{"id":"https://openalex.org/W4412909855","doi":"https://doi.org/10.1093/mam/ozaf048.416","title":"Adrenal Zona Fasciculata Nuclei of Gerbils Fed a High-Carbohydrate Diet: A Morphological and Textural Analysis","display_name":"Adrenal Zona Fasciculata Nuclei of Gerbils Fed a High-Carbohydrate Diet: A Morphological and Textural Analysis","publication_year":2025,"publication_date":"2025-07-01","ids":{"openalex":"https://openalex.org/W4412909855","doi":"https://doi.org/10.1093/mam/ozaf048.416"},"language":"en","primary_location":{"id":"doi:10.1093/mam/ozaf048.416","doi":"https://doi.org/10.1093/mam/ozaf048.416","is_oa":true,"landing_page_url":"https://doi.org/10.1093/mam/ozaf048.416","pdf_url":"https://academic.oup.com/mam/article-pdf/31/Supplement_1/ozaf048.416/63845575/ozaf048.416.pdf","source":{"id":"https://openalex.org/S98208149","display_name":"Microscopy and Microanalysis","issn_l":"1431-9276","issn":["1431-9276","1435-8115"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microscopy and Microanalysis","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/mam/article-pdf/31/Supplement_1/ozaf048.416/63845575/ozaf048.416.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061337753","display_name":"Zineb Bellahreche","orcid":"https://orcid.org/0000-0001-9476-9846","observed_orcids":["https://orcid.org/0000-0001-9476-9846"]},"institutions":[{"id":"https://openalex.org/I157169809","display_name":"University of Sciences and Technology Houari Boumediene","ror":"https://ror.org/02kb89c09","country_code":"DZ","type":"education","lineage":["https://openalex.org/I157169809"]}],"countries":["DZ"],"is_corresponding":true,"raw_author_name":"Zineb Bellahreche","raw_affiliation_strings":["LBPO/ Nutrition & metabolism, Department of Biology and Physiology of Organisms, Faculty of Biological Sciences, University of Sciences and Technology Houari Boumediene (USTHB) , Algiers ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"LBPO/ Nutrition & metabolism, Department of Biology and Physiology of Organisms, Faculty of Biological Sciences, University of Sciences and Technology Houari Boumediene (USTHB) , Algiers ,","institution_ids":["https://openalex.org/I157169809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004195691","display_name":"Nesrine Semiane","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157169809","display_name":"University of Sciences and Technology Houari Boumediene","ror":"https://ror.org/02kb89c09","country_code":"DZ","type":"education","lineage":["https://openalex.org/I157169809"]}],"countries":["DZ"],"is_corresponding":false,"raw_author_name":"Nesrine Semiane","raw_affiliation_strings":["LBPO/ Nutrition & metabolism, Department of Biology and Physiology of Organisms, Faculty of Biological Sciences, University of Sciences and Technology Houari Boumediene (USTHB) , Algiers ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"LBPO/ Nutrition & metabolism, Department of Biology and Physiology of Organisms, Faculty of Biological Sciences, University of Sciences and Technology Houari Boumediene (USTHB) , Algiers ,","institution_ids":["https://openalex.org/I157169809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003660649","display_name":"Ouahiba Sihali-Beloui","orcid":"https://orcid.org/0000-0002-6638-6394","observed_orcids":["https://orcid.org/0000-0002-6638-6394"]},"institutions":[{"id":"https://openalex.org/I157169809","display_name":"University of Sciences and Technology Houari Boumediene","ror":"https://ror.org/02kb89c09","country_code":"DZ","type":"education","lineage":["https://openalex.org/I157169809"]}],"countries":["DZ"],"is_corresponding":false,"raw_author_name":"Ouahiba Sihali-Beloui","raw_affiliation_strings":["LBPO/ Nutrition & metabolism, Department of Biology and Physiology of Organisms, Faculty of Biological Sciences, University of Sciences and Technology Houari Boumediene (USTHB) , Algiers ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"LBPO/ Nutrition & metabolism, Department of Biology and Physiology of Organisms, Faculty of Biological Sciences, University of Sciences and Technology Houari Boumediene (USTHB) , Algiers ,","institution_ids":["https://openalex.org/I157169809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113785998","display_name":"Aicha Mallek","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157169809","display_name":"University of Sciences and Technology