{"id":"https://openalex.org/W4413029470","doi":"https://doi.org/10.31083/fbl35605","title":"Dual Role of Host Toll-Like Receptor 3 in Parasitic Diseases","display_name":"Dual Role of Host Toll-Like Receptor 3 in Parasitic Diseases","publication_year":2025,"publication_date":"2025-07-29","ids":{"openalex":"https://openalex.org/W4413029470","doi":"https://doi.org/10.31083/fbl35605","pmid":"https://pubmed.ncbi.nlm.nih.gov/40765338"},"language":"en","primary_location":{"id":"doi:10.31083/fbl35605","doi":"https://doi.org/10.31083/fbl35605","is_oa":true,"landing_page_url":"https://doi.org/10.31083/fbl35605","pdf_url":null,"source":{"id":"https://openalex.org/S4210236708","display_name":"Frontiers in Bioscience-Landmark","issn_l":"2768-6698","issn":["2768-6698","2768-6701"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","oarl","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310322753","host_organization_name":"IMR Press","host_organization_lineage":["https://openalex.org/P4310322753"],"host_organization_lineage_names":["IMR Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioscience-Landmark","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.31083/fbl35605","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043679113","display_name":"Yixin Yang","orcid":"https://orcid.org/0009-0007-2792-4130","observed_orcids":["https://orcid.org/0009-0007-2792-4130"]},"institutions":[{"id":"https://openalex.org/I135836153","display_name":"Shenyang Agricultural University","ror":"https://ror.org/01n7x9n08","country_code":"CN","type":"education","lineage":["https://openalex.org/I135836153"]},{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yixin Yang","raw_affiliation_strings":["Key Laboratory of Livestock Infectious Diseases, Ministry of Education, Key Laboratory of Ruminant Infectious Disease Prevention and Control (East), Ministry of Agriculture and Rural Affairs, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, 110866 Shenyang, Liaoning, China","Research Unit for Pathogenic Mechanisms of Zoonotic Parasites, Chinese Academy of Medical Sciences, Shenyang Agricultural University, 110866 Shenyang, Liaoning, China"],"raw_orcid":"https://orcid.org/0009-0007-2792-4130","affiliations":[{"raw_affiliation_string":"Key Laboratory of Livestock Infectious Diseases, Ministry of Education, Key Laboratory of Ruminant Infectious Disease Prevention and Control (East), Ministry of Agriculture and Rural Affairs, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, 110866 Shenyang, Liaoning, China","institution_ids":["https://openalex.org/I135836153"]},{"raw_affiliation_string":"Research Unit for Pathogenic Mechanisms of Zoonotic Parasites, Chinese Academy of Medical Sciences, Shenyang Agricultural University, 110866 Shenyang, Liaoning, China","institution_ids":["https://openalex.org/I135836153","https://openalex.org/I200296433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019345418","display_name":"Qilong Li","orcid":"https://orcid.org/0000-0002-8645-3566","observed_orcids":["https://orcid.org/0000-0002-8645-3566"]},"institutions":[{"id":"https://openalex.org/I135836153","display_name":"Shenyang Agricultural University","ror":"https://ror.org/01n7x9n08","country_code":"CN","type":"education","lineage":["https://openalex.org/I135836153"]},{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qilong Li","raw_affiliation_strings":["Key Laboratory of Livestock Infectious Diseases, Ministry of Education, Key Laboratory of Ruminant Infectious Disease Prevention and Control (East), Ministry of Agriculture and Rural Affairs, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, 110866 Shenyang, Liaoning, China","Research Unit for Pathogenic Mechanisms of Zoonotic Parasites, Chinese Academy of Medical Sciences, Shenyang Agricultural University, 110866 Shenyang, Liaoning, China"],"raw_orcid":"https://orcid.org/0000-0002-8645-3566","affiliations":[{"raw_affiliation_string":"Key Laboratory of Livestock Infectious Diseases, Ministry of Education, Key Laboratory of Ruminant Infectious Disease Prevention and Control (East), Ministry of Agriculture and Rural Affairs, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, 