{"id":"https://openalex.org/W4413056142","doi":"https://doi.org/10.1182/bloodadvances.2025017398","title":"Updating clinical guidelines with limited evidence: case study of ASH/ISTH pediatric VTE treatment guidelines","display_name":"Updating clinical guidelines with limited evidence: case study of ASH/ISTH pediatric VTE treatment guidelines","publication_year":2025,"publication_date":"2025-08-08","ids":{"openalex":"https://openalex.org/W4413056142","doi":"https://doi.org/10.1182/bloodadvances.2025017398","pmid":"https://pubmed.ncbi.nlm.nih.gov/40779576","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12597629"},"language":"en","primary_location":{"id":"doi:10.1182/bloodadvances.2025017398","doi":"https://doi.org/10.1182/bloodadvances.2025017398","is_oa":true,"landing_page_url":"https://doi.org/10.1182/bloodadvances.2025017398","pdf_url":"https://ashpublications.org/bloodadvances/article-pdf/doi/10.1182/bloodadvances.2025017398/2405991/bloodadvances.2025017398.pdf","source":{"id":"https://openalex.org/S2764683450","display_name":"Blood Advances","issn_l":"2473-9529","issn":["2473-9529","2473-9537"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood Advances","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://ashpublications.org/bloodadvances/article-pdf/doi/10.1182/bloodadvances.2025017398/2405991/bloodadvances.2025017398.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058656727","display_name":"Ali Choaib","orcid":"https://orcid.org/0009-0005-3132-394X","observed_orcids":["https://orcid.org/0009-0005-3132-394X"]},"institutions":[{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ali Choaib","raw_affiliation_strings":["1Department of Internal Medicine, Evidence-Based Practice and Impact Center, The University of Kansas Medical Center, Kansas City, KS","KUMC, Fairway, Kansas, United States"],"raw_orcid":"https://orcid.org/0009-0005-3132-394X","affiliations":[{"raw_affiliation_string":"1Department of Internal Medicine, Evidence-Based Practice and Impact Center, The University of Kansas Medical Center, Kansas City, KS","institution_ids":["https://openalex.org/I4210128618"]},{"raw_affiliation_string":"KUMC, Fairway, Kansas, United States","institution_ids":["https://openalex.org/I4210128618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028529809","display_name":"Aseel Alkhader","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aseel AlKhader","raw_affiliation_strings":["1Department of Internal Medicine, Evidence-Based Practice and Impact Center, The University of Kansas Medical Center, Kansas City, KS","University of Kansas Medical Center, Kansas city, Kansas, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Internal Medicine, Evidence-Based Practice and Impact Center, The University of Kansas Medical Center, Kansas City, KS","institution_ids":["https://openalex.org/I4210128618"]},{"raw_affiliation_string":"University of Kansas Medical Center, Kansas city, Kansas, United States","institution_ids":["https://openalex.org/I4210128618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019863212","display_name":"Muayad Azzam","orcid":"https://orcid.org/0000-0002-2046-8343","observed_orcids":["https://orcid.org/0000-0002-2046-8343"]},"institutions":[{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Muayad Azzam","raw_affiliation_strings":["1Department of Internal Medicine, Evidence-Based Practice and Impact Center, The University of Kansas Medical Center, Kansas City, KS","University of Kansas Medical Center, Kansas City, Kansas, United States"],"raw_orcid":"https://orcid.org/0000-0002-2046-8343","affiliations":[{"raw_affiliation_string":"1Department of Internal Medicine, Evidence-Based Practice and Impact Center, The University of Kansas Medical Center, Kansas City, KS","institution_ids":["https://openalex.org/I4210128618"]},{"raw_affiliation_string":"University of Kansas Medical Center, Kansas City, Kansas, United States","institution_ids":["https://openalex.org/I4210128618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5096294178","display_name":"Hassan Kawtharany","orcid":"https://orcid.org/0009-0007-3725-8485","observed_orcids":["https://orcid.org/0009-0007-3725-8485"]},"institutions":[{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hassan Kawtharany","raw_affiliation_strings":["1Department of Internal Medicine, Evidence-Based Practice and Impact Center, The University of Kansas Medical Center, Kansas City, KS","University of Kansas Medical Center, Kansas City, Kansas, United States"],"raw_orcid":"https://orcid.org/0009-0007-3725-8485","affiliations":[{"raw_affiliation_string":"1Department of Internal Medicine, Evidence-Based Practice and Impact Center, The University of Kansas Medical Center, Kansas City, KS","institution_ids":["https://openalex.org/I4210128618"]},{"raw_affiliation_string":"University of Kansas Medical Center, Kansas City, Kansas, United States","institution_ids":["https://openalex.org/I4210128618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083062306","display_name":"Marisol Betensky","orcid":"https://orcid.org/0000-0001-6725-3035","observed_orcids":["https://orcid.org/0000-0001-6725-3035"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I4210098865","display_name":"Johns Hopkins All Children's Hospital","ror":"https://ror.org/013x5cp73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210098865"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marisol Betensky","raw_affiliation_strings":["2Division of Haematology, Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, MD","3Cancer and Blood Disorders Institute, Johns Hopkins All Children\u2019s Hospital, St. Petersburg, FL","Johns Hopkins All Children's Hospital, St. Petersburg, Florida, United States"],"raw_orcid":"https://orcid.org/0000-0001-6725-3035","affiliations":[{"raw_affiliation_string":"2Division