{"id":"https://openalex.org/W4413201638","doi":"https://doi.org/10.3390/ijms26167771","title":"Antimicrobial Unusual Small Molecules from Marine Streptomyces spp.","display_name":"Antimicrobial Unusual Small Molecules from Marine Streptomyces spp.","publication_year":2025,"publication_date":"2025-08-12","ids":{"openalex":"https://openalex.org/W4413201638","doi":"https://doi.org/10.3390/ijms26167771","pmid":"https://pubmed.ncbi.nlm.nih.gov/40869091"},"language":"en","primary_location":{"id":"doi:10.3390/ijms26167771","doi":"https://doi.org/10.3390/ijms26167771","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms26167771","pdf_url":"https://www.mdpi.com/1422-0067/26/16/7771/pdf?version=1754980121","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1422-0067/26/16/7771/pdf?version=1754980121","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085273633","display_name":"M.A. Mojid Mondol","orcid":"https://orcid.org/0000-0002-8495-4498","observed_orcids":["https://orcid.org/0000-0002-8495-4498","https://orcid.org/0009-0009-6028-9102"]},"institutions":[{"id":"https://openalex.org/I40515787","display_name":"Bangladesh Open University","ror":"https://ror.org/05s3ca234","country_code":"BD","type":"education","lineage":["https://openalex.org/I40515787"]}],"countries":["BD"],"is_corresponding":true,"raw_author_name":"M. A. Mojid Mondol","raw_affiliation_strings":["Food, Nutrition and Natural Product Chemistry Laboratory, School of Science and Technology, Bangladesh Open University, Gazipur 1705, Bangladesh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Food, Nutrition and Natural Product Chemistry Laboratory, School of Science and Technology, Bangladesh Open University, Gazipur 1705, Bangladesh","institution_ids":["https://openalex.org/I40515787"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5099431800","display_name":"Tanvir Islam Shovo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40515787","display_name":"Bangladesh Open University","ror":"https://ror.org/05s3ca234","country_code":"BD","type":"education","lineage":["https://openalex.org/I40515787"]}],"countries":["BD"],"is_corresponding":false,"raw_author_name":"Tanvir Islam Shovo","raw_affiliation_strings":["Food, Nutrition and Natural Product Chemistry Laboratory, School of Science and Technology, Bangladesh Open University, Gazipur 1705, Bangladesh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Food, Nutrition and Natural Product Chemistry Laboratory, School of Science and Technology, Bangladesh Open University, Gazipur 1705, Bangladesh","institution_ids":["https://openalex.org/I40515787"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025508269","display_name":"Abul Hasnat Md. Shamim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40515787","display_name":"Bangladesh Open University","ror":"https://ror.org/05s3ca234","country_code":"BD","type":"education","lineage":["https://openalex.org/I40515787"]}],"countries":["BD"],"is_corresponding":false,"raw_author_name":"Abul Hasnat Md. Shamim","raw_affiliation_strings":["Agriculture Research Laboratory, School of Agriculture and Rural Development, Bangladesh Open University, Gazipur 1705, Bangladesh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Agriculture Research Laboratory, School of Agriculture and Rural Development, Bangladesh Open University, Gazipur 1705, Bangladesh","institution_ids":["https://openalex.org/I40515787"]}]},{"author_position":"last","author":{"id":null,"display_name":"Abdullah Al Azam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40515787","display_name":"Bangladesh Open University","ror":"https://ror.org/05s3ca234","country_code":"BD","type":"education","lineage":["https://openalex.org/I40515787"]}],"countries":["BD"],"is_corresponding":false,"raw_author_name":"Abdullah Al Azam","raw_affiliation_strings":["Food, Nutrition and Natural Product Chemistry Laboratory, School of Science and Technology, Bangladesh Open University, Gazipur 1705, Bangladesh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Food, Nutrition and Natural Product Chemistry Laboratory, School of Science and Technology, Bangladesh Open University, Gazipur 1705, Bangladesh","institution_ids":["https://openalex.org/I40515787"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5085273633"],"corresponding_institution_ids":["https://openalex.org/I40515787"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3499},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3499},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.18420483,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"26","issue":"16","first_page":"7771","last_page":"7771"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11340","display_name":"Marine Sponges and Natural