110866 Shenyang, Liaoning, China","institution_ids":["https://openalex.org/I135836153"]},{"raw_affiliation_string":"Research Unit for Pathogenic Mechanisms of Zoonotic Parasites, Chinese Academy of Medical Sciences, Shenyang Agricultural University, 110866 Shenyang, Liaoning, China","institution_ids":["https://openalex.org/I135836153","https://openalex.org/I200296433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001107069","display_name":"Yiwei Zhang","orcid":"https://orcid.org/0000-0003-2303-6391","observed_orcids":["https://orcid.org/0000-0003-2303-6391"]},"institutions":[{"id":"https://openalex.org/I135836153","display_name":"Shenyang Agricultural University","ror":"https://ror.org/01n7x9n08","country_code":"CN","type":"education","lineage":["https://openalex.org/I135836153"]},{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yiwei Zhang","raw_affiliation_strings":["Key Laboratory of Livestock Infectious Diseases, Ministry of Education, Key Laboratory of Ruminant Infectious Disease Prevention and Control (East), Ministry of Agriculture and Rural Affairs, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, 110866 Shenyang, Liaoning, China","Research Unit for Pathogenic Mechanisms of Zoonotic Parasites, Chinese Academy of Medical Sciences, Shenyang Agricultural University, 110866 Shenyang, Liaoning, China"],"raw_orcid":"https://orcid.org/0000-0003-2303-6391","affiliations":[{"raw_affiliation_string":"Key Laboratory of Livestock Infectious Diseases, Ministry of Education, Key Laboratory of Ruminant Infectious Disease Prevention and Control (East), Ministry of Agriculture and Rural Affairs, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, 110866 Shenyang, Liaoning, China","institution_ids":["https://openalex.org/I135836153"]},{"raw_affiliation_string":"Research Unit for Pathogenic Mechanisms of Zoonotic Parasites, Chinese Academy of Medical Sciences, Shenyang Agricultural University, 110866 Shenyang, Liaoning, China","institution_ids":["https://openalex.org/I135836153","https://openalex.org/I200296433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075148400","display_name":"Ning Jiang","orcid":"https://orcid.org/0000-0003-0240-2233","observed_orcids":["https://orcid.org/0000-0003-0240-2233"]},"institutions":[{"id":"https://openalex.org/I135836153","display_name":"Shenyang Agricultural University","ror":"https://ror.org/01n7x9n08","country_code":"CN","type":"education","lineage":["https://openalex.org/I135836153"]},{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ning Jiang","raw_affiliation_strings":["Key Laboratory of Livestock Infectious Diseases, Ministry of Education, Key Laboratory of Ruminant Infectious Disease Prevention and Control (East), Ministry of Agriculture and Rural Affairs, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, 110866 Shenyang, Liaoning, China","Research Unit for Pathogenic Mechanisms of Zoonotic Parasites, Chinese Academy of Medical Sciences, Shenyang Agricultural University, 110866 Shenyang, Liaoning, China"],"raw_orcid":"https://orcid.org/0000-0003-0240-2233","affiliations":[{"raw_affiliation_string":"Key Laboratory of Livestock Infectious Diseases, Ministry of Education, Key Laboratory of Ruminant Infectious Disease Prevention and Control (East), Ministry of Agriculture and Rural Affairs, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, 110866 Shenyang, Liaoning, China","institution_ids":["https://openalex.org/I135836153"]},{"raw_affiliation_string":"Research Unit for Pathogenic Mechanisms of Zoonotic Parasites, Chinese Academy of Medical Sciences, Shenyang Agricultural University, 110866 Shenyang, Liaoning, China","institution_ids":["https://openalex.org/I135836153","https://openalex.org/I200296433"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101903374","display_name":"Qijun Chen","orcid":"https://orcid.org/0000-0003-0356-7435","observed_orcids":["https://orcid.org/0000-0003-0356-7435"]},"institutions":[{"id":"https://openalex.org/I135836153","display_name":"Shenyang Agricultural