://openalex.org/W2293283203","https://openalex.org/W2314311014","https://openalex.org/W2321119904","https://openalex.org/W2400667797","https://openalex.org/W2574831313","https://openalex.org/W2601311459","https://openalex.org/W2605729742","https://openalex.org/W2606356293","https://openalex.org/W2624684883","https://openalex.org/W2739049522","https://openalex.org/W2742891217","https://openalex.org/W2753306570","https://openalex.org/W2765743865","https://openalex.org/W2767537151","https://openalex.org/W2790256544","https://openalex.org/W2792190570","https://openalex.org/W2800436630","https://openalex.org/W2802947396","https://openalex.org/W2804510621","https://openalex.org/W2809765643","https://openalex.org/W2886703787","https://openalex.org/W2900497438","https://openalex.org/W2903759577","https://openalex.org/W2936316583","https://openalex.org/W2942788663","https://openalex.org/W2956729883","https://openalex.org/W2964608316","https://openalex.org/W2979577092","https://openalex.org/W2990308020","https://openalex.org/W2990470028","https://openalex.org/W3019985134","https://openalex.org/W3041316230","https://openalex.org/W3048678638","https://openalex.org/W3086781512","https://openalex.org/W3092415006","https://openalex.org/W3097258587","https://openalex.org/W3108976510","https://openalex.org/W3115201520","https://openalex.org/W3120905913","https://openalex.org/W3136330022","https://openalex.org/W3155160739","https://openalex.org/W3160991671","https://openalex.org/W3169149580","https://openalex.org/W3170009880","https://openalex.org/W3174985973","https://openalex.org/W3197035772","https://openalex.org/W3203856527","https://openalex.org/W3214386618","https://openalex.org/W4200287033","https://openalex.org/W4206020284","https://openalex.org/W4226048265","https://openalex.org/W4226096898","https://openalex.org/W4280499292","https://openalex.org/W4292416919","https://openalex.org/W4293583386","https://openalex.org/W4294839604","https://openalex.org/W4295008070","https://openalex.org/W4295836717","https://openalex.org/W4318620449","https://openalex.org/W4323364122","https://openalex.org/W4362450175","https://openalex.org/W4364361669","https://openalex.org/W4367369488","https://openalex.org/W4372357707","https://openalex.org/W4385250830","https://openalex.org/W4386583207","https://openalex.org/W4386843365","https://openalex.org/W4388593062","https://openalex.org/W4391305077","https://openalex.org/W4392295885","https://openalex.org/W4393024908","https://openalex.org/W4393497099","https://openalex.org/W4393993621","https://openalex.org/W4394568065","https://openalex.org/W4397042039","https://openalex.org/W4400158508","https://openalex.org/W4400422182","https://openalex.org/W4401418028","https://openalex.org/W4403426616","https://openalex.org/W4403825901","https://openalex.org/W4403900939","https://openalex.org/W4404814325","https://openalex.org/W4406711272","https://openalex.org/W4407593311","https://openalex.org/W4408700772","https://openalex.org/W4409513921"],"related_works":["https://openalex.org/W3169149580","https://openalex.org/W2055915731","https://openalex.org/W4387302487","https://openalex.org/W2518171840","https://openalex.org/W7118178122","https://openalex.org/W2624684883","https://openalex.org/W2754115760","https://openalex.org/W4387302507","https://openalex.org/W4407593311","https://openalex.org/W2054439074"],"abstract_inverted_index":{"Abstract":[