{"id":"https://openalex.org/W4413051992","doi":"https://doi.org/10.1007/s10735-025-10536-x","title":"Protocol for the purification and culture of primary retinal ganglion cells and development of common pathological models","display_name":"Protocol for the purification and culture of primary retinal ganglion cells and development of common pathological models","publication_year":2025,"publication_date":"2025-08-01","ids":{"openalex":"https://openalex.org/W4413051992","doi":"https://doi.org/10.1007/s10735-025-10536-x","pmid":"https://pubmed.ncbi.nlm.nih.gov/40779178"},"language":"en","primary_location":{"id":"doi:10.1007/s10735-025-10536-x","doi":"https://doi.org/10.1007/s10735-025-10536-x","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10735-025-10536-x","pdf_url":null,"source":{"id":"https://openalex.org/S172113453","display_name":"Journal of Molecular Histology","issn_l":"1567-2379","issn":["1567-2379","1567-2387"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Molecular Histology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Xiaoding Shui","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17747738","display_name":"Beijing University of Chinese Medicine","ror":"https://ror.org/05damtm70","country_code":"CN","type":"education","lineage":["https://openalex.org/I17747738"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoding Shui","raw_affiliation_strings":["Beijing University of Chinese Medicine, Beijing, 100029, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing University of Chinese Medicine, Beijing, 100029, People's Republic of China","institution_ids":["https://openalex.org/I17747738"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060542920","display_name":"Yan Wang","orcid":"https://orcid.org/0000-0003-1187-9527","observed_orcids":["https://orcid.org/0000-0003-1187-9527","https://orcid.org/0000-0002-3144-8372"]},"institutions":[{"id":"https://openalex.org/I17747738","display_name":"Beijing University of Chinese Medicine","ror":"https://ror.org/05damtm70","country_code":"CN","type":"education","lineage":["https://openalex.org/I17747738"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Wang","raw_affiliation_strings":["Beijing University of Chinese Medicine, Beijing, 100029, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing University of Chinese Medicine, Beijing, 100029, People's Republic of China","institution_ids":["https://openalex.org/I17747738"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064904136","display_name":"Yu Luo","orcid":"https://orcid.org/0000-0002-7939-5505","observed_orcids":["https://orcid.org/0000-0002-7939-5505"]},"institutions":[{"id":"https://openalex.org/I17747738","display_name":"Beijing University of Chinese Medicine","ror":"https://ror.org/05damtm70","country_code":"CN","type":"education","lineage":["https://openalex.org/I17747738"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu Luo","raw_affiliation_strings":["Beijing University of Chinese Medicine, Beijing, 100029, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing University of Chinese Medicine, Beijing, 100029, People's Republic of China","institution_ids":["https://openalex.org/I17747738"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088880930","display_name":"Xiaoyu Liang","orcid":"https://orcid.org/0000-0003-2915-214X","observed_orcids":["https://orcid.org/0000-0003-2915-214X"]},"institutions":[{"id":"https://openalex.org/I17747738","display_name":"Beijing University of Chinese Medicine","ror":"https://ror.org/05damtm70","country_code":"CN","type":"education","lineage":["https://openalex.org/I17747738"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoyu Liang","raw_affiliation_strings":["Beijing University of Chinese Medicine, Beijing, 100029, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing University of Chinese Medicine, Beijing, 100029, People's Republic of China","institution_ids":["https://openalex.org/I17747738"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100428795","display_name":"Tao Chen","orcid":"https://orcid.org/0000-0001-9588-1821","observed_orcids":["https://orcid.org/0000-0001-9588-1821"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tao Chen","raw_affiliation_strings":["Beijing Association of Chinese Medicine, Beijing, 100005, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Association of Chinese Medicine, Beijing, 100005, People's Republic of China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035011346","display_name":"Yanting Xia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17747738","display_name":"Beijing University of Chinese Medicine","ror":"https://ror.org/05damtm70","country_code":"CN","type":"education","lineage":["https://openalex.org/I17747738"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanting Xia","raw_affiliation_strings":["Ophthalmology of Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, 100078, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ophthalmology of Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, 