{"id":"https://openalex.org/W4413184635","doi":"https://doi.org/10.1016/j.insi.2025.100046","title":"Immunoinformatics-Based strategies for mRNA vaccine development against ilesha virus","display_name":"Immunoinformatics-Based strategies for mRNA vaccine development against ilesha virus","publication_year":2025,"publication_date":"2025-01-01","ids":{"openalex":"https://openalex.org/W4413184635","doi":"https://doi.org/10.1016/j.insi.2025.100046"},"language":"en","primary_location":{"id":"doi:10.1016/j.insi.2025.100046","doi":"https://doi.org/10.1016/j.insi.2025.100046","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.insi.2025.100046","pdf_url":null,"source":{"id":"https://openalex.org/S5407047481","display_name":"In Silico Research in Biomedicine","issn_l":"3050-7871","issn":["3050-7871"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"In Silico Research in Biomedicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.insi.2025.100046","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015565031","display_name":"Elijah Kolawole Oladipo","orcid":"https://orcid.org/0000-0002-9646-5122","observed_orcids":["https://orcid.org/0000-0002-9646-5122"]},"institutions":[{"id":"https://openalex.org/I2799835767","display_name":"Adeleke University","ror":"https://ror.org/03gnb6c23","country_code":"NG","type":"education","lineage":["https://openalex.org/I2799835767"]},{"id":"https://openalex.org/I4405263704","display_name":"Helix Biogen Institute","ror":"https://ror.org/054ja1t10","country_code":"NG","type":"education","lineage":["https://openalex.org/I4405263704"]},{"id":"https://openalex.org/I79619799","display_name":"University of Birmingham","ror":"https://ror.org/03angcq70","country_code":"GB","type":"education","lineage":["https://openalex.org/I79619799"]}],"countries":["GB","NG"],"is_corresponding":true,"raw_author_name":"Elijah Kolawole Oladipo","raw_affiliation_strings":["Department of Chemical Engineering, University of Birmingham, Edgbaston, Birmingham B12 2TT UK","Department of Microbiology, Laboratory of Molecular Biology, Immunology and Bioinformatics, Adeleke University, Ede, Osun State 232104 Nigeria","Division of Diagnostics Assay Development and Medical Artificial Intelligence, Ogbomoso, Oyo State Nigeria","Division of Genome and Molecular Sciences, Helix Biogen Institute, Ogbomoso, Oyo State Nigeria","Division of Vaccine and Pharmacotherapies Design and Development, Helix Biogen Institute, Ogbomoso, Oyo State Nigeria"],"raw_orcid":"https://orcid.org/0000-0002-9646-5122","affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, University of Birmingham, Edgbaston, Birmingham B12 2TT UK","institution_ids":["https://openalex.org/I79619799"]},{"raw_affiliation_string":"Department of Microbiology, Laboratory of Molecular Biology, Immunology and Bioinformatics, Adeleke University, Ede, Osun State 232104 Nigeria","institution_ids":["https://openalex.org/I2799835767"]},{"raw_affiliation_string":"Division of Diagnostics Assay Development and Medical Artificial Intelligence, Ogbomoso, Oyo State Nigeria","institution_ids":[]},{"raw_affiliation_string":"Division of Genome and Molecular Sciences, Helix Biogen Institute, Ogbomoso, Oyo State Nigeria","institution_ids":["https://openalex.org/I4405263704"]},{"raw_affiliation_string":"Division of Vaccine and Pharmacotherapies Design and Development, Helix Biogen Institute, Ogbomoso, Oyo State Nigeria","institution_ids":["https://openalex.org/I4405263704"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092311552","display_name":"James Akinwumi Ogunniran","orcid":"https://orcid.org/0009-0001-6931-5946","observed_orcids":["https://orcid.org/0009-0001-6931-5946"]},"institutions":[{"id":"https://openalex.org/I4405263704","display_name":"Helix Biogen Institute","ror":"https://ror.org/054ja1t10","country_code":"NG","type":"education","lineage":["https://openalex.org/I4405263704"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"James Akinwumi Ogunniran","raw_affiliation_strings":["Division of Vaccine and