{"id":"https://openalex.org/W4413110548","doi":"https://doi.org/10.1093/cvr/cvaf140","title":"Rethinking cardiovascular ageing","display_name":"Rethinking cardiovascular ageing","publication_year":2025,"publication_date":"2025-08-01","ids":{"openalex":"https://openalex.org/W4413110548","doi":"https://doi.org/10.1093/cvr/cvaf140","pmid":"https://pubmed.ncbi.nlm.nih.gov/40796193"},"language":"en","primary_location":{"id":"doi:10.1093/cvr/cvaf140","doi":"https://doi.org/10.1093/cvr/cvaf140","is_oa":false,"landing_page_url":"https://doi.org/10.1093/cvr/cvaf140","pdf_url":null,"source":{"id":"https://openalex.org/S91067379","display_name":"Cardiovascular Research","issn_l":"0008-6363","issn":["0008-6363","1755-3245"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovascular Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087655089","display_name":"Patrick J. Lacolley","orcid":"https://orcid.org/0000-0002-2938-1383","observed_orcids":["https://orcid.org/0000-0002-2938-1383"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4387155877","display_name":"D\u00e9faillance Cardiovasculaire Aigu\u00eb et Chronique","ror":"https://ror.org/05ft9wv42","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I4387155877","https://openalex.org/I90183372"]},{"id":"https://openalex.org/I90183372","display_name":"Universit\u00e9 de Lorraine","ror":"https://ror.org/04vfs2w97","country_code":"FR","type":"education","lineage":["https://openalex.org/I90183372"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Patrick Lacolley","raw_affiliation_strings":["Universit\u00e9 de Lorraine, Inserm, DCAC , 54000 Nancy ,","Universit\u00e9 de Lorraine, Inserm, DCAC , Nancy ,","Universit\u00e9 de Lorraine, Inserm, DCAC, Nancy, France"],"raw_orcid":"https://orcid.org/0000-0002-2938-1383","affiliations":[{"raw_affiliation_string":"Universit\u00e9 de Lorraine, Inserm, DCAC , 54000 Nancy ,","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4387155877","https://openalex.org/I90183372"]},{"raw_affiliation_string":"Universit\u00e9 de Lorraine, Inserm, DCAC , Nancy ,","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4387155877","https://openalex.org/I90183372"]},{"raw_affiliation_string":"Universit\u00e9 de Lorraine, Inserm, DCAC, Nancy, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4387155877","https://openalex.org/I90183372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032075495","display_name":"Mar\u0131\u0301a Mittelbrunn","orcid":"https://orcid.org/0000-0003-3487-8762","observed_orcids":["https://orcid.org/0000-0003-3487-8762"]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210146061","display_name":"Centro de Biolog\u00eda Molecular Severo Ochoa","ror":"https://ror.org/03v9e8t09","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210146061"]},{"id":"https://openalex.org/I63634437","display_name":"Universidad Aut\u00f3noma de Madrid","ror":"https://ror.org/01cby8j38","country_code":"ES","type":"education","lineage":["https://openalex.org/I63634437"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Mar\u00eda Mittelbrunn","raw_affiliation_strings":["Tissue and Organ Homeostais Program, Centro de Biolog\u00eda Molecular Severo Ochoa (CBM), Consejo Superior de Investigaciones Cient\u00edficas (CSIC)\u2014Universidad Aut\u00f3noma de Madrid (UAM) , Calle Nicol\u00e1s Cabrera 1, Madrid 28049 ,","Tissue and Organ Homeostais Program, Centro de Biolog\u00eda Molecular Severo Ochoa (CBM), Consejo Superior de Investigaciones Cient\u00edficas (CSIC)-Universidad Aut\u00f3noma de Madrid (UAM), Calle Nicol\u00e1s Cabrera 1, 28049 Madrid, Spain","Tissue and Organ Homeostais Program, Centro de Biolog\u00eda Molecular Severo Ochoa (CBM), Consejo Superior de Investigaciones Cient\u00edficas (CSIC)\u2014Universidad Aut\u00f3noma de Madrid (UAM) , Calle Nicol\u00e1s Cabrera 1, 28049 Madrid ,"],"raw_orcid":"https://orcid.org/0000-0003-3487-8762","affiliations":[{"raw_affiliation_string":"Tissue