{"id":"https://openalex.org/W4412935648","doi":"https://doi.org/10.1097/aln.0000000000005694","title":"Effects of Lacosamide, Pregabalin, and Tapentadol on Peripheral Nerve Excitability: A Randomized, Double-blind, Placebo-controlled, Crossover, Multicenter Trial in Healthy Subjects","display_name":"Effects of Lacosamide, Pregabalin, and Tapentadol on Peripheral Nerve Excitability: A Randomized, Double-blind, Placebo-controlled, Crossover, Multicenter Trial in Healthy Subjects","publication_year":2025,"publication_date":"2025-08-04","ids":{"openalex":"https://openalex.org/W4412935648","doi":"https://doi.org/10.1097/aln.0000000000005694","pmid":"https://pubmed.ncbi.nlm.nih.gov/40758952","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12513044"},"language":"en","primary_location":{"id":"doi:10.1097/aln.0000000000005694","doi":"https://doi.org/10.1097/aln.0000000000005694","is_oa":true,"landing_page_url":"https://doi.org/10.1097/aln.0000000000005694","pdf_url":null,"source":{"id":"https://openalex.org/S124035732","display_name":"Anesthesiology","issn_l":"0003-3022","issn":["0003-3022","1528-1175"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1097/aln.0000000000005694","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056118306","display_name":"Zahra Nochi","orcid":"https://orcid.org/0000-0002-8088-1666","observed_orcids":["https://orcid.org/0000-0002-8088-1666"]},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]},{"id":"https://openalex.org/I4210146081","display_name":"Danish Pain Research Center","ror":"https://ror.org/03r782805","country_code":"DK","type":"facility","lineage":["https://openalex.org/I4210146081"]}],"countries":["DK"],"is_corresponding":true,"raw_author_name":"Zahra Nochi","raw_affiliation_strings":["Danish Pain Research Center, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark","Danish Pain Research Center, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark. Assistant professor,"],"raw_orcid":"https://orcid.org/0000-0002-8088-1666","affiliations":[{"raw_affiliation_string":"Danish Pain Research Center, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark","institution_ids":["https://openalex.org/I204337017","https://openalex.org/I4210146081"]},{"raw_affiliation_string":"Danish Pain Research Center, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark. Assistant professor,","institution_ids":["https://openalex.org/I204337017","https://openalex.org/I4210146081"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hossein Pia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]},{"id":"https://openalex.org/I2802335433","display_name":"Aarhus University Hospital","ror":"https://ror.org/040r8fr65","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802335433"]},{"id":"https://openalex.org/I4210146081","display_name":"Danish Pain Research Center","ror":"https://ror.org/03r782805","country_code":"DK","type":"facility","lineage":["https://openalex.org/I4210146081"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Hossein Pia","raw_affiliation_strings":["Danish Pain Research Center, Department of Clinical Medicine, Aarhus University and Department of Clinical Neurophysiology, Aarhus University Hospital, Aarhus, Denmark","Danish Pain Research Center, Department of Clinical Medicine, Aarhus University & Department of Clinical Neurophysiology, Aarhus University Hospital, Aarhus, Denmark. Researcher,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Danish Pain Research Center, Department of Clinical Medicine, Aarhus University and Department of Clinical Neurophysiology, Aarhus University Hospital, Aarhus, Denmark","institution_ids":["https://openalex.org/I204337017","https://openalex.org/I2802335433","https://openalex.org/I4210146081"]},{"raw_affiliation_string":"Danish Pain Research Center, Department of Clinical Medicine, Aarhus University & Department of Clinical Neurophysiology, Aarhus University Hospital, Aarhus, Denmark. Researcher,","institution_ids":["https://openalex.org/I204337017","https://openalex.org/I2802335433","https://openalex.org/I4210146081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055755177","display_name":"Petra Bloms\u2010Funke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I9732596","display_name":"Gr\u00fcnenthal Group (Germany)","ror":"https://ror.org/03r3ww479","country_code":"DE","type":"company","lineage":["https://openalex.org/I9732596"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Petra Bloms-Funke","raw_affiliation_strings":["Translational Science and Intelligence, Gr\u00fcnenthal GmbH, Aachen, Germany","Translational Science & Intelligence, Gr\u00fcnenthal GmbH, Zieglerstrasse 6, 52078 Aachen, Germany. Head of Grants and Partnerships"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Science and Intelligence, Gr\u00fcnenthal GmbH, Aachen, Germany","institution_ids":["https://openalex.org/I9732596"]},{"raw_affiliation_string":"Translational Science & Intelligence, Gr\u00fcnenthal GmbH, Zieglerstrasse 6, 52078 Aachen, Germany. Head of Grants and Partnerships","institution_ids":["https://openalex.org/I9732596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006828536","display_name":"Irmgard Boesl","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I9732596","display_name":"Gr\u00fcnenthal Group (Germany)","ror":"https://ror.org/03r3ww479","country_code":"DE","type":"company","lineage":["https://openalex.org/I9732596"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Irmgard