100078, People's Republic of China","institution_ids":["https://openalex.org/I17747738"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052471333","display_name":"Qi-Ping Wei","orcid":"https://orcid.org/0009-0000-1369-7415","observed_orcids":["https://orcid.org/0009-0000-1369-7415"]},"institutions":[{"id":"https://openalex.org/I17747738","display_name":"Beijing University of Chinese Medicine","ror":"https://ror.org/05damtm70","country_code":"CN","type":"education","lineage":["https://openalex.org/I17747738"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiping Wei","raw_affiliation_strings":["Ophthalmology of Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, 100078, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ophthalmology of Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, 100078, People's Republic of China","institution_ids":["https://openalex.org/I17747738"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101878344","display_name":"Liang Liao","orcid":"https://orcid.org/0000-0002-7390-4540","observed_orcids":["https://orcid.org/0000-0002-7390-4540"]},"institutions":[{"id":"https://openalex.org/I17747738","display_name":"Beijing University of Chinese Medicine","ror":"https://ror.org/05damtm70","country_code":"CN","type":"education","lineage":["https://openalex.org/I17747738"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Liang Liao","raw_affiliation_strings":["Ophthalmology of Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, 100078, People's Republic of China. 58273677@qq.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ophthalmology of Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, 100078, People's Republic of China. 58273677@qq.com","institution_ids":["https://openalex.org/I17747738"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5101878344"],"corresponding_institution_ids":["https://openalex.org/I17747738"],"apc_list":{"value":3890,"currency":"USD","value_usd":3890},"apc_paid":null,"fwci":1.663,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.81870776,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":97},"biblio":{"volume":"56","issue":"4","first_page":"260","last_page":"260"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.6147000193595886,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.6147000193595886,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.17409999668598175,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.1088000014424324,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/retinal-ganglion-cells","display_name":"retinal ganglion cells","score":0.9539999961853027},{"id":"https://openalex.org/keywords/primary-cell-isolation","display_name":"primary cell isolation","score":0.7089999914169312},{"id":"https://openalex.org/keywords/immunopanning","display_name":"immunopanning","score":0.8859999775886536},{"id":"https://openalex.org/keywords/brn3a","display_name":"Brn3a","score":0.8159999847412109},{"id":"https://openalex.org/keywords/hyperglycemia","display_name":"hyperglycemia","score":0.9020000100135803},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9860000014305115},{"id":"https://openalex.org/keywords/hypoxia-reoxygenation-injury","display_name":"hypoxia/reoxygenation injury","score":0.8360000252723694},{"id":"https://openalex.org/keywords/hif-1alpha","display_name":"HIF-1\u03b1","score":0.8309999704360962},{"id":"https://openalex.org/keywords/heme-oxygenase-1","display_name":"heme oxygenase-1","score":0.8989999890327454},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9710000157356262},{"id":"https://openalex.org/keywords/optic-neuropathy","display_name":"optic neuropathy","score":0.796999990940094},{"id":"https://openalex.org/keywords/km-mice","display_name":"KM mice","score":0.6439999938011169},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.8389999866485596}],"concepts":[{"id":"https://openalex.org/C4224716","wikidata":"https://www.wikidata.org/wiki/Q10859258","display_name":"Immunostaining","level":3,"score":0.6462825536727905},{"id":"https://openalex.org/C2780070996","wikidata":"https://www.wikidata.org/wiki/Q61482373","display_name":"Trypan blue","level":3,"score":0.6255245208740234},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.6250314116477966},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.6228575110435486},{"id":"https://openalex.org/C2777624874","wikidata":"https://www.wikidata.org/wiki/Q927337","display_name":"Retinal ganglion