{"id":"https://openalex.org/W4413235697","doi":"https://doi.org/10.1016/j.ejmech.2025.118045","title":"ALK5 kinase inhibitors in drug discovery: Structural insights and therapeutic applications","display_name":"ALK5 kinase inhibitors in drug discovery: Structural insights and therapeutic applications","publication_year":2025,"publication_date":"2025-08-09","ids":{"openalex":"https://openalex.org/W4413235697","doi":"https://doi.org/10.1016/j.ejmech.2025.118045","pmid":"https://pubmed.ncbi.nlm.nih.gov/40865145"},"language":"en","primary_location":{"id":"doi:10.1016/j.ejmech.2025.118045","doi":"https://doi.org/10.1016/j.ejmech.2025.118045","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ejmech.2025.118045","pdf_url":null,"source":{"id":"https://openalex.org/S4210169613","display_name":"European Journal of Medicinal Chemistry","issn_l":"0223-5234","issn":["0223-5234","1768-3254"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025279119","display_name":"Fang-Yan Guo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1793135","display_name":"Yanbian University","ror":"https://ror.org/039xnh269","country_code":"CN","type":"education","lineage":["https://openalex.org/I1793135"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fang-Yan Guo","raw_affiliation_strings":["Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, College of Pharmacy, Yanbian University, Yanji, 133002, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, College of Pharmacy, Yanbian University, Yanji, 133002, China","institution_ids":["https://openalex.org/I1793135"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111067219","display_name":"Siqi Li","orcid":"https://orcid.org/0000-0002-6474-950X","observed_orcids":["https://orcid.org/0000-0002-6474-950X"]},"institutions":[{"id":"https://openalex.org/I1793135","display_name":"Yanbian University","ror":"https://ror.org/039xnh269","country_code":"CN","type":"education","lineage":["https://openalex.org/I1793135"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Siqi Li","raw_affiliation_strings":["Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, College of Pharmacy, Yanbian University, Yanji, 133002, China. Electronic address: lisiqi@ybu.edu.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, College of Pharmacy, Yanbian University, Yanji, 133002, China. Electronic address: lisiqi@ybu.edu.cn","institution_ids":["https://openalex.org/I1793135"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101904918","display_name":"Changhao Zhang","orcid":"https://orcid.org/0009-0005-1564-1876","observed_orcids":["https://orcid.org/0009-0005-1564-1876","https://orcid.org/0000-0002-3923-1186"]},"institutions":[{"id":"https://openalex.org/I1793135","display_name":"Yanbian University","ror":"https://ror.org/039xnh269","country_code":"CN","type":"education","lineage":["https://openalex.org/I1793135"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Changhao Zhang","raw_affiliation_strings":["Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, College of Pharmacy, Yanbian University, Yanji, 133002, China. Electronic address: zhangch@ybu.edu.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, College of Pharmacy, Yanbian University, Yanji, 133002, China. Electronic address: zhangch@ybu.edu.cn","institution_ids":["https://openalex.org/I1793135"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028991867","display_name":"Cheng Hua Jin","orcid":"https://orcid.org/0000-0001-5534-4845","observed_orcids":["https://orcid.org/0000-0001-5534-4845"]},"institutions":[{"id":"https://openalex.org/I1793135","display_name":"Yanbian University","ror":"https://ror.org/039xnh269","country_code":"CN","type":"education","lineage":["https://openalex.org/I1793135"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Cheng-Hua Jin","raw_affiliation_strings":["Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, College of Pharmacy, Yanbian University, Yanji, 133002, China. Electronic address: jinchenghua@ybu.edu.cn"],"raw_orcid":"https://orcid.org/0000-0001-5534-4845","affiliations":[{"raw_affiliation_string":"Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, College of Pharmacy, Yanbian University, Yanji, 133002, China. Electronic address: jinchenghua@ybu.edu.cn","institution_ids":["https://openalex.org/I1793135"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5028991867","https://openalex.org/A5101904918","https://openalex.org/A5111067219"],"corresponding_institution_ids":["https://openalex.org/I1793135"],"apc_list":{"value":4650,"currency":"USD","value_usd":4650},"apc_paid":null,"fwci":0.3162,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.33243073,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":98},"biblio":{"volume":"299","issue":null,"first_page":"118045","last_page":"118045"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tgf-beta-signaling","display_name":"TGF-beta signaling","score":0.8949999809265137},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.8889999985694885},{"id":"https://openalex.org/keywords/antifibrotic-agents","display_name":"antifibrotic agents","score":0.8650000095367432},{"id":"https://openalex.org/keywords/anticancer-agents","display_name":"anticancer agents","score":0.8429999947547913},{"id":"https://openalex.org/keywords/natural-product-inhibitors","display_name":"natural product inhibitors","score":0.5210000276565552},{"id":"https://openalex.org/keywords/synthetic-inhibitors","display_name":"synthetic inhibitors","score":0.6060000061988831},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.9100000262260437},{"id":"https://openalex.org/keywords/pharmacodynamics","display_name":"pharmacodynamics","score":0.9279999732971191},{"id":"https://openalex.org/keywords/cardiotoxicity","display_name":"cardiotoxicity","score":0.9769999980926514},{"id":"https://openalex.org/keywords/drug-design","display_name":"drug design","score":0.5870000123977661},{"id":"https://openalex.org/keywords/fibrosis","display_name":"fibrosis","score":0.7310000061988831}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8654846549034119},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.7809370756149292},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5597765445709229},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.4664347171783447},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4379958212375641},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.361208975315094},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2452717423439026},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000077293","descriptor_name":"Receptor, Transforming Growth Factor-beta Type I","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D000077293","descriptor_name":"Receptor, Transforming Growth Factor-beta Type I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.ejmech.2025.118045","doi":"https://doi.org/10.1016/j.ejmech.2025.118045","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ejmech.2025.118045","pdf_url":null,"source":{"id":"https://openalex.org/S4210169613","display_name":"European Journal of Medicinal Chemistry","issn_l":"0223-5234","issn":["0223-5234","1768-3254"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:40865145","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40865145","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of medicinal chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2760690805","display_name":null,"funder_award_id":"82160741","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7176804487","display_name":"\u57fa\u4e8e\u7ed3\u6784\u7684\u65b0\u578bALK5\u6291\u5236\u5242\u7684\u8bbe\u8ba1\u3001\u5408\u6210\u53ca\u5176\u6297\u809d\u7ea4\u7ef4\u5316\u6d3b\u6027\u7814\u7a76","funder_award_id":"82060623","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":140,"referenced_works":["https://openalex.org/W1700691315","https://openalex.org/W1800636867","https://openalex.org/W1815438782","https://openalex.org/W1942897646","https://openalex.org/W1967582330","https://openalex.org/W1971730330","https://openalex.org/W1971792707","https://openalex.org/W1973825719","https://openalex.org/W1980095460","https://openalex.org/W1981410750","https://openalex.org/W1986414754","https://openalex.org/W1987449859","https://openalex.org/W1998387253","https://openalex.org/W1999192620","https://openalex.org/W2000977869","https://openalex.org/W2001195644","https://openalex.org/W2003719487","https://openalex.org/W2011312875","https://openalex.org/W2020745511","https://openalex.org/W2023870504","https://openalex.org/W2028767073","https://openalex.org/W2034249923","https://openalex.org/W2039220241","https://openalex.org/W2040262650","https://openalex.org/W2040381937","https://openalex.org/W2042121916","https://openalex.org/W2047914041","https