{"id":"https://openalex.org/W4413106972","doi":"https://doi.org/10.4103/aja202549","title":"Integrated metabolomic and microbiota analysis of semen: seasonal and morphological associations","display_name":"Integrated metabolomic and microbiota analysis of semen: seasonal and morphological associations","publication_year":2025,"publication_date":"2025-08-12","ids":{"openalex":"https://openalex.org/W4413106972","doi":"https://doi.org/10.4103/aja202549","pmid":"https://pubmed.ncbi.nlm.nih.gov/40791011"},"language":"en","primary_location":{"id":"doi:10.4103/aja202549","doi":"https://doi.org/10.4103/aja202549","is_oa":true,"landing_page_url":"https://doi.org/10.4103/aja202549","pdf_url":null,"source":{"id":"https://openalex.org/S78604184","display_name":"Asian Journal of Andrology","issn_l":"1008-682X","issn":["1008-682X","1745-7262"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asian Journal of Andrology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.4103/aja202549","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100645741","display_name":"Jie Zheng","orcid":"https://orcid.org/0000-0002-9640-1604","observed_orcids":["https://orcid.org/0000-0002-9640-1604","https://orcid.org/0000-0001-9211-2875"]},"institutions":[{"id":"https://openalex.org/I4210097509","display_name":"Second Affiliated Hospital of Chongqing Medical University","ror":"https://ror.org/00r67fz39","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097509"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jie Zheng","raw_affiliation_strings":["The Center for Reproductive Medicine, Obstetrics and Gynecology Department, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Center for Reproductive Medicine, Obstetrics and Gynecology Department, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China","institution_ids":["https://openalex.org/I4210097509"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jie Liao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210097509","display_name":"Second Affiliated Hospital of Chongqing Medical University","ror":"https://ror.org/00r67fz39","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097509"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jie Liao","raw_affiliation_strings":["The Center for Reproductive Medicine, Obstetrics and Gynecology Department, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Center for Reproductive Medicine, Obstetrics and Gynecology Department, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China","institution_ids":["https://openalex.org/I4210097509"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045077341","display_name":"Cheng\u2010Guang Sun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210097509","display_name":"Second Affiliated Hospital of Chongqing Medical University","ror":"https://ror.org/00r67fz39","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097509"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Cheng-Guang Sun","raw_affiliation_strings":["The Center for Reproductive Medicine, Obstetrics and Gynecology Department, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Center for Reproductive Medicine, Obstetrics and Gynecology Department, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China","institution_ids":["https://openalex.org/I4210097509"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100649439","display_name":"Yuan Zhi","orcid":"https://orcid.org/0009-0003-0307-8727","observed_orcids":["https://orcid.org/0009-0003-0307-8727"]},"institutions":[{"id":"https://openalex.org/I4210097509","display_name":"Second Affiliated Hospital of Chongqing Medical University","ror":"https://ror.org/00r67fz39","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097509"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhi Yuan","raw_affiliation_strings":["The Center for Reproductive Medicine, Obstetrics and Gynecology Department, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Center for Reproductive Medicine, Obstetrics and Gynecology Department, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China","institution_ids":["https://openalex.org/I4210097509"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054327155","display_name":"Yuan Han Qin","orcid":"https://orcid.org/0000-0003-0205-5454","observed_orcids":["https://orcid.org/0000-0003-0205-5454"]},"institutions":[{"id":"https://openalex.org/I4210097509","display_name":"Second Affiliated Hospital of Chongqing Medical University","ror":"https://ror.org/00r67fz39","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097509"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuan Qin","raw_affiliation_strings":["The Center for Reproductive Medicine, Obstetrics and Gynecology Department, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Center for Reproductive Medicine, Obstetrics and Gynecology