{"id":"https://openalex.org/W4413103308","doi":"https://doi.org/10.1016/j.ymthe.2025.08.020","title":"Enhanced hematopoietic stem cell self-renewal and engraftment through human lung exosomal communication","display_name":"Enhanced hematopoietic stem cell self-renewal and engraftment through human lung exosomal communication","publication_year":2025,"publication_date":"2025-08-11","ids":{"openalex":"https://openalex.org/W4413103308","doi":"https://doi.org/10.1016/j.ymthe.2025.08.020","pmid":"https://pubmed.ncbi.nlm.nih.gov/40798884","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12628159"},"language":"en","primary_location":{"id":"doi:10.1016/j.ymthe.2025.08.020","doi":"https://doi.org/10.1016/j.ymthe.2025.08.020","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ymthe.2025.08.020","pdf_url":null,"source":{"id":"https://openalex.org/S51596929","display_name":"Molecular Therapy","issn_l":"1525-0016","issn":["1525-0016","1525-0024"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.ymthe.2025.08.020","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017367206","display_name":"Sanam Rezaei Benam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sanam Rezaei Benam","raw_affiliation_strings":["Division of Hematology/Oncology, Department of Medicine, Indiana University, Indianapolis, IN 46202, USA","Division of Hematology/Oncology, Department of Medicine, Indiana University, Indianapolis, IN,46202"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology/Oncology, Department of Medicine, Indiana University, Indianapolis, IN 46202, USA","institution_ids":["https://openalex.org/I4388446366"]},{"raw_affiliation_string":"Division of Hematology/Oncology, Department of Medicine, Indiana University, Indianapolis, IN,46202","institution_ids":["https://openalex.org/I4388446366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101619661","display_name":"Xuepeng Wang","orcid":"https://orcid.org/0009-0009-4349-1579","observed_orcids":["https://orcid.org/0009-0009-4349-1579"]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xuepeng Wang","raw_affiliation_strings":["Herman B Wells Center for Pediatric Research, Indiana University, Indianapolis, IN 46202, USA","Herman B Wells Center for Pediatric Research, Indiana University, Indianapolis, IN,46202"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Herman B Wells Center for Pediatric Research, Indiana University, Indianapolis, IN 46202, USA","institution_ids":["https://openalex.org/I4388446366"]},{"raw_affiliation_string":"Herman B Wells Center for Pediatric Research, Indiana University, Indianapolis, IN,46202","institution_ids":["https://openalex.org/I4388446366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068840754","display_name":"Samaneh Maleknia","orcid":"https://orcid.org/0000-0002-0691-4722","observed_orcids":["https://orcid.org/0000-0002-0691-4722"]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samaneh Maleknia","raw_affiliation_strings":["Division of Hematology/Oncology, Department of Medicine, Indiana University, Indianapolis, IN 46202, USA","Division of Hematology/Oncology, Department of Medicine, Indiana University, Indianapolis, IN,46202"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology/Oncology, Department of Medicine, Indiana University, Indianapolis, IN 46202, USA","institution_ids":["https://openalex.org/I4388446366"]},{"raw_affiliation_string":"Division of Hematology/Oncology, Department of Medicine, Indiana University, Indianapolis, IN,46202","institution_ids":["https://openalex.org/I4388446366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035841414","display_name":"Reuben Kapur","orcid":"https://orcid.org/0000-0003-2225-1700","observed_orcids":["https://orcid.org/0000-0003-2225-1700","https://orcid.org/0009-0008-1025-5126"]},"institutions":[{"id":"https://openalex.org/I1283055418","display_name":"Indiana University Health","ror":"https://ror.org/01aaptx40","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1283055418","https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4390039234","display_name":"Indiana University Melvin and Bren Simon Comprehensive Cancer Center","ror":"https://ror.org/00g1d7b60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039234","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]},{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Reuben Kapur","raw_affiliation_strings":["Herman B Wells Center for Pediatric Research, Indiana University, Indianapolis, IN 46202, USA; Hematopoiesis & Hematologic Malignancies, Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Indianapolis, IN 46202, USA","Herman B Wells Center for Pediatric Research, Indiana University, Indianapolis, IN,46202; Hematopoiesis & Hematologic