of Haematology, Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, MD","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"3Cancer and Blood Disorders Institute, Johns Hopkins All Children\u2019s Hospital, St. Petersburg, FL","institution_ids":["https://openalex.org/I4210098865"]},{"raw_affiliation_string":"Johns Hopkins All Children's Hospital, St. Petersburg, Florida, United States","institution_ids":["https://openalex.org/I4210098865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056348530","display_name":"Leslie J. Raffini","orcid":"https://orcid.org/0000-0001-8152-1040","observed_orcids":["https://orcid.org/0000-0001-8152-1040"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leslie Raffini","raw_affiliation_strings":["4Department of Pediatrics, Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA","Children's Hospital of Philadelphia, Swarthmore, Pennsylvania, United States"],"raw_orcid":"https://orcid.org/0000-0001-8152-1040","affiliations":[{"raw_affiliation_string":"4Department of Pediatrics, Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA","institution_ids":["https://openalex.org/I1335321130","https://openalex.org/I79576946"]},{"raw_affiliation_string":"Children's Hospital of Philadelphia, Swarthmore, Pennsylvania, United States","institution_ids":["https://openalex.org/I1335321130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045029316","display_name":"Rachel S. Bercovitz","orcid":"https://orcid.org/0000-0001-6653-5946","observed_orcids":["https://orcid.org/0000-0001-6653-5946","https://orcid.org/0000-0002-6399-1249"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I1294278766","display_name":"Lurie Children's Hospital","ror":"https://ror.org/03a6zw892","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1294278766"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rachel Bercovitz","raw_affiliation_strings":["5Northwestern University Feinberg School of Medicine, Ann & Robert H. Lurie Children\u2019s Hospital of Chicago, Chicago, IL","Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Northwestern University Feinberg School of Medicine, Ann & Robert H. Lurie Children\u2019s Hospital of Chicago, Chicago, IL","institution_ids":["https://openalex.org/I111979921","https://openalex.org/I1294278766"]},{"raw_affiliation_string":"Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047437197","display_name":"Sara K. Vesely","orcid":"https://orcid.org/0000-0003-3448-0156","observed_orcids":["https://orcid.org/0000-0003-3448-0156"]},"institutions":[{"id":"https://openalex.org/I49332381","display_name":"University of Oklahoma Health Sciences Center","ror":"https://ror.org/0457zbj98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I49332381"]},{"id":"https://openalex.org/I8692664","display_name":"University of Oklahoma","ror":"https://ror.org/02aqsxs83","country_code":"US","type":"education","lineage":["https://openalex.org/I8692664"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sara K. Vesely","raw_affiliation_strings":["6Department of Biostatistics and Epidemiology, University of Oklahoma Health Sciences, Hudson College of Public Health, Oklahoma City, OK","University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States"],"raw_orcid":"https://orcid.org/0000-0003-3448-0156","affiliations":[{"raw_affiliation_string":"6Department of Biostatistics and Epidemiology, University of Oklahoma Health Sciences, Hudson College of Public Health, Oklahoma City, OK","institution_ids":["https://openalex.org/I8692664"]},{"raw_affiliation_string":"University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States","institution_ids":["https://openalex.org/I49332381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065169479","display_name":"Paul Monagle","orcid":"https://orcid.org/0000-0002-3970-8984","observed_orcids":["https://orcid.org/0000-0002-3970-8984"]},"institutions":[{"id":"https://openalex.org/I1321649718","display_name":"Royal Children's Hospital","ror":"https://ror.org/02rktxt32","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I1321649718"]},{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I4210125633","display_name":"Sydney Children's Hospital","ror":"https://ror.org/02tj04e91","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210125633","https://openalex.org/I4210149013"]},{"id":"https://openalex.org/I4210150290","display_name":"Murdoch Children's Research Institute","ror":"https://ror.org/048fyec77","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I4210150290"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Paul Monagle","raw_affiliation_strings":["7Department of Clinical Haematology, Royal Children\u2019s Hospital, Department of Paediatrics, University of Melbourne and Murdoch Children\u2019s Research Institute, Melbourne, VIC, Australia","8Kids Cancer Centre, Sydney Children\u2019s Hospital, Randwick, Australia","department of Paediatrics, University of Melbourne , Australia , Australia, Parkville, Australia"],"raw_orcid":"https://orcid.org/0000-0002-3970-8984","affiliations":[{"raw_affiliation_string":"7Department of Clinical Haematology, Royal Children\u2019s Hospital, Department of Paediatrics, University of Melbourne and Murdoch Children\u2019s Research Institute, Melbourne, VIC, Australia","institution_ids":["https://openalex.org/I1321649718","https://openalex.org/I165779595","https://openalex.org/I4210150290"]},{"raw_affiliation_string":"8Kids Cancer Centre, Sydney Children\u2019s Hospital, Randwick, Australia","institution_ids":["https://openalex.org/I4210125633"]},{"raw_affiliation_string":"department of Paediatrics, University of Melbourne , Australia , Australia, Parkville, Australia","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067205817","display_name":"Reem