{"id":"https://openalex.org/W4413106917","doi":"https://doi.org/10.1101/2025.07.16.665158","title":"The Rab32-LRMDA-Retriever Complex is a Key Regulator of Intestinal Immune Homeostasis","display_name":"The Rab32-LRMDA-Retriever Complex is a Key Regulator of Intestinal Immune Homeostasis","publication_year":2025,"publication_date":"2025-07-21","ids":{"openalex":"https://openalex.org/W4413106917","doi":"https://doi.org/10.1101/2025.07.16.665158","pmid":"https://pubmed.ncbi.nlm.nih.gov/40791432"},"language":"en","primary_location":{"id":"doi:10.1101/2025.07.16.665158","doi":"https://doi.org/10.1101/2025.07.16.665158","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.07.16.665158","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2025/07/21/2025.07.16.665158.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2025/07/21/2025.07.16.665158.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032896185","display_name":"Ran Song","orcid":"https://orcid.org/0000-0002-1564-527X","observed_orcids":["https://orcid.org/0000-0002-1564-527X"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ran Song","raw_affiliation_strings":["Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, 75390, USA"],"raw_orcid":"https://orcid.org/0000-0002-1564-527X","affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, 75390, USA","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5094153663","display_name":"Chigozie Ngoka","orcid":"https://orcid.org/0009-0002-6997-4404","observed_orcids":["https://orcid.org/0009-0002-6997-4404"]},"institutions":[{"id":"https://openalex.org/I173911158","display_name":"Iowa State University","ror":"https://ror.org/04rswrd78","country_code":"US","type":"education","lineage":["https://openalex.org/I173911158"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chigozie Ngoka","raw_affiliation_strings":["Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, 75390, USA","Roy J. Carver Department of Biochemistry, Biophysics & Molecular Biology, Iowa State University, Ames, Iowa, 50011, USA"],"raw_orcid":"https://orcid.org/0009-0002-6997-4404","affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, 75390, USA","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"Roy J. Carver Department of Biochemistry, Biophysics & Molecular Biology, Iowa State University, Ames, Iowa, 50011, USA","institution_ids":["https://openalex.org/I173911158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103022695","display_name":"Amika Singla","orcid":"https://orcid.org/0000-0002-9454-9111","observed_orcids":["https://orcid.org/0000-0002-9454-9111"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amika Singla","raw_affiliation_strings":["Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, 75390, USA"],"raw_orcid":"https://orcid.org/0000-0002-9454-9111","affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, 75390, USA","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058583304","display_name":"Daniel A. Kramer","orcid":"https://orcid.org/0000-0002-7159-9562","observed_orcids":["https://orcid.org/0000-0002-7159-9562"]},"institutions":[{"id":"https://openalex.org/I173911158","display_name":"Iowa State University","ror":"https://ror.org/04rswrd78","country_code":"US","type":"education","lineage":["https://openalex.org/I173911158"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel A. Kramer","raw_affiliation_strings":["Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, 75390, USA","Roy J. Carver Department of Biochemistry, Biophysics & Molecular Biology, Iowa State University, Ames, Iowa, 50011, USA"],"raw_orcid":"https://orcid.org/0000-0002-7159-9562","affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, 75390, USA","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"Roy J. Carver Department of Biochemistry, Biophysics & Molecular Biology, Iowa State University, Ames, Iowa, 50011, USA","institution_ids":["https://openalex.org/I173911158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111398625","display_name":"Alka Diwaker","orcid":"https://orcid.org/0009-0002-2473-6074","observed_orcids":["https://orcid.org/0009-0002-2473-6074"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alka Diwaker","raw_affiliation_strings":["Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, 75390, USA"],"raw_orcid":"https://orcid.org/0009-0002-2473-6074","affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, 75390, USA","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090440097","display_name":"Daniel J. Boesch","orcid":"https://orcid.org/0009-0003-1656-9453","observed_orcids":["https://orcid.org/0009-0003-1656-9453"]},"institutions":[{"id":"https://openalex.org/I173911158","display_name":"Iowa State University","ror":"https://ror.org/04rswrd78","country_code":"US","type":"education","lineage":["https://openalex.org/I173911158"]},{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel J. Boesch","raw_affiliation_strings":["Current