{"id":"https://openalex.org/W4413019297","doi":"https://doi.org/10.1016/j.fbio.2025.107371","title":"Hydropuntia edulis extract mitigates metabolic dysregulation via DPP-4 inhibition, lipid modulation, and GLP-1/AKT1 pathway activation","display_name":"Hydropuntia edulis extract mitigates metabolic dysregulation via DPP-4 inhibition, lipid modulation, and GLP-1/AKT1 pathway activation","publication_year":2025,"publication_date":"2025-08-06","ids":{"openalex":"https://openalex.org/W4413019297","doi":"https://doi.org/10.1016/j.fbio.2025.107371"},"language":"en","primary_location":{"id":"doi:10.1016/j.fbio.2025.107371","doi":"https://doi.org/10.1016/j.fbio.2025.107371","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.fbio.2025.107371","pdf_url":null,"source":{"id":"https://openalex.org/S2764726840","display_name":"Food Bioscience","issn_l":"2212-4292","issn":["2212-4292","2212-4306"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Food Bioscience","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108342515","display_name":"Maghfirah Savitri","orcid":"https://orcid.org/0009-0000-0491-5812","observed_orcids":["https://orcid.org/0009-0000-0491-5812"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maghfirah Savitri","raw_affiliation_strings":["Robert Wolter Monginsidi Army Hospital, Manado, North Sulawesi, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Robert Wolter Monginsidi Army Hospital, Manado, North Sulawesi, Indonesia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041935655","display_name":"Trina Ekawati Tallei","orcid":"https://orcid.org/0000-0002-7963-7527","observed_orcids":["https://orcid.org/0000-0002-7963-7527"]},"institutions":[{"id":"https://openalex.org/I55214057","display_name":"Sam Ratulangi University","ror":"https://ror.org/01cn6ph21","country_code":"ID","type":"education","lineage":["https://openalex.org/I55214057"]}],"countries":["ID"],"is_corresponding":true,"raw_author_name":"Trina Ekawati Tallei","raw_affiliation_strings":["Department of Biology, Faculty of Mathematics and Natural Sciences, Sam Ratulangi University, Manado, 95115, North Sulawesi, Indonesia","Department of Biology, Faculty of Medicine, Sam Ratulangi University, Manado, 95113, North Sulawesi, Indonesia"],"raw_orcid":"https://orcid.org/0000-0002-7963-7527","affiliations":[{"raw_affiliation_string":"Department of Biology, Faculty of Mathematics and Natural Sciences, Sam Ratulangi University, Manado, 95115, North Sulawesi, Indonesia","institution_ids":["https://openalex.org/I55214057"]},{"raw_affiliation_string":"Department of Biology, Faculty of Medicine, Sam Ratulangi University, Manado, 95113, North Sulawesi, Indonesia","institution_ids":["https://openalex.org/I55214057"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112616051","display_name":"Ahmad Akroman Adam","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ahmad Akroman Adam","raw_affiliation_strings":["Cosmo Dental Care, Manado, 95115, North Sulawesi, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cosmo Dental Care, Manado, 95115, North Sulawesi, Indonesia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059297661","display_name":"Nur Balqis Maulydia","orcid":"https://orcid.org/0009-0000-6497-5825","observed_orcids":["https://orcid.org/0009-0000-6497-5825"]},"institutions":[{"id":"https://openalex.org/I187494767","display_name":"Universitas Syiah Kuala","ror":"https://ror.org/05v4dza81","country_code":"ID","type":"education","lineage":["https://openalex.org/I187494767"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Nur Balqis Maulydia","raw_affiliation_strings":["Graduate School of Mathematics and Applied Sciences, Universitas Syiah Kuala, Banda Aceh, 23111, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Mathematics and Applied Sciences, Universitas Syiah Kuala, Banda Aceh, 23111, Indonesia","institution_ids":["https://openalex.org/I187494767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042536412","display_name":"Fatimawali Fatimawali","orcid":"https://orcid.org/0000-0003-2480-5420","observed_orcids":["https://orcid.org/0000-0003-2480-5420"]},"institutions":[{"id":"https://openalex.org/I55214057","display_name":"Sam Ratulangi University","ror":"https://ror.org/01cn6ph21","country_code":"ID","type":"education","lineage":["https://openalex.org/I55214057"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Fatimawali Fatimawali","raw_affiliation_strings":["Pharmacy Study Program, Faculty of Mathematics and Natural Sciences, Sam Ratulangi University, Manado, 95115, North Sulawesi, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacy Study Program, Faculty of Mathematics and Natural Sciences, Sam Ratulangi University, Manado, 95115, North Sulawesi, Indonesia","institution_ids":["https://openalex.org/I55214057"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5119232738","display_name":"Gadis Sabrina Tanjung","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55214057","display_name":"Sam Ratulangi University","ror":"https://ror.org/01cn6ph21","country_code":"ID","type":"education","lineage":["https://openalex.org/I55214057"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Gadis Sabrina