{"id":"https://openalex.org/W4413201850","doi":"https://doi.org/10.1002/jhet.70026","title":"Synthetic Approaches to Imidazo[1,2\u2010a]indole,2,3\u2010dihydro\u2010 1H \u2010imidazo[1,2\u2010a]\u2010indoles and Benzo[4,5]imidazo[1,2\u2010a]indole Derivatives: A Comprehensive Review","display_name":"Synthetic Approaches to Imidazo[1,2\u2010a]indole,2,3\u2010dihydro\u2010 1H \u2010imidazo[1,2\u2010a]\u2010indoles and Benzo[4,5]imidazo[1,2\u2010a]indole Derivatives: A Comprehensive Review","publication_year":2025,"publication_date":"2025-08-12","ids":{"openalex":"https://openalex.org/W4413201850","doi":"https://doi.org/10.1002/jhet.70026"},"language":"en","primary_location":{"id":"doi:10.1002/jhet.70026","doi":"https://doi.org/10.1002/jhet.70026","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jhet.70026","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jhet.70026","source":{"id":"https://openalex.org/S46134040","display_name":"Journal of Heterocyclic Chemistry","issn_l":"0022-152X","issn":["0022-152X","1943-5193"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Heterocyclic Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jhet.70026","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036923795","display_name":"Elizabeth J. Diana","orcid":"https://orcid.org/0000-0003-1208-0485","observed_orcids":["https://orcid.org/0000-0003-1208-0485"]},"institutions":[{"id":"https://openalex.org/I4405277305","display_name":"Alphonsa College","ror":"https://ror.org/027cqnt50","country_code":"IN","type":"education","lineage":["https://openalex.org/I4405277305"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Elizabeth J. Diana","raw_affiliation_strings":["Department of Chemistry, Alphonsa College Pala, Kottayam, Kerala, India","Department of Chemistry, St. Thomas College Palai, Kottayam, Kerala, India"],"raw_orcid":"https://orcid.org/0000-0003-1208-0485","affiliations":[{"raw_affiliation_string":"Department of Chemistry, Alphonsa College Pala, Kottayam, Kerala, India","institution_ids":["https://openalex.org/I4405277305"]},{"raw_affiliation_string":"Department of Chemistry, St. Thomas College Palai, Kottayam, Kerala, India","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042712736","display_name":"Thomas Mathew","orcid":"https://orcid.org/0000-0001-5650-5241","observed_orcids":["https://orcid.org/0000-0001-5650-5241"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Thomas V. Mathew","raw_affiliation_strings":["Department of Chemistry, St. Thomas College Palai, Kottayam, Kerala, India"],"raw_orcid":"https://orcid.org/0000-0001-5650-5241","affiliations":[{"raw_affiliation_string":"Department of Chemistry, St. Thomas College Palai, Kottayam, Kerala, India","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5042712736"],"corresponding_institution_ids":[],"apc_list":{"value":3400,"currency":"USD","value_usd":3400},"apc_paid":null,"fwci":0.2672,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.31969439,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"62","issue":"10","first_page":"1087","last_page":"1103"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12973","display_name":"Synthesis of Indole Derivatives","score":0.7035999894142151,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12973","display_name":"Synthesis of Indole Derivatives","score":0.7035999894142151,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13230","display_name":"Synthesis and Reactivity of Heterocycles","score":0.09880000352859497,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10817","display_name":"Multicomponent Synthesis of Heterocycles","score":0.053300000727176666,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nitrogen-containing-heterocycles","display_name":"nitrogen heterocycles","score":0.9390000104904175},{"id":"https://openalex.org/keywords/heterocycle-synthesis","display_name":"heterocyclic synthesis","score":0.7850000262260437},{"id":"https://openalex.org/keywords/metal-catalyzed-synthesis","display_name":"metal-catalyzed synthesis","score":0.9670000076293945},{"id":"https://openalex.org/keywords/metal-free-synthesis","display_name":"metal-free synthesis","score":0.9570000171661377},{"id":"https://openalex.org/keywords/fused-indole-derivatives","display_name":"fused indole derivatives","score":0.625}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9187363386154175},{"id":"https://openalex.org/C192527728","wikidata":"https://www.wikidata.org/wiki/Q1465700","display_name":"Indole