{"id":"https://openalex.org/W4412989999","doi":"https://doi.org/10.3390/cells14151203","title":"Mechanistic Insights into the Pathogenesis of Polycystic Kidney Disease","display_name":"Mechanistic Insights into the Pathogenesis of Polycystic Kidney Disease","publication_year":2025,"publication_date":"2025-08-05","ids":{"openalex":"https://openalex.org/W4412989999","doi":"https://doi.org/10.3390/cells14151203","pmid":"https://pubmed.ncbi.nlm.nih.gov/40801635","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12345701"},"language":"en","primary_location":{"id":"doi:10.3390/cells14151203","doi":"https://doi.org/10.3390/cells14151203","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cells14151203","pdf_url":"https://www.mdpi.com/2073-4409/14/15/1203/pdf?version=1754405387","source":{"id":"https://openalex.org/S2736626452","display_name":"Cells","issn_l":"2073-4409","issn":["2073-4409"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cells","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2073-4409/14/15/1203/pdf?version=1754405387","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5116721535","display_name":"Qasim Alorjani","orcid":"https://orcid.org/0009-0005-2210-2678","observed_orcids":["https://orcid.org/0009-0005-2210-2678"]},"institutions":[{"id":"https://openalex.org/I90871651","display_name":"University of Toledo","ror":"https://ror.org/01pbdzh19","country_code":"US","type":"education","lineage":["https://openalex.org/I90871651"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qasim Al-orjani","raw_affiliation_strings":["Department of Pharmacology and Experimental Therapeutics, University of Toledo, Toledo, OH 43614, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Experimental Therapeutics, University of Toledo, Toledo, OH 43614, USA","institution_ids":["https://openalex.org/I90871651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114264682","display_name":"Lubna A. Alshriem","orcid":"https://orcid.org/0000-0001-5278-5311","observed_orcids":["https://orcid.org/0000-0001-5278-5311"]},"institutions":[{"id":"https://openalex.org/I156983542","display_name":"Jordan University of Science and Technology","ror":"https://ror.org/03y8mtb59","country_code":"JO","type":"education","lineage":["https://openalex.org/I156983542"]},{"id":"https://openalex.org/I90871651","display_name":"University of Toledo","ror":"https://ror.org/01pbdzh19","country_code":"US","type":"education","lineage":["https://openalex.org/I90871651"]}],"countries":["JO","US"],"is_corresponding":false,"raw_author_name":"Lubna A. Alshriem","raw_affiliation_strings":["Department of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of Science and Technology, P.O. Box 3030, Irbid 22110, Jordan","Department of Pharmacology and Experimental Therapeutics, University of Toledo, Toledo, OH 43614, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of Science and Technology, P.O. Box 3030, Irbid 22110, Jordan","institution_ids":["https://openalex.org/I156983542"]},{"raw_affiliation_string":"Department of Pharmacology and Experimental Therapeutics, University of Toledo, Toledo, OH 43614, USA","institution_ids":["https://openalex.org/I90871651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041865750","display_name":"Gillian Gallagher","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I90871651","display_name":"University of Toledo","ror":"https://ror.org/01pbdzh19","country_code":"US","type":"education","lineage":["https://openalex.org/I90871651"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gillian Gallagher","raw_affiliation_strings":["Department of Pharmacology and Experimental Therapeutics, University of Toledo, Toledo, OH 43614, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Experimental Therapeutics, University of Toledo, Toledo, OH 43614, USA","institution_ids":["https://openalex.org/I90871651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027259140","display_name":"Raghad Buqaileh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I90871651","display_name":"University of Toledo","ror":"https://ror.org/01pbdzh19","country_code":"US","type":"education","lineage":["https://openalex.org/I90871651"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Raghad