{"id":"https://openalex.org/W4412904356","doi":"https://doi.org/10.69857/joapr.v13i3.1107","title":"Spectrophotometric methods for determination of naringin, amlodipine, and nifedipine using chemometric techniques","display_name":"Spectrophotometric methods for determination of naringin, amlodipine, and nifedipine using chemometric techniques","publication_year":2025,"publication_date":"2025-06-01","ids":{"openalex":"https://openalex.org/W4412904356","doi":"https://doi.org/10.69857/joapr.v13i3.1107"},"language":"en","primary_location":{"id":"pmh:oai:doaj.org/article:5a7c84ac43f94e73880c4c155c763dae","doi":"https://doi.org/10.69857/joapr.v13i3.1107","is_oa":true,"landing_page_url":"https://doaj.org/article/5a7c84ac43f94e73880c4c155c763dae","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Applied Pharmaceutical Research, Vol 13, Iss 3, Pp 154-163 (2025)","raw_type":"article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["doaj"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doaj.org/article/5a7c84ac43f94e73880c4c155c763dae","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5095642195","display_name":"Vishala Rani Baraily","orcid":"https://orcid.org/0000-0001-6993-8775","observed_orcids":["https://orcid.org/0000-0001-6993-8775"]},"institutions":[{"id":"https://openalex.org/I49068896","display_name":"Assam Down Town University","ror":"https://ror.org/039p5s648","country_code":"IN","type":"education","lineage":["https://openalex.org/I49068896"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Vishala Rani Baraily","raw_affiliation_strings":["Assam down town University, Panikhaiti, Guwahati, Assam, 781026, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Assam down town University, Panikhaiti, Guwahati, Assam, 781026, India","institution_ids":["https://openalex.org/I49068896"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081213293","display_name":"Jithendar Reddy Mandhadi","orcid":"https://orcid.org/0000-0002-4854-9452","observed_orcids":["https://orcid.org/0000-0002-4854-9452"]},"institutions":[{"id":"https://openalex.org/I49068896","display_name":"Assam Down Town University","ror":"https://ror.org/039p5s648","country_code":"IN","type":"education","lineage":["https://openalex.org/I49068896"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Jithendar Reddy  Mandhadi","raw_affiliation_strings":["Assam down town University, Panikhaiti, Guwahati, Assam, 781026, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Assam down town University, Panikhaiti, Guwahati, Assam, 781026, India","institution_ids":["https://openalex.org/I49068896"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048210010","display_name":"Bhupendra Shrestha","orcid":"https://orcid.org/0009-0000-1073-0603","observed_orcids":["https://orcid.org/0009-0000-1073-0603"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bhupendra  Shrestha","raw_affiliation_strings":["Himalayan Pharmacy Institute, Majhitar, East Sikkim 737136, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Himalayan Pharmacy Institute, Majhitar, East Sikkim 737136, India","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5078,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.47655116,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":96},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10640","display_name":"Spectroscopy and Chemometric Analyses","score":0.7851999998092651,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10640","display_name":"Spectroscopy and Chemometric Analyses","score":0.7851999998092651,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.21089999377727509,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11709","display_name":"Traditional Chinese Medicine Analysis","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/naringin","display_name":"naringin","score":0.9959999918937683},{"id":"https://openalex.org/keywords/amlodipine","display_name":"amlodipine","score":1.0},{"id":"https://openalex.org/keywords/nifedipine","display_name":"nifedipine","score":1.0},{"id":"https://openalex.org/keywords/orthogonal-partial-least-squares","display_name":"orthogonal partial least squares","score":0.8529999852180481},{"id":"https://openalex.org/keywords/simultaneous-determination","display_name":"simultaneous determination","score":0.8769999742507935},{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":0.6520000100135803},{"id":"https://openalex.org/keywords/calcium-channel-blockers","display_name":"calcium channel blockers","score":0.996999979019165},{"id":"https://openalex.org/keywords/uv-vis-spectroscopy","display_name":"UV-Vis spectroscopy","score":0.8820000290870667},{"id":"https://openalex.org/keywords/chemometrics","display_name":"chemometrics","score":0.6990000009536743},{"id":"https://openalex.org/keywords/pharmaceutical-quality-control","display_name":"pharmaceutical quality control","score":0.6449999809265137},{"id":"https://openalex.org/keywords/overlapping-spectra","display_name":"overlapping