{"id":"https://openalex.org/W4412986187","doi":"https://doi.org/10.1002/adem.202500278","title":"Fabrication of a Stable, Low\u2010Cost, Patient\u2010Specific, Brain Phantom with Ventricles for Ultrasound Imaging","display_name":"Fabrication of a Stable, Low\u2010Cost, Patient\u2010Specific, Brain Phantom with Ventricles for Ultrasound Imaging","publication_year":2025,"publication_date":"2025-08-05","ids":{"openalex":"https://openalex.org/W4412986187","doi":"https://doi.org/10.1002/adem.202500278"},"language":"en","primary_location":{"id":"doi:10.1002/adem.202500278","doi":"https://doi.org/10.1002/adem.202500278","is_oa":true,"landing_page_url":"https://doi.org/10.1002/adem.202500278","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/adem.202500278","source":{"id":"https://openalex.org/S156255550","display_name":"Advanced Engineering Materials","issn_l":"1438-1656","issn":["1438-1656","1527-2648"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Engineering Materials","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/adem.202500278","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Kajal Chandraprakash Jain","orcid":"https://orcid.org/0000-0002-1991-5580","observed_orcids":["https://orcid.org/0000-0002-1991-5580"]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Kajal Chandraprakash Jain","raw_affiliation_strings":["BrainLinks\u2010BrainTools Center University of Freiburg  Georges\u2010Koehler\u2010Allee 201 79110 Freiburg Germany","Laboratory for Biomedical Microtechnology, Dept Microsystems Eng\u2010IMTEK University of Freiburg  Georges\u2010Koehler\u2010Allee 201 79110 Freiburg Germany","Laboratory for Design of Microsystems, Dept Microsystems Eng\u2010IMTEK University of Freiburg  Georges\u2010Koehler\u2010Allee 102 79110 Freiburg Germany"],"raw_orcid":"https://orcid.org/0000-0002-1991-5580","affiliations":[{"raw_affiliation_string":"BrainLinks\u2010BrainTools Center University of Freiburg  Georges\u2010Koehler\u2010Allee 201 79110 Freiburg Germany","institution_ids":["https://openalex.org/I161046081"]},{"raw_affiliation_string":"Laboratory for Biomedical Microtechnology, Dept Microsystems Eng\u2010IMTEK University of Freiburg  Georges\u2010Koehler\u2010Allee 201 79110 Freiburg Germany","institution_ids":["https://openalex.org/I161046081"]},{"raw_affiliation_string":"Laboratory for Design of Microsystems, Dept Microsystems Eng\u2010IMTEK University of Freiburg  Georges\u2010Koehler\u2010Allee 102 79110 Freiburg Germany","institution_ids":["https://openalex.org/I161046081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040670847","display_name":"Ana Belen Amado Rey","orcid":"https://orcid.org/0000-0002-2845-7104","observed_orcids":["https://orcid.org/0000-0002-2845-7104"]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Ana Belen Amado Rey","raw_affiliation_strings":["BrainLinks\u2010BrainTools Center University of Freiburg  Georges\u2010Koehler\u2010Allee 201 79110 Freiburg Germany","Laboratory for Biomedical Microtechnology, Dept Microsystems Eng\u2010IMTEK University of Freiburg  Georges\u2010Koehler\u2010Allee 201 79110 Freiburg Germany"],"raw_orcid":"https://orcid.org/0000-0002-2845-7104","affiliations":[{"raw_affiliation_string":"BrainLinks\u2010BrainTools Center University of Freiburg  Georges\u2010Koehler\u2010Allee 201 79110 Freiburg Germany","institution_ids":["https://openalex.org/I161046081"]},{"raw_affiliation_string":"Laboratory for Biomedical Microtechnology, Dept Microsystems Eng\u2010IMTEK University of Freiburg  Georges\u2010Koehler\u2010Allee 201 79110 Freiburg Germany","institution_ids":["https://openalex.org/I161046081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060833133","display_name":"Ana Carolina Gon\u00e7alves Seabra","orcid":"https://orcid.org/0000-0003-1481-0998","observed_orcids":["https://orcid.org/0000-0003-1481-0998"]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ana Carolina Gon\u00e7alves