Buqaileh","raw_affiliation_strings":["Department of Pharmacology and Experimental Therapeutics, University of Toledo, Toledo, OH 43614, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Experimental Therapeutics, University of Toledo, Toledo, OH 43614, USA","institution_ids":["https://openalex.org/I90871651"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Neela Azizi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I90871651","display_name":"University of Toledo","ror":"https://ror.org/01pbdzh19","country_code":"US","type":"education","lineage":["https://openalex.org/I90871651"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Neela Azizi","raw_affiliation_strings":["Department of Pharmacology and Experimental Therapeutics, University of Toledo, Toledo, OH 43614, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Experimental Therapeutics, University of Toledo, Toledo, OH 43614, USA","institution_ids":["https://openalex.org/I90871651"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006215244","display_name":"Wissam A. AbouAlaiwi","orcid":"https://orcid.org/0000-0002-8226-3108","observed_orcids":["https://orcid.org/0000-0002-8226-3108"]},"institutions":[{"id":"https://openalex.org/I90871651","display_name":"University of Toledo","ror":"https://ror.org/01pbdzh19","country_code":"US","type":"education","lineage":["https://openalex.org/I90871651"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Wissam AbouAlaiwi","raw_affiliation_strings":["Department of Pharmacology and Experimental Therapeutics, University of Toledo, Toledo, OH 43614, USA"],"raw_orcid":"https://orcid.org/0000-0002-8226-3108","affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Experimental Therapeutics, University of Toledo, Toledo, OH 43614, USA","institution_ids":["https://openalex.org/I90871651"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5006215244"],"corresponding_institution_ids":["https://openalex.org/I90871651"],"apc_list":{"value":2700,"currency":"CHF","value_usd":3258},"apc_paid":{"value":2700,"currency":"CHF","value_usd":3258},"fwci":2.9925,"has_fulltext":true,"cited_by_count":27,"citation_normalized_percentile":{"value":0.930937,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"14","issue":"15","first_page":"1203","last_page":"1203"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11412","display_name":"Genetic and Kidney Cyst Diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11412","display_name":"Genetic and Kidney Cyst Diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10665","display_name":"Cystic Fibrosis Research Advances","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12049","display_name":"Tuberous Sclerosis Complex Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/autosomal-dominant-polycystic-kidney-disease","display_name":"autosomal dominant polycystic kidney disease","score":1.0},{"id":"https://openalex.org/keywords/polycystin-1","display_name":"polycystin-1","score":0.9649999737739563},{"id":"https://openalex.org/keywords/polycystin-2","display_name":"polycystin-2","score":1.0},{"id":"https://openalex.org/keywords/pkd1","display_name":"PKD1","score":0.8650000095367432},{"id":"https://openalex.org/keywords/pkd2","display_name":"PKD2","score":1.0},{"id":"https://openalex.org/keywords/ciliopathy","display_name":"ciliopathies","score":0.9520000219345093},{"id":"https://openalex.org/keywords/cyst-formation","display_name":"cyst formation","score":0.7789999842643738},{"id":"https://openalex.org/keywords/mechanosensing","display_name":"mechanosensing","score":0.7990000247955322},{"id":"https://openalex.org/keywords/calcium-signaling","display_name":"calcium signaling","score":0.8740000128746033},{"id":"https://openalex.org/keywords/camp-signaling","display_name":"cAMP signaling","score":0.6890000104904175},{"id":"https://openalex.org/keywords/hippo-signaling-pathway","display_name":"Hippo signaling pathway","score":0.8960000276565552},{"id":"https://openalex.org/keywords/yap-taz","display_name":"YAP/TAZ","score":0.9160000085830688},{"id":"https://openalex.org/keywords/sting-pathway","display_name":"STING