Department, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China","institution_ids":["https://openalex.org/I4210097509"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111246772","display_name":"Ting-Li Han","orcid":"https://orcid.org/0000-0001-6011-7508","observed_orcids":["https://orcid.org/0000-0001-6011-7508"]},"institutions":[{"id":"https://openalex.org/I4210097509","display_name":"Second Affiliated Hospital of Chongqing Medical University","ror":"https://ror.org/00r67fz39","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097509"]},{"id":"https://openalex.org/I87780372","display_name":"Chongqing Medical University","ror":"https://ror.org/017z00e58","country_code":"CN","type":"education","lineage":["https://openalex.org/I87780372"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ting-Li Han","raw_affiliation_strings":["Joint International Research Lab for Reproduction and Development of Ministry of Education of China, Chongqing Medical University, Chongqing 400010, China","Mass Spectrometry Centre of Maternal-Fetal Medicine, Chongqing Medical University, Chongqing 400010, China","The Center for Reproductive Medicine, Obstetrics and Gynecology Department, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Joint International Research Lab for Reproduction and Development of Ministry of Education of China, Chongqing Medical University, Chongqing 400010, China","institution_ids":["https://openalex.org/I87780372"]},{"raw_affiliation_string":"Mass Spectrometry Centre of Maternal-Fetal Medicine, Chongqing Medical University, Chongqing 400010, China","institution_ids":["https://openalex.org/I87780372"]},{"raw_affiliation_string":"The Center for Reproductive Medicine, Obstetrics and Gynecology Department, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China","institution_ids":["https://openalex.org/I4210097509"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000228105","display_name":"Heng Zou","orcid":"https://orcid.org/0000-0002-3683-7916","observed_orcids":["https://orcid.org/0000-0002-3683-7916"]},"institutions":[{"id":"https://openalex.org/I4210097509","display_name":"Second Affiliated Hospital of Chongqing Medical University","ror":"https://ror.org/00r67fz39","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097509"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Heng Zou","raw_affiliation_strings":["The Center for Reproductive Medicine, Obstetrics and Gynecology Department, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Center for Reproductive Medicine, Obstetrics and Gynecology Department, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China","institution_ids":["https://openalex.org/I4210097509"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100354196","display_name":"Shen Zhang","orcid":"https://orcid.org/0000-0002-6429-8008","observed_orcids":["https://orcid.org/0000-0002-6429-8008"]},"institutions":[{"id":"https://openalex.org/I4210097509","display_name":"Second Affiliated Hospital of Chongqing Medical University","ror":"https://ror.org/00r67fz39","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097509"]},{"id":"https://openalex.org/I87780372","display_name":"Chongqing Medical University","ror":"https://ror.org/017z00e58","country_code":"CN","type":"education","lineage":["https://openalex.org/I87780372"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Shen Zhang","raw_affiliation_strings":["Joint International Research Lab for Reproduction and Development of Ministry of Education of China, Chongqing Medical University, Chongqing 400010, China","The Center for Reproductive Medicine, Obstetrics and Gynecology Department, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Joint International Research Lab for Reproduction and Development of Ministry of Education of China, Chongqing Medical University, Chongqing 400010, China","institution_ids":["https://openalex.org/I87780372"]},{"raw_affiliation_string":"The Center for Reproductive Medicine, Obstetrics and Gynecology Department, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China","institution_ids":["https://openalex.org/I4210097509"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100354196"],"corresponding_institution_ids":["https://openalex.org/I4210097509","https://openalex.org/I87780372"],"apc_list":{"value":4900,"currency":"CNY","value_usd":711},"apc_paid":{"value":4900,"currency":"CNY","value_usd":711},"fwci":0.6815,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.72113943,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"28","issue":"2","first_page":"196","last_page":"204"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12866","display_name":"Urologic and reproductive health conditions","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/semen-microbiota","display_name":"semen microbiota","score":0.9580000042915344},{"id":"https://openalex.org/keywords/teratozoospermia","display_name":"teratozoospermia","score":0.9980000257492065},{"id":"https://openalex.org/keywords/abnormal-sperm-morphology","display_name":"abnormal