://openalex.org/W2058182256","https://openalex.org/W2065096738","https://openalex.org/W2072927882","https://openalex.org/W2078288720","https://openalex.org/W2082502327","https://openalex.org/W2086727687","https://openalex.org/W2088393212","https://openalex.org/W2092537142","https://openalex.org/W2110127190","https://openalex.org/W2126227296","https://openalex.org/W2134807618","https://openalex.org/W2134928614","https://openalex.org/W2135596200","https://openalex.org/W2137842496","https://openalex.org/W2138302880","https://openalex.org/W2140740750","https://openalex.org/W2150548551","https://openalex.org/W2156668607","https://openalex.org/W2160583073","https://openalex.org/W2163797065","https://openalex.org/W2172546656","https://openalex.org/W2302011199","https://openalex.org/W2346141251","https://openalex.org/W2417972854","https://openalex.org/W2468291556","https://openalex.org/W2487308871","https://openalex.org/W2537197812","https://openalex.org/W2573708441","https://openalex.org/W2580021216","https://openalex.org/W2596387485","https://openalex.org/W2604349752","https://openalex.org/W2619527359","https://openalex.org/W2711258373","https://openalex.org/W2739623064","https://openalex.org/W2752706970","https://openalex.org/W2763265928","https://openalex.org/W2785803176","https://openalex.org/W2785897149","https://openalex.org/W2792661655","https://openalex.org/W2799656331","https://openalex.org/W2807263356","https://openalex.org/W2881438881","https://openalex.org/W2897662141","https://openalex.org/W2904214782","https://openalex.org/W2907447362","https://openalex.org/W2912331311","https://openalex.org/W2949175487","https://openalex.org/W2953396229","https://openalex.org/W2954119768","https://openalex.org/W2957400139","https://openalex.org/W2979416763","https://openalex.org/W2989285795","https://openalex.org/W3003926961","https://openalex.org/W3004981835","https://openalex.org/W3008198347","https://openalex.org/W3009892656","https://openalex.org/W3011364584","https://openalex.org/W3022322639","https://openalex.org/W3034236188","https://openalex.org/W3111278897","https://openalex.org/W3119664087","https://openalex.org/W3130154636","https://openalex.org/W3138561609","https://openalex.org/W3149714833","https://openalex.org/W3175268592","https://openalex.org/W3201084964","https://openalex.org/W3215423945","https://openalex.org/W4205513041","https://openalex.org/W4205882487","https://openalex.org/W4213152682","https://openalex.org/W4214858177","https://openalex.org/W4220727783","https://openalex.org/W4224221174","https://openalex.org/W4230655240","https://openalex.org/W4293252982","https://openalex.org/W4294958333","https://openalex.org/W4296773729","https://openalex.org/W4318940219","https://openalex.org/W4322487689","https://openalex.org/W4324387078","https://openalex.org/W4362543559","https://openalex.org/W4367317337","https://openalex.org/W4383896737","https://openalex.org/W4385295513","https://openalex.org/W4385342714","https://openalex.org/W4386788919","https://openalex.org/W4388487165","https://openalex.org/W4391581754","https://openalex.org/W4391786835","https://openalex.org/W4391884871","https://openalex.org/W4392401838","https://openalex.org/W4392752811","https://openalex.org/W4394691991","https://openalex.org/W4394744203","https://openalex.org/W4394747404","https://openalex.org/W4395955243","https://openalex.org/W4396974737","https://openalex.org/W4399382574","https://openalex.org/W4400049923","https://openalex.org/W4401366786","https://openalex.org/W4401991958","https://openalex.org/W4402069556","https://openalex.org/W4402177058","https://openalex.org/W4402580557","https://openalex.org/W4403020535","https://openalex.org/W4403664765","https://openalex.org/W4408663059","https://openalex.org/W4408946472","https://openalex.org/W6731921538","https://openalex.org/W6769878850","https://openalex.org/W6773910784","https://openalex.org/W6876211606","https://openalex.org/W7045810429"],"related_works":["https://openalex.org/W4394019143","https://openalex.org/W2009308766","https://openalex.org/W7154472366","https://openalex.org/W1999957113","https://openalex.org/W4394744203","https://openalex.org/W3000058071","https://openalex.org/W4205513041","https://openalex.org/W7081977357","https://openalex.org/W7022387646","https://openalex.org/W2166670383"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2025-10-10T00:00:00"}
