{"id":"https://openalex.org/W4413008751","doi":"https://doi.org/10.1016/j.neuropharm.2025.110627","title":"Perinatal and prenatal alcohol exposure impairs striatal cholinergic function and cognitive flexibility in adult offspring","display_name":"Perinatal and prenatal alcohol exposure impairs striatal cholinergic function and cognitive flexibility in adult offspring","publication_year":2025,"publication_date":"2025-08-06","ids":{"openalex":"https://openalex.org/W4413008751","doi":"https://doi.org/10.1016/j.neuropharm.2025.110627","pmid":"https://pubmed.ncbi.nlm.nih.gov/40502065","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12154635"},"language":"en","primary_location":{"id":"doi:10.1016/j.neuropharm.2025.110627","doi":"https://doi.org/10.1016/j.neuropharm.2025.110627","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neuropharm.2025.110627","pdf_url":null,"source":{"id":"https://openalex.org/S160566677","display_name":"Neuropharmacology","issn_l":"0028-3908","issn":["0028-3908","1873-7064"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.neuropharm.2025.110627","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005126622","display_name":"William Purvines","orcid":"https://orcid.org/0000-0001-9509-8642","observed_orcids":["https://orcid.org/0000-0001-9509-8642"]},"institutions":[{"id":"https://openalex.org/I125029298","display_name":"Texas A&M Health Science Center","ror":"https://ror.org/01tx6pn92","country_code":"US","type":"education","lineage":["https://openalex.org/I125029298","https://openalex.org/I91045830"]},{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William Purvines","raw_affiliation_strings":["Department of Neuroscience and Experimental Therapeutics, College of Medicine, Texas A&M University Health Science Center, Bryan, TX, 77807, United States; Texas A&M Institute for Neuroscience, Texas A&M University, College Station, TX, 77843, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience and Experimental Therapeutics, College of Medicine, Texas A&M University Health Science Center, Bryan, TX, 77807, United States; Texas A&M Institute for Neuroscience, Texas A&M University, College Station, TX, 77843, United States","institution_ids":["https://openalex.org/I125029298","https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090458135","display_name":"Himanshu Gangal","orcid":"https://orcid.org/0000-0002-6901-3067","observed_orcids":["https://orcid.org/0000-0002-6901-3067"]},"institutions":[{"id":"https://openalex.org/I125029298","display_name":"Texas A&M Health Science Center","ror":"https://ror.org/01tx6pn92","country_code":"US","type":"education","lineage":["https://openalex.org/I125029298","https://openalex.org/I91045830"]},{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Himanshu Gangal","raw_affiliation_strings":["Department of Neuroscience and Experimental Therapeutics, College of Medicine, Texas A&M University Health Science Center, Bryan, TX, 77807, United States; Texas A&M Institute for Neuroscience, Texas A&M University, College Station, TX, 77843, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience and Experimental Therapeutics, College of Medicine, Texas A&M University Health Science Center, Bryan, TX, 77807, United States; Texas A&M Institute for Neuroscience, Texas A&M University, College Station, TX, 77843, United States","institution_ids":["https://openalex.org/I125029298","https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016250687","display_name":"Xueyi Xie","orcid":"https://orcid.org/0000-0002-2349-1223","observed_orcids":["https://orcid.org/0000-0002-2349-1223"]},"institutions":[{"id":"https://openalex.org/I125029298","display_name":"Texas A&M Health Science Center","ror":"https://ror.org/01tx6pn92","country_code":"US","type":"education","lineage":["https://openalex.org/I125029298","https://openalex.org/I91045830"]},{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xueyi Xie","raw_affiliation_strings":["Department of Neuroscience and Experimental Therapeutics, College of Medicine, Texas A&M University Health Science Center, Bryan, TX, 77807, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience and Experimental Therapeutics, College of Medicine, Texas A&M University Health Science Center, Bryan, TX, 77807, United States","institution_ids":["https://openalex.org/I125029298","https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086449691","display_name":"Joseph Ramos","orcid":"https://orcid.org/0009-0002-1178-4587","observed_orcids":["https://orcid.org/0009-0002-1178-4587"]},"institutions":[{"id":"https://openalex.org/I125029298","display_name":"Texas A&M Health Science Center","ror":"https://ror.org/01tx6pn92","country_code":"US","type":"education","lineage":["https://openalex.org/I125029298","https://openalex.org/I91045830"]},{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph Ramos","raw_affiliation_strings":["Department of Neuroscience and Experimental Therapeutics, College of Medicine, Texas A&M University Health Science Center, Bryan, TX, 