test","level":2,"score":0.8768759369850159},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.51903235912323},{"id":"https://openalex.org/C24961977","wikidata":"https://www.wikidata.org/wiki/Q225972","display_name":"Bicyclic molecule","level":2,"score":0.4896286129951477},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.48037537932395935}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/jhet.70026","doi":"https://doi.org/10.1002/jhet.70026","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jhet.70026","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jhet.70026","source":{"id":"https://openalex.org/S46134040","display_name":"Journal of Heterocyclic Chemistry","issn_l":"0022-152X","issn":["0022-152X","1943-5193"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Heterocyclic Chemistry","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1002/jhet.70026","doi":"https://doi.org/10.1002/jhet.70026","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jhet.70026","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jhet.70026","source":{"id":"https://openalex.org/S46134040","display_name":"Journal of Heterocyclic Chemistry","issn_l":"0022-152X","issn":["0022-152X","1943-5193"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Heterocyclic Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4413201850.pdf","grobid_xml":"https://content.openalex.org/works/W4413201850.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W1980350181","https://openalex.org/W1989202995","https://openalex.org/W1997819681","https://openalex.org/W2001508924","https://openalex.org/W2021102670","https://openalex.org/W2038552915","https://openalex.org/W2053500888","https://openalex.org/W2068206113","https://openalex.org/W2072261779","https://openalex.org/W2081998136","https://openalex.org/W2120667707","https://openalex.org/W2140994507","https://openalex.org/W2172635564","https://openalex.org/W2231899422","https://openalex.org/W2253066198","https://openalex.org/W2307908310","https://openalex.org/W2468700037","https://openalex.org/W2589388636","https://openalex.org/W2598717607","https://openalex.org/W2750660792","https://openalex.org/W2790311088","https://openalex.org/W2797723978","https://openalex.org/W2911486318","https://openalex.org/W2951338140","https://openalex.org/W2952589233","https://openalex.org/W2976394500","https://openalex.org/W3005140807","https://openalex.org/W3045146980","https://openalex.org/W3048003640","https://openalex.org/W3112064743","https://openalex.org/W3141275363","https://openalex.org/W3168321288","https://openalex.org/W3178332941","https://openalex.org/W3193424183","https://openalex.org/W4287010204","https://openalex.org/W4289638407","https://openalex.org/W4307996353","https://openalex.org/W4308530287","https://openalex.org/W4391298203","https://openalex.org/W4401934090","https://openalex.org/W4402765698","https://openalex.org/W4405926500"],"related_works":["https://openalex.org/W3207197178","https://openalex.org/W1996168541","https://openalex.org/W4401934090","https://openalex.org/W4415458220","https://openalex.org/W4402765698","https://openalex.org/W4415172901","https://openalex.org/W2010600306","https://openalex.org/W4413276766","https://openalex.org/W4403490255","https://openalex.org/W4403699724"],"abstract_inverted_index":{"ABSTRACT":[0],"Imidazo[1,2\u2010a]indoles,":[1],"2,3\u2010dihydro\u20101H\u2010imidazo[1,2\u2010a]\u2010indoles":[2],"and":[3,19,48,52],"benzo[4,5]imidazo[1,2\u2010a]indoles":[4],"are":[5],"rare":[6],"yet":[7],"valuable":[8,63],"classes":[9],"of":[10,42,60],"nitrogen\u2010containing":[11],"heterocycles,":[12],"offering":[13,62],"diverse":[14],"applications":[15],"in":[16],"pharmaceutical":[17],"development":[18],"advanced":[20],"materials":[21],"research.":[22],"Despite":[23],"their":[24],"potential":[25],"medicinal":[26],"applications,":[27],"efficient":[28],"synthesis":[29,59],"methods":[30],"for":[31,46],"these":[32],"substances":[33],"remain":[34],"limited.":[35],"This":[36],"review":[37],"provides":[38],"an":[39],"in\u2010depth":[40],"analysis":[41],"emerging":[43],"synthetic":[44,67],"approaches":[45],"imidazo[1,2\u2010a]indoles":[47],"benzo[4,5]imidazo[1,2\u2010a]indoles,":[49],"including":[50],"metal\u2010catalyzed":[51,58],"metal\u2010free":[53],"methods,":[54],"as":[55,57],"well":[56],"2,3\u2010dihydro\u20101H\u2010imidazo[1,2\u2010a]indoles,":[61],"insights":[64],"into":[65],"effective":[66],"strategies.":[68]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2025-10-10T00:00:00"}