address: Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, Virginia 22901, USA","Roy J. Carver Department of Biochemistry, Biophysics & Molecular Biology, Iowa State University, Ames, Iowa, 50011, USA","Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, Virginia 22901, USA"],"raw_orcid":"https://orcid.org/0009-0003-1656-9453","affiliations":[{"raw_affiliation_string":"Current address: Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, Virginia 22901, USA","institution_ids":["https://openalex.org/I51556381"]},{"raw_affiliation_string":"Roy J. Carver Department of Biochemistry, Biophysics & Molecular Biology, Iowa State University, Ames, Iowa, 50011, USA","institution_ids":["https://openalex.org/I173911158"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, Virginia 22901, USA","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101496444","display_name":"Qi Liu","orcid":"https://orcid.org/0000-0002-4876-2405","observed_orcids":["https://orcid.org/0000-0002-4876-2405"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qi Liu","raw_affiliation_strings":["Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, 75390, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, 75390, USA","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057509206","display_name":"James J. Moresco","orcid":"https://orcid.org/0000-0003-1178-1642","observed_orcids":["https://orcid.org/0000-0003-1178-1642"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James J. Moresco","raw_affiliation_strings":["Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, Texas, 75390, USA"],"raw_orcid":"https://orcid.org/0000-0003-1178-1642","affiliations":[{"raw_affiliation_string":"Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, Texas, 75390, USA","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059140393","display_name":"Bruce Beutler","orcid":"https://orcid.org/0000-0002-3639-246X","observed_orcids":["https://orcid.org/0000-0002-3639-246X"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bruce Beutler","raw_affiliation_strings":["Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, Texas, 75390, USA"],"raw_orcid":"https://orcid.org/0000-0002-3639-246X","affiliations":[{"raw_affiliation_string":"Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, Texas, 75390, USA","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111894287","display_name":"Hans\u2010Christian Reinecker","orcid":"https://orcid.org/0000-0001-8283-644X","observed_orcids":["https://orcid.org/0000-0001-8283-644X"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hans-Christian Reinecker","raw_affiliation_strings":["Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, 75390, USA"],"raw_orcid":"https://orcid.org/0000-0001-8283-644X","affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, 75390, USA","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054946822","display_name":"Ezra Burstein","orcid":"https://orcid.org/0000-0003-4341-6367","observed_orcids":["https://orcid.org/0000-0003-4341-6367"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ezra Burstein","raw_affiliation_strings":["Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, 75390, USA","Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas, 75390, USA"],"raw_orcid":"https://orcid.org/0000-0003-4341-6367","affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, 75390, USA","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas, 75390, USA","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008046219","display_name":"Baoyu Chen","orcid":"https://orcid.org/0000-0002-6366-159X","observed_orcids":["https://orcid.org/0000-0002-6366-159X"]},"institutions":[{"id":"https://openalex.org/I173911158","display_name":"Iowa State University","ror":"https://ror.org/04rswrd78","country_code":"US","type":"education","lineage":["https://openalex.org/I173911158"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Baoyu Chen","raw_affiliation_strings":["Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, Texas, 75390, USA","Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, 75390, USA","Roy J. Carver Department of Biochemistry, Biophysics & Molecular Biology, Iowa State University, Ames, Iowa, 50011, USA"],"raw_orcid":"https://orcid.org/0000-0002-6366-159X","affiliations":[{"raw_affiliation_string":"Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, Texas, 75390, USA","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, 75390, USA","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"Roy J. Carver Department of Biochemistry, Biophysics & Molecular Biology, Iowa State University, Ames, Iowa, 50011, USA","institution_ids":["https://openalex.org/I173911158"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064000737","display_name":"Emre E. Turer","orcid":"https://orcid.org/0000-0001-8782-3648","observed_orcids":["https://orcid.org/0000-0001-8782-3648"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Emre E. Turer","raw_affiliation_strings":["Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, 