University","ror":"https://ror.org/01n7x9n08","country_code":"CN","type":"education","lineage":["https://openalex.org/I135836153"]},{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Qijun Chen","raw_affiliation_strings":["Key Laboratory of Livestock Infectious Diseases, Ministry of Education, Key Laboratory of Ruminant Infectious Disease Prevention and Control (East), Ministry of Agriculture and Rural Affairs, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, 110866 Shenyang, Liaoning, China","Research Unit for Pathogenic Mechanisms of Zoonotic Parasites, Chinese Academy of Medical Sciences, Shenyang Agricultural University, 110866 Shenyang, Liaoning, China"],"raw_orcid":"https://orcid.org/0000-0003-0356-7435","affiliations":[{"raw_affiliation_string":"Key Laboratory of Livestock Infectious Diseases, Ministry of Education, Key Laboratory of Ruminant Infectious Disease Prevention and Control (East), Ministry of Agriculture and Rural Affairs, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, 110866 Shenyang, Liaoning, China","institution_ids":["https://openalex.org/I135836153"]},{"raw_affiliation_string":"Research Unit for Pathogenic Mechanisms of Zoonotic Parasites, Chinese Academy of Medical Sciences, Shenyang Agricultural University, 110866 Shenyang, Liaoning, China","institution_ids":["https://openalex.org/I135836153","https://openalex.org/I200296433"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5101903374"],"corresponding_institution_ids":["https://openalex.org/I135836153","https://openalex.org/I200296433"],"apc_list":{"value":2500,"currency":"USD","value_usd":2500},"apc_paid":{"value":2500,"currency":"USD","value_usd":2500},"fwci":0.0778,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.11018813,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"30","issue":"7","first_page":"35605","last_page":"35605"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.9785000085830688,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.9785000085830688,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10695","display_name":"Parasites and Host Interactions","score":0.007899999618530273,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11403","display_name":"Invertebrate Immune Response Mechanisms","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tlr3","display_name":"TLR3","score":0.9940000176429749},{"id":"https://openalex.org/keywords/parasitic-infection","display_name":"parasitic infection","score":0.9539999961853027},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.8980000019073486},{"id":"https://openalex.org/keywords/trif-signaling","display_name":"TRIF signaling","score":0.8050000071525574},{"id":"https://openalex.org/keywords/double-stranded-rna","display_name":"double-stranded RNA","score":0.8090000152587891},{"id":"https://openalex.org/keywords/exosomal-rna","display_name":"exosomal RNA","score":0.7720000147819519},{"id":"https://openalex.org/keywords/long-non-coding-rna","display_name":"long non-coding RNA","score":0.9980000257492065},{"id":"https://openalex.org/keywords/type-i-interferon","display_name":"type I interferon","score":0.8889999985694885},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.8659999966621399},{"id":"https://openalex.org/keywords/tlr2","display_name":"TLR2","score":0.5830000042915344},{"id":"https://openalex.org/keywords/tlr4","display_name":"TLR4","score":0.9909999966621399},{"id":"https://openalex.org/keywords/plasmodium","display_name":"Plasmodium","score":0.8180000185966492},{"id":"https://openalex.org/keywords/leishmania","display_name":"Leishmania","score":0.9990000128746033},{"id":"https://openalex.org/keywords/clonorchis-sinensis","display_name":"Clonorchis sinensis","score":0.9950000047683716},{"id":"https://openalex.org/keywords/schistosoma-japonicum","display_name":"Schistosoma japonicum","score":1.0},{"id":"https://openalex.org/keywords/trichinella-spiralis","display_name":"Trichinella spiralis","score":1.0},{"id":"https://openalex.org/keywords/neospora-caninum","display_name":"Neospora caninum","score":0.9990000128746033},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.328000009059906},{"id":"https://openalex.org/keywords/parasite-clearance","display_name":"parasite