Pharmacotherapies Design and Development, Helix Biogen Institute, Ogbomoso, Oyo State Nigeria"],"raw_orcid":"https://orcid.org/0009-0001-6931-5946","affiliations":[{"raw_affiliation_string":"Division of Vaccine and Pharmacotherapies Design and Development, Helix Biogen Institute, Ogbomoso, Oyo State Nigeria","institution_ids":["https://openalex.org/I4405263704"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108990588","display_name":"Oluwaseyi Samuel Akinpelu","orcid":"https://orcid.org/0009-0005-5233-3725","observed_orcids":["https://orcid.org/0009-0005-5233-3725"]},"institutions":[{"id":"https://openalex.org/I4405263704","display_name":"Helix Biogen Institute","ror":"https://ror.org/054ja1t10","country_code":"NG","type":"education","lineage":["https://openalex.org/I4405263704"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Oluwaseyi Samuel Akinpelu","raw_affiliation_strings":["Division of Vaccine and Pharmacotherapies Design and Development, Helix Biogen Institute, Ogbomoso, Oyo State Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Vaccine and Pharmacotherapies Design and Development, Helix Biogen Institute, Ogbomoso, Oyo State Nigeria","institution_ids":["https://openalex.org/I4405263704"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008675329","display_name":"Glory Jesudara Oluwasanya","orcid":"https://orcid.org/0000-0001-8640-7773","observed_orcids":["https://orcid.org/0000-0001-8640-7773"]},"institutions":[{"id":"https://openalex.org/I4405263704","display_name":"Helix Biogen Institute","ror":"https://ror.org/054ja1t10","country_code":"NG","type":"education","lineage":["https://openalex.org/I4405263704"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Glory Jesudara Oluwasanya","raw_affiliation_strings":["Division of Genome and Molecular Sciences, Helix Biogen Institute, Ogbomoso, Oyo State Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Genome and Molecular Sciences, Helix Biogen Institute, Ogbomoso, Oyo State Nigeria","institution_ids":["https://openalex.org/I4405263704"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031528181","display_name":"Esther Moradeyo Jimah","orcid":"https://orcid.org/0000-0001-8584-5181","observed_orcids":["https://orcid.org/0000-0001-8584-5181"]},"institutions":[{"id":"https://openalex.org/I4405263704","display_name":"Helix Biogen Institute","ror":"https://ror.org/054ja1t10","country_code":"NG","type":"education","lineage":["https://openalex.org/I4405263704"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Esther Moradeyo Jimah","raw_affiliation_strings":["Division of Vaccine and Pharmacotherapies Design and Development, Helix Biogen Institute, Ogbomoso, Oyo State Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Vaccine and Pharmacotherapies Design and Development, Helix Biogen Institute, Ogbomoso, Oyo State Nigeria","institution_ids":["https://openalex.org/I4405263704"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046160608","display_name":"Bamidele Abiodun Iwalokun","orcid":"https://orcid.org/0000-0003-4247-2797","observed_orcids":["https://orcid.org/0000-0003-4247-2797"]},"institutions":[{"id":"https://openalex.org/I49433721","display_name":"Nigerian Institute of Medical Research","ror":"https://ror.org/03kk9k137","country_code":"NG","type":"healthcare","lineage":["https://openalex.org/I49433721"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Bamidele Abiodun Iwalokun","raw_affiliation_strings":["Molecular Biology and Biotechnology Department, Nigeria Institute of Medical Research, Lagos, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Biology and Biotechnology Department, Nigeria Institute of Medical Research, Lagos, Nigeria","institution_ids":["https://openalex.org/I49433721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023534304","display_name":"Olatunji Matthew Kolawole","orcid":"https://orcid.org/0000-0003-1914-6766","observed_orcids":["https://orcid.org/0000-0003-1914-6766"]},"institutions":[{"id":"https://openalex.org/I134542131","display_name":"University