Boesl","raw_affiliation_strings":["Gr\u00fcnenthal GmbH, Aachen, Germany","Gr\u00fcnenthal GmbH, Aachen, Germany. Clinical Development Lead,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gr\u00fcnenthal GmbH, Aachen, Germany","institution_ids":["https://openalex.org/I9732596"]},{"raw_affiliation_string":"Gr\u00fcnenthal GmbH, Aachen, Germany. Clinical Development Lead,","institution_ids":["https://openalex.org/I9732596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045834162","display_name":"Ombretta Caspani","orcid":"https://orcid.org/0000-0002-9700-3149","observed_orcids":["https://orcid.org/0000-0002-9700-3149"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ombretta Caspani","raw_affiliation_strings":["Department of Neurophysiology, Mannheim Center for Translational Neurosciences, University of Heidelberg, Mannheim, Germany","Department of Neurophysiology, Mannheim Center for Translational Neurosciences (MCTN), University of Heidelberg, Mannheim, Germany. Scientific Project Manager,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurophysiology, Mannheim Center for Translational Neurosciences, University of Heidelberg, Mannheim, Germany","institution_ids":["https://openalex.org/I223822909"]},{"raw_affiliation_string":"Department of Neurophysiology, Mannheim Center for Translational Neurosciences (MCTN), University of Heidelberg, Mannheim, Germany. Scientific Project Manager,","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108273185","display_name":"Sonya C. Chapman","orcid":"https://orcid.org/0000-0002-6453-2749","observed_orcids":["https://orcid.org/0000-0002-6453-2749"]},"institutions":[{"id":"https://openalex.org/I4210095227","display_name":"Eli Lilly (United Kingdom)","ror":"https://ror.org/00psab413","country_code":"GB","type":"company","lineage":["https://openalex.org/I168537998","https://openalex.org/I4210095227"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sonya C. Chapman","raw_affiliation_strings":["Eli Lilly and Company, Bracknell, United Kingdom","Eli Lilly and Company, Arlington Square, Bracknell, UK. Employee and shareholder,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eli Lilly and Company, Bracknell, United Kingdom","institution_ids":["https://openalex.org/I4210095227"]},{"raw_affiliation_string":"Eli Lilly and Company, Arlington Square, Bracknell, UK. Employee and shareholder,","institution_ids":["https://openalex.org/I4210095227"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046961308","display_name":"Giuseppe Di Pietro","orcid":"https://orcid.org/0000-0002-9645-3578","observed_orcids":["https://orcid.org/0000-0002-9645-3578"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giuseppe Di Pietro","raw_affiliation_strings":["Department of Human Neuroscience, Sapienza University, Rome, Italy","Department of human Neuroscience, Sapienza University, Rome, Italy. Postdoc,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Neuroscience, Sapienza University, Rome, Italy","institution_ids":["https://openalex.org/I861853513"]},{"raw_affiliation_string":"Department of human Neuroscience, Sapienza University, Rome, Italy. Postdoc,","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069448467","display_name":"Francesca Fardo","orcid":"https://orcid.org/0000-0002-9974-6261","observed_orcids":["https://orcid.org/0000-0002-9974-6261"]},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]},{"id":"https://openalex.org/I4210146081","display_name":"Danish Pain Research Center","ror":"https://ror.org/03r782805","country_code":"DK","type":"facility","lineage":["https://openalex.org/I4210146081"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Francesca Fardo","raw_affiliation_strings":["Center of Functionally Integrative Neuroscience and Danish Pain Research Center, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark","Center of Functionally Integrative Neuroscience and Danish Pain Research Center, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark. Associate professor,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Functionally Integrative Neuroscience and Danish Pain Research Center, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark","institution_ids":["https://openalex.org/I204337017","https://openalex.org/I4210146081"]},{"raw_affiliation_string":"Center of Functionally Integrative Neuroscience and Danish Pain Research Center, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark. Associate professor,","institution_ids":["https://openalex.org/I204337017","https://openalex.org/I4210146081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039500726","display_name":"Bernd Genser","orcid":"https://orcid.org/0000-0001-5787-0902","observed_orcids":["https://orcid.org/0000-0001-5787-0902"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bernd Genser","raw_affiliation_strings":["High5Data GmbH, Heidelberg, Germany","High5Data GmbH, Heidelberg, Germany. Managing Director,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"High5Data GmbH, Heidelberg, Germany","institution_ids":[]},{"raw_affiliation_string":"High5Data GmbH, Heidelberg, Germany. Managing Director,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023163178","display_name":"Marcus H. Goetz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marcus Goetz","raw_affiliation_strings":["MRC Systems GmbH, Heidelberg, Germany","MRC Systems GmbH, Heidelberg, Germany. Managing director,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Systems