{"id":"https://openalex.org/W4413190855","doi":"https://doi.org/10.3390/pharmaceutics17081045","title":"Anti-Neuroinflammation Effect of Standardized Ethanol Extract of Leaves of Perilla frutescens var. acuta on A\u03b2-Induced Alzheimer\u2019s Disease-like Mouse Model","display_name":"Anti-Neuroinflammation Effect of Standardized Ethanol Extract of Leaves of Perilla frutescens var. acuta on A\u03b2-Induced Alzheimer\u2019s Disease-like Mouse Model","publication_year":2025,"publication_date":"2025-08-12","ids":{"openalex":"https://openalex.org/W4413190855","doi":"https://doi.org/10.3390/pharmaceutics17081045","pmid":"https://pubmed.ncbi.nlm.nih.gov/40871065","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12389061"},"language":"en","primary_location":{"id":"doi:10.3390/pharmaceutics17081045","doi":"https://doi.org/10.3390/pharmaceutics17081045","is_oa":true,"landing_page_url":"https://doi.org/10.3390/pharmaceutics17081045","pdf_url":"https://www.mdpi.com/1999-4923/17/8/1045/pdf?version=1755571474","source":{"id":"https://openalex.org/S30283931","display_name":"Pharmaceutics","issn_l":"1999-4923","issn":["1999-4923"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1999-4923/17/8/1045/pdf?version=1755571474","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Hyunji Kwon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24062138","display_name":"Konkuk University","ror":"https://ror.org/025h1m602","country_code":"KR","type":"education","lineage":["https://openalex.org/I24062138"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hyunji Kwon","raw_affiliation_strings":["Department of Advanced Translational Medicine, School of Medicine, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Advanced Translational Medicine, School of Medicine, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Republic of Korea","institution_ids":["https://openalex.org/I24062138"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100414516","display_name":"Jihye Lee","orcid":"https://orcid.org/0000-0002-1279-5037","observed_orcids":["https://orcid.org/0000-0002-1279-5037"]},"institutions":[{"id":"https://openalex.org/I138826464","display_name":"Daegu Haany University","ror":"https://ror.org/045wr3278","country_code":"KR","type":"education","lineage":["https://openalex.org/I138826464"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jihye Lee","raw_affiliation_strings":["Industry Academic Cooperation Foundation, Daegu Haany University, 1 Hanuidae-ro, Gyeongsan-si 38610, Gyeongsangbuk-do, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Industry Academic Cooperation Foundation, Daegu Haany University, 1 Hanuidae-ro, Gyeongsan-si 38610, Gyeongsangbuk-do, Republic of Korea","institution_ids":["https://openalex.org/I138826464"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061289686","display_name":"Eunhong Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55240360","display_name":"Yeungnam University","ror":"https://ror.org/05yc6p159","country_code":"KR","type":"education","lineage":["https://openalex.org/I55240360"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Eunhong Lee","raw_affiliation_strings":["Department of Chemical Engineering, Yeungnam University, 280 Daehak-ro, Gyeongsan-si 38541, Gyeongsangbuk-do, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Yeungnam University, 280 Daehak-ro, Gyeongsan-si 38541, Gyeongsangbuk-do, Republic of Korea","institution_ids":["https://openalex.org/I55240360"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083991590","display_name":"Somin Moon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24062138","display_name":"Konkuk University","ror":"https://ror.org/025h1m602","country_code":"KR","type":"education","lineage":["https://openalex.org/I24062138"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Somin Moon","raw_affiliation_strings":["Department of Advanced Translational Medicine, School of Medicine, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Advanced Translational Medicine, School of Medicine, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Republic of Korea","institution_ids":["https://openalex.org/I24062138"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103194804","display_name":"Eunbi Cho","orcid":"https://orcid.org/0009-0009-0937-3958","observed_orcids":["https://orcid.org/0009-0009-0937-3958"]},"institutions":[{"id":"https://openalex.org/I24062138","display_name":"Konkuk