0],"Anti-mitochondrial":[1],"antibody":[2],"(AMA)-positive":[3],"myositis":[4,202],"is":[5],"an":[6,204],"under-recognized":[7],"subtype":[8],"of":[9,27,82,188,246],"idiopathic":[10],"inflammatory":[11],"myopathies":[12],"(IIMs).":[13],"A":[14],"systematic":[15],"literature":[16],"review":[17],"was":[18,43],"conducted":[19],"to":[20,37,231],"clarify":[21],"the":[22],"clinical":[23,244],"and":[24,31,40,69,77,102,114,126,141,158,165,172,209,224,242],"pathological":[25],"features":[26],"AMA-positive":[28,201,247],"myositis.":[29,248],"PubMed/Medline":[30],"Scopus":[32],"databases":[33],"were":[34,50,168],"searched":[35],"up":[36],"April":[38],"2025,":[39],"individual":[41],"data":[42],"analyzed.":[44],"From":[45],"50":[46],"articles,":[47],"123":[48],"patients":[49],"included":[51],"(age":[52],"54.5":[53],"years;":[54],"female":[55],"66.7%;":[56],"disease":[57,98,235],"duration":[58],"18.0":[59],"months),":[60],"with":[61,96,110,221],"limb":[62],"muscle":[63,67,147],"weakness,":[64],"axial":[65],"myopathy,":[66],"atrophy,":[68],"respiratory":[70,100],"failure":[71],"reported":[72],"in":[73,119,146,170,178,185,195,239],"90.7%,":[74],"64.9%,":[75],"58.4%,":[76],"36.7%,":[78],"respectively.":[79,174],"Coexistence":[80],"(58.5%)":[81],"cardiac":[83],"involvements":[84],"(CIs)":[85],"(arrhythmias,":[86],"94.1%;":[87],"cardiomyopathy,":[88],"74.6%;":[89],"myocarditis,":[90],"45.0%;":[91],"pulmonary":[92],"hypertension,":[93],"40.0%)":[94],"correlated":[95,109],"long":[97],"duration,":[99],"disturbance,":[101],"primary":[103],"biliary":[104],"cholangitis":[105],"(PBC),":[106],"but":[107,134],"inversely":[108],"initial":[111],"muscular":[112,223],"presentations":[113],"dermatomyositis-specific":[115],"rash.":[116],"PBC":[117,133,216],"coexisted":[118],"52.5%,":[120],"who":[121],"demonstrated":[122],"significantly":[123],"more":[124],"CIs":[125,183,218],"extra-muscular":[127,225],"autoimmune":[128],"disorders":[129],"than":[130],"those":[131],"without":[132],"fewer":[135],"cancers.":[136],"Muscle":[137,175],"histopathology":[138],"detected":[139],"necrotic":[140],"regenerating":[142],"fibers":[143],"(87.3%),":[144],"variation":[145],"fiber":[148],"size":[149],"(83.0%),":[150],"major":[151],"histocompatibility":[152],"complex":[153,161],"class":[154],"I":[155],"expression":[156],"(72.7%),":[157],"membrane":[159],"attack":[160],"deposition":[162],"(65.5%).":[163],"Glucocorticoids":[164],"immunomodulatory/immunosuppressive":[166],"agents":[167],"introduced":[169],"92.1%":[171],"39.1%,":[173],"strength":[176],"improved":[177],"77.5%;":[179],"however,":[180],"20.7%":[181],"relapsed.":[182],"deteriorated":[184],"46.0%,":[186],"44.1%":[187],"which":[189,227],"required":[190],"electronic":[191],"devices.":[192],"Death":[193],"occurred":[194],"7.3%":[196],"within":[197],"15.0":[198],"median":[199],"months.":[200],"represents":[203],"independent":[205],"phenotype":[206],"among":[207],"IIMs":[208],"pathologically":[210],"immune-mediated":[211],"necrotizing":[212],"myopathy-like":[213],"findings.":[214],"Concurrent":[215],"or":[217],"are":[219,228],"associated":[220],"characteristic":[222],"domains,":[226],"sometimes":[229],"difficult":[230],"manage.":[232],"Understanding":[233],"unique":[234],"behaviors":[236],"may":[237],"aid":[238],"early":[240],"diagnosis":[241],"improve":[243],"management":[245]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2025-10-10T00:00:00"}