pathway","score":0.8809999823570251},{"id":"https://openalex.org/keywords/mitochondrial-dna-release","display_name":"mitochondrial DNA release","score":0.8560000061988831},{"id":"https://openalex.org/keywords/nf-kappab-inflammation","display_name":"NF-\u03baB inflammation","score":0.9169999957084656},{"id":"https://openalex.org/keywords/mtor","display_name":"mTOR","score":0.5329999923706055},{"id":"https://openalex.org/keywords/wnt-signaling","display_name":"Wnt signaling","score":0.9480000138282776},{"id":"https://openalex.org/keywords/fibrosis","display_name":"fibrosis","score":0.5559999942779541},{"id":"https://openalex.org/keywords/epithelial-cell-proliferation","display_name":"epithelial cell proliferation","score":0.7609999775886536},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.5770000219345093},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7099999785423279},{"id":"https://openalex.org/keywords/extracellular-matrix-remodeling","display_name":"extracellular matrix remodeling","score":0.9200000166893005},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.44999998807907104}],"concepts":[{"id":"https://openalex.org/C2776266639","wikidata":"https://www.wikidata.org/wiki/Q2732398","display_name":"Autosomal dominant polycystic kidney disease","level":3,"score":0.78802490234375},{"id":"https://openalex.org/C2780145431","wikidata":"https://www.wikidata.org/wiki/Q15443105","display_name":"Polycystic kidney disease","level":3,"score":0.6294223070144653},{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.6088666319847107},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6047534346580505},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5631086230278015},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.5541613698005676},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5338889956474304},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5068002343177795},{"id":"https://openalex.org/C100773827","wikidata":"https://www.wikidata.org/wiki/Q82302467","display_name":"PKD1","level":4,"score":0.4933563768863678},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.43504273891448975},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3216354250907898},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.25337955355644226},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.1932862401008606}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007690","descriptor_name":"Polycystic Kidney Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007690","descriptor_name":"Polycystic Kidney Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016891","descriptor_name":"Polycystic Kidney, Autosomal Dominant","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016891","descriptor_name":"Polycystic Kidney, Autosomal Dominant","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016891","descriptor_name":"Polycystic Kidney, Autosomal Dominant","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D050396","descriptor_name":"TRPP Cation Channels","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050396","descriptor_name":"TRPP Cation Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.3390/cells14151203","doi":"https://doi.org/10.3390/cells14151203","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cells14151203","pdf_url":"https://www.mdpi.com/2073-4409/14/15/1203/pdf?version=1754405387","source":{"id":"https://openalex.org/S2736626452","display_name":"Cells","issn_l":"2073-4409","issn":["2073-4409"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cells","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:11155342","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12345701","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:40801635","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40801635","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cells","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12345701","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12345701/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cells","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:79e08598303c4fef908f8610b623a698","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/79e08598303c4fef908f8610b623a698","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cells, Vol 