75390, USA"],"raw_orcid":"https://orcid.org/0000-0001-8782-3648","affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, 75390, USA","institution_ids":["https://openalex.org/I867280407"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5064000737"],"corresponding_institution_ids":["https://openalex.org/I867280407"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.007300000172108412,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rab32","display_name":"Rab32","score":0.9539999961853027},{"id":"https://openalex.org/keywords/retriever","display_name":"Retriever","score":0.9549999833106995},{"id":"https://openalex.org/keywords/intestinal-immune-homeostasis","display_name":"intestinal immune homeostasis","score":0.8830000162124634},{"id":"https://openalex.org/keywords/endolysosomal-trafficking","display_name":"endolysosomal trafficking","score":0.9819999933242798},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.7799999713897705},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.9769999980926514},{"id":"https://openalex.org/keywords/dss-induced-colitis","display_name":"DSS-induced colitis","score":0.902999997138977},{"id":"https://openalex.org/keywords/endosomal-recycling","display_name":"endosomal recycling","score":0.6349999904632568}],"concepts":[{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.8392074108123779},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6254575252532959},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.5802584290504456},{"id":"https://openalex.org/C26517878","wikidata":"https://www.wikidata.org/wiki/Q228039","display_name":"Key (lock)","level":2,"score":0.5731068849563599},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2872946262359619},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.266696035861969},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.21900048851966858},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.05662816762924194},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1101/2025.07.16.665158","doi":"https://doi.org/10.1101/2025.07.16.665158","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.07.16.665158","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2025/07/21/2025.07.16.665158.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:40791432","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40791432","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12338710","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12338710","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"Text"},{"id":"pmh:oai:dr.lib.iastate.edu:20.500.12876/107891","doi":null,"is_oa":true,"landing_page_url":"https://dr.lib.iastate.edu/handle/20.500.12876/107891","pdf_url":null,"source":{"id":"https://openalex.org/S4377196104","display_name":"Iowa State University Digital Repository (Iowa State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I173911158","host_organization_name":"Iowa State University","host_organization_lineage":["https://openalex.org/I173911158"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://doi.org/10.1101/2025.07.16.665158","raw_type":"preprint"}],"best_oa_location":{"id":"doi:10.1101/2025.07.16.665158","doi":"https://doi.org/10.1101/2025.07.16.665158","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.07.16.665158","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2025/07/21/2025.07.16.665158.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G492720758","display_name":"TVP23B and Golgi Mediated Control of Intestinal Secretory Cells","funder_award_id":"1r01dk133229-01a1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5300734369","display_name":"The Role of the Smcr8-Wdr41-C9orf72 (SWC) Complex in the Maintenance of Intestinal Homeostasis","funder_award_id":"R01DK119360","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G8690376093","display_name":"CAREER: Biochemical and Structural Mechanism of the WASH Regulatory Complex","funder_award_id":"2047640","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G9000044621","display_name":null,"funder_award_id":"GM128786","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000097502","display_name":null,"funder_award_id":"R35-GM128786","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000137213","display_name":null,"funder_award_id":"R01DK107733","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000334115","display_name":null,"funder_award_id":"DK107733","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000911172","display_name":"Cholesterol Regulation Through Retriever-Dependent LDL Receptor Recycling","funder_award_id":"1r01hl179813-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320310169","display_name":"University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690"},{"id":"https://openalex.org/F4320322927","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4413106917.pdf","grobid_xml":"https://content.openalex.org/works/W4413106917.