GmbH, Heidelberg, Germany","institution_ids":[]},{"raw_affiliation_string":"MRC Systems GmbH, Heidelberg, Germany. Managing director,","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Bo Jiang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210139373","display_name":"Teva Pharmaceuticals (United States)","ror":"https://ror.org/03etg4523","country_code":"US","type":"company","lineage":["https://openalex.org/I4210109720","https://openalex.org/I4210139373"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bo Jiang","raw_affiliation_strings":["Teva Branded Pharmaceutical Products R&D, Inc, West Chester, Pennsylvania","Teva Branded Pharmaceutical Products R&D, Inc, West Chester, PA, USA. Head of ADaM Programming"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Teva Branded Pharmaceutical Products R&D, Inc, West Chester, Pennsylvania","institution_ids":["https://openalex.org/I4210139373"]},{"raw_affiliation_string":"Teva Branded Pharmaceutical Products R&D, Inc, West Chester, PA, USA. Head of ADaM Programming","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049013376","display_name":"Anna V. Kostenko","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Anna V. Kostenko","raw_affiliation_strings":["Department of Neurophysiology, Mannheim Center for Translational Neurosciences, University of Heidelberg, Mannheim, Germany","Department of Neurophysiology, Mannheim Center for Translational Neurosciences (MCTN), University of Heidelberg, Mannheim, Germany. Research assistant,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurophysiology, Mannheim Center for Translational Neurosciences, University of Heidelberg, Mannheim, Germany","institution_ids":["https://openalex.org/I223822909"]},{"raw_affiliation_string":"Department of Neurophysiology, Mannheim Center for Translational Neurosciences (MCTN), University of Heidelberg, Mannheim, Germany. Research assistant,","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072109339","display_name":"Louisien Lebrun","orcid":"https://orcid.org/0000-0002-2459-0354","observed_orcids":["https://orcid.org/0000-0002-2459-0354"]},"institutions":[{"id":"https://openalex.org/I95674353","display_name":"UCLouvain","ror":"https://ror.org/02495e989","country_code":"BE","type":"education","lineage":["https://openalex.org/I95674353"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Louisien Lebrun","raw_affiliation_strings":["Institute of Neuroscience, UCLouvain, Brussels, Belgium","Institute of Neuroscience (IoNS), UCLouvain, Brussels, Belgium. PhD Student,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Neuroscience, UCLouvain, Brussels, Belgium","institution_ids":["https://openalex.org/I95674353"]},{"raw_affiliation_string":"Institute of Neuroscience (IoNS), UCLouvain, Brussels, Belgium. PhD Student,","institution_ids":["https://openalex.org/I95674353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001799128","display_name":"Caterina Maria Leone","orcid":"https://orcid.org/0000-0002-8828-361X","observed_orcids":["https://orcid.org/0000-0002-8828-361X"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Caterina M. Leone","raw_affiliation_strings":["Department of Human Neuroscience, Sapienza University, Rome, Italy","Department of Human Neuroscience, Sapienza University, Rome, Italy. Researcher,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Neuroscience, Sapienza University, Rome, Italy","institution_ids":["https://openalex.org/I861853513"]},{"raw_affiliation_string":"Department of Human Neuroscience, Sapienza University, Rome, Italy. Researcher,","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016322200","display_name":"Thomas Li","orcid":"https://orcid.org/0000-0002-4207-4652","observed_orcids":["https://orcid.org/0000-0002-4207-4652","https://orcid.org/0000-0001-9950-4679"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas Li","raw_affiliation_strings":["Teva Branded Pharmaceutical Products R&D, Inc., West Chester, Pennsylvania","Teva Branded Pharmaceutical Products R&D, Inc, West Chester, PA, USA. Director, Global Statistics"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Teva Branded Pharmaceutical Products R&D, Inc., West Chester, Pennsylvania","institution_ids":[]},{"raw_affiliation_string":"Teva Branded Pharmaceutical Products R&D, Inc, West Chester, PA, USA. Director, Global Statistics","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5119201372","display_name":"Niko M\u00f6ller-Grell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105615","display_name":"Central Institute of Mental Health","ror":"https://ror.org/01hynnt93","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210105615"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Niko M\u00f6ller-Grell","raw_affiliation_strings":["Central Institute of Mental Health (CIMH), Mannheim, Germany","Zentralinstitut f\u00fcr Seelische Gesundheit Mannheim. Research assistant,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central Institute of Mental Health (CIMH), Mannheim, Germany","institution_ids":["https://openalex.org/I4210105615"]},{"raw_affiliation_string":"Zentralinstitut f\u00fcr Seelische Gesundheit Mannheim. Research assistant,","institution_ids":["https://openalex.org/I4210105615"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016778062","display_name":"Andr\u00e9 