14, Iss 15, p 1203 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/cells14151203","doi":"https://doi.org/10.3390/cells14151203","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cells14151203","pdf_url":"https://www.mdpi.com/2073-4409/14/15/1203/pdf?version=1754405387","source":{"id":"https://openalex.org/S2736626452","display_name":"Cells","issn_l":"2073-4409","issn":["2073-4409"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cells","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4224631287","display_name":"Cerebrovascular endothelial cilia in the pathogenesis and therapy of Alzheimer's disease","funder_award_id":"R03AG080418","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G4437109330","display_name":"Cerebrovascular endothelial cilia in Alzheimer's Disease and hypertension","funder_award_id":"AARGD-NTF-22-972749","funder_id":"https://openalex.org/F4320306219","funder_display_name":"Alzheimer's Association"},{"id":"https://openalex.org/G6786933086","display_name":null,"funder_award_id":"AARGD-NTF-22-972749","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000911033","display_name":"Program to Increase Diversity in Cardiovascular Health-Related Research(PRIDE-CVD)","funder_award_id":"R25HL105446","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320306219","display_name":"Alzheimer's Association","ror":"https://ror.org/0375f4d26"},{"id":"https://openalex.org/F4320308528","display_name":"American Foundation for Pharmaceutical Education","ror":"https://ror.org/006dn3r34"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4412989999.pdf","grobid_xml":"https://content.openalex.org/works/W4412989999.grobid-xml"},"referenced_works_count":222,"referenced_works":["https://openalex.org/W68056817","https://openalex.org/W134066561","https://openalex.org/W1527149822","https://openalex.org/W1558069575","https://openalex.org/W1762350556","https://openalex.org/W1802574002","https://openalex.org/W1973963740","https://openalex.org/W1976740798","https://openalex.org/W1978201430","https://openalex.org/W1981137206","https://openalex.org/W1981456173","https://openalex.org/W1981628318","https://openalex.org/W1981839032","https://openalex.org/W1986503317","https://openalex.org/W1986687747","https://openalex.org/W1990515559","https://openalex.org/W1991407207","https://openalex.org/W1995864606","https://openalex.org/W1997055377","https://openalex.org/W1999095798","https://openalex.org/W1999155904","https://openalex.org/W2001176843","https://openalex.org/W2005938853","https://openalex.org/W2008757142","https://openalex.org/W2021835939","https://openalex.org/W2021866570","https://openalex.org/W2024254525","https://openalex.org/W2033457930","https://openalex.org/W2041453089","https://openalex.org/W2044403270","https://openalex.org/W2045833339","https://openalex.org/W2046980708","https://openalex.org/W2047124888","https://openalex.org/W2048128334","https://openalex.org/W2050475853","https://openalex.org/W2051301625","https://openalex.org/W2053062434","https://openalex.org/W2054770198","https://openalex.org/W2056642205","https://openalex.org/W2060647510","https://openalex.org/W2062719156","https://openalex.org/W2062853648","https://openalex.org/W2063072026","https://openalex.org/W2064479533","https://openalex.org/W2072924349","https://openalex.org/W2073637975","https://openalex.org/W2081330746","https://openalex.org/W2089808777","https://openalex.org/W2095869636","https://openalex.org/W2095953562","https://openalex.org/W2096013870","https://openalex.org/W2098708707","https://openalex.org/W2099544753","https://openalex.org/W2101853571","https://openalex.org/W2102992385","https://openalex.org/W2103690924","https://openalex.org/W2106617929","https://openalex.org/W2107211482","https://openalex.org/W2107890949","https://openalex.org/W2111689719","https://openalex.org/W2116663997","https://openalex.org/W2116811919","https://openalex.org/W2124577658","https://openalex.org/W2126267654","https://openalex.org/W2127063807","https://openalex.org/W2134481236","https://openalex.org/W2134554223","https://openalex.org/W2134970518","https://openalex.org/W2140057203","https://openalex