of Ilorin","ror":"https://ror.org/032kdwk38","country_code":"NG","type":"education","lineage":["https://openalex.org/I134542131"]},{"id":"https://openalex.org/I39555362","display_name":"University of Warwick","ror":"https://ror.org/01a77tt86","country_code":"GB","type":"education","lineage":["https://openalex.org/I39555362"]}],"countries":["GB","NG"],"is_corresponding":false,"raw_author_name":"Olatunji Matthew Kolawole","raw_affiliation_strings":["Department of Microbiology, University of Ilorin, Ilorin 234031, Nigeria","Department of Public Health, Warwick Medical School, University of Warwick, Coventry, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, University of Ilorin, Ilorin 234031, Nigeria","institution_ids":["https://openalex.org/I134542131"]},{"raw_affiliation_string":"Department of Public Health, Warwick Medical School, University of Warwick, Coventry, United Kingdom","institution_ids":["https://openalex.org/I39555362"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041537386","display_name":"Titilayo Mabel Olotu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149910238","display_name":"Kent State University","ror":"https://ror.org/049pfb863","country_code":"US","type":"education","lineage":["https://openalex.org/I149910238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Titilayo Olotu","raw_affiliation_strings":["Department of Biomedical Sciences, Kent State University, Kent, Ohio. USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, Kent State University, Kent, Ohio. USA","institution_ids":["https://openalex.org/I149910238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077208574","display_name":"Elukunbi Hilda Awoyelu","orcid":"https://orcid.org/0000-0001-7925-772X","observed_orcids":["https://orcid.org/0000-0001-7925-772X"]},"institutions":[{"id":"https://openalex.org/I4405263704","display_name":"Helix Biogen Institute","ror":"https://ror.org/054ja1t10","country_code":"NG","type":"education","lineage":["https://openalex.org/I4405263704"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Elukunbi Hilda Awoyelu","raw_affiliation_strings":["Division of Genome and Molecular Sciences, Helix Biogen Institute, Ogbomoso, Oyo State Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Genome and Molecular Sciences, Helix Biogen Institute, Ogbomoso, Oyo State Nigeria","institution_ids":["https://openalex.org/I4405263704"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038425165","display_name":"Tajudeen Oladunni Ganiyu","orcid":"https://orcid.org/0000-0003-3706-2398","observed_orcids":["https://orcid.org/0000-0003-3706-2398"]},"institutions":[{"id":"https://openalex.org/I123698207","display_name":"Fountain University","ror":"https://ror.org/00ah3j950","country_code":"NG","type":"education","lineage":["https://openalex.org/I123698207"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Tajudeen Oladunni Ganiyu","raw_affiliation_strings":["Department of Biological Sciences, Fountain University, Osogbo, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Fountain University, Osogbo, Nigeria","institution_ids":["https://openalex.org/I123698207"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058807619","display_name":"Helen N. Onyeaka","orcid":"https://orcid.org/0000-0003-3846-847X","observed_orcids":["https://orcid.org/0000-0003-3846-847X"]},"institutions":[{"id":"https://openalex.org/I79619799","display_name":"University of Birmingham","ror":"https://ror.org/03angcq70","country_code":"GB","type":"education","lineage":["https://openalex.org/I79619799"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Helen Onyeaka","raw_affiliation_strings":["Department of Chemical Engineering, University of Birmingham, Edgbaston, Birmingham B12 2TT UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, University of Birmingham, Edgbaston, Birmingham B12 2TT