Products","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12257","display_name":"Bioactive natural compounds","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/streptomyces","display_name":"Streptomyces","score":0.8460000157356262},{"id":"https://openalex.org/keywords/marine-sediment-bacteria","display_name":"marine sediment bacteria","score":0.6449999809265137},{"id":"https://openalex.org/keywords/antimicrobial-natural-products","display_name":"antimicrobial natural products","score":0.8050000071525574},{"id":"https://openalex.org/keywords/antimicrobial-resistance","display_name":"antimicrobial resistance","score":0.7250000238418579},{"id":"https://openalex.org/keywords/gram-positive-bacteria","display_name":"Gram-positive bacteria","score":0.7170000076293945},{"id":"https://openalex.org/keywords/marine-derived-antibiotics","display_name":"marine-derived antibiotics","score":0.39100000262260437},{"id":"https://openalex.org/keywords/structure-elucidation","display_name":"structure elucidation","score":0.5830000042915344},{"id":"https://openalex.org/keywords/ethyl-acetate-extract","display_name":"ethyl acetate extract","score":0.6800000071525574}],"concepts":[{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.8850947618484497},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.5898679494857788},{"id":"https://openalex.org/C94665300","wikidata":"https://www.wikidata.org/wiki/Q63391344","display_name":"Antibiotic resistance","level":3,"score":0.5359379053115845},{"id":"https://openalex.org/C2779920670","wikidata":"https://www.wikidata.org/wiki/Q1144013","display_name":"Streptomyces","level":3,"score":0.5260441303253174},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.5164799690246582},{"id":"https://openalex.org/C2779396153","wikidata":"https://www.wikidata.org/wiki/Q901227","display_name":"Natural product","level":2,"score":0.5039789080619812},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.4872936010360718},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4840499758720398},{"id":"https://openalex.org/C175605896","wikidata":"https://www.wikidata.org/wiki/Q39833","display_name":"Microorganism","level":3,"score":0.4514086842536926},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3471164107322693},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18862462043762207},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000890","descriptor_name":"Anti-Infective Agents","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D000890","descriptor_name":"Anti-Infective Agents","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D000890","descriptor_name":"Anti-Infective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000890","descriptor_name":"Anti-Infective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000890","descriptor_name":"Anti-Infective Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000890","descriptor_name":"Anti-Infective Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006090","descriptor_name":"Gram-Negative Bacteria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006090","descriptor_name":"Gram-Negative Bacteria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006094","descriptor_name":"Gram-Positive Bacteria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006094","descriptor_name":"Gram-Positive Bacteria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013302","descriptor_name":"Streptomyces","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013302","descriptor_name":"Streptomyces","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013302","descriptor_name":"Streptomyces","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013302","descriptor_name":"Streptomyces","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D019015","descriptor_name":"Geologic Sediments","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D019015","descriptor_name":"Geologic Sediments","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D059001","descriptor_name":"Aquatic Organisms","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D059001","descriptor_name":"Aquatic Organisms","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.3390/ijms26167771","doi":"https://doi.org/10.3390/ijms26167771","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms26167771","pdf_url":"https://www.mdpi.com/1422-0067/26/16/7771/pdf?version=1754980121","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmid:40869091","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40869091","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:11194747","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12386958","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:12386958","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12386958","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Int J Mol Sci","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3390/ijms26167771","doi":"https://doi.org/10.3390/ijms26167771","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms26167771","pdf_url":"https://www.mdpi.com/1422-0067/26/16/7771/pdf?version=1754980121","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4413201638.pdf","grobid_xml":"https://content.openalex.org/works/W4413201638.