Houari Boumediene","ror":"https://ror.org/02kb89c09","country_code":"DZ","type":"education","lineage":["https://openalex.org/I157169809"]}],"countries":["DZ"],"is_corresponding":false,"raw_author_name":"Aicha Mallek","raw_affiliation_strings":["LBPO/ Nutrition & metabolism, Department of Biology and Physiology of Organisms, Faculty of Biological Sciences, University of Sciences and Technology Houari Boumediene (USTHB) , Algiers ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"LBPO/ Nutrition & metabolism, Department of Biology and Physiology of Organisms, Faculty of Biological Sciences, University of Sciences and Technology Houari Boumediene (USTHB) , Algiers ,","institution_ids":["https://openalex.org/I157169809"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113305649","display_name":"Y. Dahmani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157169809","display_name":"University of Sciences and Technology Houari Boumediene","ror":"https://ror.org/02kb89c09","country_code":"DZ","type":"education","lineage":["https://openalex.org/I157169809"]}],"countries":["DZ"],"is_corresponding":false,"raw_author_name":"Yasmina Dahmani","raw_affiliation_strings":["LBPO/ Nutrition & metabolism, Department of Biology and Physiology of Organisms, Faculty of Biological Sciences, University of Sciences and Technology Houari Boumediene (USTHB) , Algiers ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"LBPO/ Nutrition & metabolism, Department of Biology and Physiology of Organisms, Faculty of Biological Sciences, University of Sciences and Technology Houari Boumediene (USTHB) , Algiers ,","institution_ids":["https://openalex.org/I157169809"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5061337753"],"corresponding_institution_ids":["https://openalex.org/I157169809"],"apc_list":{"value":3554,"currency":"USD","value_usd":3554},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.20858909,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"31","issue":"Supplement_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12964","display_name":"Diet, Metabolism, and Disease","score":0.3167000114917755,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12964","display_name":"Diet, Metabolism, and Disease","score":0.3167000114917755,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.14059999585151672,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.11620000004768372,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adrenal-zona-fasciculata","display_name":"adrenal zona fasciculata","score":0.8640000224113464},{"id":"https://openalex.org/keywords/high-carbohydrate-diet","display_name":"high-carbohydrate diet","score":0.902999997138977},{"id":"https://openalex.org/keywords/glucocorticoids","display_name":"glucocorticoids","score":0.7319999933242798},{"id":"https://openalex.org/keywords/cortisol","display_name":"cortisol","score":0.968999981880188},{"id":"https://openalex.org/keywords/nuclear-morphology","display_name":"nuclear morphology","score":0.6639999747276306},{"id":"https://openalex.org/keywords/nuclear-texture","display_name":"nuclear texture","score":0.7599999904632568},{"id":"https://openalex.org/keywords/fractal-dimension","display_name":"fractal dimension","score":0.7289999723434448},{"id":"https://openalex.org/keywords/euchromatin","display_name":"euchromatin","score":0.7559999823570251},{"id":"https://openalex.org/keywords/heterochromatin","display_name":"heterochromatin","score":0.9929999709129333},{"id":"https://openalex.org/keywords/chromatin-organization","display_name":"chromatin organization","score":0.8679999709129333},{"id":"https://openalex.org/keywords/gerbils","display_name":"gerbils","score":0.6399999856948853},{"id":"https://openalex.org/keywords/nutrient-stress","display_name":"nutritional stress","score":0.5180000066757202},{"id":"https://openalex.org/keywords/nuclear-surface-area","display_name":"nuclear surface area","score":0.5389999747276306},{"id":"https://openalex.org/keywords/transmission-electron-microscopy","display_name":"transmission electron microscopy","score":0.42399999499320984}],"concepts":[{"id":"https://openalex.org/C2778736161","wikidata":"https://www.wikidata.org/wiki/Q3301573","display_name":"Zona