{"id":"https://openalex.org/W4412927491","doi":"https://doi.org/10.7759/cureus.88695","title":"Treatment of Refractory Grover\u2019s Disease With Dupilumab: A Case Study","display_name":"Treatment of Refractory Grover\u2019s Disease With Dupilumab: A Case Study","publication_year":2025,"publication_date":"2025-07-24","ids":{"openalex":"https://openalex.org/W4412927491","doi":"https://doi.org/10.7759/cureus.88695","pmid":"https://pubmed.ncbi.nlm.nih.gov/40861695","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12374847"},"language":"en","primary_location":{"id":"doi:10.7759/cureus.88695","doi":"https://doi.org/10.7759/cureus.88695","is_oa":true,"landing_page_url":"https://doi.org/10.7759/cureus.88695","pdf_url":"https://www.cureus.com/articles/392522-treatment-of-refractory-grovers-disease-with-dupilumab-a-case-study.pdf","source":{"id":"https://openalex.org/S2738950867","display_name":"Cureus","issn_l":"2168-8184","issn":["2168-8184"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310316779","host_organization_name":"Cureus, Inc.","host_organization_lineage":["https://openalex.org/P4310316779"],"host_organization_lineage_names":["Cureus, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.cureus.com/articles/392522-treatment-of-refractory-grovers-disease-with-dupilumab-a-case-study.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5119198209","display_name":"Maclaine McCarter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4584351","display_name":"A.T. Still University","ror":"https://ror.org/05hr6q169","country_code":"US","type":"education","lineage":["https://openalex.org/I4584351"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Maclaine McCarter","raw_affiliation_strings":["Dermatology, A.T. Still University - Kirksville College of Osteopathic Medicine, Kirksville, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dermatology, A.T. Still University - Kirksville College of Osteopathic Medicine, Kirksville, USA","institution_ids":["https://openalex.org/I4584351"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020715435","display_name":"David Cleaver","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David Cleaver","raw_affiliation_strings":["Dermatology, Cleaver Dermatology, Kirksville, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dermatology, Cleaver Dermatology, Kirksville, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050956275","display_name":"Jordan Lane","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210098088","display_name":"Unity Health System","ror":"https://ror.org/00yfpz909","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098088"]},{"id":"https://openalex.org/I4405261117","display_name":"Community Health Systems - Northeast Regional Medical Center","ror":"https://ror.org/04tfx6r65","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4405259010","https://openalex.org/I4405261117"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jordan Lane","raw_affiliation_strings":["Dermatology, Northeast Regional Medical Center, Kirksville, USA","Dermatology, Unity Health - White County Medical Center, Searcy, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dermatology, Northeast Regional Medical Center, Kirksville, USA","institution_ids":["https://openalex.org/I4405261117"]},{"raw_affiliation_string":"Dermatology, Unity Health - White County Medical Center, Searcy, USA","institution_ids":["https://openalex.org/I4210098088"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5119198209"],"corresponding_institution_ids":["https://openalex.org/I4584351"],"apc_list":null,"apc_paid":null,"fwci":1.6554,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.83392149,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":96},"biblio":{"volume":"17","issue":"7","first_page":"e88695","last_page":"e88695"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.9589999914169312,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.9589999914169312,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12355","display_name":"Genetic and rare skin diseases.","score":0.018699999898672104,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12433","display_name":"Skin Diseases and Diabetes","score":0.006200000178068876,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/grover-s-disease","display_name":"Grover's disease","score":0.9959999918937683},{"id":"https://openalex.org/keywords/dupilumab","display_name":"dupilumab","score":0.9909999966621399},{"id":"https://openalex.org/keywords/refractory-pruritus","display_name":"refractory pruritus","score":0.8740000128746033},{"id":"https://openalex.org/keywords/immune-mediated-pathogenesis","display_name":"immune-mediated pathogenesis","score":0.6639999747276306},{"id":"https://openalex.org/keywords/biological-therapy","display_name":"biologic therapy","score":0.5699999928474426},{"id":"https://openalex.org/keywords/elderly-patients","display_name":"elderly patients","score":0.41200000047683716},{"id":"https://openalex.org/keywords/treatment-resistant-dermatosis","display_name":"treatment-resistant