spectra","score":0.4650000035762787}],"concepts":[{"id":"https://openalex.org/C2777335409","wikidata":"https://www.wikidata.org/wiki/Q418469","display_name":"Naringin","level":2,"score":0.947759747505188},{"id":"https://openalex.org/C2779066535","wikidata":"https://www.wikidata.org/wiki/Q39111","display_name":"Nifedipine","level":3,"score":0.8306450843811035},{"id":"https://openalex.org/C2779646130","wikidata":"https://www.wikidata.org/wiki/Q411347","display_name":"Amlodipine","level":3,"score":0.7700638175010681},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.5536254644393921},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4914180040359497},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3524366021156311},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.26431238651275635},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18103930354118347},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.07930770516395569},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:doaj.org/article:5a7c84ac43f94e73880c4c155c763dae","doi":"https://doi.org/10.69857/joapr.v13i3.1107","is_oa":true,"landing_page_url":"https://doaj.org/article/5a7c84ac43f94e73880c4c155c763dae","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Applied Pharmaceutical Research, Vol 13, Iss 3, Pp 154-163 (2025)","raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:doaj.org/article:5a7c84ac43f94e73880c4c155c763dae","doi":"https://doi.org/10.69857/joapr.v13i3.1107","is_oa":true,"landing_page_url":"https://doaj.org/article/5a7c84ac43f94e73880c4c155c763dae","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Applied Pharmaceutical Research, Vol 13, Iss 3, Pp 154-163 (2025)","raw_type":"article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4390863720","https://openalex.org/W7170063232","https://openalex.org/W4411710176","https://openalex.org/W3112546369","https://openalex.org/W4214527891","https://openalex.org/W2084040172","https://openalex.org/W3035656188","https://openalex.org/W2528941998","https://openalex.org/W3202836960","https://openalex.org/W2006048789"],"abstract_inverted_index":{"Background:":[0],"Chemometrics":[1],"articulates":[2],"statistical":[3],"and":[4,42,72,80,113,132,136,152,174,229,241],"mathematical":[5],"aspects":[6],"to":[7,83,188],"analyse":[8],"the":[9,22,28,36,66,126,178,192,195],"effectiveness":[10,193],"of":[11,39,78,96,128,142,147,194,224],"chemical":[12],"data,":[13,214],"playing":[14],"a":[15,44,50,85,207],"pivotal":[16],"role":[17],"in":[18,63,75,231],"spectroscopy.":[19],"Among":[20],"all":[21],"chemometrics":[23,225],"techniques,":[24],"this":[25],"study":[26],"utilizes":[27],"Orthogonal":[29],"partial":[30],"least":[31],"squares":[32],"(OPLS)":[33],"model":[34,87,117,159,162],"for":[35,69,88,101,130,134,150,155,210,238],"simultaneous":[37,76],"analysis":[38,176,218,233],"naringin,":[40],"amlodipine,":[41],"nifedipine,":[43],"well-established":[45],"calcium":[46],"channel":[47],"blocker.":[48],"Naringin,":[49],"citrus":[51],"flavonoid":[52],"exhibiting":[53],"notable":[54],"pharmacological":[55],"activities.":[56],"Methodology:":[57],"This":[58],"research":[59,199],"employs":[60],"UV-visible":[61],"spectrophotometry":[62],"conjunction":[64],"with":[65,122,219],"OPLS":[67,116,201],"method":[68],"both":[70],"calibration":[71,105,131],"prediction":[73],"sets":[74,106],"studies":[77,184],"Amlodipine\u2013Naringin":[79],"Nifedipine\u2013Naringin,":[81],"aiming":[82],"develop":[84],"precise":[86],"measuring":[89],"drug":[90,217],"concentrations.":[91],"A":[92],"linear":[93],"dynamic":[94],"range":[95,127],"5-20":[97],"\u00b5g/mL":[98],"was":[99],"achieved":[100],"standard":[102],"solutions,":[103],"while":[104,234],"were":[107],"developed":[108],"using":[109,165],"factorial":[110],"designs.":[111],"Result":[112],"Discussion:":[114],"The":[115,161,182,198,222],"had":[118],"significant":[119,172],"predictive":[120],"performance":[121],"R2":[123],"values":[124,146,186],"within":[125],"0.9947-0.9976":[129],"0.9947-0.9985":[133],"prediction,":[135],"low":[137],"root":[138],"mean":[139],"square":[140],"error":[141],"cross":[143],"validation":[144,163],"(RMSECV)":[145],"0.6191-":[148],"0.4353":[149],"NIF-NAR,":[151],"0.3978-":[153],"0.4418":[154],"AML-NAR,":[156],"indicating":[157],"robust":[158],"performance.":[160],"process,":[164],"Hotelling\u2019s":[166],"T2":[167],"test,":[168],"DModx,":[169],"established":[170],"no":[171],"outliers,":[173],"permutation":[175],"validated":[177],"model\u2019s":[179],"reliable":[180],"fit.":[181],"recovery":[183],"showed":[185],"close":[187],"100%,":[189],"thus":[190],"verifying":[191],"methodology.":[196],"Conclusion:":[197],"demonstrated":[200,227],"(Orthogonal":[202],"Partial":[203],"Least":[204],"Squares)":[205],"as":[206],"powerful":[208],"solution":[209],"resolving":[211],"overlapping":[212],"spectral":[213],"providing":[215],"high-precision":[216],"minimal":[220],"interference.":[221],"development":[223],"methods":[226],"efficiency":[228],"precision":[230],"pharmaceutical":[232],"also":[235],"offering":[236],"cost-effectiveness":[237],"quality":[239],"control":[240],"formulation":[242],"development.":[243]},"counts_by_year":[{"year":2026,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-10-10T00:00:00"}