Tanjung","raw_affiliation_strings":["Department of Biology, Faculty of Mathematics and Natural Sciences, Sam Ratulangi University, Manado, 95115, North Sulawesi, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Faculty of Mathematics and Natural Sciences, Sam Ratulangi University, Manado, 95115, North Sulawesi, Indonesia","institution_ids":["https://openalex.org/I55214057"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100700223","display_name":"Muhammad Dafik Kholik Firdaus","orcid":"https://orcid.org/0000-0002-1899-8644","observed_orcids":["https://orcid.org/0000-0002-1899-8644"]},"institutions":[{"id":"https://openalex.org/I4387154144","display_name":"National Research and Innovation Agency","ror":"https://ror.org/02hmjzt55","country_code":"ID","type":"government","lineage":["https://openalex.org/I4387154144"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Muhammad Firdaus","raw_affiliation_strings":["Research Center for Marine and Land Bioindustry, National Research and Innovation Agency (BRIN), North Lombok, 83352, Indonesia"],"raw_orcid":"https://orcid.org/0000-0002-1899-8644","affiliations":[{"raw_affiliation_string":"Research Center for Marine and Land Bioindustry, National Research and Innovation Agency (BRIN), North Lombok, 83352, Indonesia","institution_ids":["https://openalex.org/I4387154144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076440214","display_name":"Rony Abdi Syahputra","orcid":"https://orcid.org/0000-0003-2016-0151","observed_orcids":["https://orcid.org/0000-0003-2016-0151"]},"institutions":[{"id":"https://openalex.org/I254887060","display_name":"Universitas Sumatera Utara","ror":"https://ror.org/01kknrc90","country_code":"ID","type":"education","lineage":["https://openalex.org/I254887060"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Rony Abdi Syahputra","raw_affiliation_strings":["Department of Pharmacology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, 20155, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, 20155, Indonesia","institution_ids":["https://openalex.org/I254887060"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034601041","display_name":"Fahrul Nurkolis","orcid":"https://orcid.org/0000-0003-2151-0854","observed_orcids":["https://orcid.org/0000-0003-2151-0854"]},"institutions":[{"id":"https://openalex.org/I181085462","display_name":"Sunan Kalijaga State Islamic University Yogyakarta","ror":"https://ror.org/00nmvbd84","country_code":"ID","type":"education","lineage":["https://openalex.org/I181085462"]},{"id":"https://openalex.org/I205133468","display_name":"Universitas Airlangga","ror":"https://ror.org/04ctejd88","country_code":"ID","type":"education","lineage":["https://openalex.org/I205133468"]}],"countries":["ID"],"is_corresponding":true,"raw_author_name":"Fahrul Nurkolis","raw_affiliation_strings":["Master of Basic Medical Science, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia","Medical Research Center of Indonesia, Surabaya, Indonesia","State Islamic University of Sunan Kalijaga (UIN Sunan Kalijaga), Yogyakarta, 55281, Indonesia"],"raw_orcid":"https://orcid.org/0000-0003-2151-0854","affiliations":[{"raw_affiliation_string":"Master of Basic Medical Science, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia","institution_ids":["https://openalex.org/I205133468"]},{"raw_affiliation_string":"Medical Research Center of Indonesia, Surabaya, Indonesia","institution_ids":[]},{"raw_affiliation_string":"State Islamic University of Sunan Kalijaga (UIN Sunan Kalijaga), Yogyakarta, 55281, Indonesia","institution_ids":["https://openalex.org/I181085462"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5034601041","https://openalex.org/A5041935655"],"corresponding_institution_ids":["https://openalex.org/I181085462","https://openalex.org/I205133468","https://openalex.org/I55214057"],"apc_list":{"value":3380,"currency":"USD","value_usd":3380},"apc_paid":null,"fwci":2.035,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.85820852,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":98},"biblio":{"volume":"71","issue":null,"first_page":"107371","last_page":"107371"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11390","display_name":"Seaweed-derived Bioactive Compounds","score":0.008899999782443047,"subfield":{"id":"https://openalex.org/subfields/1104","display_name":"Aquatic Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.8840000033378601},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.996999979019165},{"id":"https://openalex.org/keywords/dpp-4-inhibition","display_name":"DPP-4 inhibition","score":0.9300000071525574},{"id":"https://openalex.org/keywords/srebp-1c","display_name":"SREBP-1c","score":0.824999988079071},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.5139999985694885},{"id":"https://openalex.org/keywords/dyslipidemia","display_name":"dyslipidemia","score":0.8550000190734863},{"id":"https://openalex.org/keywords/alpha-glucosidase-inhibition","display_name":"\u03b1-glucosidase inhibition","score":0.8339999914169312},{"id":"https://openalex.org/keywords/alpha-amylase-inhibition","display_name":"\u03b1-amylase inhibition","score":0.9980000257492065},{"id":"https://openalex.org/keywords/glucose-homeostasis","display_name":"glucose