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W1563940013","https://openalex.org/W1971308951","https://openalex.org/W1987628482","https://openalex.org/W2002047195","https://openalex.org/W2009256745","https://openalex.org/W2010327987","https://openalex.org/W2011848880","https://openalex.org/W2025065287","https://openalex.org/W2033727288","https://openalex.org/W2043274355","https://openalex.org/W2046819049","https://openalex.org/W2050250362","https://openalex.org/W2061314812","https://openalex.org/W2110817313","https://openalex.org/W2141121523","https://openalex.org/W2266433488","https://openalex.org/W2274102999","https://openalex.org/W2300801637","https://openalex.org/W2340562172","https://openalex.org/W2415304653","https://openalex.org/W2521129278","https://openalex.org/W2579940769","https://openalex.org/W2607247042","https://openalex.org/W2754145575","https://openalex.org/W2759963226","https://openalex.org/W2776438024","https://openalex.org/W2889335647","https://openalex.org/W2900551238","https://openalex.org/W2919895918","https://openalex.org/W2950521315","https://openalex.org/W2963622568","https://openalex.org/W2967781016","https://openalex.org/W2985005852","https://openalex.org/W3044130457","https://openalex.org/W3179848646","https://openalex.org/W3199687825","https://openalex.org/W3211795435","https://openalex.org/W4200511666","https://openalex.org/W4205574430","https://openalex.org/W4212998579","https://openalex.org/W4294992943","https://openalex.org/W4307847680","https://openalex.org/W4308294602","https://openalex.org/W4376126637","https://openalex.org/W4381429209","https://openalex.org/W4384523448","https://openalex.org/W4385727322","https://openalex.org/W4385898544","https://openalex.org/W4386710469","https://openalex.org/W4389440027","https://openalex.org/W4389626401","https://openalex.org/W4393341644","https://openalex.org/W4396721167","https://openalex.org/W4404666777"],"related_works":["https://openalex.org/W2354064740","https://openalex.org/W2389923937","https://openalex.org/W2380273283","https://openalex.org/W2386858378","https://openalex.org/W2347280302","https://openalex.org/W2369640577","https://openalex.org/W1849276116","https://openalex.org/W2363047424","https://openalex.org/W1571263303","https://openalex.org/W2389443558"],"abstract_inverted_index":{"Abstract":[0],"Maintaining":[1],"intestinal":[2,107,203],"homeostasis":[3],"relies":[4],"on":[5],"the":[6,10,31,62,71,150,156,186],"intricate":[7],"interplay":[8],"among":[9],"mucosal":[11,126],"epithelium,":[12],"immune":[13,24,198,204],"system,":[14],"and":[15,27,46,57,77,89,112,130,139,146,155,175],"host":[16,72],"microbiome.":[17],"A":[18],"key":[19,104],"question":[20],"is":[21],"how":[22],"innate":[23,197],"cells":[25,128],"sense":[26],"process":[28,56],"microbes":[29,45],"in":[30,121,134,196],"gut":[32],"lumen,":[33],"eliciting":[34],"appropriate":[35],"protective":[36],"responses":[37,51],"without":[38],"causing":[39],"tissue":[40],"injury.":[41],"Clearance":[42],"of":[43,48,61,66,85,106,162,178,193],"invading":[44],"initiation":[47],"downstream":[49],"inflammatory":[50,75],"are":[52],"central":[53],"to":[54,73,169],"this":[55,67],"require":[58],"proper":[59],"function":[60,166],"endolysosomal":[63,194],"system.":[64],"Dysfunction":[65],"system":[68],"can":[69],"predispose":[70],"chronic":[74],"disorders":[76],"acute":[78],"infections.":[79],"Here,":[80],"through":[81],"forward":[82],"genetic":[83],"screening":[84],"N-ethyl-N-nitrosourea":[86],"(ENU)-mutagenized":[87],"mice":[88],"CRISPR/Cas9":[90],"validation,":[91],"we":[92,115],"identify":[93],"Lrmda":[94],",":[95],"encoding":[96],"leucine-rich":[97],"melanocyte":[98],"differentiation-associated":[99],"protein":[100],"(LRMDA),":[101],"as":[102,189],"a":[103,190],"regulator":[105,192],"homeostasis.":[108,205],"Using":[109],"hematopoietic":[110],"chimera":[111],"conditional":[113],"knockouts,":[114],"show":[116],"that":[117,143],"LRMDA":[118,144,163],"functions":[119],"primarily":[120],"CD11c":[122],"+":[123],"cells,":[124,199],"including":[125],"dendritic":[127],"(DCs)":[129],"macrophages,":[131],"but":[132],"not":[133],"non-hematopoietic":[135],"cells.":[136],"Proteomic,":[137],"cellular,":[138],"biochemical":[140],"analyses":[141],"reveal":[142],"directly":[145],"cooperatively":[147],"interacts":[148],"with":[149],"endolysosome-specific":[151],"small":[152],"GTPase":[153],"Rab32":[154],"endosomal":[157],"recycling":[158],"complex":[159,188],"Retriever.":[160],"Loss":[161],"or":[164],"Retriever":[165],"increases":[167],"susceptibility":[168],"dextran":[170],"sodium":[171],"sulfate":[172],"(DSS)-induced":[173],"colitis":[174],"impairs":[176],"clearance":[177],"Listeria":[179],"monocytogenes":[180],".":[181],"Together,":[182],"our":[183],"findings":[184],"establish":[185],"Rab32-LRMDA-Retriever":[187],"critical":[191],"trafficking":[195],"essential":[200],"for":[201],"maintaining":[202]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}