cell","level":3,"score":0.591992974281311},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5624628663063049},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.4740445613861084},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47190791368484497},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.4598553776741028},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.42024660110473633},{"id":"https://openalex.org/C2778236600","wikidata":"https://www.wikidata.org/wiki/Q592324","display_name":"Immunofluorescence","level":3,"score":0.4143815040588379},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3317999839782715},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.3061973452568054},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.28155142068862915},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.27492135763168335},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2269749939441681},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.21687054634094238},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21491113305091858},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.2139124870300293},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18579638004302979}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002469","descriptor_name":"Cell Separation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006861","descriptor_name":"Hydrogen Peroxide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006943","descriptor_name":"Hyperglycemia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006943","descriptor_name":"Hyperglycemia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012165","descriptor_name":"Retinal Ganglion Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D012165","descriptor_name":"Retinal Ganglion Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D012165","descriptor_name":"Retinal Ganglion Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012165","descriptor_name":"Retinal Ganglion Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/s10735-025-10536-x","doi":"https://doi.org/10.1007/s10735-025-10536-x","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10735-025-10536-x","pdf_url":null,"source":{"id":"https://openalex.org/S172113453","display_name":"Journal of Molecular Histology","issn_l":"1567-2379","issn":["1567-2379","1567-2387"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Molecular Histology","raw_type":"journal-article"},{"id":"pmid:40779178","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40779178","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of molecular histology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322935","display_name":"Beijing University of Chinese Medicine","ror":"https://ror.org/05damtm70"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":66,"referenced_works":["https://openalex.org/W1532082751","https://openalex.org/W1982357280","https://openalex.org/W2001424858","https://openalex.org/W2039127036","https://openalex.org/W2041320011","https://openalex.org/W2044858838","https://openalex.org/W2053221182","https://openalex.org/W2072322692","https://openalex.org/W2104810311","https://openalex.org/W2111434225","https://openalex.org/W2119509728","https://openalex.org/W2136487382","https://openalex.org/W2159810213","https://openalex.org/W2180485531","https://openalex.org/W2276700085","https://openalex.org/W2330439121","https://openalex.org/W2342522220","https://openalex.org/W2409480575","https://openalex.org/W2601960749","https://openalex.org/W2611271565","https://openalex.org/W2741887876","https://openalex.org/W2761739377","https://openalex.org/W2792793487","https://openalex.org/W2885438581","https://openalex.org/W2888050814","https://openalex.org/W2894302604","https://openalex.org/W2955521507","https://openalex.org/W2968265343","https://openalex.org/W2970001284","https://openalex.org/W2988320821","https://openalex.org/W2997232610","https://openalex.org/W3013432812","https://openalex.org/W3034625135","https://openalex.org/W3087086004","https://openalex.org/W3112239941","https://openalex.org/W4294575999","https://openalex.org/W4306662158","https://openalex.org/W4383347331","https://openalex.org/W4385069137","https://openalex.org/W4385422019","https://openalex.org/W4386496630","https://openalex.org/W4387630248","https://openalex.org/W4388771490","https://openalex.org/W4388945690","https://openalex.org/W4389549916","https://openalex.org/W4389670704","https://openalex.org/W4390274606","https://openalex.org/W4390747527","https://openalex.org/W4395010580","https://openalex.org/W4401493898","https://openalex.org/W4402133146","https://openalex.org/W4402415322","https://openalex.org/W4402478867","https://openalex.org/W4402829459","https://openalex.org/W4404690783","https://openalex.org/W4405394814","https://openalex.org/W4406486728","https://openalex.org/W4406560588","https://openalex.org/W4406844929","https://openalex.org/W4408465971","https://openalex.org/W4408960990","https://openalex.org/W4409030006","https://openalex.org/W4409371855","https://openalex.org/W4410510737","https://openalex.org/W4411834681","https://openalex.org/W4412526597"],"related_works":["https://openalex.org/W4289774889","https://openalex.org/W2402954452","https://openalex.org/W2358839046","https://openalex.org/W3165856663","https://openalex.org/W4385704175","https://openalex.org/W1993415861","https://openalex.org/W2885438581","https://openalex.org/W2342522220","https://openalex.org/W2168504128","https://openalex.org/W4324009105"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2025-10-10T00:00:00"}
