{"id":"https://openalex.org/W4412918293","doi":"https://doi.org/10.3389/fphar.2025.1644315","title":"Chaihu Longgu Muli Decoction inhibits chronic stress-induced lung cancer epithelial-mesenchymal transition process by suppressing Rap1/ERK signal pathway","display_name":"Chaihu Longgu Muli Decoction inhibits chronic stress-induced lung cancer epithelial-mesenchymal transition process by suppressing Rap1/ERK signal pathway","publication_year":2025,"publication_date":"2025-07-25","ids":{"openalex":"https://openalex.org/W4412918293","doi":"https://doi.org/10.3389/fphar.2025.1644315","pmid":"https://pubmed.ncbi.nlm.nih.gov/40786046","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12332513"},"language":"en","primary_location":{"id":"doi:10.3389/fphar.2025.1644315","doi":"https://doi.org/10.3389/fphar.2025.1644315","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2025.1644315","pdf_url":"https://public-pages-files-2025.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1644315/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W4412918293"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://public-pages-files-2025.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1644315/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Zibo Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I160354188","display_name":"Henan University of Chinese Medicine","ror":"https://ror.org/01tsmvz08","country_code":"CN","type":"education","lineage":["https://openalex.org/I160354188"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zibo Li","raw_affiliation_strings":["Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, China","Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao, Henan Province, Henan University of Chinese Medicine, Zhengzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, China","institution_ids":["https://openalex.org/I160354188"]},{"raw_affiliation_string":"Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao, Henan Province, Henan University of Chinese Medicine, Zhengzhou, China","institution_ids":["https://openalex.org/I160354188"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102151077","display_name":"Ziyang Huang","orcid":"https://orcid.org/0000-0002-6496-5173","observed_orcids":["https://orcid.org/0000-0002-6496-5173"]},"institutions":[{"id":"https://openalex.org/I160354188","display_name":"Henan University of Chinese Medicine","ror":"https://ror.org/01tsmvz08","country_code":"CN","type":"education","lineage":["https://openalex.org/I160354188"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ziyang Huang","raw_affiliation_strings":["Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, China","Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao, Henan Province, Henan University of Chinese Medicine, Zhengzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, China","institution_ids":["https://openalex.org/I160354188"]},{"raw_affiliation_string":"Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao, Henan Province, Henan University of Chinese Medicine, Zhengzhou, China","institution_ids":["https://openalex.org/I160354188"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111101201","display_name":"Zhiyi Wang","orcid":"https://orcid.org/0009-0002-0729-2395","observed_orcids":["https://orcid.org/0009-0002-0729-2395","https://orcid.org/0009-0008-1688-3342"]},"institutions":[{"id":"https://openalex.org/I160354188","display_name":"Henan University of Chinese Medicine","ror":"https://ror.org/01tsmvz08","country_code":"CN","type":"education","lineage":["https://openalex.org/I160354188"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhiyi Wang","raw_affiliation_strings":["Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, China","Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao, Henan Province, Henan University of Chinese Medicine, Zhengzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, China","institution_ids":["https://openalex.org/I160354188"]},{"raw_affiliation_string":"Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao, Henan Province, Henan University of Chinese Medicine, Zhengzhou, China","institution_ids":["https://openalex.org/I160354188"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024587451","display_name":"Zhenzhen Guo","orcid":"https://orcid.org/0000-0002-3228-3741","observed_orcids":["https://orcid.org/0000-0002-3228-3741"]},"institutions":[{"id":"https://openalex.org/I4210110718","display_name":"Nanyang Normal University","ror":"https://ror.org/01f7yer47","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210110718"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhenzhen Guo","raw_affiliation_strings":["Henan Province Engineering Research Center of Zhang Zhongjing Classic Prescriptions Analysis and Development, Nanyang Normal University, Nanyang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Henan Province Engineering Research Center of Zhang Zhongjing Classic Prescriptions Analysis and Development, Nanyang Normal University, Nanyang, China","institution_ids":["https://openalex.org/I4210110718"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Baoying Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I160354188","display_name":"Henan University of Chinese Medicine","ror":"https://ror.org/01tsmvz08","country_code":"CN","type":"education","lineage":["https://openalex.org/I160354188"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Baoying Wang","raw_affiliation_strings":["Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, China","Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao, Henan Province, Henan University of Chinese Medicine, Zhengzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, China","institution_ids":["https://openalex.org/I160354188"]},{"raw_affiliation_string":"Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao, Henan Province, Henan University of Chinese Medicine, Zhengzhou, China","institution_ids":["https://openalex.org/I160354188"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yucheng Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I160354188","display_name":"Henan University of Chinese Medicine","ror":"https://ror.org/01tsmvz08","country_code":"CN","type":"education","lineage":["https://openalex.org/I160354188"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yucheng Li","raw_affiliation_strings":["Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, China","Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao, Henan Province, Henan University of Chinese Medicine, Zhengzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, China","institution_ids":["https://openalex.org/I160354188"]},{"raw_affiliation_string":"Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao, Henan Province, Henan University of Chinese Medicine, Zhengzhou, China","institution_ids":["https://openalex.org/I160354188"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091196284","display_name":"Erping Xu","orcid":"https://orcid.org/0000-0001-7384-9839","observed_orcids":["https://orcid.org/0000-0001-7384-9839","https://orcid.org/0000-0002-6610-1387"]},"institutions":[{"id":"https://openalex.org/I160354188","display_name":"Henan University of Chinese Medicine","ror":"https://ror.org/01tsmvz08","country_code":"CN","type":"education","lineage":["https://openalex.org/I160354188"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Erping Xu","raw_affiliation_strings":["Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, China","Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao, Henan Province, Henan University of Chinese Medicine, Zhengzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, China","institution_ids":["https://openalex.org/I160354188"]},{"raw_affiliation_string":"Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao, Henan Province, Henan University of Chinese Medicine, Zhengzhou, China","institution_ids":["https://openalex.org/I160354188"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5091196284"],"corresponding_institution_ids":["https://openalex.org/I160354188"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":1.4025,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.78188414,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":96},"biblio":{"volume":"16","issue":null,"first_page":"1644315","last_page":"1644315"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12626","display_name":"Cancer, Stress, Anesthesia, and Immune Response","score":0.9110999703407288,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12626","display_name":"Cancer, Stress, Anesthesia, and Immune Response","score":0.9110999703407288,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.06069999933242798,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13651","display_name":"Medicinal Plants and Bioactive Compounds","score":0.004900000058114529,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.8659999966621399},{"id":"https://openalex.org/keywords/chronic-stress","display_name":"chronic stress","score":0.8550000190734863},{"id":"https://openalex.org/keywords/chronic-unpredictable-mild-stress","display_name":"chronic unpredictable mild