Malignancies, Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Indianapolis, IN,46202"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Herman B Wells Center for Pediatric Research, Indiana University, Indianapolis, IN 46202, USA; Hematopoiesis & Hematologic Malignancies, Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Indianapolis, IN 46202, USA","institution_ids":["https://openalex.org/I1283055418","https://openalex.org/I4388446366","https://openalex.org/I4390039234","https://openalex.org/I4394709130","https://openalex.org/I55769427"]},{"raw_affiliation_string":"Herman B Wells Center for Pediatric Research, Indiana University, Indianapolis, IN,46202; Hematopoiesis & Hematologic Malignancies, Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Indianapolis, IN,46202","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4390039234","https://openalex.org/I4394709130","https://openalex.org/I55769427"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076836182","display_name":"Reza Shahbazi","orcid":"https://orcid.org/0000-0002-0816-0733","observed_orcids":["https://orcid.org/0000-0002-0816-0733"]},"institutions":[{"id":"https://openalex.org/I1283055418","display_name":"Indiana University Health","ror":"https://ror.org/01aaptx40","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1283055418","https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4390039234","display_name":"Indiana University Melvin and Bren Simon Comprehensive Cancer Center","ror":"https://ror.org/00g1d7b60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039234","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]},{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Reza Shahbazi","raw_affiliation_strings":["Division of Hematology/Oncology, Department of Medicine, Indiana University, Indianapolis, IN 46202, USA; Tumor Microenvironment & Metastasis, Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Indianapolis, IN 46202, USA; Brown Center for Immunotherapy, Indiana University, Indianapolis, IN 46202, USA. Electronic address: rshahbaz@iu.edu","Division of Hematology/Oncology, Department of Medicine, Indiana University, Indianapolis, IN,46202; Tumor Microenvironment & Metastasis, Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Indianapolis, IN,46202; Brown Center for Immunotherapy, Indiana University, Indianapolis, IN,46202. Electronic address: rshahbaz@iu.edu"],"raw_orcid":"https://orcid.org/0000-0002-0816-0733","affiliations":[{"raw_affiliation_string":"Division of Hematology/Oncology, Department of Medicine, Indiana University, Indianapolis, IN 46202, USA; Tumor Microenvironment & Metastasis, Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Indianapolis, IN 46202, USA; Brown Center for Immunotherapy, Indiana University, Indianapolis, IN 46202, USA. Electronic address: rshahbaz@iu.edu","institution_ids":["https://openalex.org/I1283055418","https://openalex.org/I4388446366","https://openalex.org/I4390039234","https://openalex.org/I4394709130","https://openalex.org/I55769427"]},{"raw_affiliation_string":"Division of Hematology/Oncology, Department of Medicine, Indiana University, Indianapolis, IN,46202; Tumor Microenvironment & Metastasis, Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Indianapolis, IN,46202; Brown Center for Immunotherapy, Indiana University, Indianapolis, IN,46202. Electronic address: rshahbaz@iu.edu","institution_ids":["https://openalex.org/I1283055418","https://openalex.org/I4388446366","https://openalex.org/I4390039234","https://openalex.org/I4394709130","https://openalex.org/I55769427"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5076836182"],"corresponding_institution_ids":["https://openalex.org/I1283055418","https://openalex.org/I4388446366","https://openalex.org/I4390039234","https://openalex.org/I4394709130","https://openalex.org/I55769427"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":{"value":4500,"currency":"USD","value_usd":4500},"fwci":0.7341,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.72924909,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"33","issue":"11","first_page":"5704","last_page":"5720"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.5112000107765198,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.5112000107765198,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.4763000011444092,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.00559999980032444,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hematopoietic-stem-cells","display_name":"hematopoietic stem cells","score":0.9869999885559082},{"id":"https://openalex.org/keywords/hsc-self-renewal","display_name":"HSC self-renewal","score":0.8949999809265137},{"id":"https://openalex.org/keywords/hsc-engraftment","display_name":"HSC