fasciculata","level":3,"score":0.6744325160980225},{"id":"https://openalex.org/C2780188749","wikidata":"https://www.wikidata.org/wiki/Q134492","display_name":"Zona","level":4,"score":0.45827174186706543},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3918999433517456},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3745250701904297},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3528215289115906},{"id":"https://openalex.org/C2780694816","wikidata":"https://www.wikidata.org/wiki/Q712294","display_name":"Adrenal gland","level":2,"score":0.19912481307983398},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17404323816299438},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.06123536825180054},{"id":"https://openalex.org/C2780727368","wikidata":"https://www.wikidata.org/wiki/Q1928978","display_name":"Viral disease","level":3,"score":0.0},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1093/mam/ozaf048.416","doi":"https://doi.org/10.1093/mam/ozaf048.416","is_oa":true,"landing_page_url":"https://doi.org/10.1093/mam/ozaf048.416","pdf_url":"https://academic.oup.com/mam/article-pdf/31/Supplement_1/ozaf048.416/63845575/ozaf048.416.pdf","source":{"id":"https://openalex.org/S98208149","display_name":"Microscopy and Microanalysis","issn_l":"1431-9276","issn":["1431-9276","1435-8115"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microscopy and Microanalysis","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1093/mam/ozaf048.416","doi":"https://doi.org/10.1093/mam/ozaf048.416","is_oa":true,"landing_page_url":"https://doi.org/10.1093/mam/ozaf048.416","pdf_url":"https://academic.oup.com/mam/article-pdf/31/Supplement_1/ozaf048.416/63845575/ozaf048.416.pdf","source":{"id":"https://openalex.org/S98208149","display_name":"Microscopy and Microanalysis","issn_l":"1431-9276","issn":["1431-9276","1435-8115"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microscopy and Microanalysis","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4412909855.pdf","grobid_xml":"https://content.openalex.org/works/W4412909855.grobid-xml"},"referenced_works_count":3,"referenced_works":["https://openalex.org/W2802499193","https://openalex.org/W3036637668","https://openalex.org/W4386046853"],"related_works":["https://openalex.org/W4205353898","https://openalex.org/W2911964474","https://openalex.org/W4386046853","https://openalex.org/W2324483331","https://openalex.org/W4413006009","https://openalex.org/W2965514021","https://openalex.org/W2030327807","https://openalex.org/W308455083","https://openalex.org/W2921562517","https://openalex.org/W4312553444"],"abstract_inverted_index":{"The":[0,56,450,535,549],"adrenal":[1,34,283,379,386,442,447,465,478],"cortex":[2],"plays":[3],"a":[4,42,63,68,76,190,233,239,257,262,324,396,417,438,509],"critical":[5],"role":[6],"in":[7,30,38,183,193,199,212,223,235,241,251,259,276],"the":[8,31,107,119,132,184,200,277,294,300,316,320,343,361,428,453,463,472],"regulation":[9],"of":[10,17,33,265,385,437,462,474,572],"metabolic":[11],"and":[12,27,47,50,71,94,116,128,140,176,197,222,256,306,319,334,336,393,423,446,457,484,498,574],"stress":[13,228],"responses":[14],"through":[15],"secretion":[16],"glucocorticoids,":[18],"particularly":[19],"cortisol.":[20],"In":[21,359],"this":[22],"study,":[23],"we":[24],"investigated":[25],"morphological":[26],"textural":[28,330,371],"changes":[29,269],"nuclei":[32,112,445,468],"fasciculata":[35,111,388,444,467],"zone":[36],"cells":[37],"gerbils":[39,57,224,321,394],"submitted":[40],"to":[41,130,204,226,298,323,409,545],"high-carbohydrate":[43,77,278,325,362,397,439,510],"diet":[44,70,78,279,326,363,398,440,475,547],"(high":[45],"fructose":[46],"glucose":[48],"diet)":[49],"their":[51],"correlation":[52],"with":[53,98,125,272,342,370,378],"cell":[54],"hyperactivity.":[55],"were":[58,86,96,113,152,270,339,469,501],"divided":[59],"into":[60],"two":[61],"groups:":[62],"control":[64,317,344,504,541],"group":[65,74,202,318,364,391],"(CD)":[66,392],"fed":[67,75,395,508],"standard":[69],"an":[72,99,249,410],"experimental":[73,185],"for":[79,88,160,414,420],"20":[80],"weeks":[81],"(HCD).":[82],"Adrenal":[83],"tissue":[84],"samples":[85],"processed":[87,115],"transmission":[89],"electron":[90,100],"microscopy":[91],"(TEM)":[92],"imaging":[93],"sections":[95],"viewed":[97],"microscope":[101],"(Zeiss":[102],"Gemini":[103],"SEM),":[104],"focusing":[105],"on":[106,293,441,452,476],"zona":[108,387,443,466],"fasciculata.":[109],"Zona":[110],"individually":[114],"analyzed":[117],"using":[118,154],"freely":[120],"available":[121],"software":[122,157],"