A. Mustafa","orcid":"https://orcid.org/0000-0002-2091-0875","observed_orcids":["https://orcid.org/0000-0002-2091-0875"]},"institutions":[{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Reem A. Mustafa","raw_affiliation_strings":["1Department of Internal Medicine, Evidence-Based Practice and Impact Center, The University of Kansas Medical Center, Kansas City, KS","9Division of Nephrology and Hypertension, Department of Internal Medicine, The University of Kansas Medical Center, Kansas City, KS","University of Kansas Medical Center, Kansas City, Kansas, United States"],"raw_orcid":"https://orcid.org/0000-0002-2091-0875","affiliations":[{"raw_affiliation_string":"1Department of Internal Medicine, Evidence-Based Practice and Impact Center, The University of Kansas Medical Center, Kansas City, KS","institution_ids":["https://openalex.org/I4210128618"]},{"raw_affiliation_string":"9Division of Nephrology and Hypertension, Department of Internal Medicine, The University of Kansas Medical Center, Kansas City, KS","institution_ids":["https://openalex.org/I4210128618"]},{"raw_affiliation_string":"University of Kansas Medical Center, Kansas City, Kansas, United States","institution_ids":["https://openalex.org/I4210128618"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":14,"corresponding_author_ids":["https://openalex.org/A5067205817"],"corresponding_institution_ids":["https://openalex.org/I4210128618"],"apc_list":{"value":3800,"currency":"USD","value_usd":3800},"apc_paid":{"value":3800,"currency":"USD","value_usd":3800},"fwci":1.0396,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.76314162,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"9","issue":"20","first_page":"5347","last_page":"5349"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10285","display_name":"Venous Thromboembolism Diagnosis and Management","score":0.6104000210762024,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10285","display_name":"Venous Thromboembolism Diagnosis and Management","score":0.6104000210762024,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12664","display_name":"Clinical practice guidelines implementation","score":0.37229999899864197,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/limited-evidence","display_name":"limited evidence","score":0.9359999895095825},{"id":"https://openalex.org/keywords/pediatric-venous-thromboembolism","display_name":"pediatric venous thromboembolism","score":0.9610000252723694},{"id":"https://openalex.org/keywords/anticoagulation","display_name":"anticoagulation","score":0.7369999885559082},{"id":"https://openalex.org/keywords/guideline-development","display_name":"guideline development","score":0.3930000066757202}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6522645354270935},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.47482022643089294},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.4587997794151306},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14047157764434814},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1182/bloodadvances.2025017398","doi":"https://doi.org/10.1182/bloodadvances.2025017398","is_oa":true,"landing_page_url":"https://doi.org/10.1182/bloodadvances.2025017398","pdf_url":"https://ashpublications.org/bloodadvances/article-pdf/doi/10.1182/bloodadvances.2025017398/2405991/bloodadvances.2025017398.pdf","source":{"id":"https://openalex.org/S2764683450","display_name":"Blood Advances","issn_l":"2473-9529","issn":["2473-9529","2473-9537"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood Advances","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:11408031","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12597629","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:40779576","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40779576","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood advances","raw_type":"Journal Article"},{"id":"pmh:oai:jupiter.its.unimelb.edu.au:11343/367853","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11343/367853","pdf_url":null,"source":{"id":"https://openalex.org/S4377196259","display_name":"Minerva Access (University of Melbourne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I165779595","host_organization_name":"The University of Melbourne","host_organization_lineage":["https://openalex.org/I165779595"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1182/bloodadvances.2025017398","doi":"https://doi.org/10.1182/bloodadvances.2025017398","is_oa":true,"landing_page_url":"https://doi.org/10.1182/bloodadvances.2025017398","pdf_url":"https://ashpublications.org/bloodadvances/article-pdf/doi/10.1182/bloodadvances.2025017398/2405991/bloodadvances.2025017398.pdf","source":{"id":"https://openalex.org/S2764683450","display_name":"Blood Advances","issn_l":"2473-9529","issn":["2473-9529","2473-9537"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood Advances","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4413056142.pdf","grobid_xml":"https://content.openalex.org/works/W4413056142.grobid-xml"},"referenced_works_count":7,"referenced_works":["https://openalex.org/W1991340886","https://openalex.org/W2902418274","https://openalex.org/W2968200046","https://openalex.org/W2987943866","https://openalex.org/W3111617049","https://openalex.org/W4361246542","https://openalex.org/W4410773604"],"related_works":["https://openalex.org/W4409199408","https://openalex.org/W4327900019","https://openalex.org/W7130392744","https://openalex.org/W4410773604","https://openalex.org/W2902418274","https://openalex.org/W2912152347","https://openalex.org/W7106337074","https://openalex.org/W2903037230","https://openalex.org/W3045101147","https://openalex.org/W4237451485"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2025-10-10T00:00:00"}