Seabra","raw_affiliation_strings":["BrainLinks\u2010BrainTools Center University of Freiburg  Georges\u2010Koehler\u2010Allee 201 79110 Freiburg Germany","Laboratory for Biomedical Microtechnology, Dept Microsystems Eng\u2010IMTEK University of Freiburg  Georges\u2010Koehler\u2010Allee 201 79110 Freiburg Germany"],"raw_orcid":"https://orcid.org/0000-0003-1481-0998","affiliations":[{"raw_affiliation_string":"BrainLinks\u2010BrainTools Center University of Freiburg  Georges\u2010Koehler\u2010Allee 201 79110 Freiburg Germany","institution_ids":["https://openalex.org/I161046081"]},{"raw_affiliation_string":"Laboratory for Biomedical Microtechnology, Dept Microsystems Eng\u2010IMTEK University of Freiburg  Georges\u2010Koehler\u2010Allee 201 79110 Freiburg Germany","institution_ids":["https://openalex.org/I161046081"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058067206","display_name":"Thomas Stieglitz","orcid":"https://orcid.org/0000-0002-7349-4254","observed_orcids":["https://orcid.org/0000-0002-7349-4254"]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Thomas Stieglitz","raw_affiliation_strings":["Bernstein Center Freiburg University of Freiburg  Hansastrasse 9a 79104 Freiburg Germany","BrainLinks\u2010BrainTools Center University of Freiburg  Georges\u2010Koehler\u2010Allee 201 79110 Freiburg Germany","Laboratory for Biomedical Microtechnology, Dept Microsystems Eng\u2010IMTEK University of Freiburg  Georges\u2010Koehler\u2010Allee 201 79110 Freiburg Germany"],"raw_orcid":"https://orcid.org/0000-0002-7349-4254","affiliations":[{"raw_affiliation_string":"Bernstein Center Freiburg University of Freiburg  Hansastrasse 9a 79104 Freiburg Germany","institution_ids":["https://openalex.org/I161046081"]},{"raw_affiliation_string":"BrainLinks\u2010BrainTools Center University of Freiburg  Georges\u2010Koehler\u2010Allee 201 79110 Freiburg Germany","institution_ids":["https://openalex.org/I161046081"]},{"raw_affiliation_string":"Laboratory for Biomedical Microtechnology, Dept Microsystems Eng\u2010IMTEK University of Freiburg  Georges\u2010Koehler\u2010Allee 201 79110 Freiburg Germany","institution_ids":["https://openalex.org/I161046081"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5040670847"],"corresponding_institution_ids":["https://openalex.org/I161046081"],"apc_list":{"value":4520,"currency":"USD","value_usd":4520},"apc_paid":{"value":4520,"currency":"USD","value_usd":4520},"fwci":0.2359,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.42976495,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"27","issue":"18","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11984","display_name":"Anatomy and Medical Technology","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11984","display_name":"Anatomy and Medical Technology","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.0044999998062849045,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/brain-phantom","display_name":"brain phantom","score":0.9539999961853027},{"id":"https://openalex.org/keywords/patient-specific-phantoms","display_name":"patient-specific phantoms","score":0.7770000100135803},{"id":"https://openalex.org/keywords/ventricles","display_name":"ventricles","score":0.7429999709129333},{"id":"https://openalex.org/keywords/ultrasonography","display_name":"ultrasonography","score":0.781000018119812},{"id":"https://openalex.org/keywords/polyvinyl-alcohol-cryogel","display_name":"polyvinyl alcohol cryogel","score":0.9079999923706055},{"id":"https://openalex.org/keywords/talc-particles","display_name":"talc particles","score":0.9409999847412109},{"id":"https://openalex.org/keywords/freeze-thaw-crosslinking","display_name":"freeze-thaw crosslinking","score":0.9169999957084656},{"id":"https://openalex.org/keywords/hydrocephalus","display_name":"hydrocephalus","score":0.8320000171661377},{"id":"https://openalex.org/keywords/cerebrospinal-fluid-flow","display_name":"cerebrospinal fluid