Mouraux","orcid":"https://orcid.org/0000-0003-1056-5980","observed_orcids":["https://orcid.org/0000-0003-1056-5980"]},"institutions":[{"id":"https://openalex.org/I95674353","display_name":"UCLouvain","ror":"https://ror.org/02495e989","country_code":"BE","type":"education","lineage":["https://openalex.org/I95674353"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Andr\u00e9 Mouraux","raw_affiliation_strings":["Institute of Neuroscience, UCLouvain, Brussels, Belgium","Institute of Neuroscience (IoNS), UCLouvain, Brussels, Belgium. Professor,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Neuroscience, UCLouvain, Brussels, Belgium","institution_ids":["https://openalex.org/I95674353"]},{"raw_affiliation_string":"Institute of Neuroscience (IoNS), UCLouvain, Brussels, Belgium. Professor,","institution_ids":["https://openalex.org/I95674353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042323343","display_name":"Bernhard Pelz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bernhard Pelz","raw_affiliation_strings":["MRC Systems GmbH, Heidelberg, Germany","MRC Systems GmbH, Heidelberg, Germany. Senior Project Manager,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Systems GmbH, Heidelberg, Germany","institution_ids":[]},{"raw_affiliation_string":"MRC Systems GmbH, Heidelberg, Germany. Senior Project Manager,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025049560","display_name":"Esther Miriam Pogatzki-Zahn","orcid":"https://orcid.org/0000-0003-0981-3940","observed_orcids":["https://orcid.org/0000-0003-0981-3940"]},"institutions":[{"id":"https://openalex.org/I4210103666","display_name":"University Hospital M\u00fcnster","ror":"https://ror.org/01856cw59","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210103666"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Esther Pogatzki-Zahn","raw_affiliation_strings":["Department of Anesthesiology, Intensive Care and Pain Medicine, University Hospital M\u00fcnster, M\u00fcnster, Germany","Department of Anesthesiology, Intensive Care and Pain Medicine, University Hospital M\u00fcnster, M\u00fcnster, Germany. Professor,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Intensive Care and Pain Medicine, University Hospital M\u00fcnster, M\u00fcnster, Germany","institution_ids":["https://openalex.org/I4210103666"]},{"raw_affiliation_string":"Department of Anesthesiology, Intensive Care and Pain Medicine, University Hospital M\u00fcnster, M\u00fcnster, Germany. Professor,","institution_ids":["https://openalex.org/I4210103666"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Clarence Rong","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Clarence Rong","raw_affiliation_strings":["Teva Branded Pharmaceutical Products R&D, Inc., West Chester, Pennsylvania","Teva Branded Pharmaceutical Products R&D, Inc, West Chester, PA, USA. Clinical Programming Consultant,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Teva Branded Pharmaceutical Products R&D, Inc., West Chester, Pennsylvania","institution_ids":[]},{"raw_affiliation_string":"Teva Branded Pharmaceutical Products R&D, Inc, West Chester, PA, USA. Clinical Programming Consultant,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017753238","display_name":"Andreas Schilder","orcid":"https://orcid.org/0000-0001-7525-2497","observed_orcids":["https://orcid.org/0000-0001-7525-2497"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I4210156450","display_name":"University Medical Centre Mannheim","ror":"https://ror.org/05sxbyd35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210156450"]},{"id":"https://openalex.org/I4387153978","display_name":"Medizinische Fakult\u00e4t Mannheim","ror":"https://ror.org/02m1z0a87","country_code":"DE","type":"education","lineage":["https://openalex.org/I4387153978"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Andreas Schilder","raw_affiliation_strings":["Department of Orthopaedic and Trauma Surgery, University Medical Centre Mannheim, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany","Department of Orthopaedic and Trauma Surgery, University Medical Centre Mannheim, Medical Faculty Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany. Section Head of the Research Laboratory,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic and Trauma Surgery, University Medical Centre Mannheim, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany","institution_ids":["https://openalex.org/I223822909","https://openalex.org/I4210156450","https://openalex.org/I4387153978"]},{"raw_affiliation_string":"Department of Orthopaedic and Trauma Surgery, University Medical Centre Mannheim, Medical Faculty Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany. Section Head of the Research Laboratory,","institution_ids":["https://openalex.org/I223822909","https://openalex.org/I4210156450","https://openalex.org/I4387153978"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006280073","display_name":"Erik Schnetter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Erik Schnetter","raw_affiliation_strings":["Heidelberg University Computer Center, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Heidelberg University Computer Center, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021596323","display_name":"Karin Schubart","orcid":"https://orcid.org/0000-0002-3364-6575","observed_orcids":["https://orcid.org/0000-0002-3364-6575"]},"institutions":[{"id":"https://openalex.org/I4405284214","display_name":"ConsulTech GmbH (Germany)","ror":"https://ror.org/035k5ve33","country_code":"DE","type":"company","lineage":["https://openalex.org/I4405284214"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Karin