University","ror":"https://ror.org/025h1m602","country_code":"KR","type":"education","lineage":["https://openalex.org/I24062138"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Eunbi Cho","raw_affiliation_strings":["Department of Advanced Translational Medicine, School of Medicine, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Advanced Translational Medicine, School of Medicine, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Republic of Korea","institution_ids":["https://openalex.org/I24062138"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057607866","display_name":"Jieun Jeon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24062138","display_name":"Konkuk University","ror":"https://ror.org/025h1m602","country_code":"KR","type":"education","lineage":["https://openalex.org/I24062138"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jieun Jeon","raw_affiliation_strings":["Department of Advanced Translational Medicine, School of Medicine, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Advanced Translational Medicine, School of Medicine, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Republic of Korea","institution_ids":["https://openalex.org/I24062138"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064731065","display_name":"A Young Park","orcid":"https://orcid.org/0009-0007-0354-9081","observed_orcids":["https://orcid.org/0009-0007-0354-9081"]},"institutions":[{"id":"https://openalex.org/I24062138","display_name":"Konkuk University","ror":"https://ror.org/025h1m602","country_code":"KR","type":"education","lineage":["https://openalex.org/I24062138"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"A Young Park","raw_affiliation_strings":["Department of Advanced Translational Medicine, School of Medicine, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Advanced Translational Medicine, School of Medicine, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Republic of Korea","institution_ids":["https://openalex.org/I24062138"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111751002","display_name":"Joon\u2010Ho Hwang","orcid":"https://orcid.org/0000-0001-8950-1589","observed_orcids":["https://orcid.org/0000-0001-8950-1589"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joon-Ho Hwang","raw_affiliation_strings":["Borambio Co., Ltd., 119 Dandae-ro, Dongnam-gu, Cheonan 31116, Chungcheongnam, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Borambio Co., Ltd., 119 Dandae-ro, Dongnam-gu, Cheonan 31116, Chungcheongnam, Republic of Korea","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101447667","display_name":"Gun Hee Cho","orcid":"https://orcid.org/0000-0001-8199-4278","observed_orcids":["https://orcid.org/0000-0001-8199-4278"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gun Hee Cho","raw_affiliation_strings":["Borambio Co., Ltd., 119 Dandae-ro, Dongnam-gu, Cheonan 31116, Chungcheongnam, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Borambio Co., Ltd., 119 Dandae-ro, Dongnam-gu, Cheonan 31116, Chungcheongnam, Republic of Korea","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Haram Kong","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Haram Kong","raw_affiliation_strings":["Borambio Co., Ltd., 119 Dandae-ro, Dongnam-gu, Cheonan 31116, Chungcheongnam, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Borambio Co., Ltd., 119 Dandae-ro, Dongnam-gu, Cheonan 31116, Chungcheongnam, Republic of Korea","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045201385","display_name":"Mi-Houn Park","orcid":"https://orcid.org/0000-0003-4834-5668","observed_orcids":["https://orcid.org/0000-0003-4834-5668"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mi-Houn Park","raw_affiliation_strings":["Borambio Co., Ltd., 119 Dandae-ro, Dongnam-gu, Cheonan 31116, Chungcheongnam, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Borambio Co., Ltd., 119 Dandae-ro, Dongnam-gu, Cheonan 31116, Chungcheongnam, Republic of Korea","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101673352","display_name":"Sung\u2010Kyu Kim","orcid":"https://orcid.org/0000-0003-3597-748X","observed_orcids":["https://orcid.org/0000-0003-3597-748X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sung-Kyu Kim","raw_affiliation_strings":["Borambio Co., Ltd., 119 Dandae-ro, Dongnam-gu, Cheonan 31116, Chungcheongnam, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Borambio Co., Ltd., 119 Dandae-ro, Dongnam-gu, Cheonan 31116, Chungcheongnam, Republic of