{"id":"https://openalex.org/W4412959294","doi":"https://doi.org/10.1007/s10068-025-01946-4","title":"Solasodine inhibited the proliferation of gastric cancer cells through suppression of Hedgehog/Gli1 signaling","display_name":"Solasodine inhibited the proliferation of gastric cancer cells through suppression of Hedgehog/Gli1 signaling","publication_year":2025,"publication_date":"2025-07-19","ids":{"openalex":"https://openalex.org/W4412959294","doi":"https://doi.org/10.1007/s10068-025-01946-4","pmid":"https://pubmed.ncbi.nlm.nih.gov/41113265"},"language":"en","primary_location":{"id":"doi:10.1007/s10068-025-01946-4","doi":"https://doi.org/10.1007/s10068-025-01946-4","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10068-025-01946-4","pdf_url":"https://link.springer.com/content/pdf/10.1007/s10068-025-01946-4.pdf","source":{"id":"https://openalex.org/S35861910","display_name":"Food Science and Biotechnology","issn_l":"1226-7708","issn":["1226-7708","2092-6456"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","kci-registered","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Food Science and Biotechnology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s10068-025-01946-4.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015202575","display_name":"Yimeng Zhou","orcid":"https://orcid.org/0009-0004-2689-7837","observed_orcids":["https://orcid.org/0009-0004-2689-7837"]},"institutions":[{"id":"https://openalex.org/I67900169","display_name":"Chung-Ang University","ror":"https://ror.org/01r024a98","country_code":"KR","type":"education","lineage":["https://openalex.org/I67900169"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yimeng Zhou","raw_affiliation_strings":["Department of Food Science and Biotechnology, Chung-Ang University, Anseong, 17546 Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food Science and Biotechnology, Chung-Ang University, Anseong, 17546 Republic of Korea","institution_ids":["https://openalex.org/I67900169"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101802673","display_name":"Jin Tae Kim","orcid":"https://orcid.org/0000-0003-4296-7095","observed_orcids":["https://orcid.org/0000-0003-4296-7095"]},"institutions":[{"id":"https://openalex.org/I67900169","display_name":"Chung-Ang University","ror":"https://ror.org/01r024a98","country_code":"KR","type":"education","lineage":["https://openalex.org/I67900169"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jin Tae Kim","raw_affiliation_strings":["Department of Food Science and Biotechnology, Chung-Ang University, Anseong, 17546 Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food Science and Biotechnology, Chung-Ang University, Anseong, 17546 Republic of Korea","institution_ids":["https://openalex.org/I67900169"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041770308","display_name":"Xiaoman Zhan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I67900169","display_name":"Chung-Ang University","ror":"https://ror.org/01r024a98","country_code":"KR","type":"education","lineage":["https://openalex.org/I67900169"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Xiaoman Zhan","raw_affiliation_strings":["Department of Food Science and Biotechnology, Chung-Ang University, Anseong, 17546 Republic of Korea","GreenTech-Based Food Safety Research Group, BK21 Four, Chung-Ang University, Anseong, 17546 Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food Science and Biotechnology, Chung-Ang University, Anseong, 17546 Republic of Korea","institution_ids":["https://openalex.org/I67900169"]},{"raw_affiliation_string":"GreenTech-Based Food Safety Research Group, BK21 Four, Chung-Ang University, Anseong, 17546 Republic of Korea","institution_ids":["https://openalex.org/I67900169"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5119210627","display_name":"Alina Ghimire","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I67900169","display_name":"Chung-Ang University","ror":"https://ror.org/01r024a98","country_code":"KR","type":"education","lineage":["https://openalex.org/I67900169"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Alina Ghimire","raw_affiliation_strings":["Department of Food Science and Biotechnology, Chung-Ang University, Anseong, 17546 Republic of Korea","GreenTech-Based Food Safety Research Group, BK21 Four, Chung-Ang University, Anseong, 17546 Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food Science and Biotechnology, Chung-Ang University, Anseong, 17546 Republic of Korea","institution_ids":["https://openalex.org/I67900169"]},{"raw_affiliation_string":"GreenTech-Based Food Safety Research Group, BK21 Four, Chung-Ang University, Anseong, 17546 Republic of Korea","institution_ids":["https://openalex.org/I67900169"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063134916","display_name":"Kang Hyuk Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I67900169","display_name":"Chung-Ang University","ror":"https://ror.org/01r024a98","country_code":"KR","type":"education","lineage":["https://openalex.org/I67900169"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Kang Hyuk Lee","raw_affiliation_strings":["Department of Food Science and Biotechnology, Chung-Ang University, Anseong, 17546 Republic of Korea","GreenTech-Based Food Safety Research Group, BK21 Four, Chung-Ang University, Anseong, 17546 Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food Science and Biotechnology, Chung-Ang University, Anseong, 17546 Republic of Korea","institution_ids":["https://openalex.org/I67900169"]},{"raw_affiliation_string":"GreenTech-Based Food Safety Research Group, BK21 Four, Chung-Ang University, Anseong, 17546 Republic of Korea","institution_ids":["https://openalex.org/I67900169"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113152001","display_name":"Hui Mang Son","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I67900169","display_name":"Chung-Ang University","ror":"https://ror.org/01r024a98","country_code":"KR","type":"education","lineage":["https://openalex.org/I67900169"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hui Mang Son","raw_affiliation_strings":["Department of Food Science and Biotechnology, Chung-Ang University, Anseong, 17546 Republic of Korea","GreenTech-Based Food Safety Research Group, BK21 Four, Chung-Ang University, Anseong, 17546 Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food Science and Biotechnology, Chung-Ang University, Anseong, 17546 Republic of Korea","institution_ids":["https://openalex.org/I67900169"]},{"raw_affiliation_string":"GreenTech-Based Food Safety Research Group, BK21 Four, Chung-Ang University, Anseong, 17546 Republic of Korea","institution_ids":["https://openalex.org/I67900169"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072563298","display_name":"Hong Jin Lee","orcid":"https://orcid.org/0000-0001-7719-3101","observed_orcids":["https://orcid.org/0000-0001-7719-3101"]},"institutions":[{"id":"https://openalex.org/I67900169","display_name":"Chung-Ang University","ror":"https://ror.org/01r024a98","country_code":"KR","type":"education","lineage":["https://openalex.org/I67900169"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Hong Jin Lee","raw_affiliation_strings":["Department of Food Science and Biotechnology, Chung-Ang University, Anseong, 17546 Republic of Korea","GreenTech-Based Food Safety Research Group, BK21 Four, Chung-Ang University, Anseong, 17546 Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0001-7719-3101","affiliations":[{"raw_affiliation_string":"Department of Food Science and Biotechnology, Chung-Ang University, Anseong, 17546 Republic of Korea","institution_ids":["https://openalex.org/I67900169"]},{"raw_affiliation_string":"GreenTech-Based Food Safety Research Group, BK21 Four, Chung-Ang University, Anseong, 17546 Republic of Korea","institution_ids":["https://openalex.org/I67900169"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5072563298"],"corresponding_institution_ids":["https://openalex.org/I67900169"],"apc_list":{"value":2190,"currency":"USD","value_usd":2190},"apc_paid":{"value":2190,"currency":"USD","value_usd":2190},"fwci":0.2548,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.4604882,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"34","issue":"15","first_page":"3693","last_page":"3702"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12009","display_name":"Hedgehog Signaling Pathway Studies","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12009","display_name":"Hedgehog Signaling Pathway Studies","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12215","display_name":"Phytochemical Studies and Bioactivities","score":0.007199999876320362,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11385","display_name":"Natural