and Organ Homeostais Program, Centro de Biolog\u00eda Molecular Severo Ochoa (CBM), Consejo Superior de Investigaciones Cient\u00edficas (CSIC)\u2014Universidad Aut\u00f3noma de Madrid (UAM) , Calle Nicol\u00e1s Cabrera 1, Madrid 28049 ,","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210146061","https://openalex.org/I63634437"]},{"raw_affiliation_string":"Tissue and Organ Homeostais Program, Centro de Biolog\u00eda Molecular Severo Ochoa (CBM), Consejo Superior de Investigaciones Cient\u00edficas (CSIC)-Universidad Aut\u00f3noma de Madrid (UAM), Calle Nicol\u00e1s Cabrera 1, 28049 Madrid, Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210146061","https://openalex.org/I63634437"]},{"raw_affiliation_string":"Tissue and Organ Homeostais Program, Centro de Biolog\u00eda Molecular Severo Ochoa (CBM), Consejo Superior de Investigaciones Cient\u00edficas (CSIC)\u2014Universidad Aut\u00f3noma de Madrid (UAM) , Calle Nicol\u00e1s Cabrera 1, 28049 Madrid ,","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210146061","https://openalex.org/I63634437"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025706940","display_name":"Stefanie Dimmeler","orcid":"https://orcid.org/0000-0002-1045-2436","observed_orcids":["https://orcid.org/0000-0002-1045-2436"]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]},{"id":"https://openalex.org/I4210127591","display_name":"German Centre for Cardiovascular Research","ror":"https://ror.org/031t5w623","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210127591","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Stefanie Dimmeler","raw_affiliation_strings":["Cardiopulmonary Institute, Goethe University Frankfurt , Frankfurt am Main 60590 ,","German Center for Cardiovascular Research DZHK , Frankfurt am Main 60590 ,","Institute of Cardiovascular Regeneration, Center of Molecular Medicine, Goethe University Frankfurt , Frankfurt am Main 60590 ,","Cardiopulmonary Institute, Goethe University Frankfurt , Frankfurt am Main ,","Cardiopulmonary Institute, Goethe University Frankfurt, Frankfurt am Main, Germany","German Center for Cardiovascular Research DZHK , Frankfurt am Main ,","German Center for Cardiovascular Research DZHK, Frankfurt am Main, Germany","Institute of Cardiovascular Regeneration, Center of Molecular Medicine, Goethe University Frankfurt , Frankfurt am Main ,","Institute of Cardiovascular Regeneration, Center of Molecular Medicine, Goethe University Frankfurt, Frankfurt am Main, Germany"],"raw_orcid":"https://orcid.org/0000-0002-1045-2436","affiliations":[{"raw_affiliation_string":"Cardiopulmonary Institute, Goethe University Frankfurt , Frankfurt am Main 60590 ,","institution_ids":["https://openalex.org/I114090438"]},{"raw_affiliation_string":"German Center for Cardiovascular Research DZHK , Frankfurt am Main 60590 ,","institution_ids":["https://openalex.org/I4210127591"]},{"raw_affiliation_string":"Institute of Cardiovascular Regeneration, Center of Molecular Medicine, Goethe University Frankfurt , Frankfurt am Main 60590 ,","institution_ids":["https://openalex.org/I114090438"]},{"raw_affiliation_string":"Cardiopulmonary Institute, Goethe University Frankfurt , Frankfurt am Main ,","institution_ids":["https://openalex.org/I114090438"]},{"raw_affiliation_string":"Cardiopulmonary Institute, Goethe University Frankfurt, Frankfurt am Main, Germany","institution_ids":["https://openalex.org/I114090438"]},{"raw_affiliation_string":"German Center for Cardiovascular Research DZHK , Frankfurt am Main ,","institution_ids":["https://openalex.org/I4210127591"]},{"raw_affiliation_string":"German Center for Cardiovascular Research DZHK, Frankfurt am Main, Germany","institution_ids":["https://openalex.org/I4210127591"]},{"raw_affiliation_string":"Institute of Cardiovascular Regeneration, Center of Molecular Medicine, Goethe University Frankfurt , Frankfurt am Main ,","institution_ids":["https://openalex.org/I114090438"]},{"raw_affiliation_string":"Institute of Cardiovascular Regeneration, Center of Molecular Medicine, Goethe University Frankfurt, Frankfurt am Main, Germany","institution_ids":["https://openalex.org/I114090438"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5087655089"],"corresponding_institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4387155877","https://openalex.org/I90183372"],"apc_list":{"value":4715,"currency":"EUR","value_usd":5329},"apc_paid":null,"fwci":0.6453,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.68898039,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"121","issue":"10","first_page":"1465","last_page":"1467"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.9667999744415283,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.9667999744415283,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.00860000029206276,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cardiovascular-aging","display_name":"cardiovascular aging","score":0.9990000128746033},{"id":"https://openalex.org/keywords/accelerated-aging","display_name":"accelerated aging","score":0.6150000095367432},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cellular-senescence","display_name":"cellular senescence","score":1.0},{"id":"https://openalex.org/keywords/epigenetics","display_name":"epigenetics","score":0.890999972820282},{"id":"https://openalex.org/keywords/telomerase","display_name":"telomerase","score":0.824999988079071},{"id":"https://openalex.org/keywords/clonal-hematopoiesis","display_name":"clonal hematopoiesis","score":0.9480000138282776},{"id":"https://openalex.org/keywords/lacunar-stroke","display_name":"lacunar stroke","score":0.9629999995231628},{"id":"https://openalex.org/keywords/cardiac-amyloidosis","display_name":"cardiac amyloidosis","score":0.8069999814033508},{"id":"https://openalex.org/keywords/prealbumin","display_name":"prealbumin","score":0.9549999833106995},{"id":"https://openalex.org/keywords/senolytics","display_name":"senolytics","score":0.8259999752044678},{"id":"https://openalex.org/keywords/metalloproteinase-inhibitors","display_name":"metalloproteinase inhibitors","score":0.9129999876022339},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.652999997138977},{"id":"https://openalex.org/keywords/trimethylamine-n-oxide","display_name":"trimethylamine N-oxide","score":0.9879999756813049},{"id":"https://openalex.org/keywords/sirtuin-activators","display_name":"sirtuin activators","score":0.8759999871253967},{"id":"https://openalex.org/keywords/sglt2-inhibitors","display_name":"SGLT2 inhibitors","score":0.9959999918937683},{"id":"https://openalex.org/keywords/glp-1-receptor-agonists","display_name":"GLP-1 receptor agonists","score":0.9539999961853027},{"id":"https://openalex.org/keywords/energy-metabolism","display_name":"energy metabolism","score":0.41200000047683716}],"concepts":[{"id":"https://openalex.org/C500499127","wikidata":"https://www.wikidata.org/wiki/Q332154","display_name":"Ageing","level":2,"score":0.7335234880447388},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.45414188504219055},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.41804227232933044},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35083937644958496},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.34934282302856445}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1093/cvr/cvaf140","doi":"https://doi.org/10.1093/cvr/cvaf140","is_oa":false,"landing_page_url":"https://doi.org/10.1093/cvr/cvaf140","pdf_url":null,"source":{"id":"https://openalex.org/S91067379","display_name":"Cardiovascular Research","issn_l":"0008-6363","issn":["0008-6363","1755-3245"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovascular Research","raw_type":"journal-article"},{"id":"pmid:40796193","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40796193","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovascular research","raw_type":"Journal Article"},{"id":"pmh:oai:digital.csic.es:10261/426070","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10261/426070","pdf_url":null,"source":{"id":"https://openalex.org/S4306400616","display_name":"DIGITAL.CSIC (Spanish National Research Council (CSIC))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I134820265","host_organization_name":"Consejo Superior de Investigaciones Cient\u00edficas","host_organization_lineage":["https://openalex.org/I134820265"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W4393981288","https://openalex.org/W4399780809","https://openalex.org/W4400059262","https://openalex.org/W4401834919","https://openalex.org/W4401834942","https://openalex.org/W4404276532","https://openalex.org/W4408744779","https://openalex.org/W4412726009","https://openalex.org/W4412727580","https://openalex.org/W4413115593","https://openalex.org/W4413137829","https://openalex.org/W4413771025"],"related_works":["https://openalex.org/W7154984864","https://openalex.org/W4413094159","https://openalex.org/W4367461588","https://openalex.org/W7124605851","https://openalex.org/W7161164173","https://openalex.org/W2023084664","https://openalex.org/W3198540150","https://openalex.org/W7122857630","https://openalex.org/W4401834919","https://openalex.org/W2031568274"],"abstract_inverted_index":{"This":[0],"spotlight":[1],"issue":[2],"aims":[3],"to":[4,162,164],"give":[5],"an":[6],"update":[7],"on":[8,12],"the":[9,13,59,71,74,78,92,100,132],"recent":[10,67],"insights":[11],"physiological":[14],"and":[15,32,42,45,54,64,104,107,115,143,154],"accelerated":[16],"forms":[17],"of":[18,40,58,73,77,94,102,119,127,134,140,147,181],"cardiovascular":[19],"(CV)":[20],"ageing":[21,44],"involving":[22],"a":[23],"complex":[24,80],"interaction":[25],"between":[26],"immuno-inflammation,":[27],"oxidative":[28],"stress,":[29],"cellular":[30],"senescence,":[31],"epigenetics.":[33],"Ministrini":[34],"et":[35],"al.1":[36],"review":[37],"molecular":[38],"biomarkers":[39],"CV":[41],"cerebrovascular":[43],"new":[46,135,178],"drugs":[47],"or":[48,188],"lifestyle":[49],"interventions":[50],"either":[51],"for":[52,55],"prevention":[53],"treatment.":[56],"Each":[57],"major":[60],"mechanisms":[61],"is":[62,84,97,172],"extended":[63],"supported":[65],"by":[66,86,170,174],"findings.":[68],"For":[69],"example,":[70],"role":[72,93],"TERT":[75],"component":[76],"telomerase":[79],"in":[81,109,122,131],"genomic":[82],"instability":[83],"highlighted":[85,173],"its":[87],"association":[88],"with":[89,99],"clonal":[90],"hematopoiesis;":[91],"lncRNA":[95],"H19":[96],"associated":[98],"risk":[101],"death":[103],"lacunar":[105],"stroke,":[106],"dysfunction":[108],"energy":[110],"metabolism":[111],"via":[112],"growth":[113],"factors":[114],"their":[116],"receptors,":[117],"deposition":[118],"misfolded":[120],"transthyretin":[121],"cardiac":[123],"amyloidosis.":[124],"The":[125],"accumulation":[126],"senescence":[128],"cells":[129],"resulted":[130],"emergence":[133],"senolytic":[136],"drugs.":[137],"Likewise,":[138],"inhibitors":[139],"metalloproteinases,":[141],"cell\u2013cell":[142],"cell\u2013matrix":[144],"communications,":[145],"preponderance":[146],"pro-inflammatory":[148],"pathways":[149],"over":[150],"immune-inflammation":[151,171],"resolution":[152],"signalling,":[153],"gut":[155],"microbial-metabolite":[156],"TMAO":[157],"(trimethyl-lamine":[158],"N-oxide)":[159],"are":[160,191],"considered":[161],"contribute":[163],"ageing.":[165],"Accelerated":[166],"epigenetic":[167],"age":[168],"mediated":[169],"considerable":[175],"research":[176],"into":[177],"molecules;":[179],"some":[180],"which,":[182],"as":[183],"sirtuin":[184],"activators,":[185],"SGLT2":[186],"inhibitors,":[187],"GLP-1":[189],"agonists,":[190],"already":[192],"undergoing":[193],"clinical":[194],"trials.":[195]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2025-10-10T00:00:00"}
