{"id":"https://openalex.org/W4413005353","doi":"https://doi.org/10.1158/2767-9764.29836672","title":"Figure 4 from Evaluation of Ferroptosis as a Biomarker to Predict Treatment Outcomes of Cancer Immunotherapy","display_name":"Figure 4 from Evaluation of Ferroptosis as a Biomarker to Predict Treatment Outcomes of Cancer Immunotherapy","publication_year":2025,"publication_date":"2025-08-06","ids":{"openalex":"https://openalex.org/W4413005353","doi":"https://doi.org/10.1158/2767-9764.29836672"},"language":"en","primary_location":{"id":"doi:10.1158/2767-9764.29836672","doi":"https://doi.org/10.1158/2767-9764.29836672","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2767-9764.29836672","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/2767-9764.29836672","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051324146","display_name":"Zhijun Zhou","orcid":"https://orcid.org/0000-0003-2226-2223","observed_orcids":["https://orcid.org/0000-0003-2226-2223"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhijun Zhou","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2226-2223","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109303622","display_name":"Yang Cai","orcid":"https://orcid.org/0009-0008-3428-1855","observed_orcids":["https://orcid.org/0009-0008-3428-1855"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yang Cai","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0008-3428-1855","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108579714","display_name":"Hao Yuan","orcid":"https://orcid.org/0009-0007-4848-3354","observed_orcids":["https://orcid.org/0009-0007-4848-3354"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hao Yuan","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0007-4848-3354","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103827857","display_name":"Qun Chen","orcid":"https://orcid.org/0009-0008-1782-6999","observed_orcids":["https://orcid.org/0009-0008-1782-6999"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Qun Chen","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0008-1782-6999","affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Sophia W. Zhao","orcid":"https://orcid.org/0009-0006-1400-7061","observed_orcids":["https://orcid.org/0009-0006-1400-7061"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sophia W. Zhao","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0006-1400-7061","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011227285","display_name":"Jingxuan Yang","orcid":"https://orcid.org/0000-0003-3265-161X","observed_orcids":["https://orcid.org/0000-0003-3265-161X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jingxuan Yang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3265-161X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067677121","display_name":"Mingyang Liu","orcid":"https://orcid.org/0000-0001-9121-2591","observed_orcids":["https://orcid.org/0000-0001-9121-2591"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mingyang Liu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9121-2591","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076934227","display_name":"Alex X. Arreola","orcid":"https://orcid.org/0009-0002-8854-2295","observed_orcids":["https://orcid.org/0009-0002-8854-2295"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alex X. Arreola","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0002-8854-2295","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102945102","display_name":"Yu Ren","orcid":"https://orcid.org/0000-0003-3066-5209","observed_orcids":["https://orcid.org/0000-0003-3066-5209"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yu Ren","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3066-5209","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072237935","display_name":"Chao Xu","orcid":"https://orcid.org/0000-0002-3821-6187","observed_orcids":["https://orcid.org/0000-0002-3821-6187"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chao Xu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3821-6187","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045193979","display_name":"Lacey R. McNally","orcid":"https://orcid.org/0000-0001-6756-129X","observed_orcids":["https://orcid.org/0000-0001-6756-129X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lacey R. McNally","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6756-129X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102884707","display_name":"Michael S. Bronze","orcid":"https://orcid.org/0000-0002-8770-0872","observed_orcids":["https://orcid.org/0000-0002-8770-0872"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael S. Bronze","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8770-0872","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064340210","display_name":"Courtney W. Houchen","orcid":"https://orcid.org/0000-0003-2487-5242","observed_orcids":["https://orcid.org/0000-0003-2487-5242"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Courtney