flow","score":0.9959999918937683},{"id":"https://openalex.org/keywords/3d-printing","display_name":"3D printing","score":0.7760000228881836},{"id":"https://openalex.org/keywords/transcranial-ultrasound","display_name":"transcranial ultrasound","score":0.5910000205039978}],"concepts":[{"id":"https://openalex.org/C104293457","wikidata":"https://www.wikidata.org/wiki/Q28324852","display_name":"Imaging phantom","level":2,"score":0.8281551003456116},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.7062497735023499},{"id":"https://openalex.org/C136525101","wikidata":"https://www.wikidata.org/wiki/Q5428139","display_name":"Fabrication","level":3,"score":0.6917652487754822},{"id":"https://openalex.org/C143753070","wikidata":"https://www.wikidata.org/wiki/Q162564","display_name":"Ultrasound","level":2,"score":0.5827572345733643},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.5329099297523499},{"id":"https://openalex.org/C2780744974","wikidata":"https://www.wikidata.org/wiki/Q1929623","display_name":"Lateral ventricles","level":2,"score":0.4317428171634674},{"id":"https://openalex.org/C19527891","wikidata":"https://www.wikidata.org/wiki/Q1120908","display_name":"Medical physics","level":1,"score":0.3852596879005432},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.2947991192340851},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23209288716316223},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.14379292726516724},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.09779208898544312},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1002/adem.202500278","doi":"https://doi.org/10.1002/adem.202500278","is_oa":true,"landing_page_url":"https://doi.org/10.1002/adem.202500278","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/adem.202500278","source":{"id":"https://openalex.org/S156255550","display_name":"Advanced Engineering Materials","issn_l":"1438-1656","issn":["1438-1656","1527-2648"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Engineering Materials","raw_type":"journal-article"},{"id":"pmh:oai:freidok.uni-freiburg.de:269787","doi":null,"is_oa":false,"landing_page_url":"https://freidok.uni-freiburg.de/data/269787","pdf_url":null,"source":{"id":"https://openalex.org/S4306401057","display_name":"FreiDok plus (Universit\u00e4tsbibliothek Freiburg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I161046081","host_organization_name":"University of Freiburg","host_organization_lineage":["https://openalex.org/I161046081"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Advanced engineering materials. - 27, 18 (2025) , 2500278, ISSN: 1527-2648","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1002/adem.202500278","doi":"https://doi.org/10.1002/adem.202500278","is_oa":true,"landing_page_url":"https://doi.org/10.1002/adem.202500278","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/adem.202500278","source":{"id":"https://openalex.org/S156255550","display_name":"Advanced Engineering Materials","issn_l":"1438-1656","issn":["1438-1656","1527-2648"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Engineering Materials","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.46810001134872437}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2717542597","display_name":null,"funder_award_id":"R03 MH096321","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G2990223308","display_name":null,"funder_award_id":"K23MH087770","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"}],"funders":[{"id":"https://openalex.org/F4320309445","display_name":"Leon Levy Foundation","ror":"https://ror.org/033hnyq61"},{"id":"https://openalex.org/F4320317808","display_name":"Child Mind Institute","ror":"https://ror.org/01bfgxw09"},{"id":"https://openalex.org/F4320322565","display_name":"Stavros Niarchos Foundation","ror":"https://ror.org/0210rze73"},{"id":"https://openalex.org/F4320336677","display_name":"BrainLinks-BrainTools","ror":null},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4412986187.pdf","grobid_xml":"https://content.openalex.org/works/W4412986187.