engraftment","score":0.9259999990463257},{"id":"https://openalex.org/keywords/exosomes","display_name":"exosomes","score":0.765999972820282},{"id":"https://openalex.org/keywords/small-airway-epithelial-cells","display_name":"small airway epithelial cells","score":0.9039999842643738},{"id":"https://openalex.org/keywords/exosomal-mirna","display_name":"exosomal microRNAs","score":0.8190000057220459},{"id":"https://openalex.org/keywords/hsc-homeostasis","display_name":"HSC homeostasis","score":0.8119999766349792},{"id":"https://openalex.org/keywords/bone-marrow-microenvironment","display_name":"bone marrow microenvironment","score":0.8259999752044678},{"id":"https://openalex.org/keywords/sickle-cell-disease","display_name":"sickle cell disease","score":0.8090000152587891},{"id":"https://openalex.org/keywords/bone-marrow-failure","display_name":"bone marrow failure","score":0.9150000214576721}],"concepts":[{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.8067392110824585},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7414974570274353},{"id":"https://openalex.org/C20518536","wikidata":"https://www.wikidata.org/wiki/Q6840469","display_name":"Microvesicles","level":4,"score":0.6534498333930969},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6356557011604309},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.6318250298500061},{"id":"https://openalex.org/C2778086970","wikidata":"https://www.wikidata.org/wiki/Q514525","display_name":"Hematopoietic stem cell","level":4,"score":0.6110846400260925},{"id":"https://openalex.org/C2781261824","wikidata":"https://www.wikidata.org/wiki/Q903634","display_name":"Exosome","level":5,"score":0.5034274458885193},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.4431183934211731},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4221951961517334},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.2898268699645996},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08876895904541016},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.076008141040802}],"mesh":[{"descriptor_ui":"D000066673","descriptor_name":"Cell Self Renewal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000092386","descriptor_name":"Single-Cell Gene Expression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000095028","descriptor_name":"Multiomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002450","descriptor_name":"Cell Communication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D018380","descriptor_name":"Hematopoietic Stem Cell Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055354","descriptor_name":"Exosomes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1016/j.ymthe.2025.08.020","doi":"https://doi.org/10.1016/j.ymthe.2025.08.020","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ymthe.2025.08.020","pdf_url":null,"source":{"id":"https://openalex.org/S51596929","display_name":"Molecular Therapy","issn_l":"1525-0016","issn":["1525-0016","1525-0024"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:11688501","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12628159","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:40798884","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40798884","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular therapy : the journal of the American Society of Gene Therapy","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12628159","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12628159/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Ther","raw_type":"Text"},{"id":"pmh:oai:scholarworks.indianapolis.iu.edu:1805/54267","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/1805/54267","pdf_url":null,"source":{"id":"https://openalex.org/S4306400987","display_name":"IUScholarWorks (Indiana University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I592451","host_organization_name":"Indiana University","host_organization_lineage":["https://openalex.org/I592451"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PMC","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1016/j.ymthe.2025.08.020","doi":"https://doi.org/10.1016/j.ymthe.2025.08.020","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ymthe.2025.08.020","pdf_url":null,"source":{"id":"https://openalex.org/S51596929","display_name":"Molecular Therapy","issn_l":"1525-0016","issn":["1525-0016","1525-0024"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000856330","display_name":"Hematology Central Coordinating Center (HCCC) for the NIDDK Hematology Centers Program","funder_award_id":"U24DK126127","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000893466","display_name":"Stem Cell and Transplantation Biology","funder_award_id":"U54DK106829","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000906626","display_name":"Hematopoietic stem and