77807, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience and Experimental Therapeutics, College of Medicine, Texas A&M University Health Science Center, Bryan, TX, 77807, United States","institution_ids":["https://openalex.org/I125029298","https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101962350","display_name":"Xuehua Wang","orcid":"https://orcid.org/0000-0002-5317-6822","observed_orcids":["https://orcid.org/0000-0002-5317-6822"]},"institutions":[{"id":"https://openalex.org/I125029298","display_name":"Texas A&M Health Science Center","ror":"https://ror.org/01tx6pn92","country_code":"US","type":"education","lineage":["https://openalex.org/I125029298","https://openalex.org/I91045830"]},{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Xuehua Wang","raw_affiliation_strings":["Department of Neuroscience and Experimental Therapeutics, College of Medicine, Texas A&M University Health Science Center, Bryan, TX, 77807, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience and Experimental Therapeutics, College of Medicine, Texas A&M University Health Science Center, Bryan, TX, 77807, United States","institution_ids":["https://openalex.org/I125029298","https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159837389","display_name":"Rajesh Miranda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I125029298","display_name":"Texas A&M Health Science Center","ror":"https://ror.org/01tx6pn92","country_code":"US","type":"education","lineage":["https://openalex.org/I125029298","https://openalex.org/I91045830"]},{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rajesh Miranda","raw_affiliation_strings":["Department of Neuroscience and Experimental Therapeutics, College of Medicine, Texas A&M University Health Science Center, Bryan, TX, 77807, United States; Texas A&M Institute for Neuroscience, Texas A&M University, College Station, TX, 77843, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience and Experimental Therapeutics, College of Medicine, Texas A&M University Health Science Center, Bryan, TX, 77807, United States; Texas A&M Institute for Neuroscience, Texas A&M University, College Station, TX, 77843, United States","institution_ids":["https://openalex.org/I125029298","https://openalex.org/I91045830"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100384673","display_name":"Jun Wang","orcid":"https://orcid.org/0000-0002-0085-4722","observed_orcids":["https://orcid.org/0000-0002-0085-4722"]},"institutions":[{"id":"https://openalex.org/I125029298","display_name":"Texas A&M Health Science Center","ror":"https://ror.org/01tx6pn92","country_code":"US","type":"education","lineage":["https://openalex.org/I125029298","https://openalex.org/I91045830"]},{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jun Wang","raw_affiliation_strings":["Department of Neuroscience and Experimental Therapeutics, College of Medicine, Texas A&M University Health Science Center, Bryan, TX, 77807, United States; Texas A&M Institute for Neuroscience, Texas A&M University, College Station, TX, 77843, United States. Electronic address: jwang188@tamu.edu"],"raw_orcid":"https://orcid.org/0000-0002-0085-4722","affiliations":[{"raw_affiliation_string":"Department of Neuroscience and Experimental Therapeutics, College of Medicine, Texas A&M University Health Science Center, Bryan, TX, 77807, United States; Texas A&M Institute for Neuroscience, Texas A&M University, College Station, TX, 77843, United States. Electronic address: jwang188@tamu.edu","institution_ids":["https://openalex.org/I125029298","https://openalex.org/I91045830"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100384673","https://openalex.org/A5101962350"],"corresponding_institution_ids":["https://openalex.org/I125029298","https://openalex.org/I91045830"],"apc_list":{"value":4300,"currency":"USD","value_usd":4300},"apc_paid":{"value":4300,"currency":"USD","value_usd":4300},"fwci":12.3177,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.99184081,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"279","issue":null,"first_page":"110627","last_page":"110627"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11633","display_name":"Prenatal Substance Exposure Effects","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11633","display_name":"Prenatal Substance Exposure Effects","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fetal-alcohol-spectrum-disorders","display_name":"fetal alcohol spectrum disorders","score":0.9480000138282776},{"id":"https://openalex.org/keywords/prenatal-alcohol-exposure","display_name":"prenatal alcohol exposure","score":1.0},{"id":"https://openalex.org/keywords/cholinergic-interneurons","display_name":"cholinergic interneurons","score":0.9679999947547913},{"id":"https://openalex.org/keywords/dorsomedial-striatum","display_name":"dorsomedial striatum","score":0.8550000190734863},{"id":"https://openalex.org/keywords/cognitive-flexibility","display_name":"cognitive flexibility","score":0.9129999876022339},{"id":"https://openalex.org/keywords/acetylcholine-release","display_name":"acetylcholine