Korea","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100413839","display_name":"Dong Hyun Kim","orcid":"https://orcid.org/0000-0003-3394-2400","observed_orcids":["https://orcid.org/0000-0003-3394-2400"]},"institutions":[{"id":"https://openalex.org/I24062138","display_name":"Konkuk University","ror":"https://ror.org/025h1m602","country_code":"KR","type":"education","lineage":["https://openalex.org/I24062138"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Dong Hyun Kim","raw_affiliation_strings":["Department of Advanced Translational Medicine, School of Medicine, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Republic of Korea","Department of Pharmacology, School of Medicine, Konkuk University, 268 Chungwon-daero, Chungju-si 27478, Chungcheongbuk-do, Republic of Korea","Research Institute of Medical Science, Konkuk University School of Medicine, 268 Chungwon-daero, Chungju-si 27478, Chungcheongbuk-do, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Advanced Translational Medicine, School of Medicine, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Republic of Korea","institution_ids":["https://openalex.org/I24062138"]},{"raw_affiliation_string":"Department of Pharmacology, School of Medicine, Konkuk University, 268 Chungwon-daero, Chungju-si 27478, Chungcheongbuk-do, Republic of Korea","institution_ids":["https://openalex.org/I24062138"]},{"raw_affiliation_string":"Research Institute of Medical Science, Konkuk University School of Medicine, 268 Chungwon-daero, Chungju-si 27478, Chungcheongbuk-do, Republic of Korea","institution_ids":["https://openalex.org/I24062138"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006651790","display_name":"Ji Wook Jung","orcid":"https://orcid.org/0000-0002-1205-5696","observed_orcids":["https://orcid.org/0000-0002-1205-5696"]},"institutions":[{"id":"https://openalex.org/I138826464","display_name":"Daegu Haany University","ror":"https://ror.org/045wr3278","country_code":"KR","type":"education","lineage":["https://openalex.org/I138826464"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Ji Wook Jung","raw_affiliation_strings":["Department of Cosmetic, Daegu Haany University, 1 Hanuidae-ro, Gyeongsan-si 38610, Gyeongsangbuk-do, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cosmetic, Daegu Haany University, 1 Hanuidae-ro, Gyeongsan-si 38610, Gyeongsangbuk-do, Republic of Korea","institution_ids":["https://openalex.org/I138826464"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5006651790","https://openalex.org/A5100413839"],"corresponding_institution_ids":["https://openalex.org/I138826464","https://openalex.org/I24062138"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3499},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3499},"fwci":3.9462,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.91456415,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":98},"biblio":{"volume":"17","issue":"8","first_page":"1045","last_page":"1045"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12891","display_name":"Medicinal Plants and Neuroprotection","score":0.4738999903202057,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12891","display_name":"Medicinal Plants and Neuroprotection","score":0.4738999903202057,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.357699990272522,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.1574999988079071,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/perilla-frutescens-var-acuta","display_name":"Perilla frutescens var. acuta","score":1.0},{"id":"https://openalex.org/keywords/ethanolic-leaf-extract","display_name":"ethanolic leaf extract","score":0.8420000076293945},{"id":"https://openalex.org/keywords/anti-neuroinflammation","display_name":"anti-neuroinflammation","score":0.9039999842643738},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9679999947547913},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.8569999933242798},{"id":"https://openalex.org/keywords/microglial-activation","display_name":"microglial activation","score":0.6899999976158142},{"id":"https://openalex.org/keywords/bv2-cells","display_name":"BV-2 cells","score":0.6970000267028809},{"id":"https://openalex.org/keywords/lps-induced-inflammation","display_name":"lipopolysaccharide-induced inflammation","score":0.7089999914169312},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.6830000281333923},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.8309999704360962},{"id":"https://openalex.org/keywords/jnk","display_name":"JNK","score":0.6029999852180481},{"id":"https://openalex.org/keywords/p38-mapk","display_name":"p38 