UK","institution_ids":["https://openalex.org/I79619799"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5015565031"],"corresponding_institution_ids":["https://openalex.org/I2799835767","https://openalex.org/I4405263704","https://openalex.org/I79619799"],"apc_list":{"value":2000,"currency":"USD","value_usd":2000},"apc_paid":{"value":2000,"currency":"USD","value_usd":2000},"fwci":1.2687,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.78751022,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"1","issue":null,"first_page":"100046","last_page":"100046"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mrna-vaccine-design","display_name":"mRNA vaccine design","score":0.7910000085830688},{"id":"https://openalex.org/keywords/immunoinformatics","display_name":"immunoinformatics","score":0.8569999933242798},{"id":"https://openalex.org/keywords/multiepitope-vaccine","display_name":"multi-epitope vaccine","score":0.8289999961853027},{"id":"https://openalex.org/keywords/ctl-epitopes","display_name":"CTL epitopes","score":0.7379999756813049},{"id":"https://openalex.org/keywords/helper-t-cell-epitopes","display_name":"helper T cell epitopes","score":0.8740000128746033},{"id":"https://openalex.org/keywords/b-cell-epitopes","display_name":"B-cell epitopes","score":0.9980000257492065},{"id":"https://openalex.org/keywords/arboviruses","display_name":"arboviruses","score":0.7009999752044678},{"id":"https://openalex.org/keywords/orthobunyavirus","display_name":"Orthobunyavirus","score":0.902999997138977}],"concepts":[{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6669341325759888},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.4880944490432739},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.4790412187576294},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4730362594127655},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3695957064628601},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1661148965358734},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12837523221969604}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.insi.2025.100046","doi":"https://doi.org/10.1016/j.insi.2025.100046","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.insi.2025.100046","pdf_url":null,"source":{"id":"https://openalex.org/S5407047481","display_name":"In Silico Research in Biomedicine","issn_l":"3050-7871","issn":["3050-7871"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"In Silico Research in Biomedicine","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.insi.2025.100046","doi":"https://doi.org/10.1016/j.insi.2025.100046","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.insi.2025.100046","pdf_url":null,"source":{"id":"https://openalex.org/S5407047481","display_name":"In Silico Research in Biomedicine","issn_l":"3050-7871","issn":["3050-7871"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"In Silico Research in Biomedicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W1976749028","https://openalex.org/W1986191025","https://openalex.org/W1989017867","https://openalex.org/W2012625502","https://openalex.org/W2015176909","https://openalex.org/W2021449399","https://openalex.org/W2025190578","https://openalex.org/W2035240910","https://openalex.org/W2078397942","https://openalex.org/W2102367710","https://openalex.org/W2110298304","https://openalex.org/W2118817344","https://openalex.org/W2134855545","https://openalex.org/W2150537020","https://openalex.org/W2572080171","https://openalex.org/W2611314002","https://openalex.org/W2620185010","https://openalex.org/W2777980778","https://openalex.org/W2784190155","https://openalex.org/W2804822363","https://openalex.org/W2898389621","https://openalex.org/W3014553071","https://openalex.org/W3024570138","https://openalex.org/W3091432157","https://openalex.org/W3200104592","https://openalex.org/W3206720061","https://openalex.org/W4226068113","https://openalex.org/W4237627452","https://openalex.org/W4244736178","https://openalex.org/W4281254240","https://openalex.org/W4281746438","https://openalex.org/W4289274885","https://openalex.org/W4310380747","https://openalex.org/W4366481755","https://openalex.org/W4385620554","https://openalex.org/W4391577074","https://