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W1518601645","https://openalex.org/W1582926274","https://openalex.org/W1874122563","https://openalex.org/W1982060257","https://openalex.org/W1982904105","https://openalex.org/W1999055779","https://openalex.org/W2008054708","https://openalex.org/W2014509356","https://openalex.org/W2051824782","https://openalex.org/W2068690704","https://openalex.org/W2087996087","https://openalex.org/W2096166235","https://openalex.org/W2105472132","https://openalex.org/W2106324926","https://openalex.org/W2107000518","https://openalex.org/W2108638835","https://openalex.org/W2108833494","https://openalex.org/W2116809953","https://openalex.org/W2121791697","https://openalex.org/W2137940593","https://openalex.org/W2152207030","https://openalex.org/W2155903907","https://openalex.org/W2164333312","https://openalex.org/W2165127024","https://openalex.org/W2167730341","https://openalex.org/W2738348025","https://openalex.org/W2792801198","https://openalex.org/W2890767151","https://openalex.org/W2922427968","https://openalex.org/W3024583240","https://openalex.org/W3092363747","https://openalex.org/W3119952098","https://openalex.org/W3173455641","https://openalex.org/W3209603403","https://openalex.org/W4251751280","https://openalex.org/W4308181764","https://openalex.org/W4386046407","https://openalex.org/W4406416825","https://openalex.org/W4410188585","https://openalex.org/W6676128747","https://openalex.org/W6783922290"],"related_works":["https://openalex.org/W2358368915","https://openalex.org/W2380741856","https://openalex.org/W2348658803","https://openalex.org/W2390464063","https://openalex.org/W2365669377","https://openalex.org/W2502459038","https://openalex.org/W4321232597","https://openalex.org/W2964912953","https://openalex.org/W2079637514","https://openalex.org/W4236139680"],"abstract_inverted_index":{"The":[0,152],"widespread":[1],"emergence":[2],"of":[3,11,38,103,117,142,155,165,178],"resistant":[4],"pathogenic":[5],"microorganisms":[6],"are":[7,52],"diminishing":[8],"the":[9,34,45,67,110,115,139],"effectiveness":[10],"existing":[12],"antimicrobial":[13,27,39,56,75],"drugs,":[14],"posing":[15],"an":[16,122],"enormous":[17],"threat":[18],"to":[19,49,72,114,160],"global":[20],"public":[21],"health.":[22],"This":[23],"phenomenon,":[24],"known":[25,131],"as":[26,66,147,149],"resistance":[28],"(AMR),":[29],"is":[30],"primarily":[31],"driven":[32],"by":[33,87,138],"misuse":[35],"and":[36,92,128,144,163,171,181,196],"overuse":[37],"drugs.":[40],"Natural":[41],"product":[42],"researchers":[43],"around":[44],"globe,":[46],"in":[47,95],"response":[48],"antibiotics":[50],"resistance,":[51],"searching":[53],"for":[54,168],"new":[55,74,119],"lead":[57,76],"compounds":[58,135,179,186],"from":[59,83,109],"unexplored":[60],"or":[61],"underexplored":[62],"ecological":[63],"niches":[64],"such":[65],"marine":[68,84],"environment.":[69],"In":[70,174],"order":[71],"isolate":[73],"compounds,":[77],"two":[78],"Streptomyces":[79],"spp.":[80],"were":[81,136],"isolated":[82],"sediment":[85],"samples":[86],"a":[88,118,129],"serial":[89],"dilution":[90],"technique":[91],"subsequently":[93],"cultured":[94],"modified":[96],"Bennett\u2019s":[97],"broth":[98,112],"medium.":[99],"Repeated":[100],"chromatographic":[101],"steps":[102],"ethyl":[104],"acetate":[105],"(EtOAc)":[106],"extracts":[107],"obtained":[108],"culture":[111],"led":[113],"isolation":[116],"compound":[120],"with":[121],"unusual":[123],"chemical":[124],"skeleton,":[125],"streptopiperithiazol":[126],"(1),":[127],"synthetically":[130],"(2)":[132],"compound.":[133],"These":[134],"characterized":[137],"extensive":[140],"analysis":[141],"1D":[143],"2D":[145],"spectroscopic":[146],"well":[148],"HRMS":[150],"data.":[151],"absolute":[153],"configuration":[154],"1":[156,180],"was":[157],"unresolved":[158],"due":[159],"limited":[161],"yield":[162],"lack":[164],"proper":[166],"facilities":[167],"taking":[169],"CD":[170],"ECD":[172],"spectra.":[173],"vitro":[175],"activity":[176,189],"study":[177],"2":[182],"revealed":[183],"that":[184],"these":[185],"had":[187],"better":[188],"against":[190],"Gram-positive":[191],"bacteria":[192,195],"than":[193],"Gram-negative":[194],"yeast.":[197]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2025-08-17T00:00:00"}