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W1564896476","https://openalex.org/W1601976844","https://openalex.org/W1771017207","https://openalex.org/W1974745323","https://openalex.org/W1983962889","https://openalex.org/W1984690585","https://openalex.org/W2005312792","https://openalex.org/W2011481459","https://openalex.org/W2026616100","https://openalex.org/W2046181411","https://openalex.org/W2086118747","https://openalex.org/W2092471525","https://openalex.org/W2102423385","https://openalex.org/W2164573106","https://openalex.org/W2560343943","https://openalex.org/W2893448622","https://openalex.org/W2945264001","https://openalex.org/W2945591156","https://openalex.org/W2946803945","https://openalex.org/W2952628689","https://openalex.org/W2969006869","https://openalex.org/W2974172021","https://openalex.org/W3089381374","https://openalex.org/W3096638455","https://openalex.org/W3133591106","https://openalex.org/W3164109073","https://openalex.org/W4221122403","https://openalex.org/W4229839063","https://openalex.org/W4303943982","https://openalex.org/W4315928756","https://openalex.org/W4319303572","https://openalex.org/W4392644705","https://openalex.org/W4407727586"],"related_works":["https://openalex.org/W2082914599","https://openalex.org/W2756570351","https://openalex.org/W2417440389","https://openalex.org/W3031331673","https://openalex.org/W4244157427","https://openalex.org/W2734382758","https://openalex.org/W4385556839","https://openalex.org/W4378746257","https://openalex.org/W2109481748","https://openalex.org/W3164202441"],"abstract_inverted_index":{"Phantoms":[0],"are":[1,84,147],"a":[2,139],"valuable":[3],"step":[4],"in":[5,18,45,179],"the":[6,9,79,82,100,107,125,128,135,150,153,164,187],"course":[7],"of":[8,81,94,127,152],"3R":[10],"principle":[11],"by":[12],"reducing":[13],"reliance":[14],"on":[15],"animal":[16],"models":[17],"translational":[19],"research":[20,44],"from":[21],"bench":[22],"to":[23,64,113,186],"bedside.":[24],"In":[25],"this":[26],"work,":[27],"an":[28,66,172],"anatomically":[29,173],"accurate":[30,174],"brain":[31,72,115,129,144,155,169],"phantom":[32,73,83,108,170],"is":[33,62],"developed":[34],"for":[35,38,55,74,78,124,149],"ultrasound":[36,180],"diagnosis":[37],"presurgery":[39],"applications,":[40],"cerebrospinal":[41],"fluid":[42],"flow":[43],"hydrocephalus,":[46],"and":[47,52,57,70,104,130,182],"many":[48],"other":[49],"transcranial":[50],"diagnostic":[51],"treatment":[53],"applications":[54],"medicine":[56],"research.":[58],"A":[59],"practical":[60],"guide":[61],"designed":[63],"fabricate":[65],"affordable,":[67],"easy\u2010to\u2010produce,":[68],"long\u2010lasting,":[69],"patient\u2010specific":[71,136],"ultrasonic":[75],"applications.":[76],"Materials":[77],"fabrication":[80],"polyvinyl":[85,101],"alcohol":[86,102],"cryogel":[87],"combined":[88],"with":[89,157],"talc":[90],"particles.":[91],"Repeated":[92],"steps":[93],"freeze\u2010thawing":[95],"cycles":[96],"enhance":[97],"crosslinking":[98],"between":[99],"molecules":[103],"ensure":[105],"that":[106,146],"achieves":[109],"acoustic":[110],"characteristics":[111,185],"similar":[112,183],"human":[114,188],"tissue.":[116],"Open\u2010source":[117],"magnetic":[118],"resonance":[119],"images":[120],"(MRI)":[121],"datasets":[122],"serve":[123],"extraction":[126],"ventricles":[131],"geometries.":[132],"After":[133],"processing":[134],"MRI":[137],"images,":[138],"high\u2010resolution":[140],"3D":[141,161],"printer":[142],"produces":[143],"structures":[145],"used":[148],"creation":[151],"negative":[154],"mold":[156],"flexible":[158],"silicone.":[159],"Water\u2010soluble":[160],"material":[162],"provides":[163,171],"ventricle":[165],"cavity.":[166],"The":[167],"resulting":[168],"ventricular":[175],"cavity,":[176],"as":[177],"observed":[178],"scans,":[181],"tissue":[184],"brain.":[189]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}