clearance","score":0.6669999957084656}],"concepts":[{"id":"https://openalex.org/C43929388","wikidata":"https://www.wikidata.org/wiki/Q4050587","display_name":"TRIF","level":5,"score":0.7747223377227783},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7109948396682739},{"id":"https://openalex.org/C2778420691","wikidata":"https://www.wikidata.org/wiki/Q14866230","display_name":"TLR3","level":5,"score":0.642911434173584},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5530216097831726},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5114678144454956},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.4977302849292755},{"id":"https://openalex.org/C2776709828","wikidata":"https://www.wikidata.org/wiki/Q408004","display_name":"Toll-like receptor","level":4,"score":0.49000850319862366},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.4795393943786621},{"id":"https://openalex.org/C2781236682","wikidata":"https://www.wikidata.org/wiki/Q410015","display_name":"TLR2","level":4,"score":0.4496699273586273},{"id":"https://openalex.org/C9173399","wikidata":"https://www.wikidata.org/wiki/Q6046461","display_name":"Interferon regulatory factors","level":4,"score":0.4313224256038666},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.4247901439666748},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.35557821393013},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.3554152250289917}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006790","descriptor_name":"Host-Parasite Interactions","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010272","descriptor_name":"Parasitic Diseases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D010272","descriptor_name":"Parasitic Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010272","descriptor_name":"Parasitic Diseases","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051196","descriptor_name":"Toll-Like Receptor 3","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D051196","descriptor_name":"Toll-Like Receptor 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.31083/fbl35605","doi":"https://doi.org/10.31083/fbl35605","is_oa":true,"landing_page_url":"https://doi.org/10.31083/fbl35605","pdf_url":null,"source":{"id":"https://openalex.org/S4210236708","display_name":"Frontiers in Bioscience-Landmark","issn_l":"2768-6698","issn":["2768-6698","2768-6701"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","oarl","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310322753","host_organization_name":"IMR Press","host_organization_lineage":["https://openalex.org/P4310322753"],"host_organization_lineage_names":["IMR Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioscience-Landmark","raw_type":"journal-article"},{"id":"pmid:40765338","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40765338","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in bioscience (Landmark edition)","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:3b06084b9a1e46d7b44efab68a785116","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/3b06084b9a1e46d7b44efab68a785116","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Bioscience-Landmark, Vol 30, Iss 7, p 35605 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.31083/fbl35605","doi":"https://doi.org/10.31083/fbl35605","is_oa":true,"landing_page_url":"https://doi.org/10.31083/fbl35605","pdf_url":null,"source":{"id":"https://openalex.org/S4210236708","display_name":"Frontiers in Bioscience-Landmark","issn_l":"2768-6698","issn":["2768-6698","2768-6701"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","oarl","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310322753","host_organization_name":"IMR