MAPK","score":0.9869999885559082},{"id":"https://openalex.org/keywords/creb-bdnf-signaling","display_name":"CREB/BDNF signaling","score":0.9179999828338623},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.6729999780654907},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.7630000114440918},{"id":"https://openalex.org/keywords/functional-food-ingredients","display_name":"functional food ingredients","score":0.7379999756813049}],"concepts":[{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.8195464611053467},{"id":"https://openalex.org/C44752575","wikidata":"https://www.wikidata.org/wiki/Q1417562","display_name":"Morris water navigation task","level":3,"score":0.7881640195846558},{"id":"https://openalex.org/C2777259179","wikidata":"https://www.wikidata.org/wiki/Q1076038","display_name":"Perilla frutescens","level":2,"score":0.7201094031333923},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.637009859085083},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6340873837471008},{"id":"https://openalex.org/C1629964","wikidata":"https://www.wikidata.org/wiki/Q106950729","display_name":"CREB","level":4,"score":0.592900276184082},{"id":"https://openalex.org/C51551487","wikidata":"https://www.wikidata.org/wiki/Q2043632","display_name":"p38 mitogen-activated protein kinases","level":4,"score":0.5249742865562439},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.45421233773231506},{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.4516656696796417},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.3935166001319885},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37589889764785767},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.369667649269104},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36186254024505615},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.25856029987335205},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.2534397840499878},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.24496397376060486},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.18534493446350098},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15674364566802979},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.15348321199417114},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3390/pharmaceutics17081045","doi":"https://doi.org/10.3390/pharmaceutics17081045","is_oa":true,"landing_page_url":"https://doi.org/10.3390/pharmaceutics17081045","pdf_url":"https://www.mdpi.com/1999-4923/17/8/1045/pdf?version=1755571474","source":{"id":"https://openalex.org/S30283931","display_name":"Pharmaceutics","issn_l":"1999-4923","issn":["1999-4923"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:11196870","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12389061","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:40871065","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40871065","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12389061","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12389061/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:9bbf1d36519c42ffa67ad13d4ac78d77","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/9bbf1d36519c42ffa67ad13d4ac78d77","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pharmaceutics, Vol 17, Iss 8, p 1045 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/pharmaceutics17081045","doi":"https://doi.org/10.3390/pharmaceutics17081045","is_oa":true,"landing_page_url":"https://doi.org/10.3390/pharmaceutics17081045","pdf_url":"https://www.mdpi.com/1999-4923/17/8/1045/pdf?version=1755571474","source":{"id":"https://openalex.org/S30283931","display_name":"Pharmaceutics","issn_l":"1999-4923","issn":["1999-4923"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7023715084","display_name":null,"funder_award_id":"S3400191","funder_id":"https://openalex.org/F4320327819","funder_display_name":"Ministry of SMEs and Startups"}],"funders":[{"id":"https://openalex.org/F4320321206","display_name":"Daegu Haany University","ror":"https://ror.org/045wr3278"},{"id":"https://openalex.org/F4320327819","display_name":"Ministry of SMEs and Startups","ror":null},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320335977","display_name":"Korea Technology and Information Promotion Agency for SMEs","ror":"https://ror.org/02kxx1z36"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4413190855.pdf","grobid_xml":"https://content.openalex.org/works/W4413190855.