stress","score":0.871999979019165},{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.7689999938011169},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.9739999771118164},{"id":"https://openalex.org/keywords/rap1gap","display_name":"Rap1GAP","score":0.9649999737739563},{"id":"https://openalex.org/keywords/erk1-2-phosphorylation","display_name":"ERK1/2 phosphorylation","score":0.8730000257492065},{"id":"https://openalex.org/keywords/corticosterone","display_name":"corticosterone","score":0.8100000023841858},{"id":"https://openalex.org/keywords/cortisol","display_name":"cortisol","score":0.9290000200271606},{"id":"https://openalex.org/keywords/tumor-growth","display_name":"tumor growth","score":0.6809999942779541},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.7839999794960022},{"id":"https://openalex.org/keywords/traditional-chinese-medicine","display_name":"traditional Chinese medicine","score":0.6539999842643738},{"id":"https://openalex.org/keywords/herbal-formula","display_name":"herbal formula","score":0.48399999737739563}],"concepts":[{"id":"https://openalex.org/C76419328","wikidata":"https://www.wikidata.org/wiki/Q74419","display_name":"Epithelial\u2013mesenchymal transition","level":4,"score":0.7390955686569214},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.7388249635696411},{"id":"https://openalex.org/C2776179587","wikidata":"https://www.wikidata.org/wiki/Q54461864","display_name":"Rap1","level":3,"score":0.7129313945770264},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6277279257774353},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.6142351627349854},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.576930046081543},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5523815155029297},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.43577536940574646},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40151822566986084},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3699434995651245},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3277550935745239},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23504167795181274},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.10350635647773743}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fphar.2025.1644315","doi":"https://doi.org/10.3389/fphar.2025.1644315","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2025.1644315","pdf_url":"https://public-pages-files-2025.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1644315/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},{"id":"pmid:40786046","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40786046","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12332513","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12332513/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Pharmacol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:1cd1481378074915b610707760c31def","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/1cd1481378074915b610707760c31def","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Pharmacology, Vol 16 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fphar.2025.1644315","doi":"https://doi.org/10.3389/fphar.2025.1644315","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2025.1644315","pdf_url":"https://public-pages-files-2025.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1644315/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320317526","display_name":"Henan University of Chinese Medicine","ror":"https://ror.org/01tsmvz08"},{"id":"https://openalex.org/F4320322878","display_name":"Henan University","ror":"https://ror.org/003xyzq10"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4412918293.pdf","grobid_xml":"https://content.openalex.org/works/W4412918293.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W1560032775","https://openalex.org/W1963727743","https://openalex.org/W1989830384","https://openalex.org/W2084343441","https://openalex.org/W2151356556","https://openalex.org/W2548665248","https://openalex.org/W2552386543","https://openalex.org/W2566451247","https://openalex.org/W2587062450","https://openalex.org/W2796336382","https://openalex.org/W2888413393","https://openalex.org/W2902038118","https://openalex.org/W2943005115","https://openalex.org/W2972373703","https://openalex.org/W2981115917","https://openalex.org/W3075199484","https://openalex.org/W3083741621","https://openalex.org/W3096477926","https://openalex.org/W3097511607","https://openalex.org/W3124808705","https://openalex.org/W3130096279","https://openalex.org/W3138873660","https://openalex.org/W3146961678","https://openalex.org/W3158985447","https://openalex.org/W3166851108","https://openalex.org/W3183