Press","host_organization_lineage":["https://openalex.org/P4310322753"],"host_organization_lineage_names":["IMR Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioscience-Landmark","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6667795457","display_name":null,"funder_award_id":"2022YFD1800200","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G7034167846","display_name":null,"funder_award_id":"82030060","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":139,"referenced_works":["https://openalex.org/W1679367724","https://openalex.org/W1954877463","https://openalex.org/W1965663173","https://openalex.org/W1975515991","https://openalex.org/W1987047581","https://openalex.org/W1990861050","https://openalex.org/W1992977053","https://openalex.org/W2000177767","https://openalex.org/W2005884645","https://openalex.org/W2022010288","https://openalex.org/W2026512029","https://openalex.org/W2039135956","https://openalex.org/W2042433863","https://openalex.org/W2043390800","https://openalex.org/W2050676604","https://openalex.org/W2060996643","https://openalex.org/W2071436774","https://openalex.org/W2078014742","https://openalex.org/W2088683355","https://openalex.org/W2096472109","https://openalex.org/W2100541792","https://openalex.org/W2107869453","https://openalex.org/W2116249489","https://openalex.org/W2124778856","https://openalex.org/W2133945584","https://openalex.org/W2140990000","https://openalex.org/W2143986273","https://openalex.org/W2144787399","https://openalex.org/W2156414024","https://openalex.org/W2168984022","https://openalex.org/W2169749928","https://openalex.org/W2170697062","https://openalex.org/W2238877049","https://openalex.org/W2300735552","https://openalex.org/W2394725514","https://openalex.org/W2466811948","https://openalex.org/W2482783327","https://openalex.org/W2482895700","https://openalex.org/W2499609130","https://openalex.org/W2511294319","https://openalex.org/W2512646584","https://openalex.org/W2514096051","https://openalex.org/W2527204935","https://openalex.org/W2594224471","https://openalex.org/W2615086721","https://openalex.org/W2626390315","https://openalex.org/W2627553069","https://openalex.org/W2662093608","https://openalex.org/W2735725998","https://openalex.org/W2755388057","https://openalex.org/W2780932379","https://openalex.org/W2792478862","https://openalex.org/W2792976722","https://openalex.org/W2806305953","https://openalex.org/W2889108107","https://openalex.org/W2913936032","https://openalex.org/W2922526007","https://openalex.org/W2923885098","https://openalex.org/W2939916006","https://openalex.org/W2941327646","https://openalex.org/W2944592180","https://openalex.org/W2966139534","https://openalex.org/W2984992371","https://openalex.org/W2985348368","https://openalex.org/W2990037291","https://openalex.org/W2992697133","https://openalex.org/W2995092540","https://openalex.org/W2997128830","https://openalex.org/W2997389909","https://openalex.org/W3004298044","https://openalex.org/W3004973964","https://openalex.org/W3008040042","https://openalex.org/W3012283572","https://openalex.org/W3024303670","https://openalex.org/W3024725656","https://openalex.org/W3025497717","https://openalex.org/W3031646205","https://openalex.org/W3032346199","https://openalex.org/W3033852017","https://openalex.org/W3034560620","https://openalex.org/W3042581723","https://openalex.org/W3045465434","https://openalex.org/W3083711031","https://openalex.org/W3084836046","https://openalex.org/W3095682175","https://openalex.org/W3097769006","https://openalex.org/W3098508729","https://openalex.org/W3131711061","https://openalex.org/W3158953228","https://openalex.org/W3162358267","https://openalex.org/W3162379660","https://openalex.org/W3164046636","https://openalex.org/W3183909715","https://openalex.org/W3193445073","https://openalex.org/W3200289227","https://openalex.org/W3205966845","https://openalex.org/W3207328751","https://openalex.org/W4206944364","https://openalex.org/W4210440364","https://openalex.org/W4210582840","https://openalex.org/W4211064719","https://openalex.org/W4225648129","https://openalex.org/W4283397894","https://openalex.org/W4283445965","https://openalex.org/W4284975012","https://openalex.org/W4290612166","https://openalex.org/W4292608201","https://openalex.org/W4292849306","https://openalex.org/W4293024974","https://openalex.org/W4306907921","https://openalex.org/W4307707867","https://openalex.org/W4308360609","https://openalex.org/W4310713044","https://openalex.org/W4311983509","https://openalex.org/W4317436404","https://openalex.org/W4319332789","https://openalex.org/W4365998157","https://openalex.org/W