{"id":"https://openalex.org/W4413020046","doi":"https://doi.org/10.1016/j.matt.2025.102330","title":"Polarity reversal in A\u03b2 plaques: A fluorescent lifespan probe illuminates photobiomodulation therapy for Alzheimer\u2019s disease","display_name":"Polarity reversal in A\u03b2 plaques: A fluorescent lifespan probe illuminates photobiomodulation therapy for Alzheimer\u2019s disease","publication_year":2025,"publication_date":"2025-08-01","ids":{"openalex":"https://openalex.org/W4413020046","doi":"https://doi.org/10.1016/j.matt.2025.102330"},"language":"en","primary_location":{"id":"doi:10.1016/j.matt.2025.102330","doi":"https://doi.org/10.1016/j.matt.2025.102330","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.matt.2025.102330","pdf_url":null,"source":{"id":"https://openalex.org/S4210178557","display_name":"Matter","issn_l":"2590-2385","issn":["2590-2385","2590-2393"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Matter","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102005196","display_name":"Huizhi Wang","orcid":"https://orcid.org/0000-0001-7692-2106","observed_orcids":["https://orcid.org/0000-0001-7692-2106"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210087691","display_name":"Beijing Tian Tan Hospital","ror":"https://ror.org/003regz62","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210087691"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huizhi Wang","raw_affiliation_strings":["Beijing Neurosurgical Institute, Capital Medical University, Beijing 100070, China","Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Neurosurgical Institute, Capital Medical University, Beijing 100070, China","institution_ids":["https://openalex.org/I183519381"]},{"raw_affiliation_string":"Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210087691"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111426022","display_name":"Liuliu Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210141942","display_name":"Peking University Third Hospital","ror":"https://ror.org/04wwqze12","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141942"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liuliu Wu","raw_affiliation_strings":["Research Center of Clinical Epidemiology, Peking University Third Hospital, Beijing 100191, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Center of Clinical Epidemiology, Peking University Third Hospital, Beijing 100191, China","institution_ids":["https://openalex.org/I4210141942"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100542542","display_name":"Chunlei Han","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210087691","display_name":"Beijing Tian Tan Hospital","ror":"https://ror.org/003regz62","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210087691"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chunlei Han","raw_affiliation_strings":["Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210087691"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041499359","display_name":"Tao Feng","orcid":"https://orcid.org/0000-0002-8530-4622","observed_orcids":["https://orcid.org/0000-0002-8530-4622"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210087691","display_name":"Beijing Tian Tan Hospital","ror":"https://ror.org/003regz62","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210087691"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Tao Feng","raw_affiliation_strings":["Center for Movement Disorders, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Movement Disorders, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210087691"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100461798","display_name":"Jianguo Zhang","orcid":"https://orcid.org/0000-0003-0723-1701","observed_orcids":["https://orcid.org/0000-0003-0723-1701"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210087691","display_name":"Beijing Tian Tan Hospital","ror":"https://ror.org/003regz62","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210087691"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jianguo Zhang","raw_affiliation_strings":["Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210087691"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101805929","display_name":"Fangang Meng","orcid":"https://orcid.org/0000-0002-8577-6443","observed_orcids":["https://orcid.org/0000-0002-8577-6443"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210087691","display_name":"Beijing Tian Tan Hospital","ror":"https://ror.org/003regz62","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210087691"]},{"id":"https://openalex.org/I4210115644","display_name":"Chinese Institute for Brain Research","ror":"https://ror.org/029819q61","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210115644"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Fangang Meng","raw_affiliation_strings":["Beijing Neurosurgical Institute, Capital Medical University, Beijing 100070, China","Chinese Institute for Brain Research, Beijing 102206, China","Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Neurosurgical Institute, Capital Medical University, Beijing 100070, China","institution_ids":["https://openalex.org/I183519381"]},{"raw_affiliation_string":"Chinese Institute for Brain Research, Beijing 102206, China","institution_ids":["https://openalex.org/I4210115644"]},{"raw_affiliation_string":"Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210087691"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5041499359","https://openalex.org/A5100461798","https://openalex.org/A5101805929"],"corresponding_institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210087691","https://openalex.org/I4210115644"],"apc_list":{"value":9350,"currency":"USD","value_usd":9350},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.13980376,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"8","issue":"8","first_page":"102330","last_page":"102330"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10532","display_name":"Molecular Sensors and Ion Detection","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9909999966621399},{"id":"https://openalex.org/keywords/amyloid-plaques","display_name":"amyloid plaques","score":0.9700000286102295},{"id":"https://openalex.org/keywords/low-level-laser-therapy","display_name":"low-level laser therapy","score":0.9290000200271606},{"id":"https://openalex.org/keywords/twisted-intramolecular-charge-transfer","display_name":"twisted intramolecular charge transfer","score":0.9200000166893005},{"id":"https://openalex.org/keywords/fluorescence-lifetime-imaging-microscopy","display_name":"fluorescence lifetime imaging","score":0.746999979019165},{"id":"https://openalex.org/keywords/hydrophobic-to-hydrophilic-transition","display_name":"hydrophilic-hydrophobic transition","score":0.9570000171661377},{"id":"https://openalex.org/keywords/plaque-clearance","display_name":"plaque clearance","score":0.6039999723434448},{"id":"https://openalex.org/keywords/cognitive-recovery","display_name":"cognitive recovery","score":0.7749999761581421},{"id":"https://openalex.org/keywords/near-infrared-fluorescent-probe","display_name":"near-infrared fluorescent probe","score":0.5559999942779541},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.4300000071525574}],"concepts":[{"id":"https://openalex.org/C2777361361","wikidata":"https://www.wikidata.org/wiki/Q1112585","display_name":"Polarity (international relations)","level":3,"score":0.5192651748657227},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5031444430351257},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.44597744941711426},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.4209301173686981},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.41561487317085266},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.2760317921638489},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.24987176060676575},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2082011103630066},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.09018433094024658},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.08596709370613098},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06820225715637207},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.matt.2025.102330","doi":"https://doi.org/10.1016/j.matt.2025.102330","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.matt.2025.102330","pdf_url":null,"source":{"id":"https://openalex.org/S4210178557","display_name":"Matter","issn_l":"2590-2385","issn":["2590-2385","2590-2393"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Matter","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7629576561","display_name":null,"funder_award_id":"82471265","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7691370438","display_name":null,"funder_award_id":"81971070","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W274427711","https://openalex.org/W2069638680","https://openalex.org/W2560234750","https://openalex.org/W2624625549","https://openalex.org/W4206046172","https://openalex.org/W4225741213","https://openalex.org/W4319310840","https://openalex.org/W4390858028","https://openalex.org/W4398173192","https://openalex.org/W4411548567"],"related_works":["https://openalex.org/W4409253159","https://openalex.org/W4414580301","https://openalex.org/W3171475385","https://openalex.org/W4389738189","https://openalex.org/W4390807417","https://openalex.org/W4315701281","https://openalex.org/W2905856350","https://openalex.org/W4392682468","https://openalex.org/W4213290930","https://openalex.org/W2963039221"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-10-10T00:00:00"}