Schubart","raw_affiliation_strings":["ConsulTech GmbH, Berlin, Germany","ConsulTech GmbH, Bel\u00dfstrasse 19, 12277 Berlin, DE. Senior Scientist & Project Manager,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ConsulTech GmbH, Berlin, Germany","institution_ids":["https://openalex.org/I4405284214"]},{"raw_affiliation_string":"ConsulTech GmbH, Bel\u00dfstrasse 19, 12277 Berlin, DE. Senior Scientist & Project Manager,","institution_ids":["https://openalex.org/I4405284214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035274081","display_name":"Irene Tracey","orcid":"https://orcid.org/0000-0003-4134-6115","observed_orcids":["https://orcid.org/0000-0003-4134-6115"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4210101881","display_name":"Wellcome Centre for Integrative Neuroimaging","ror":"https://ror.org/0172mzb45","country_code":"GB","type":"facility","lineage":["https://openalex.org/I40120149","https://openalex.org/I4210101881","https://openalex.org/I87048295"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Irene Tracey","raw_affiliation_strings":["Wellcome Centre for Integrative Neuroimaging, Functional Magnetic Resonance Imaging of the Brain Centre, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom","Wellcome Centre for Integrative Neuroimaging, FMRIB Centre, Nuffield Department of Clinical Neurosciences, University of Oxford, UK. Professor and Vice-Chancellor,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wellcome Centre for Integrative Neuroimaging, Functional Magnetic Resonance Imaging of the Brain Centre, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom","institution_ids":["https://openalex.org/I40120149","https://openalex.org/I4210101881"]},{"raw_affiliation_string":"Wellcome Centre for Integrative Neuroimaging, FMRIB Centre, Nuffield Department of Clinical Neurosciences, University of Oxford, UK. Professor and Vice-Chancellor,","institution_ids":["https://openalex.org/I40120149","https://openalex.org/I4210101881"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018071089","display_name":"Andrea Truini","orcid":"https://orcid.org/0000-0002-2630-7647","observed_orcids":["https://orcid.org/0000-0002-2630-7647"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Andrea Truini","raw_affiliation_strings":["Department of Human Neuroscience, Sapienza University, Rome, Italy","Department of Human Neuroscience, Sapienza University, Rome, Italy. Professor,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Neuroscience, Sapienza University, Rome, Italy","institution_ids":["https://openalex.org/I861853513"]},{"raw_affiliation_string":"Department of Human Neuroscience, Sapienza University, Rome, Italy. Professor,","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035704725","display_name":"Katy Vincent","orcid":"https://orcid.org/0000-0001-9249-2492","observed_orcids":["https://orcid.org/0000-0001-9249-2492"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Katy Vincent","raw_affiliation_strings":["Nuffield Department of Women\u2019s and Reproductive Health, University of Oxford, Oxford, United Kingdom","Nuffield Department of Women\u2019s and Reproductive Health, University of Oxford, Oxford, UK. Professor,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuffield Department of Women\u2019s and Reproductive Health, University of Oxford, Oxford, United Kingdom","institution_ids":["https://openalex.org/I40120149"]},{"raw_affiliation_string":"Nuffield Department of Women\u2019s and Reproductive Health, University of Oxford, Oxford, UK. Professor,","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077860334","display_name":"Jan Vollert","orcid":"https://orcid.org/0000-0003-0733-5201","observed_orcids":["https://orcid.org/0000-0003-0733-5201"]},"institutions":[{"id":"https://openalex.org/I23923803","display_name":"University of Exeter","ror":"https://ror.org/03yghzc09","country_code":"GB","type":"education","lineage":["https://openalex.org/I23923803"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jan Vollert","raw_affiliation_strings":["Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, United Kingdom","Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, UK. Lecturer,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, United Kingdom","institution_ids":["https://openalex.org/I23923803"]},{"raw_affiliation_string":"Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, UK. Lecturer,","institution_ids":["https://openalex.org/I23923803"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090613746","display_name":"Vishvarani Wanigasekera","orcid":"https://orcid.org/0000-0001-9922-8993","observed_orcids":["https://orcid.org/0000-0001-9922-8993"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Vishvarani Wanigasekera","raw_affiliation_strings":["Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom","Nuffield Department of Clinical Neurosciences, University of Oxford. Clinical Research Fellow,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom","institution_ids":["https://openalex.org/I40120149"]},{"raw_affiliation_string":"Nuffield Department of Clinical Neurosciences, University of Oxford. Clinical Research Fellow,","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030360533","display_name":"Matthias Wittayer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Matthias Wittayer","raw_affiliation_strings":["Department of Neurophysiology, Mannheim Center for Translational Neurosciences, University