sperm morphology","score":0.949999988079071},{"id":"https://openalex.org/keywords/male-infertility","display_name":"male infertility","score":0.9829999804496765},{"id":"https://openalex.org/keywords/seasonal-variation","display_name":"seasonal variation","score":0.9879999756813049},{"id":"https://openalex.org/keywords/phenylpyruvic-acid","display_name":"phenylpyruvic acid","score":0.9940000176429749},{"id":"https://openalex.org/keywords/n-acetylaspartate","display_name":"N-acetylaspartate","score":0.9990000128746033},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8759999871253967},{"id":"https://openalex.org/keywords/energy-metabolism","display_name":"energy metabolism","score":0.8029999732971191},{"id":"https://openalex.org/keywords/lactobacillus","display_name":"Lactobacillus","score":0.878000020980835},{"id":"https://openalex.org/keywords/proteobacteria","display_name":"Proteobacteria","score":0.7979999780654907},{"id":"https://openalex.org/keywords/firmicutes","display_name":"Firmicutes","score":0.9739999771118164},{"id":"https://openalex.org/keywords/actinobacteriota","display_name":"Actinobacteriota","score":0.8479999899864197},{"id":"https://openalex.org/keywords/undecanoic-acid","display_name":"undecanoic acid","score":0.7879999876022339}],"concepts":[{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.7089715003967285},{"id":"https://openalex.org/C2778093475","wikidata":"https://www.wikidata.org/wiki/Q9715","display_name":"Semen","level":2,"score":0.5817066431045532},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5427922606468201},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.3251732587814331},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.22896799445152283},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18297433853149414}],"mesh":[{"descriptor_ui":"D000072660","descriptor_name":"Teratozoospermia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000072660","descriptor_name":"Teratozoospermia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000072660","descriptor_name":"Teratozoospermia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000072660","descriptor_name":"Teratozoospermia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000072660","descriptor_name":"Teratozoospermia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000072660","descriptor_name":"Teratozoospermia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000072660","descriptor_name":"Teratozoospermia","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D000072660","descriptor_name":"Teratozoospermia","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D000072660","descriptor_name":"Teratozoospermia","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D000072660","descriptor_name":"Teratozoospermia","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D000072660","descriptor_name":"Teratozoospermia","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D000072660","descriptor_name":"Teratozoospermia","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002681","descriptor_name":"China","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002681","descriptor_name":"China","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002681","descriptor_name":"China","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002681","descriptor_name":"China","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002681","descriptor_name":"China","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002681","descriptor_name":"China","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008401","descriptor_name":"Gas Chromatography-Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008401","descriptor_name":"Gas Chromatography-Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008401","descriptor_name":"Gas Chromatography-Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008401","descriptor_name":"Gas Chromatography-Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008401","descriptor_name":"Gas Chromatography-Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008401","descriptor_name":"Gas Chromatography-Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012336","descriptor_name":"RNA, Ribosomal, 16S","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012336","descriptor_name":"RNA, Ribosomal, 16S","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012336","descriptor_name":"RNA, Ribosomal, 16S","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012336","descriptor_name":"RNA, Ribosomal, 16S","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012336","descriptor_name":"RNA, Ribosomal, 16S","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012336","descriptor_name":"RNA, Ribosomal, 