W. Houchen","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2487-5242","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029987881","display_name":"Kuirong Jiang","orcid":"https://orcid.org/0000-0002-2849-5450","observed_orcids":["https://orcid.org/0000-0002-2849-5450"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kuirong Jiang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2849-5450","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001447073","display_name":"Wei R. Chen","orcid":"https://orcid.org/0000-0002-7133-5794","observed_orcids":["https://orcid.org/0000-0002-7133-5794"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wei R. Chen","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7133-5794","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111362940","display_name":"Yuqing Zhang","orcid":"https://orcid.org/0000-0001-8839-4849","observed_orcids":["https://orcid.org/0000-0001-8839-4849"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yuqing Zhang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8839-4849","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5100400736","display_name":"Min Li","orcid":"https://orcid.org/0000-0002-3971-9130","observed_orcids":["https://orcid.org/0000-0002-3971-9130"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Min Li","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3971-9130","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.01640000008046627,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ferroptosis","display_name":"ferroptosis","score":1.0},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.9440000057220459},{"id":"https://openalex.org/keywords/immunogenic-cell-death","display_name":"immunogenic cell death","score":0.6470000147819519},{"id":"https://openalex.org/keywords/tumor-immune-microenvironment","display_name":"tumor immune microenvironment","score":0.8199999928474426},{"id":"https://openalex.org/keywords/treatment-outcome-prediction","display_name":"treatment outcome prediction","score":0.5759999752044678},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.6370000243186951},{"id":"https://openalex.org/keywords/imvigor210","display_name":"IMvigor210","score":0.859000027179718},{"id":"https://openalex.org/keywords/biomarker-genes","display_name":"biomarker genes","score":0.47600001096725464},{"id":"https://openalex.org/keywords/immunotherapy-resistance","display_name":"immunotherapy resistance","score":0.36500000953674316},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.4169999957084656}],"concepts":[{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.72817063331604},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.6422501802444458},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5683425664901733},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.509928822517395},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4865821599960327},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.4672163724899292},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.46188443899154663},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1352165937423706},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06025776267051697}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/2767-9764.29836672","doi":"https://doi.org/10.1158/2767-9764.29836672","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2767-9764.29836672","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/2767-9764.29836672","doi":"https://doi.org/10.1158/2767-9764.29836672","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2767-9764.29836672","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4413023349","https://openalex.org/W4413023351","https://openalex.org/W4413005377","https://openalex.org/W4413023300","https://openalex.org/W4412573818","https://openalex.org/W4283155711","https://openalex.org/W4225820071","https://openalex.org/W4315648223","https://openalex.org/W4287448799","https://openalex.org/W3212614143"],"abstract_inverted_index":{"Ferroptosis":[0],"is":[1],"associated":[2],"with":[3],"increased":[4],"immunogenicity":[5],"and":[6,20,36,65],"favorable":[7],"TIME":[8,32,50],"subtypes.":[9],"A\u2013D,":[10],"Compare":[11],"the":[12,24,29,40,53,72],"expression":[13],"of":[14,31,46,59],"ICD":[15],"biomarker":[16],"genes":[17],"in":[18,23,34,39,52,68,71],"ferroptosis-low":[19,35],"ferroptosis-high":[21,37],"tumors":[22,38],"IMvigor210":[25,41,54,73],"cohort.":[26,42,55,74],"E,":[27],"Examine":[28],"proportions":[30],"subtypes":[33,51],"F,":[43],"OS":[44,57],"analysis":[45,58],"patients":[47,60],"based":[48,61],"on":[49,62],"G,":[56],"cancer-immune":[63],"phenotypes":[64],"ferroptosis":[66],"levels":[67],"tumor":[69],"tissue":[70],"*,":[75],"P":[76,80],"<":[77,81],"0.05;":[78],"***,":[79],"0.001.":[82],"ANXA1,":[83],"annexin":[84],"A1;":[85],"ATP8A2,":[86],"ATPase":[87],"phospholipid":[88],"transporting":[89],"8A2;":[90],"CALR,":[91],"calreticulin;":[92],"TPM,":[93],"transcripts":[94],"per":[95],"million.":[96]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2025-10-10T00:00:00"}