of Heidelberg, Mannheim, Germany","Department of Neurophysiology, Mannheim Center for Translational Neurosciences (MCTN), University of Heidelberg, Mannheim, Germany. Research assistant,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurophysiology, Mannheim Center for Translational Neurosciences, University of Heidelberg, Mannheim, Germany","institution_ids":["https://openalex.org/I223822909"]},{"raw_affiliation_string":"Department of Neurophysiology, Mannheim Center for Translational Neurosciences (MCTN), University of Heidelberg, Mannheim, Germany. Research assistant,","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027144651","display_name":"Rolf\u2010Detlef Treede","orcid":"https://orcid.org/0000-0001-8065-1708","observed_orcids":["https://orcid.org/0000-0001-8065-1708"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Rolf-Detlef Treede","raw_affiliation_strings":["Department of Neurophysiology, Mannheim Center for Translational Neurosciences, University of Heidelberg, Mannheim, Germany","Department of Neurophysiology, Mannheim Center for Translational Neurosciences (MCTN), University of Heidelberg, Mannheim, Germany. Professor,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurophysiology, Mannheim Center for Translational Neurosciences, University of Heidelberg, Mannheim, Germany","institution_ids":["https://openalex.org/I223822909"]},{"raw_affiliation_string":"Department of Neurophysiology, Mannheim Center for Translational Neurosciences (MCTN), University of Heidelberg, Mannheim, Germany. Professor,","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055252200","display_name":"Hatice Tanki\u015fi","orcid":"https://orcid.org/0000-0001-8495-9769","observed_orcids":["https://orcid.org/0000-0001-8495-9769"]},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]},{"id":"https://openalex.org/I2802335433","display_name":"Aarhus University Hospital","ror":"https://ror.org/040r8fr65","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802335433"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Hatice Tankisi","raw_affiliation_strings":["Department of Clinical Medicine, Aarhus University and Department of Clinical Neurophysiology, Aarhus University Hospital, Aarhus, Denmark","Department of Clinical Medicine, Aarhus University and Department of Clinical Neurophysiology, Aarhus University Hospital, Aarhus, Denmark. Clinical professor"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Medicine, Aarhus University and Department of Clinical Neurophysiology, Aarhus University Hospital, Aarhus, Denmark","institution_ids":["https://openalex.org/I204337017","https://openalex.org/I2802335433"]},{"raw_affiliation_string":"Department of Clinical Medicine, Aarhus University and Department of Clinical Neurophysiology, Aarhus University Hospital, Aarhus, Denmark. Clinical professor","institution_ids":["https://openalex.org/I204337017","https://openalex.org/I2802335433"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041298056","display_name":"Nanna Brix Finnerup","orcid":"https://orcid.org/0000-0001-5541-0240","observed_orcids":["https://orcid.org/0000-0001-5541-0240"]},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]},{"id":"https://openalex.org/I4210146081","display_name":"Danish Pain Research Center","ror":"https://ror.org/03r782805","country_code":"DK","type":"facility","lineage":["https://openalex.org/I4210146081"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Nanna B. Finnerup","raw_affiliation_strings":["Danish Pain Research Center, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark","Danish Pain Research Center, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark. Professor, Director"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Danish Pain Research Center, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark","institution_ids":["https://openalex.org/I204337017","https://openalex.org/I4210146081"]},{"raw_affiliation_string":"Danish Pain Research Center, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark. Professor, Director","institution_ids":["https://openalex.org/I204337017","https://openalex.org/I4210146081"]}]}],"institutions":[],"countries_distinct_count":6,"institutions_distinct_count":17,"corresponding_author_ids":["https://openalex.org/A5056118306"],"corresponding_institution_ids":["https://openalex.org/I204337017","https://openalex.org/I4210146081"],"apc_list":null,"apc_paid":null,"fwci":1.9197,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.81475915,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":98},"biblio":{"volume":"143","issue":"5","first_page":"1279","last_page":"1295"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11840","display_name":"Pain Management and Treatment","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10189","display_name":"Anesthesia and Pain Management","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lacosamide","display_name":"lacosamide","score":0.9990000128746033},{"id":"https://openalex.org/keywords/pregabalin","display_name":"pregabalin","score":1.0},{"id":"https://openalex.org/keywords/tapentadol","display_name":"tapentadol","score":1.0},{"id":"https://openalex.org/keywords/peripheral-nerve-excitability","display_name":"peripheral nerve excitability","score":1.0},{"id":"https://openalex.org/keywords/strength-duration-time-constant","display_name":"strength-duration time constant","score":0.8949999809265137},{"id":"https://openalex.org/keywords/sensory-nerve-fibers","display_name":"sensory