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W1969033401","https://openalex.org/W2020047037","https://openalex.org/W2098143177","https://openalex.org/W2333744589","https://openalex.org/W2417708879","https://openalex.org/W2903826746","https://openalex.org/W2949773701","https://openalex.org/W2996690586","https://openalex.org/W2999437268","https://openalex.org/W3028268674","https://openalex.org/W3085381257","https://openalex.org/W3101879438","https://openalex.org/W3122001059","https://openalex.org/W3174757275","https://openalex.org/W3186942734","https://openalex.org/W3192723837","https://openalex.org/W3201187692","https://openalex.org/W4205891377","https://openalex.org/W4210324338","https://openalex.org/W4210839794","https://openalex.org/W4242516942","https://openalex.org/W4312086555","https://openalex.org/W4321498274","https://openalex.org/W4324342651","https://openalex.org/W4362523938","https://openalex.org/W4367396619","https://openalex.org/W4381252723","https://openalex.org/W4390402956","https://openalex.org/W4390666665","https://openalex.org/W4394623050","https://openalex.org/W4399676393","https://openalex.org/W4400677637","https://openalex.org/W4405108729","https://openalex.org/W4406235440","https://openalex.org/W4410832457","https://openalex.org/W4411535855"],"related_works":["https://openalex.org/W4210839794","https://openalex.org/W2333744589","https://openalex.org/W2908513543","https://openalex.org/W2913160509","https://openalex.org/W4205891377","https://openalex.org/W7139055063","https://openalex.org/W2731055478","https://openalex.org/W7154470701","https://openalex.org/W3118335066","https://openalex.org/W2920192616"],"abstract_inverted_index":{"Background/Objectives:":[0],"Perilla":[1,45],"frutescens":[2],"var.":[3],"acuta":[4],"Kudo,":[5],"a":[6,39,195],"member":[7],"of":[8,38,44,78,92,104,120,147],"the":[9,35,64,101,158,173],"Lamiaceae":[10],"family,":[11],"has":[12],"been":[13],"previously":[14],"reported":[15],"to":[16,33],"reduce":[17],"neuroinflammation":[18],"and":[19,63,86,107,115,122,130,151,153,170,188],"potentially":[20],"decrease":[21],"A\u03b2":[22],"plaque":[23],"accumulation":[24],"in":[25,58,69,157,175],"5XFAD":[26],"mice.":[27],"In":[28,133],"this":[29],"study,":[30],"we":[31,95],"aimed":[32],"evaluate":[34],"anti-neuroinflammatory":[36,187],"potential":[37,193],"standardized":[40],"60%":[41],"ethanol":[42],"extract":[43],"leaves":[46],"(PE),":[47],"optimized":[48],"for":[49,198],"commercial":[50],"application.":[51],"Methods:":[52],"The":[53],"inflammatory":[54],"response":[55],"was":[56,67],"assessed":[57],"LPS-stimulated":[59,82],"BV2":[60,83],"microglial":[61,84],"cells,":[62],"cognitive":[65,139,176,199],"improvement":[66,174],"evaluated":[68],"an":[70,87],"AD":[71],"animal":[72],"model":[73,91],"induced":[74],"by":[75],"intracerebroventricular":[76],"injection":[77],"A\u03b2.":[79],"Results:":[80],"Using":[81],"cells":[85],"A\u03b2-injected":[88],"ICR":[89],"mouse":[90],"Alzheimer\u2019s":[93],"disease,":[94],"found":[96],"that":[97,183],"PE":[98,127,135,184],"significantly":[99],"suppressed":[100],"LPS-induced":[102],"production":[103],"nitric":[105],"oxide":[106],"pro-inflammatory":[108],"mediators,":[109],"including":[110],"IL-6,":[111],"TNF-\u03b1,":[112],"NF-\u03baB,":[113,149],"iNOS,":[114,150],"COX-2,":[116],"along":[117],"with":[118,144],"inhibition":[119],"JNK":[121],"p38":[123],"MAPK":[124],"activation.":[125],"Furthermore,":[126],"upregulated":[128],"CREB":[129],"BDNF":[131],"expression.":[132],"vivo,":[134],"administration":[136],"alleviated":[137],"A\u03b2-induced":[138],"deficits,":[140],"which":[141],"were":[142],"associated":[143],"reduced":[145],"expression":[146],"JNK,":[148],"COX":[152],"increased":[154],"CREB/BDNF":[155],"signaling":[156],"hippocampus.":[159],"Behavioral":[160],"assessments\u2014including":[161],"passive":[162],"avoidance,":[163],"Morris":[164],"water":[165],"maze,":[166],"novel":[167],"object":[168],"recognition,":[169],"Y-maze":[171],"tests\u2014confirmed":[172],"function.":[177],"Conclusions:":[178],"Collectively,":[179],"these":[180],"findings":[181],"demonstrate":[182],"exerts":[185],"significant":[186],"neuroprotective":[189],"effects,":[190],"supporting":[191],"its":[192],"as":[194],"functional":[196],"ingredient":[197],"enhancement.":[200]},"counts_by_year":[{"year":2026,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2025-08-17T00:00:00"}