dermatosis","score":0.42500001192092896}],"concepts":[{"id":"https://openalex.org/C2779824493","wikidata":"https://www.wikidata.org/wiki/Q5315925","display_name":"Dupilumab","level":3,"score":0.9809141159057617},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9516370892524719},{"id":"https://openalex.org/C142424586","wikidata":"https://www.wikidata.org/wiki/Q7307572","display_name":"Refractory (planetary science)","level":2,"score":0.7247239947319031},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5230261087417603},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.4981365203857422},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17008811235427856},{"id":"https://openalex.org/C87355193","wikidata":"https://www.wikidata.org/wiki/Q411","display_name":"Astrobiology","level":1,"score":0.07498207688331604},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C2778329239","wikidata":"https://www.wikidata.org/wiki/Q268667","display_name":"Atopic dermatitis","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.7759/cureus.88695","doi":"https://doi.org/10.7759/cureus.88695","is_oa":true,"landing_page_url":"https://doi.org/10.7759/cureus.88695","pdf_url":"https://www.cureus.com/articles/392522-treatment-of-refractory-grovers-disease-with-dupilumab-a-case-study.pdf","source":{"id":"https://openalex.org/S2738950867","display_name":"Cureus","issn_l":"2168-8184","issn":["2168-8184"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310316779","host_organization_name":"Cureus, Inc.","host_organization_lineage":["https://openalex.org/P4310316779"],"host_organization_lineage_names":["Cureus, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:11183879","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12374847","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:12374847","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12374847","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"Text"},{"id":"pmid:40861695","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40861695","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"Case Reports"}],"best_oa_location":{"id":"doi:10.7759/cureus.88695","doi":"https://doi.org/10.7759/cureus.88695","is_oa":true,"landing_page_url":"https://doi.org/10.7759/cureus.88695","pdf_url":"https://www.cureus.com/articles/392522-treatment-of-refractory-grovers-disease-with-dupilumab-a-case-study.pdf","source":{"id":"https://openalex.org/S2738950867","display_name":"Cureus","issn_l":"2168-8184","issn":["2168-8184"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310316779","host_organization_name":"Cureus, Inc.","host_organization_lineage":["https://openalex.org/P4310316779"],"host_organization_lineage_names":["Cureus, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4412927491.pdf","grobid_xml":"https://content.openalex.org/works/W4412927491.grobid-xml"},"referenced_works_count":9,"referenced_works":["https://openalex.org/W1993158127","https://openalex.org/W1995342878","https://openalex.org/W2001973472","https://openalex.org/W2040179700","https://openalex.org/W2064085790","https://openalex.org/W3048144142","https://openalex.org/W3125121030","https://openalex.org/W4394566498","https://openalex.org/W4401194817"],"related_works":["https://openalex.org/W7128474911","https://openalex.org/W4406920563","https://openalex.org/W7214464358","https://openalex.org/W4411290324","https://openalex.org/W4394566498","https://openalex.org/W4220916797","https://openalex.org/W2983023397","https://openalex.org/W4384469499","https://openalex.org/W7203580670","https://openalex.org/W3125121030"],"abstract_inverted_index":{"Grover's":[0],"disease":[1],"(GD)":[2],"is":[3],"a":[4,33,79],"pruritic":[5],"skin":[6],"condition":[7],"characterized":[8],"by":[9],"erythematous,":[10],"scaly":[11],"papules":[12],"on":[13],"the":[14,49,89],"trunk,":[15],"often":[16],"resolving":[17],"spontaneously":[18],"but":[19],"sometimes":[20],"becoming":[21],"persistent":[22],"and":[23,56,68],"difficult":[24],"to":[25],"manage.":[26],"In":[27],"this":[28],"case":[29,74],"study,":[30],"we":[31],"discuss":[32],"73-year-old":[34],"male":[35],"with":[36,43,58],"treatment-resistant":[37],"GD":[38],"who":[39],"experienced":[40],"significant":[41],"improvement":[42,53],"dupilumab":[44,77],"injections.":[45],"Within":[46],"two":[47],"weeks,":[48],"patient":[50],"reported":[51],"noticeable":[52],"in":[54],"pruritus":[55],"rash,":[57],"complete":[59],"resolution":[60],"achieved":[61],"after":[62],"five":[63],"months":[64],"of":[65,91,95],"continued":[66],"treatment":[67],"no":[69],"notable":[70],"adverse":[71],"effects.":[72],"This":[73],"can":[75],"highlight":[76],"as":[78,85,87],"promising":[80],"option":[81],"for":[82],"refractory":[83],"GD,":[84],"well":[86],"support":[88],"hypothesis":[90],"an":[92],"immune-mediated":[93],"pathogenesis":[94],"GD.":[96]},"counts_by_year":[{"year":2026,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-10-10T00:00:00"}