Fiji/ImageJ":[123],"(https://imagej.net/FijI/Downloads)":[124],"pre-developed":[126],"plugins":[127],"macros":[129],"determine":[131],"circularity":[133,198],"(in":[134],"shape":[135],"descriptor),":[136],"GLCM":[137,245,415,485],"texture":[138,246,368,486],"parameters,":[139],"fractal":[141,236,337,429,482],"analysis.":[142],"It":[143],"was":[144,291,407,424],"performed":[145,153,292],"as":[146,215,515],"previously":[147],"described":[148],"[1].":[149,229],"Statistical":[150],"analyses":[151],"GraphPad":[155],"Prism":[156],"(version":[158],"10.00":[159],"Windows,":[161],"San":[162],"Diego,":[163],"CA,":[164],"USA).":[165],"Nuclei":[166],"analysis":[167,231,247,289,312,538],"revealed":[168],"significant":[169,191],"nuclear":[170,194,303,332,353,367],"changes,":[171],"including":[172],"increased":[173,180],"euchromatin":[174],"content":[175],"reduced":[177],"heterochromatin,":[178],"indicating":[179],"transcriptional":[181],"activity":[182],"group.":[186],"We":[187],"also":[188],"reported":[189],"decrease":[192,234,258],"surface":[195],"area":[196,333,460],"HCD":[201],"compared":[203],"CD.":[205],"Nuclear":[206],"contour":[207],"irregularity":[208],"has":[209],"been":[210],"detected":[211],"pathologies":[213],"such":[214],"cancer":[216],"[2],":[217],"type":[218],"2":[219,433],"diabetes":[220],"[3],":[221],"subjected":[225,322,544],"nutritional":[227],"Fractal":[230],"showed":[232,248],"dimension,":[237],"suggesting":[238,346],"reduction":[240],"chromatin":[242,266,307],"complexity,":[243],"whereas":[244],"increase":[250],"angular":[252,372,489],"second":[253,373,490,567],"momentum":[254],"(ASM)":[255,375],"entropy,":[260,331],"reflecting":[261],"greater":[263],"uniformity":[264],"texture.":[267],"These":[268],"associated":[271,341],"elevated":[273],"cortisol":[274,380,448,479,554],"levels":[275],"group,":[280,345],"thus":[281],"confirming":[282],"hyperactivity":[284],"(Fig.":[285,327],"1).":[286],"Principal":[287],"component":[288,537],"(PCA)":[290],"eight":[295],"studied":[296],"variables":[297,550],"disentangle":[299],"associations":[301],"between":[302,315],"texture,":[304],"shape,":[305],"quantity":[308],"across":[309],"gerbils.":[310],"This":[311],"effectively":[313],"distinguished":[314],"2).":[328],"Notably,":[329],"circularity,":[335,456],"dimension":[338],"strongly":[340],"that":[347],"these":[348],"parameters":[349],"may":[350],"reflect":[351],"stable":[352],"organization":[354],"under":[355],"normal":[356],"physiological":[357],"conditions.":[358],"contrast,":[360],"exhibited":[365],"distinct":[366],"features,":[369],"moment":[374,491,496],"positively":[376],"correlated":[377],"content.":[381],"A.":[382],"Representative":[383],"photomicrographs":[384],"nuclei.":[389],"Control":[390],"(HCD)":[399],"are":[400,513,520],"shown.":[401],"A":[402],"single":[403],"nucleus":[404],"per":[405],"photomicrograph":[406],"converted":[408],"8-bit":[411],"grayscale":[412],"format":[413],"analysis,":[416],"threshold":[418],"method":[419],"heterochromatin":[421,459],"quantification,":[422],"binarized":[425],"before":[426],"calculating":[427],"dimension.":[430],"Scale":[431],"bars:":[432],"\u00b5m.":[434],"B.":[435],"Effects":[436],"levels.":[449],"effects":[451],"area,":[454],"C.":[455],"D.":[458],"fraction":[461,571],"gerbil":[464],"analyzed.":[470],"Additionally,":[471],"impact":[473],"E.":[477],"levels,":[480,555],"F.":[481],"dimensions":[483],"parameters:":[487],"G.":[488],"(ASM),":[492],"H.":[493],"inverse":[494],"difference":[495,577],"(IDM)":[497],"I.":[499],"entropy":[500],"assessed.":[502],"CD,":[503],"animals;":[505],"HCD,":[506],"animals":[507,543],"diet.":[511],"Values":[512],"presented":[514],"mean":[516],"\u00b1":[517],"SEM.":[518],"Comparisons":[519],"statistically":[521],"significant:":[522],"ns":[523],"(not":[524],"significant)":[525],"P":[526],"\u2265":[527],"0.05;":[528,531],"*P":[529],"<":[530,533],"***P":[532],"0.001.":[534],"principal":[536],"(PCA).":[539],"CD":[540],",HCD":[542],"high-carbohydrates":[546],".":[548],"were:":[551],"AC":[552],"(adrenal":[553],"Area,":[556],"Circ":[557],"(nuclear":[558],"circularity),":[559],"ENT":[560],"(entropy),":[561],"FD":[562],"(fractal":[563],"dimension),":[564],"ASM":[565],"(angular":[566],"moment),":[568],"HAF":[569],"(area":[570],"heterochromatin)":[573],"IDM":[575],"(inverse":[576],"moment).":[578]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2025-10-10T00:00:00"}