4376224881","https://openalex.org/W4376226319","https://openalex.org/W4379509004","https://openalex.org/W4381308071","https://openalex.org/W4385614522","https://openalex.org/W4385652239","https://openalex.org/W4386930614","https://openalex.org/W4388035546","https://openalex.org/W4388227111","https://openalex.org/W4388487330","https://openalex.org/W4390533264","https://openalex.org/W4391379888","https://openalex.org/W4394062233","https://openalex.org/W4394853493","https://openalex.org/W4395664079","https://openalex.org/W4396558399","https://openalex.org/W4396617681","https://openalex.org/W4398762805","https://openalex.org/W4399121310","https://openalex.org/W4399458989","https://openalex.org/W4401421768","https://openalex.org/W4402005215"],"related_works":["https://openalex.org/W2016800881","https://openalex.org/W7025051353","https://openalex.org/W4394853493","https://openalex.org/W2108548328","https://openalex.org/W2939168657","https://openalex.org/W186837204","https://openalex.org/W2351254541","https://openalex.org/W2923885098","https://openalex.org/W3193445073","https://openalex.org/W1982293312"],"abstract_inverted_index":{"Parasitic":[0],"diseases,":[1],"caused":[2,211],"by":[3,30,141,212],"a":[4,10,21],"diverse":[5],"array":[6],"of":[7,85,93,103,136],"parasites,":[8],"remain":[9],"substantial":[11],"threat":[12],"to":[13,33,148,166],"global":[14],"health.":[15],"Toll-like":[16],"receptor":[17],"3":[18],"(TLR3)":[19],"represents":[20],"pivotal":[22],"element":[23],"in":[24,65,138,189,205],"the":[25,36,83,90,101,133,197],"innate":[26],"immune":[27,67,126,191],"system,":[28],"distinguished":[29],"an":[31],"ability":[32],"signal":[34],"via":[35],"TIR-domain-containing":[37],"adapter-inducing":[38],"interferon-\u03b2":[39],"(TRIF)-dependent":[40],"pathway":[41,200],"upon":[42],"detecting":[43,142],"pathogen-derived":[44],"double-stranded":[45],"RNA":[46,49,54],"(dsRNA),":[47],"exosomal":[48],"(exoRNA),":[50],"and":[51,70,89,108,117,151,164,170,182,201,223],"long":[52],"non-coding":[53],"(lncRNA).":[55],"Predominantly":[56],"localized":[57],"on":[58],"endosomal":[59],"membranes,":[60],"TLR3":[61,75,137,155,175,198],"is":[62],"extensively":[63],"expressed":[64],"neurons,":[66],"cells,":[68],"fibroblasts,":[69],"epithelial":[71],"cells.":[72,154],"Upon":[73],"activation,":[74],"engages":[76],"adaptor":[77],"molecules":[78],"such":[79,111,161],"as":[80,112,162],"TRIF,":[81],"facilitating":[82],"phosphorylation":[84],"TANK-binding":[86],"kinase":[87],"1":[88],"subsequent":[91],"activation":[92],"interferon":[94],"regulatory":[95],"factors.":[96],"This":[97,193],"signaling":[98,199],"cascade":[99],"triggers":[100],"production":[102,169],"type":[104],"I":[105],"interferons":[106],"(IFN-\u03b1/\u03b2)":[107],"proinflammatory":[109],"cytokines":[110],"interleukin":[113],"(IL)-6,":[114],"IL-8,":[115],"IL-12,":[116],"tumor":[118],"necrosis":[119],"factor-alpha,":[120],"which":[121],"are":[122],"crucial":[123],"for":[124],"effective":[125],"defense":[127],"against":[128],"infections.":[129],"Recent":[130],"findings":[131],"highlight":[132],"essential":[134],"role":[135,188,204],"parasitic":[139,207],"infections":[140],"nucleic":[143],"acids":[144],"from":[145],"damaged":[146],"cells":[147],"activate":[149],"dendritic":[150],"natural":[152],"killer":[153],"also":[156],"functions":[157],"with":[158],"other":[159],"receptors,":[160],"TLR2":[163],"TLR4,":[165],"enhance":[167],"cytokine":[168],"improve":[171],"parasite":[172],"clearance.":[173],"However,":[174],"overactivation":[176],"can":[177],"induce":[178],"excessive,":[179],"harmful":[180],"inflammation":[181],"tissue":[183],"damage,":[184],"highlighting":[185],"its":[186,202],"dual":[187],"balancing":[190],"defense.":[192],"review":[194],"comprehensively":[195],"examines":[196],"multifaceted":[203],"various":[206],"infections,":[208],"including":[209],"those":[210],"Plasmodium":[213],"spp.,":[214,216],"Leishmania":[215],"Clonorchis":[217],"sinensis,":[218],"Schistosoma":[219],"japonicum,":[220],"Trichinella":[221],"spiralis,":[222],"Neospora":[224],"caninum.":[225]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2025-10-10T00:00:00"}