16S","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012621","descriptor_name":"Seasons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012621","descriptor_name":"Seasons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012621","descriptor_name":"Seasons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012621","descriptor_name":"Seasons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012621","descriptor_name":"Seasons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012621","descriptor_name":"Seasons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012661","descriptor_name":"Semen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012661","descriptor_name":"Semen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012661","descriptor_name":"Semen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012661","descriptor_name":"Semen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012661","descriptor_name":"Semen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012661","descriptor_name":"Semen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012661","descriptor_name":"Semen","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D012661","descriptor_name":"Semen","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D012661","descriptor_name":"Semen","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D012661","descriptor_name":"Semen","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D012661","descriptor_name":"Semen","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D012661","descriptor_name":"Semen","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D013094","descriptor_name":"Spermatozoa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013094","descriptor_name":"Spermatozoa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013094","descriptor_name":"Spermatozoa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013094","descriptor_name":"Spermatozoa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013094","descriptor_name":"Spermatozoa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013094","descriptor_name":"Spermatozoa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055101","descriptor_name":"Semen Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055101","descriptor_name":"Semen Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055101","descriptor_name":"Semen Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055101","descriptor_name":"Semen Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055101","descriptor_name":"Semen Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055101","descriptor_name":"Semen Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064307","descriptor_name":"Microbiota","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D064307","descriptor_name":"Microbiota","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D064307","descriptor_name":"Microbiota","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D064307","descriptor_name":"Microbiota","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D064307","descriptor_name":"Microbiota","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D064307","descriptor_name":"Microbiota","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.4103/aja202549","doi":"https://doi.org/10.4103/aja202549","is_oa":true,"landing_page_url":"https://doi.org/10.4103/aja202549","pdf_url":null,"source":{"id":"https://openalex.org/S78604184","display_name":"Asian Journal of Andrology","issn_l":"1008-682X","issn":["1008-682X","1745-7262"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asian Journal of Andrology","raw_type":"journal-article"},{"id":"pmid:40791011","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40791011","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asian journal of andrology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13065319","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13065319/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13065319/pdf/AJA-28-196.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Asian J Androl","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:7277c47bce764e9d99f051ab4fe5df0a","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/7277c47bce764e9d99f051ab4fe5df0a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Asian Journal of Andrology, Vol 28, Iss 2, Pp 196-204 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.4103/aja202549","doi":"https://doi.org/10.4103/aja202549","is_oa":true,"landing_page_url":"https://doi.org/10.4103/aja202549","pdf_url":null,"source":{"id":"https://openalex.org/S78604184","display_name":"Asian Journal of Andrology","issn_l":"1008-682X","issn":["1008-682X","1745-7262"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asian Journal of Andrology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8560000061988831}],"sustainable_development_goals_aurora":[],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320322595","display_name":"Chongqing Medical