.org/W2141331673","https://openalex.org/W2141634694","https://openalex.org/W2141710755","https://openalex.org/W2144515265","https://openalex.org/W2155990718","https://openalex.org/W2160683202","https://openalex.org/W2162838622","https://openalex.org/W2164333942","https://openalex.org/W2167129189","https://openalex.org/W2170138980","https://openalex.org/W2176166968","https://openalex.org/W2315475351","https://openalex.org/W2330008013","https://openalex.org/W2399751470","https://openalex.org/W2418240946","https://openalex.org/W2468631392","https://openalex.org/W2475072425","https://openalex.org/W2494069393","https://openalex.org/W2519516928","https://openalex.org/W2528390156","https://openalex.org/W2607216118","https://openalex.org/W2612015400","https://openalex.org/W2619310164","https://openalex.org/W2619440395","https://openalex.org/W2709557052","https://openalex.org/W2723541404","https://openalex.org/W2743483389","https://openalex.org/W2764162783","https://openalex.org/W2789248221","https://openalex.org/W2790033552","https://openalex.org/W2792579847","https://openalex.org/W2799340062","https://openalex.org/W2802411840","https://openalex.org/W2803499747","https://openalex.org/W2806965875","https://openalex.org/W2808015402","https://openalex.org/W2808936581","https://openalex.org/W2810367637","https://openalex.org/W2868736533","https://openalex.org/W2885111416","https://openalex.org/W2895602084","https://openalex.org/W2897443321","https://openalex.org/W2898236331","https://openalex.org/W2909454760","https://openalex.org/W2922417801","https://openalex.org/W2943481524","https://openalex.org/W2943494219","https://openalex.org/W2944576398","https://openalex.org/W2945168377","https://openalex.org/W2952033439","https://openalex.org/W2956734284","https://openalex.org/W2968510883","https://openalex.org/W2968838706","https://openalex.org/W2972128634","https://openalex.org/W2972936815","https://openalex.org/W2988338433","https://openalex.org/W2994090564","https://openalex.org/W2998381053","https://openalex.org/W3008953225","https://openalex.org/W3011073278","https://openalex.org/W3012354264","https://openalex.org/W3014393039","https://openalex.org/W3016932145","https://openalex.org/W3017231462","https://openalex.org/W3029187477","https://openalex.org/W3037285907","https://openalex.org/W3037435587","https://openalex.org/W3037551917","https://openalex.org/W3047610946","https://openalex.org/W3082422748","https://openalex.org/W3088343061","https://openalex.org/W3092373489","https://openalex.org/W3095388792","https://openalex.org/W3097767979","https://openalex.org/W3100156809","https://openalex.org/W3125136729","https://openalex.org/W3133796576","https://openalex.org/W3164461087","https://openalex.org/W3168821034","https://openalex.org/W3174988876","https://openalex.org/W3175895330","https://openalex.org/W3190933370","https://openalex.org/W3197225849","https://openalex.org/W3199190123","https://openalex.org/W3199962659","https://openalex.org/W3213004523","https://openalex.org/W3214259766","https://openalex.org/W4200291373","https://openalex.org/W4211159471","https://openalex.org/W4212880283","https://openalex.org/W4214845413","https://openalex.org/W4220970506","https://openalex.org/W4251009255","https://openalex.org/W4283015011","https://openalex.org/W4283528986","https://openalex.org/W4283814733","https://openalex.org/W4284704161","https://openalex.org/W4285820344","https://openalex.org/W4292833477","https://openalex.org/W4294176648","https://openalex.org/W4306885089","https://openalex.org/W4308202827","https://openalex.org/W4311785088","https://openalex.org/W4321186873","https://openalex.org/W4322766300","https://openalex.org/W4323532768","https://openalex.org/W4324029258","https://openalex.org/W4327960070","https://openalex.org/W4360612283","https://openalex.org/W4362456317","https://openalex.org/W4376130805","https://openalex.org/W4377042954","https://openalex.org/W4380085243","https://openalex.org/W4383498683","https://openalex.org/W4385583003","https://openalex.org/W4385684519","https://openalex.org/W4387137623","https://openalex.org/W4388348958","https://openalex.org/W4388638820","https://openalex.org/W4388730724","https://openalex.org