homeostasis","score":0.7070000171661377},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":0.6179999709129333},{"id":"https://openalex.org/keywords/functional-foods","display_name":"functional foods","score":0.5860000252723694},{"id":"https://openalex.org/keywords/metabolic-syndrome","display_name":"metabolic syndrome","score":0.7070000171661377}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6229043006896973},{"id":"https://openalex.org/C156490143","wikidata":"https://www.wikidata.org/wiki/Q412214","display_name":"Dipeptidyl peptidase-4","level":4,"score":0.5901584029197693},{"id":"https://openalex.org/C123079801","wikidata":"https://www.wikidata.org/wiki/Q750240","display_name":"Modulation (music)","level":2,"score":0.4496942460536957},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.42185696959495544},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3589552342891693},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2379240095615387},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.20345532894134521},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19336029887199402},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.19023698568344116},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C107038049","wikidata":"https://www.wikidata.org/wiki/Q35986","display_name":"Aesthetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.fbio.2025.107371","doi":"https://doi.org/10.1016/j.fbio.2025.107371","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.fbio.2025.107371","pdf_url":null,"source":{"id":"https://openalex.org/S2764726840","display_name":"Food Bioscience","issn_l":"2212-4292","issn":["2212-4292","2212-4306"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Food Bioscience","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320330149","display_name":"Universitas Sam Ratulangi","ror":"https://ror.org/01cn6ph21"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":79,"referenced_works":["https://openalex.org/W140545298","https://openalex.org/W1031578623","https://openalex.org/W1759879204","https://openalex.org/W2041791898","https://openalex.org/W2051381895","https://openalex.org/W2081693079","https://openalex.org/W2095719702","https://openalex.org/W2100076167","https://openalex.org/W2110649303","https://openalex.org/W2120850582","https://openalex.org/W2143238378","https://openalex.org/W2152094665","https://openalex.org/W2292301738","https://openalex.org/W2297554319","https://openalex.org/W2555870966","https://openalex.org/W2635415917","https://openalex.org/W2743822989","https://openalex.org/W2883665668","https://openalex.org/W2900848270","https://openalex.org/W2904295834","https://openalex.org/W2912818999","https://openalex.org/W2964440676","https://openalex.org/W2970628659","https://openalex.org/W2980837695","https://openalex.org/W3014757079","https://openalex.org/W3015741518","https://openalex.org/W3080168504","https://openalex.org/W3095684596","https://openalex.org/W3121555004","https://openalex.org/W3127936579","https://openalex.org/W3137080614","https://openalex.org/W3156844513","https://openalex.org/W3176459555","https://openalex.org/W3202287440","https://openalex.org/W4205325198","https://openalex.org/W4210849414","https://openalex.org/W4225789903","https://openalex.org/W4280518658","https://openalex.org/W4280588491","https://openalex.org/W4281401997","https://openalex.org/W4294216483","https://openalex.org/W4296252632","https://openalex.org/W4296802076","https://openalex.org/W4307468223","https://openalex.org/W4308516386","https://openalex.org/W4308834893","https://openalex.org/W4309737905","https://openalex.org/W4311521606","https://openalex.org/W4320481312","https://openalex.org/W4320728860","https://openalex.org/W4362666262","https://openalex.org/W4363677540","https://openalex.org/W4366775306","https://openalex.org/W4377824358","https://openalex.org/W4383301921","https://openalex.org/W4385337252","https://openalex.org/W4386283731","https://openalex.org/W4386998464","https://openalex.org/W4387387410","https://openalex.org/W4387971751","https://openalex.org/W4392986459","https://openalex.org/W4393072771","https://openalex.org/W4397000108","https://openalex.org/W4399979386","https://openalex.org/W4401820868","https://openalex.org/W4401960973","https://openalex.org/W4402312238","https://openalex.org/W4402999424","https://openalex.org/W4403091757","https://openalex.org/W4403376531","https://openalex.org/W4403751974","https://openalex.org/W4403866989","https://openalex.org/W4403934225","https://openalex.org/W4404110352","https://openalex.org/W4404563310","https://openalex.org/W4406463325","https://openalex.org/W4406884251","https://openalex.org/W4409443734","https://openalex.org/W4412962986"],"related_works":["https://openalex.org/W4411475726","https://openalex.org/W2980837695","https://openalex.org/W4403971720","https://openalex.org/W7144034950","https://openalex.org/W7203738008","https://openalex.org/W7110901951","https://openalex.org/W7134829865","https://openalex.org/W3162123848","https://openalex.org/W1859055330","https://openalex.org/W7212218583"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-10-10T00:00:00"}