product bioactivities and synthesis","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/solasodine","display_name":"solasodine","score":1.0},{"id":"https://openalex.org/keywords/gastric-cancer","display_name":"gastric cancer","score":0.9129999876022339},{"id":"https://openalex.org/keywords/hedgehog-signaling","display_name":"Hedgehog signaling","score":0.9829999804496765},{"id":"https://openalex.org/keywords/gli1","display_name":"Gli1","score":0.9959999918937683},{"id":"https://openalex.org/keywords/smo","display_name":"SMO","score":0.6520000100135803},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.5590000152587891},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.925000011920929},{"id":"https://openalex.org/keywords/cell-cycle-regulation","display_name":"cell cycle regulation","score":0.8619999885559082},{"id":"https://openalex.org/keywords/cyclin-d1","display_name":"cyclin D1","score":0.9150000214576721},{"id":"https://openalex.org/keywords/p27","display_name":"p27","score":0.9919999837875366},{"id":"https://openalex.org/keywords/bax","display_name":"Bax","score":0.8220000267028809},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/gant61","display_name":"GANT61","score":0.7829999923706055},{"id":"https://openalex.org/keywords/vismodegib","display_name":"vismodegib","score":0.984000027179718},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.7730000019073486},{"id":"https://openalex.org/keywords/anticancer-natural-products","display_name":"anticancer natural products","score":0.5699999928474426}],"concepts":[{"id":"https://openalex.org/C2777926911","wikidata":"https://www.wikidata.org/wiki/Q740439","display_name":"Solasodine","level":3,"score":0.9447693824768066},{"id":"https://openalex.org/C2779933373","wikidata":"https://www.wikidata.org/wiki/Q14886430","display_name":"GLI1","level":4,"score":0.9006061553955078},{"id":"https://openalex.org/C2778539099","wikidata":"https://www.wikidata.org/wiki/Q6120","display_name":"Hedgehog","level":3,"score":0.7364391088485718},{"id":"https://openalex.org/C88498014","wikidata":"https://www.wikidata.org/wiki/Q14859918","display_name":"Hedgehog signaling pathway","level":3,"score":0.6093732118606567},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5528249740600586},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5070836544036865},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4433436393737793},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3365188539028168},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30177223682403564},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2936479449272156},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.28525489568710327},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23562929034233093},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22701752185821533},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.14904507994651794},{"id":"https://openalex.org/C2781083041","wikidata":"https://www.wikidata.org/wiki/Q146555","display_name":"Solanum","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1007/s10068-025-01946-4","doi":"https://doi.org/10.1007/s10068-025-01946-4","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10068-025-01946-4","pdf_url":"https://link.springer.com/content/pdf/10.1007/s10068-025-01946-4.pdf","source":{"id":"https://openalex.org/S35861910","display_name":"Food Science and Biotechnology","issn_l":"1226-7708","issn":["1226-7708","2092-6456"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","kci-registered","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Food Science and Biotechnology","raw_type":"journal-article"},{"id":"pmid:41113265","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41113265","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Food science and biotechnology","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:11333839","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12528605","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1007/s10068-025-01946-4","doi":"https://doi.org/10.1007/s10068-025-01946-4","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10068-025-01946-4","pdf_url":"https://link.springer.com/content/pdf/10.1007/s10068-025-01946-4.pdf","source":{"id":"https://openalex.org/S35861910","display_name":"Food Science and