340257","https://openalex.org/W3187706513","https://openalex.org/W3216852312","https://openalex.org/W4200417257","https://openalex.org/W4282967881","https://openalex.org/W4283315190","https://openalex.org/W4301394077","https://openalex.org/W4386924168","https://openalex.org/W4387330567","https://openalex.org/W4387602070","https://openalex.org/W4390577739","https://openalex.org/W4392039528","https://openalex.org/W4400922141","https://openalex.org/W4402641557","https://openalex.org/W4404598604","https://openalex.org/W4406855520"],"related_works":["https://openalex.org/W4414677412","https://openalex.org/W7160246422","https://openalex.org/W3209479177","https://openalex.org/W3025889786","https://openalex.org/W1855655862","https://openalex.org/W2521861590","https://openalex.org/W4388235826","https://openalex.org/W2731845861","https://openalex.org/W3108195178","https://openalex.org/W2332761735"],"abstract_inverted_index":{"Background":[0],"Chaihu":[1],"Longgu":[2],"Muli":[3],"Decoction":[4],"(CLM)":[5],"is":[6,42,288],"a":[7,144,191,289,307],"classical":[8],"herbal":[9],"formula":[10],"originally":[11],"documented":[12],"in":[13,30,57,114,139,190,227,249,269],"Shang":[14],"Han":[15],"Lun.":[16],"With":[17],"an":[18],"1800-year":[19],"clinical":[20],"history,":[21],"CLM":[22,56,83,99,131,172,231,242,262,297],"remains":[23,60],"widely":[24],"prescribed":[25],"for":[26],"depression":[27,41],"(\u201cYu":[28],"Zheng\u201d":[29],"Traditional":[31],"Chinese":[32],"Medicine":[33],"theory).":[34],"Emerging":[35],"evidence":[36],"suggests":[37],"that":[38,202,285],"chronic":[39,71,292],"stress-induced":[40],"closely":[43],"linked":[44],"to":[45,78,92,111,125,310],"lung":[46,64,85,102,140,146,155,193,228,250,294],"cancer":[47,65,86,103,141,147,156,194,229,251,295],"progression":[48,138],"and":[49,107,143,167,220,247,253,266],"metastasis.":[50],"However,":[51],"the":[52,80,94,127,160,163,211],"therapeutic":[53,128,300],"potential":[54],"of":[55,82,130,162,210,291],"this":[58,304],"context":[59],"unexplored.":[61],"Methods":[62],"A":[63],"cell":[66],"xenograft":[67,157],"model":[68,195],"combined":[69,196],"with":[70,197,208],"unpredictable":[72],"mild":[73],"stress":[74],"(CUMS)":[75],"was":[76,90],"used":[77],"evaluate":[79],"effect":[81],"on":[84,132],"growth.":[87,185,280],"Proteomic":[88,199],"analysis":[89,200],"performed":[91],"explore":[93],"underlying":[95],"mechanisms":[96],"by":[97,236,258,302],"which":[98],"alleviates":[100],"CUMS-induced":[101,177],"progression.":[104,119,296],"Western":[105],"blot":[106],"qPCR":[108],"were":[109,123,188,206,256],"conducted":[110],"detect":[112],"changes":[113],"Rap1/ERK-mediated":[115,238,286],"epithelial-mesenchymal":[116],"transition":[117],"(EMT)":[118],"Finally,":[120],"Rap1":[121,212,219,259,272],"agonists":[122],"utilized":[124],"determine":[126],"mechanism":[129],"cortisol":[133],"or":[134],"corticosterone":[135],"(Cort)-induced":[136],"EMT":[137,226,248,265,287],"cells":[142],"mouse":[145],"model.":[148],"Results":[149],"In":[150,240],"our":[151],"study,":[152],"CUMS":[153,215],"promoted":[154],"growth,":[158],"increased":[159],"expression":[161],"proliferation":[164],"marker":[165],"Ki67,":[166],"elevated":[168],"serum":[169],"Cort":[170],"levels.":[171],"treatment":[173],"not":[174],"only":[175],"alleviated":[176],"depression-like":[178,267],"behaviors,":[179],"but":[180],"also":[181],"suppressed":[182,243],"stress-driven":[183],"tumor":[184,279],"These":[186,282],"effects":[187,205,235,255,301],"replicated":[189],"urethane-induced":[192],"CUMS.":[198],"revealed":[201],"CLM\u2019s":[203,275],"anti-tumor":[204],"associated":[207],"modulation":[209],"pathway.":[213],"Mechanistically,":[214],"downregulated":[216],"Rap1GAP,":[217],"activating":[218],"subsequent":[221],"ERK1/2":[222],"phosphorylation,":[223],"thereby":[224],"promoting":[225],"tissues.":[230],"effectively":[232],"reversed":[233],"these":[234,254],"inhibiting":[237],"EMT.":[239],"vitro,":[241],"cortisol-induced":[244],"migration,":[245],"invasion,":[246],"cells,":[252],"attenuated":[257],"agonists.":[260],"Furthermore,":[261],"inhibited":[263],"Cort-induced":[264],"behaviors":[268],"vivo,":[270],"while":[271],"activation":[273],"diminished":[274],"efficacy":[276],"against":[277],"Cort-driven":[278],"Conclusion":[281],"findings":[283],"suggest":[284],"hallmark":[290],"stress-associated":[293],"exerts":[298],"its":[299],"targeting":[303],"pathway,":[305],"offering":[306],"novel":[308],"strategy":[309],"mitigate":[311],"stress-aggravated":[312],"oncogenesis.":[313]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2025-10-10T00:00:00"}