nerve fibers","score":0.5540000200271606},{"id":"https://openalex.org/keywords/motor-fibers","display_name":"motor fibers","score":0.8309999704360962},{"id":"https://openalex.org/keywords/threshold-electrotonus","display_name":"threshold electrotonus","score":0.8109999895095825},{"id":"https://openalex.org/keywords/refractoriness","display_name":"refractoriness","score":0.6200000047683716},{"id":"https://openalex.org/keywords/pharmacodynamics","display_name":"pharmacodynamics","score":0.5120000243186951},{"id":"https://openalex.org/keywords/chronic-pain","display_name":"chronic pain","score":0.6650000214576721},{"id":"https://openalex.org/keywords/analgesics","display_name":"analgesics","score":0.5360000133514404},{"id":"https://openalex.org/keywords/healthy-volunteers","display_name":"healthy volunteers","score":0.421999990940094}],"concepts":[{"id":"https://openalex.org/C2776468701","wikidata":"https://www.wikidata.org/wiki/Q412174","display_name":"Pregabalin","level":2,"score":0.9499686360359192},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9133563041687012},{"id":"https://openalex.org/C2778139780","wikidata":"https://www.wikidata.org/wiki/Q420077","display_name":"Lacosamide","level":3,"score":0.9072006940841675},{"id":"https://openalex.org/C2780505013","wikidata":"https://www.wikidata.org/wiki/Q414463","display_name":"Tapentadol","level":4,"score":0.8769729137420654},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.693659782409668},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.6571964621543884},{"id":"https://openalex.org/C87813604","wikidata":"https://www.wikidata.org/wiki/Q1242899","display_name":"Crossover study","level":4,"score":0.6060178875923157},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.4263076186180115},{"id":"https://openalex.org/C2777014857","wikidata":"https://www.wikidata.org/wiki/Q1383410","display_name":"Exacerbation","level":2,"score":0.4228593111038208},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3164753317832947},{"id":"https://openalex.org/C2781063702","wikidata":"https://www.wikidata.org/wiki/Q427523","display_name":"Opioid","level":3,"score":0.15896353125572205},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.14885640144348145},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000069583","descriptor_name":"Pregabalin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000069583","descriptor_name":"Pregabalin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000077432","descriptor_name":"Tapentadol","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000077432","descriptor_name":"Tapentadol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000078334","descriptor_name":"Lacosamide","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000078334","descriptor_name":"Lacosamide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000700","descriptor_name":"Analgesics","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010525","descriptor_name":"Peripheral Nerves","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D010525","descriptor_name":"Peripheral Nerves","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018592","descriptor_name":"Cross-Over Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064368","descriptor_name":"Healthy Volunteers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1097/aln.0000000000005694","doi":"https://doi.org/10.1097/aln.0000000000005694","is_oa":true,"landing_page_url":"https://doi.org/10.1097/aln.0000000000005694","pdf_url":null,"source":{"id":"https://openalex.org/S124035732","display_name":"Anesthesiology","issn_l":"0003-3022","issn":["0003-3022","1528-1175"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesiology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12513044","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12513044/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12513044/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesiology","raw_type":"Text"},{"id":"pmh:oai:europepmc.org:11320788","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12513044","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:40758952","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40758952","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesiology","raw_type":"Journal Article"},{"id":"pmh:oai:iris.uniroma1.it:11573/1748730","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/11573/1748730","pdf_url":null,"source":{"id":"https://openalex.org/S4377196107","display_name":"IRIS Research product catalog (Sapienza University of Rome)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pure.atira.dk:openaire/0c3acd41-6b2f-4fa5-9427-f519425ec284","doi":null,"is_oa":true,"landing_page_url":"https://pure.au.dk/portal/en/publications/0c3acd41-6b2f-4fa5-9427-f519425ec284","pdf_url":null,"source":null,"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1097/aln.0000000000005694","doi":"https://doi.org/10.1097/aln.0000000000005694","is_oa":true,"landing_page_url":"https://doi.org/10.1097/aln.0000000000005694","pdf_url":null,"source":{"id":"https://openalex.org/S124035732","display_name":"Anesthesiology","issn_l":"0003-3022","issn":["0003-3022","1528-1175"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesiology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4412935648.pdf","grobid_xml":"https://content.openalex.org/works/W4412935648.