Biotechnology","issn_l":"1226-7708","issn":["1226-7708","2092-6456"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","kci-registered","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Food Science and Biotechnology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.5099999904632568,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"},{"score":0.4399999976158142,"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1649453032","display_name":null,"funder_award_id":"NRF-2022R1A2C1092959","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"}],"funders":[{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320321202","display_name":"Chung-Ang University","ror":"https://ror.org/01r024a98"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4412959294.pdf","grobid_xml":"https://content.openalex.org/works/W4412959294.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W1512072225","https://openalex.org/W1569836364","https://openalex.org/W1896596810","https://openalex.org/W1910017043","https://openalex.org/W1979911360","https://openalex.org/W2016884881","https://openalex.org/W2151907359","https://openalex.org/W2161604940","https://openalex.org/W2471966320","https://openalex.org/W2552985993","https://openalex.org/W2600443679","https://openalex.org/W2742620638","https://openalex.org/W2769134990","https://openalex.org/W2807907317","https://openalex.org/W2900187612","https://openalex.org/W2910517153","https://openalex.org/W2950970502","https://openalex.org/W2966787235","https://openalex.org/W2990156137","https://openalex.org/W3033366394","https://openalex.org/W3033695328","https://openalex.org/W3145072879","https://openalex.org/W3179452994","https://openalex.org/W4200166673","https://openalex.org/W4200531859","https://openalex.org/W4212871543","https://openalex.org/W4225308808","https://openalex.org/W4229017497","https://openalex.org/W4282913408","https://openalex.org/W4282938497","https://openalex.org/W4283313046","https://openalex.org/W4283372108","https://openalex.org/W4285587857","https://openalex.org/W4294804942","https://openalex.org/W4378530286","https://openalex.org/W4404018558","https://openalex.org/W4407575430","https://openalex.org/W4408178199","https://openalex.org/W4416755742"],"related_works":["https://openalex.org/W4297903474","https://openalex.org/W2153559483","https://openalex.org/W2033277150","https://openalex.org/W2247617572","https://openalex.org/W2570884861","https://openalex.org/W2391224254","https://openalex.org/W3150709242","https://openalex.org/W2008715546","https://openalex.org/W4308977430","https://openalex.org/W2970355440"],"abstract_inverted_index":{"In":[0],"this":[1],"study,":[2],"we":[3],"investigated":[4],"the":[5,18,31,60,66],"beneficial":[6],"effect":[7],"of":[8,20,33,96,104,147],"solasodine,":[9],"a":[10,55,101,140],"steroidal":[11],"alkaloid":[12],"from":[13],"Solanaceae":[14],"plants,":[15],"on":[16],"suppressing":[17],"proliferation":[19,32,131],"gastric":[21,37,129,148],"cancer":[22,38,130],"cells":[23,39],"by":[24,78,132],"targeting":[25,133],"Hedgehog":[26],"(Hh)":[27],"signaling.":[28],"Solasodine":[29],"inhibited":[30,75,109],"AGS":[34],"and":[35,40,46,48,51,82],"MKN74":[36],"regulated":[41],"cell":[42],"cycle":[43],"(Cyclin":[44],"D1":[45],"p27)":[47],"apoptosis":[49],"(Bax":[50],"Bcl-2)":[52],"markers":[53],"in":[54,115],"dose-dependent":[56],"manner,":[57],"consistent":[58],"with":[59,100],"Gli1/2":[61],"inhibitor":[62,68],"Gant61":[63],"but":[64],"not":[65],"Smo":[67,89,113],"vismodegib.":[69],"As":[70],"an":[71],"upstream":[72],"regulator,":[73],"solasodine":[74,97,108,127],"Hh":[76,116],"signaling":[77,117],"down-regulating":[79],"Gli1":[80,110],"expression":[81,114],"blocking":[83],"its":[84,137],"nuclear":[85],"localization":[86],"without":[87],"affecting":[88],"levels.":[90],"Molecular":[91],"docking":[92],"revealed":[93],"stable":[94],"binding":[95,102],"to":[98],"Gli1,":[99],"affinity":[103],"-7.4":[105],"kcal/mol.":[106],"Moreover,":[107],"rather":[111],"than":[112],"overexpressed":[118],"Ptch":[119],"(-/-)":[120],"MEF":[121],"cells.":[122],"Our":[123],"findings":[124],"demonstrate":[125],"that":[126],"inhibits":[128],"Hh/Gli1":[134],"signaling,":[135],"underscoring":[136],"potential":[138],"as":[139],"potent":[141],"agent":[142],"for":[143],"prevention":[144],"and/or":[145],"inhibition":[146],"cancer.":[149]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}