progenitor cell regulation for enhanced clinical efficacy","funder_award_id":"U54DK106846","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000918645","display_name":"Indiana University Melvin and Bren Simon Comprehensive Cancer Center Support Grant","funder_award_id":"P30CA082709","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306168","display_name":"Cystic Fibrosis Foundation","ror":"https://ror.org/00ax59295"},{"id":"https://openalex.org/F4320309291","display_name":"Indiana University","ror":"https://ror.org/01kg8sb98"},{"id":"https://openalex.org/F4320309520","display_name":"Ralph W. and Grace M. Showalter Research Trust Fund","ror":"https://ror.org/02dqehb95"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320333230","display_name":"Melvin and Bren Simon Cancer Center, Indiana University","ror":"https://ror.org/00g1d7b60"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W2010847848","https://openalex.org/W2159675211","https://openalex.org/W2160666689","https://openalex.org/W2168526937","https://openalex.org/W2170258627","https://openalex.org/W2171172082","https://openalex.org/W2270798645","https://openalex.org/W2588333910","https://openalex.org/W2600669583","https://openalex.org/W2739492614","https://openalex.org/W2749078154","https://openalex.org/W2765177269","https://openalex.org/W2792066204","https://openalex.org/W2793266847","https://openalex.org/W2794437526","https://openalex.org/W2905270996","https://openalex.org/W2947834670","https://openalex.org/W2974786109","https://openalex.org/W2997839207","https://openalex.org/W3085756871","https://openalex.org/W3091230421","https://openalex.org/W3093447280","https://openalex.org/W3164692211","https://openalex.org/W3213709497","https://openalex.org/W4214933741","https://openalex.org/W4232687496","https://openalex.org/W4311679464","https://openalex.org/W4324360401","https://openalex.org/W4385762414","https://openalex.org/W4408015528"],"related_works":["https://openalex.org/W4388455456","https://openalex.org/W4388455487","https://openalex.org/W4224059925","https://openalex.org/W4402915112","https://openalex.org/W4408277975","https://openalex.org/W2979393554","https://openalex.org/W4408822529","https://openalex.org/W1987737240","https://openalex.org/W6927283433","https://openalex.org/W3172779388"],"abstract_inverted_index":{"Hematopoietic":[0],"stem":[1,178],"cells":[2,73,102],"(HSCs)":[3],"are":[4,21],"essential":[5],"for":[6,32],"sustaining":[7],"the":[8,16,23,26,53,154],"hematopoietic":[9],"system":[10,27],"throughout":[11],"an":[12],"individual's":[13],"life.":[14],"Within":[15],"HSC":[17,47,105,147,167],"hierarchy,":[18],"long-term":[19,46],"HSCs":[20],"at":[22],"apex,":[24],"maintaining":[25],"by":[28],"their":[29,120],"unique":[30],"capacity":[31],"self-renewal":[33],"and":[34,65,88,118,135,143,185],"differentiation":[35],"into":[36],"all":[37],"blood":[38],"cell":[39,61,124,179,183],"lineages.":[40],"Traditionally,":[41],"it":[42],"was":[43],"believed":[44],"that":[45,71,93,145],"homeostasis":[48],"is":[49],"solely":[50],"regulated":[51],"within":[52],"bone":[54,186],"marrow":[55,187],"niche.":[56],"However,":[57],"our":[58],"innovative":[59],"single":[60],"exosomal":[62,82,131],"tracking":[63,112],"analysis":[64],"in":[66,78,85,158,165,173],"vivo":[67,86],"transplantation":[68],"studies":[69,91],"revealed":[70],"lung":[72],"play":[74],"a":[75,109,150],"significant":[76],"role":[77],"this":[79],"regulation":[80],"through":[81],"communication.":[83],"Our":[84],"primary":[87,98],"secondary":[89],"engraftment":[90],"demonstrate":[92],"exosomes":[94,117],"derived":[95],"from":[96],"human":[97],"small":[99],"airway":[100],"epithelial":[101],"significantly":[103],"enhance":[104],"engraftment.":[106],"We":[107],"developed":[108],"single-cell":[110,128],"exosome":[111],"pipeline":[113],"to":[114],"track":[115],"these":[116],"elucidated":[119],"effects":[121],"on":[122],"target":[123],"populations.":[125],"By":[126],"integrating":[127],"RNA":[129],"sequencing,":[130],"microRNA":[132],"(miRNA)":[133],"profiling,":[134],"proteomics,":[136],"we":[137],"have":[138],"identified":[139],"specific":[140],"genes,":[141],"miRNAs,":[142],"proteins":[144],"regulate":[146],"function,":[148],"providing":[149],"comprehensive":[151],"understanding":[152],"of":[153],"molecular":[155],"mechanisms":[156],"involved":[157],"homeostasis.":[159],"This":[160],"insight":[161],"suggests":[162],"potential":[163],"utility":[164],"modulating":[166],"function":[168],"under":[169],"experimental":[170],"conditions,":[171],"especially":[172],"conditions":[174],"associated":[175],"with":[176],"low":[177],"fitness":[180],"including":[181],"sickle":[182],"disease":[184],"failure.":[188]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2025-10-10T00:00:00"}