release","score":0.9039999842643738},{"id":"https://openalex.org/keywords/choline-acetyltransferase","display_name":"choline acetyltransferase","score":0.9139999747276306},{"id":"https://openalex.org/keywords/adult-offspring","display_name":"adult offspring","score":0.7250000238418579}],"concepts":[{"id":"https://openalex.org/C112672928","wikidata":"https://www.wikidata.org/wiki/Q239526","display_name":"Offspring","level":3,"score":0.8525702357292175},{"id":"https://openalex.org/C22885893","wikidata":"https://www.wikidata.org/wiki/Q4862743","display_name":"Cholinergic","level":2,"score":0.6619038581848145},{"id":"https://openalex.org/C66102695","wikidata":"https://www.wikidata.org/wiki/Q5141208","display_name":"Cognitive flexibility","level":3,"score":0.6363822221755981},{"id":"https://openalex.org/C3018923374","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Prenatal exposure","level":4,"score":0.5912309885025024},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.5485417246818542},{"id":"https://openalex.org/C2909481879","wikidata":"https://www.wikidata.org/wiki/Q400277","display_name":"Prenatal alcohol exposure","level":3,"score":0.5090053081512451},{"id":"https://openalex.org/C2780598303","wikidata":"https://www.wikidata.org/wiki/Q65921492","display_name":"Flexibility (engineering)","level":2,"score":0.48002567887306213},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.47900813817977905},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4099532663822174},{"id":"https://openalex.org/C138496976","wikidata":"https://www.wikidata.org/wiki/Q175002","display_name":"Developmental psychology","level":1,"score":0.3721887469291687},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.33867454528808594},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.32454246282577515},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1556999385356903},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07773292064666748},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.1016/j.neuropharm.2025.110627","doi":"https://doi.org/10.1016/j.neuropharm.2025.110627","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neuropharm.2025.110627","pdf_url":null,"source":{"id":"https://openalex.org/S160566677","display_name":"Neuropharmacology","issn_l":"0028-3908","issn":["0028-3908","1873-7064"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropharmacology","raw_type":"journal-article"},{"id":"doi:10.1101/2025.05.27.656351","doi":"https://doi.org/10.1101/2025.05.27.656351","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.05.27.656351","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2025/05/31/2025.05.27.656351.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:40502065","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40502065","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmid:40780568","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40780568","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13271524","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13271524/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Neuropharmacology","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:12154635","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12154635/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/j.neuropharm.2025.110627","doi":"https://doi.org/10.1016/j.neuropharm.2025.110627","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neuropharm.2025.110627","pdf_url":null,"source":{"id":"https://openalex.org/S160566677","display_name":"Neuropharmacology","issn_l":"0028-3908","issn":["0028-3908","1873-7064"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1251324082","display_name":"Prenatal microRNA neuro-therapeutics for fetal alcohol exposure","funder_award_id":"R01AA024659","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G2858557326","display_name":"Ethanol drinking and the basal ganglia circuitry","funder_award_id":"R01AA027768","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G5138970847","display_name":"Ethanol and glutamatergic transmission in the dorsal striatum","funder_award_id":"R01AA021505","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G6353216312","display_name":"Synaptic Plasticity and Alcohol Use Disorder","funder_award_id":"U01AA025932","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G9000899915","display_name":"Striatal ensemble plasticity in alcohol use disorder","funder_award_id":"R01AA030293","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"}],"funders":[{"id":"https://openalex.org/F4320337330","display_name":"National Institute on Alcohol Abuse and Alcoholism","ror":"https://ror.org/02jzrsm59"},{"id":"https://openalex.org/F4320337380","display_name":"Division of Mathematical Sciences","ror":"https://ror.org/051fftw81"},{"id":"https://openalex.org/F5543199986","display_name":"Canadian Initiative for Nordic Studies","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4413008751.pdf","grobid_xml":"https://content.openalex.org/works/W4413008751.