{"id":"https://openalex.org/W4413038337","doi":"https://doi.org/10.1016/j.devcel.2025.07.018","title":"PINK1 and PARK2 Suppress Pancreatic Tumorigenesis through Control of Mitochondrial Iron-Mediated Immunometabolism","display_name":"PINK1 and PARK2 Suppress Pancreatic Tumorigenesis through Control of Mitochondrial Iron-Mediated Immunometabolism","publication_year":2025,"publication_date":"2025-08-01","ids":{"openalex":"https://openalex.org/W4413038337","doi":"https://doi.org/10.1016/j.devcel.2025.07.018","pmid":"https://pubmed.ncbi.nlm.nih.gov/40780210"},"language":"en","primary_location":{"id":"doi:10.1016/j.devcel.2025.07.018","doi":"https://doi.org/10.1016/j.devcel.2025.07.018","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.devcel.2025.07.018","pdf_url":null,"source":{"id":"https://openalex.org/S83804233","display_name":"Developmental Cell","issn_l":"1534-5807","issn":["1534-5807","1878-1551"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Developmental Cell","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101712896","display_name":"Changfeng Li","orcid":"https://orcid.org/0000-0003-3264-1390","observed_orcids":["https://orcid.org/0000-0003-3264-1390"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Changfeng Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Ying Zhang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ying Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Xing Cheng","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xing Cheng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100642861","display_name":"Hua Yuan","orcid":"https://orcid.org/0000-0002-1107-8036","observed_orcids":["https://orcid.org/0000-0002-1107-8036"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hua Yuan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101751628","display_name":"Shan Zhu","orcid":"https://orcid.org/0000-0003-1531-6174","observed_orcids":["https://orcid.org/0000-0003-1531-6174"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shan Zhu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Jiao Liu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jiao Liu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049645115","display_name":"Qirong Wen","orcid":"https://orcid.org/0009-0006-5169-5238","observed_orcids":["https://orcid.org/0009-0006-5169-5238"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Qirong Wen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057974824","display_name":"Yangchun Xie","orcid":"https://orcid.org/0000-0003-2571-4774","observed_orcids":["https://orcid.org/0000-0003-2571-4774"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yangchun Xie","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101840463","display_name":"Jinbao Liu","orcid":"https://orcid.org/0000-0003-2220-2407","observed_orcids":["https://orcid.org/0000-0003-2220-2407"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jinbao Liu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075296559","display_name":"Guido Kroemer","orcid":"https://orcid.org/0000-0002-9334-4405","observed_orcids":["https://orcid.org/0000-0002-9334-4405"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Guido Kroemer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066515392","display_name":"Daniel J. Klionsky","orcid":"https://orcid.org/0000-0002-7828-8118","observed_orcids":["https://orcid.org/0000-0002-7828-8118"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniel J. Klionsky","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024528047","display_name":"Michael T. Lotze","orcid":"https://orcid.org/0000-0003-3988-5419","observed_orcids":["https://orcid.org/0000-0003-3988-5419"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael T. Lotze","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073859061","display_name":"Herbert J. Zeh","orcid":"https://orcid.org/0000-0003-2017-1934","observed_orcids":["https://orcid.org/0000-0003-2017-1934"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Herbert J. Zeh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091664811","display_name":"Rui Kang","orcid":"https://orcid.org/0000-0003-2725-1574","observed_orcids":["https://orcid.org/0000-0003-2725-1574"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rui Kang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5055468442","display_name":"Daolin Tang","orcid":"https://orcid.org/0000-0002-1903-6180","observed_orcids":["https://orcid.org/0000-0002-1903-6180","https://orcid.org/0000-0002-2650-3816"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Daolin Tang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5055468442","https://openalex.org/A5101712896"],"corresponding_institution_ids":[],"apc_list":{"value":10400,"currency":"USD","value_usd":10400},"apc_paid":null,"fwci":0.416,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.62356117,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"60","issue":"16","first_page":"2209","last_page":"2210"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.3752000033855438,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.3752000033855438,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.26510000228881836,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.06239999830722809,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pink1","display_name":"PINK1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/park2","display_name":"PARK2","score":0.9610000252723694},{"id":"https://openalex.org/keywords/pancreatic-carcinogenesis","display_name":"pancreatic carcinogenesis","score":0.8600000143051147},{"id":"https://openalex.org/keywords/mitochondrial-iron","display_name":"mitochondrial iron","score":0.8019999861717224},{"id":"https://openalex.org/keywords/immunometabolism","display_name":"immunometabolism","score":0.9940000176429749},{"id":"https://openalex.org/keywords/mitochondrial-quality-control","display_name":"mitochondrial quality control","score":0.5040000081062317},{"id":"https://openalex.org/keywords/iron-metabolism","display_name":"iron metabolism","score":0.36399999260902405},{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"pancreatic cancer","score":0.39899998903274536}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9251161217689514},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5879405736923218},{"id":"https://openalex.org/C2776804853","wikidata":"https://www.wikidata.org/wiki/Q18045837","display_name":"PINK1","level":5,"score":0.540113091468811},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4710526466369629},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.4265247583389282},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.34779924154281616},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.23236852884292603},{"id":"https://openalex.org/C2779324830","wikidata":"https://www.wikidata.org/wiki/Q1806192","display_name":"Mitophagy","level":4,"score":0.17897257208824158},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.1599341630935669},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.11392417550086975},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.07848617434501648}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/j.devcel.2025.07.018","doi":"https://doi.org/10.1016/j.devcel.2025.07.018","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.devcel.2025.07.018","pdf_url":null,"source":{"id":"https://openalex.org/S83804233","display_name":"Developmental Cell","issn_l":"1534-5807","issn":["1534-5807","1878-1551"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Developmental Cell","raw_type":"journal-article"},{"id":"pmid:40780210","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40780210","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Developmental cell","raw_type":"Published Erratum"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2894278828","https://openalex.org/W3147615383","https://openalex.org/W4410839789","https://openalex.org/W4415716733","https://openalex.org/W3182355796","https://openalex.org/W2340173828","https://openalex.org/W7146163589","https://openalex.org/W2519565782","https://openalex.org/W7008169099","https://openalex.org/W1542722804"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2025-10-10T00:00:00"}