openalex.org/W4392292648","https://openalex.org/W4399580117","https://openalex.org/W4400949958","https://openalex.org/W4401171233","https://openalex.org/W4401645068","https://openalex.org/W4404513517","https://openalex.org/W4411853065","https://openalex.org/W4412438441"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2082860237","https://openalex.org/W2119695867","https://openalex.org/W2130076355","https://openalex.org/W1990804418","https://openalex.org/W1993764875","https://openalex.org/W2188759708","https://openalex.org/W2097433578","https://openalex.org/W4386371748","https://openalex.org/W2147145791"],"abstract_inverted_index":{"Ilesha":[0,63,235],"virus":[1,5],"is":[2,255],"an":[3,127,129,231],"arthropod-borne":[4],"belonging":[6],"to":[7,54,82,115,147,160,189,257],"the":[8,12,62,66,187],"genus":[9],"Orthobunyavirus":[10],"within":[11],"family":[13],"Bunyaviridae.":[14],"It":[15],"has":[16],"been":[17,45],"isolated":[18],"from":[19],"humans":[20],"in":[21,249,252],"several":[22],"African":[23],"countries,":[24],"primarily":[25],"associated":[26],"with":[27,65,167,200,208],"febrile":[28],"illness":[29],"and":[30,40,76,92,105,139,144,151,165,171,179,195,213,218,251,261],"erythema,":[31],"although":[32],"more":[33],"severe":[34],"manifestations":[35],"such":[36],"as":[37],"fatal":[38],"meningoencephalitis":[39],"hemorrhagic":[41],"fever":[42],"have":[43],"also":[44],"reported.":[46],"In":[47],"this":[48],"study,":[49],"we":[50],"employed":[51],"immunoinformatics":[52],"approaches":[53],"design":[55],"a":[56,135,225],"rational":[57],"mRNA":[58,119,155,232],"vaccine":[59,120,156,233,238],"construct":[60,116,123],"targeting":[61],"virus,":[64],"aim":[67],"of":[68,174,211],"preventing":[69],"infection.":[70],"Antigenic":[71],"viral":[72],"proteins":[73],"were":[74,98,113,158],"retrieved":[75],"analyzed":[77],"using":[78],"various":[79],"bioinformatics":[80],"tools":[81],"predict":[83],"cytotoxic":[84],"T":[85,89],"lymphocyte":[86,90],"(CTL),":[87],"helper":[88],"(HTL),":[91],"B-cell":[93],"epitopes.":[94],"These":[95],"predicted":[96,159],"epitopes":[97,112],"further":[99,248],"evaluated":[100],"for":[101,215,229,242],"antigenicity,":[102],"allergenicity,":[103],"toxicity,":[104],"population":[106],"coverage.":[107],"The":[108,237],"most":[109],"immunologically":[110],"promising":[111,226],"selected":[114],"two":[117],"multi-epitope":[118],"candidates.":[121],"Each":[122],"comprised":[124],"nine":[125],"epitopes,":[126],"adjuvant,":[128],"MHC":[130],"class":[131],"I-targeting":[132],"domain":[133],"(MITD),":[134],"Kozak":[136],"sequence,":[137],"5\u2032":[138],"3\u2032":[140],"untranslated":[141],"regions":[142],"(UTRs),":[143],"appropriate":[145],"linkers":[146],"ensure":[148],"efficient":[149],"expression":[150],"immune":[152,245],"recognition.":[153],"Both":[154],"constructs":[157,188,239],"be":[161,190],"highly":[162],"antigenic,":[163],"non-toxic,":[164],"non-allergenic,":[166],"favorable":[168],"physicochemical":[169],"properties":[170],"molecular":[172],"weights":[173],"118,528.86":[175],"Da":[176,181],"(Construct":[177,182],"1)":[178],"118,084.27":[180],"2).":[183],"Structural":[184],"modeling":[185],"revealed":[186],"stable":[191],"at":[192],"both":[193],"secondary":[194],"tertiary":[196],"levels.":[197],"Molecular":[198],"docking":[199,209],"Toll-like":[201],"receptors":[202],"(TLRs)":[203],"demonstrated":[204],"strong":[205],"binding":[206],"affinities,":[207],"scores":[210],"\u20131149.5":[212],"\u2013882.6":[214],"Construct":[216,219],"1":[217],"2,":[220],"respectively.":[221],"This":[222],"study":[223],"presents":[224],"immunoinformatic":[227],"strategy":[228],"developing":[230],"against":[234],"virus.":[236],"show":[240],"potential":[241],"eliciting":[243],"protective":[244],"responses;":[246],"however,":[247],"vitro":[250],"vivo":[253],"validation":[254],"necessary":[256],"confirm":[258],"their":[259],"efficacy":[260],"safety.":[262]},"counts_by_year":[{"year":2026,"cited_by_count":5}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}