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W1603807626","https://openalex.org/W1951474008","https://openalex.org/W1982977141","https://openalex.org/W1996329987","https://openalex.org/W2003612627","https://openalex.org/W2010860074","https://openalex.org/W2040653032","https://openalex.org/W2059863959","https://openalex.org/W2063217599","https://openalex.org/W2066848874","https://openalex.org/W2075994330","https://openalex.org/W2077549033","https://openalex.org/W2093896463","https://openalex.org/W2107258454","https://openalex.org/W2108467277","https://openalex.org/W2110925924","https://openalex.org/W2118830830","https://openalex.org/W2129232151","https://openalex.org/W2135116344","https://openalex.org/W2135250105","https://openalex.org/W2156178383","https://openalex.org/W2166823205","https://openalex.org/W2168844172","https://openalex.org/W2325707468","https://openalex.org/W2396428346","https://openalex.org/W2759785505","https://openalex.org/W2792288381","https://openalex.org/W2792899097","https://openalex.org/W2800494954","https://openalex.org/W2805760166","https://openalex.org/W2899228174","https://openalex.org/W3003973921","https://openalex.org/W3009041476","https://openalex.org/W3087698647","https://openalex.org/W3090462036","https://openalex.org/W3196551337","https://openalex.org/W4210243178","https://openalex.org/W4220694306","https://openalex.org/W4226128274","https://openalex.org/W4311896052","https://openalex.org/W4320915104","https://openalex.org/W4376602271","https://openalex.org/W4379515710","https://openalex.org/W4381943746","https://openalex.org/W4382011609","https://openalex.org/W4382752558","https://openalex.org/W4388513754","https://openalex.org/W4393313264","https://openalex.org/W4403325408","https://openalex.org/W4405516899","https://openalex.org/W4412527638"],"related_works":["https://openalex.org/W3098866473","https://openalex.org/W6955675618","https://openalex.org/W4223944778","https://openalex.org/W2884372292","https://openalex.org/W4376602271","https://openalex.org/W3104913301","https://openalex.org/W4391616894","https://openalex.org/W4237231644","https://openalex.org/W3026771294","https://openalex.org/W4401306238"],"abstract_inverted_index":{"Fetal":[0],"Alcohol":[1],"Spectrum":[2],"Disorder":[3],"(FASD),":[4],"caused":[5],"by":[6,18,85,130,170],"perinatal":[7],"alcohol":[8,13,166],"exposure":[9,14],"(PeAE)":[10],"and":[11,41,64,69,73,93,113,120,133,173,192,198,216],"prenatal":[12],"(PAE),":[15],"is":[16],"characterized":[17,169],"significant":[19,96,148],"cognitive":[20,24,40,71,191,215],"impairments,":[21],"including":[22],"reduced":[23,121],"flexibility.":[25],"Despite":[26],"the":[27,35,60,101,126,182,190],"critical":[28,183],"role":[29,184],"of":[30,62,104,185],"cholinergic":[31,187,202],"interneurons":[32],"(CINs)":[33],"in":[34,49,77,98,125,150,189],"dorsomedial":[36],"striatum":[37,103],"(DMS)":[38],"for":[39,89,175,208],"behavioral":[42,193,217],"flexibility,":[43,72],"their":[44],"contribution":[45],"to":[46,152],"neurobehavioral":[47],"deficits":[48,194],"FASD":[50],"remains":[51],"unclear.":[52],"To":[53],"address":[54],"this":[55,57,201],"gap,":[56],"research":[58],"explored":[59],"impact":[61],"PeAE":[63,106,112,144,162,197],"PAE":[65,114],"on":[66],"CIN":[67,83,117],"populations":[68],"activity,":[70],"compulsive":[74,165],"drinking":[75,167],"behaviors":[76],"adult":[78,105],"offspring.":[79,107],"We":[80],"first":[81],"assessed":[82],"number":[84],"staining":[86],"striatal":[87],"sections":[88],"choline":[90],"acetyltransferase":[91],"(ChAT)":[92],"observed":[94,195],"a":[95,138,147],"reduction":[97],"CINs":[99],"within":[100],"posterior":[102],"Functional":[108],"assessments":[109],"revealed":[110],"that":[111],"markedly":[115],"decreased":[116],"firing":[118],"activity":[119],"acetylcholine":[122],"(ACh)":[123],"release":[124],"DMS,":[127],"as":[128],"measured":[129],"electrophysiology":[131],"recordings":[132],"live-tissue":[134],"confocal":[135],"imaging":[136],"using":[137],"genetically":[139],"encoded":[140],"ACh":[141],"sensor.":[142],"Behaviorally,":[143],"offspring":[145],"exhibited":[146,164],"deficit":[149],"adapting":[151],"reversed":[153],"action-outcome":[154],"contingencies":[155],"despite":[156],"intact":[157],"initial":[158],"learning":[159],"capabilities.":[160],"Moreover,":[161],"mice":[163],"behavior,":[168],"elevated":[171],"consumption":[172],"preference":[174],"quinine-adulterated":[176],"alcohol.":[177],"These":[178],"findings":[179],"collectively":[180],"highlight":[181],"impaired":[186],"signaling":[188],"following":[196],"PAE.":[199],"Understanding":[200],"dysfunction":[203],"provides":[204],"valuable":[205],"insights":[206],"necessary":[207],"developing":[209],"targeted":[210],"interventions":[211],"aimed":[212],"at":[213],"mitigating":[214],"consequences":[218],"associated":[219],"with":[220],"FASD.":[221]},"counts_by_year":[{"year":2026,"cited_by_count":11},{"year":2025,"cited_by_count":2}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2025-10-10T00:00:00"}