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W258491374","https://openalex.org/W1596747195","https://openalex.org/W1980075122","https://openalex.org/W1986237027","https://openalex.org/W1990437244","https://openalex.org/W1992356360","https://openalex.org/W2012335416","https://openalex.org/W2015795623","https://openalex.org/W2028140282","https://openalex.org/W2029149408","https://openalex.org/W2031422758","https://openalex.org/W2032208962","https://openalex.org/W2035461406","https://openalex.org/W2036785454","https://openalex.org/W2042741271","https://openalex.org/W2044601721","https://openalex.org/W2054260401","https://openalex.org/W2057913235","https://openalex.org/W2068754041","https://openalex.org/W2079286087","https://openalex.org/W2086721869","https://openalex.org/W2092593347","https://openalex.org/W2093403276","https://openalex.org/W2100817237","https://openalex.org/W2101236938","https://openalex.org/W2104818454","https://openalex.org/W2107936912","https://openalex.org/W2108197576","https://openalex.org/W2108621039","https://openalex.org/W2109212172","https://openalex.org/W2137070227","https://openalex.org/W2140044940","https://openalex.org/W2141678708","https://openalex.org/W2153515555","https://openalex.org/W2157249610","https://openalex.org/W2158799063","https://openalex.org/W2313125952","https://openalex.org/W2325416065","https://openalex.org/W2580587976","https://openalex.org/W2768679933","https://openalex.org/W2801995663","https://openalex.org/W2906590066","https://openalex.org/W2911078142","https://openalex.org/W3048534895","https://openalex.org/W3156671609","https://openalex.org/W3168353964","https://openalex.org/W4213103755","https://openalex.org/W4283644910","https://openalex.org/W4288067447","https://openalex.org/W4328111571","https://openalex.org/W4361246533","https://openalex.org/W4385752262","https://openalex.org/W4407247239"],"related_works":["https://openalex.org/W4213103755","https://openalex.org/W4294578987","https://openalex.org/W7127041917","https://openalex.org/W3168353964","https://openalex.org/W4385752262","https://openalex.org/W2979597072","https://openalex.org/W2132909425","https://openalex.org/W6958676892","https://openalex.org/W2079286087","https://openalex.org/W4386861127"],"abstract_inverted_index":{"BACKGROUND:":[0],"Chronic":[1],"pain":[2],"is":[3],"a":[4,49],"leading":[5],"cause":[6],"of":[7,36,78,145,204],"disability":[8],"globally,":[9],"with":[10],"limited":[11],"treatment":[12,70],"options":[13],"and":[14,39,111,116,138,147,170,206,224],"frequent":[15],"adverse":[16],"effects.":[17],"The":[18,56,97],"IMI-PainCare-BioPain":[19],"project":[20],"aimed":[21],"to":[22,64,94,125,165,180,198,249],"enhance":[23],"analgesic":[24],"drug":[25],"development":[26],"by":[27],"standardizing":[28],"biomarkers.":[29],"This":[30,252],"study,":[31],"IMI2-PainCare-BioPain-RCT1,":[32],"evaluated":[33],"the":[34,120,194,245],"effects":[35,144,203,262],"lacosamide,":[37],"pregabalin,":[38],"tapentadol":[40,85,207],"on":[41,189,208,263],"peripheral":[42,274],"nerve":[43,256,275],"excitability":[44,257],"in":[45,103,108,155,171,219,226,236,267,278],"healthy":[46,60,268],"subjects":[47],"through":[48],"randomized,":[50],"double-blind,":[51],"placebo-controlled":[52],"crossover":[53],"trial.":[54],"METHODS:":[55],"study":[57,253],"included":[58,132],"43":[59],"participants":[61],"aged":[62],"18":[63],"45":[65],"yr.":[66],"Participants":[67],"underwent":[68],"four":[69],"periods":[71,118],"during":[72],"which":[73],"they":[74],"received":[75],"single":[76],"doses":[77],"lacosamide":[79,115,214],"(200":[80],"mg),":[81,84,87],"pregabalin":[82,146,205],"(150":[83],"(100":[86],"or":[88,241],"placebo.":[89,199,250],"High-frequency":[90],"stimulation":[91],"was":[92],"applied":[93],"induce":[95],"hyperalgesia.":[96],"two":[98],"primary":[99],"endpoints":[100,131],"were":[101,201,234],"changes":[102,218,233],"strength-duration":[104],"time":[105],"constant":[106],"(SDTC)":[107],"large":[109,156,227,264,279],"sensory":[110,157,191,228,280],"motor":[112,172],"fibers":[113,158,173,192,266],"between":[114],"placebo":[117],"at":[119,193,244],"first":[121,195,246],"postdose":[122],"timepoint":[123,196,247],"compared":[124,197,248],"baseline":[126],"(60":[127],"min).":[128],"Other":[129],"predefined":[130,212],"recovery":[133],"cycle,":[134],"threshold":[135],"electrotonus":[136],"(TEd),":[137],"S2":[139,221],"accommodation,":[140],"as":[141,143],"well":[142],"tapentadol.":[148],"RESULTS:":[149],"Lacosamide":[150,270],"statistically":[151,216,231,271],"significantly":[152,272],"reduced":[153,273],"SDTC":[154],"(mean":[159,174],"reduction,":[160,175],"0.04;":[161,176],"95%":[162,177],"CI,":[163,178],"0.01":[164],"0.08;":[166],"P":[167,182],"=":[168,183],"0.012)":[169],"0.00":[179],"0.07;":[181],"0.039)":[184],"but":[185],"had":[186],"no":[187,202],"effect":[188],"small":[190],"There":[200],"SDTC.":[209],"Of":[210],"other":[211],"endpoints,":[213],"produced":[215],"significant":[217,232],"subexcitability,":[220],"accommodation":[222,242],"TEd(peak),":[223],"TEd40(Accom)":[225],"fibers.":[229,281],"No":[230],"observed":[235],"refractoriness,":[237],"relative":[238],"refractory":[239],"period,":[240],"half-time":[243],"CONCLUSIONS:":[251],"demonstrates":[254],"that":[255],"testing":[258],"can":[259],"detect":[260],"pharmacodynamic":[261],"myelinated":[265],"subjects.":[269],"excitability,":[276],"particularly":[277]},"counts_by_year":[{"year":2026,"cited_by_count":4}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2025-10-10T00:00:00"}