University","ror":"https://ror.org/017z00e58"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W1599574575","https://openalex.org/W2006972107","https://openalex.org/W2025407650","https://openalex.org/W2057838384","https://openalex.org/W2060184814","https://openalex.org/W2062139818","https://openalex.org/W2063218600","https://openalex.org/W2075194339","https://openalex.org/W2098722265","https://openalex.org/W2144147626","https://openalex.org/W2157441506","https://openalex.org/W2163250554","https://openalex.org/W2231999257","https://openalex.org/W2792750014","https://openalex.org/W2884396458","https://openalex.org/W2914159241","https://openalex.org/W2917491985","https://openalex.org/W2922006436","https://openalex.org/W2938391042","https://openalex.org/W2963606930","https://openalex.org/W3047353442","https://openalex.org/W3047879054","https://openalex.org/W3049591358","https://openalex.org/W3090281687","https://openalex.org/W3193674027","https://openalex.org/W3216044194","https://openalex.org/W4200257052","https://openalex.org/W4205878348","https://openalex.org/W4206757948","https://openalex.org/W4220688888","https://openalex.org/W4281617166","https://openalex.org/W4313585705","https://openalex.org/W4366213842","https://openalex.org/W4367183875","https://openalex.org/W4391042069","https://openalex.org/W4391567835","https://openalex.org/W4392192533","https://openalex.org/W4392888320","https://openalex.org/W4393052314","https://openalex.org/W4394578957","https://openalex.org/W4401706936"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2082860237","https://openalex.org/W2119695867","https://openalex.org/W2130076355","https://openalex.org/W1990804418","https://openalex.org/W1993764875","https://openalex.org/W2046158694","https://openalex.org/W2788277189","https://openalex.org/W2013243191","https://openalex.org/W1971568933"],"abstract_inverted_index":{"Recent":[0],"studies":[1],"have":[2],"begun":[3],"to":[4,33,131,145],"investigate":[5],"the":[6,235,243],"metabolic":[7,226,236],"and":[8,29,39,57,78,99,121,134,150,158,167,177,186,217,227,237,250],"microbiota":[9,79,218],"profiles":[10],"in":[11,21,68,97,128,137],"semen,":[12,241],"yet":[13],"their":[14,141],"association":[15],"with":[16,55,60,94,111,183,197],"abnormal":[17],"sperm":[18,62,146],"morphology,":[19,63],"particularly":[20],"teratozoospermia,":[22,112,172],"remains":[23],"insufficiently":[24],"characterized.":[25],"Identifying":[26],"specific":[27],"metabolites":[28,108,125,185],"microbial":[30,228,238],"taxa":[31],"linked":[32],"this":[34],"condition":[35],"could":[36],"improve":[37],"diagnostics":[38],"management":[40],"for":[41,253],"male":[42,254],"infertility.":[43,255],"This":[44],"study":[45,231],"analyzed":[46],"semen":[47,215],"samples":[48],"from":[49],"231":[50],"patients,":[51],"including":[52,113],"30":[53,58],"patients":[54,59],"teratozoospermia":[56,220],"normal":[61],"collected":[64],"over":[65],"four":[66],"seasons":[67,157],"Chongqing,":[69],"China.":[70],"Metabolomic":[71],"profiling":[72],"by":[73,223],"gas":[74],"chromatography-mass":[75],"spectrometry":[76],"(GC-MS)":[77],"composition":[80],"analysis":[81],"via":[82],"16S":[83],"ribosomal":[84],"ribonucleic":[85],"acid":[86],"(rRNA)":[87],"sequencing":[88],"revealed":[89],"distinct":[90],"seasonal":[91,211],"metabolomic":[92],"shifts,":[93],"significant":[95,161,194],"changes":[96,212],"summer":[98],"autumn.":[100],"After":[101],"excluding":[102],"seasonally":[103],"affected":[104],"metabolites,":[105],"14":[106],"key":[107,184],"were":[109,152,169],"associated":[110],"reduced":[114],"levels":[115],"of":[116,240,245],"4-hydroxyphenylpyruvic":[117],"acid,":[118,120,199],"phenylpyruvic":[119],"N-acetyl-L-aspartic":[122],"acid.":[123],"These":[124,206],"are":[126],"involved":[127],"pathways":[129],"related":[130],"oxidative":[132],"stress":[133],"energy":[135],"metabolism":[136],"spermatozoa,":[138],"suggesting":[139,187,242],"that":[140,209],"depletion":[142],"may":[143],"contribute":[144],"abnormalities.":[147],"Proteobacteria,":[148],"Firmicutes,":[149],"Actinobacteriota":[151],"predominant":[153],"phyla":[154],"across":[155],"all":[156],"groups,":[159],"but":[160],"genus-level":[162],"fluctuations,":[163],"such":[164,174],"as":[165,175],"Acinetobacter":[166],"Staphylococcus,":[168],"observed.":[170],"In":[171],"genera":[173],"Lactobacillus":[176,201],"Limnochordaceae":[178,191],"showed":[179,192,202],"differential":[180],"abundance,":[181],"correlating":[182],"potential":[188],"functional":[189],"interactions.":[190],"a":[193,203],"positive":[195],"correlation":[196],"undecanoic":[198],"whereas":[200],"negative":[204],"correlation.":[205],"findings":[207],"highlight":[208],"while":[210],"significantly":[213],"influence":[214],"metabolomics":[216],"composition,":[219],"is":[221],"characterized":[222],"specific,":[224],"season-independent":[225],"signatures.":[229],"Our":[230],"provides":[232],"insights":[233],"into":[234],"dynamics":[239],"possibility":[244],"developing":[246],"novel":[247],"diagnostic":[248],"tools":[249],"therapeutic":[251],"strategies":[252]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}