/W4389190002","https://openalex.org/W4391018025","https://openalex.org/W4391109376","https://openalex.org/W4391530494","https://openalex.org/W4391543470","https://openalex.org/W4392045601","https://openalex.org/W4392375108","https://openalex.org/W4397046395","https://openalex.org/W4399892274","https://openalex.org/W4400623874","https://openalex.org/W4400962960","https://openalex.org/W4401321773","https://openalex.org/W4402865295","https://openalex.org/W4402903154","https://openalex.org/W4402994583","https://openalex.org/W4403419477","https://openalex.org/W4403873600","https://openalex.org/W4405201387","https://openalex.org/W4405986871","https://openalex.org/W4405987784","https://openalex.org/W4406293596","https://openalex.org/W4407398280","https://openalex.org/W4407449372","https://openalex.org/W4407748211","https://openalex.org/W4407993689","https://openalex.org/W4408135404","https://openalex.org/W4408671163","https://openalex.org/W4410382854","https://openalex.org/W4410587239","https://openalex.org/W6784618367","https://openalex.org/W7128677565","https://openalex.org/W7152003572","https://openalex.org/W7214061408"],"related_works":["https://openalex.org/W2053062434","https://openalex.org/W2059955122","https://openalex.org/W2403551577","https://openalex.org/W7125637065","https://openalex.org/W2909454760","https://openalex.org/W2102819778","https://openalex.org/W2071133433","https://openalex.org/W2146079760","https://openalex.org/W2114129426","https://openalex.org/W2418240946"],"abstract_inverted_index":{"Autosomal":[0],"Dominant":[1],"Polycystic":[2],"Kidney":[3],"Disease":[4],"(ADPKD)":[5],"is":[6,102],"a":[7,155],"systemic":[8],"ciliopathy":[9],"resulting":[10],"from":[11],"loss-of-function":[12],"mutations":[13],"in":[14,80,130,181],"the":[15,84,94,116],"PKD1":[16],"and":[17,24,29,35,42,52,60,71,108,113,115,122,127,137,160,169,173],"PKD2":[18],"genes,":[19],"which":[20,101,119],"encode":[21],"polycystin-1":[22],"(PC1)":[23],"polycystin-2":[25],"(PC2),":[26],"respectively.":[27],"PC1":[28],"PC2":[30],"regulate":[31],"mechanosensation,":[32],"calcium":[33,48],"signaling,":[34],"key":[36],"pathways":[37],"controlling":[38],"tubular":[39,131],"epithelial":[40,65],"structure":[41],"function.":[43],"Loss":[44],"of":[45,96,149],"PC1/PC2":[46],"disrupts":[47],"homeostasis,":[49],"elevates":[50],"cAMP,":[51],"activates":[53],"proliferative":[54],"cascades":[55],"such":[56],"as":[57],"PKA-B-Raf-MEK-ERK,":[58],"mTOR,":[59],"Wnt,":[61],"driving":[62],"cystogenesis":[63],"via":[64,125],"proliferation,":[66],"impaired":[67],"apoptosis,":[68],"fluid":[69],"secretion,":[70],"fibrosis.":[72],"Recent":[73],"evidence":[74],"also":[75],"implicates":[76],"novel":[77],"signaling":[78,152],"axes":[79],"ADPKD":[81],"progression":[82],"including,":[83],"Hippo":[85],"pathway,":[86,100,118],"where":[87],"dysregulated":[88],"YAP/TAZ":[89],"activity":[90],"enhances":[91],"c-Myc-mediated":[92],"proliferation;":[93],"stimulator":[95],"interferon":[97],"genes":[98],"(STING)":[99],"activated":[103],"by":[104],"mitochondrial":[105],"DNA":[106],"release":[107],"linked":[109],"to":[110,176],"NF-\u03baB-driven":[111],"inflammation":[112],"fibrosis;":[114],"TWEAK/Fn14":[117],"mediates":[120],"pro-inflammatory":[121],"pro-apoptotic":[123],"responses":[124],"ERK":[126],"NF-\u03baB":[128],"activation":[129],"cells.":[132],"Mitochondrial":[133],"dysfunction,":[134],"oxidative":[135],"stress,":[136],"maladaptive":[138],"extracellular":[139],"matrix":[140],"remodeling":[141],"further":[142],"exacerbate":[143],"disease":[144],"progression.":[145],"A":[146],"refined":[147],"understanding":[148],"ADPKD's":[150],"complex":[151],"networks":[153],"provides":[154],"foundation":[156],"for":[157],"precision":[158],"medicine":[159],"next-generation":[161],"therapeutics.":[162],"This":[163],"review":[164],"gathers":[165],"recent":[166],"molecular":[167],"insights":[168],"highlights":[170],"both":[171],"established":[172],"emerging":[174],"targets":[175],"guide":[177],"targeted":[178],"treatment":[179],"strategies":[180],"ADPKD.":[182]},"counts_by_year":[{"year":2026,"cited_by_count":23},{"year":2025,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2025-10-10T00:00:00"}
