{"id":"https://openalex.org/W4412902602","doi":"https://doi.org/10.1002/anie.202508562","title":"Expanding the Repertoire of Photoswitchable Unnatural Amino Acids for Enzyme Engineering","display_name":"Expanding the Repertoire of Photoswitchable Unnatural Amino Acids for Enzyme Engineering","publication_year":2025,"publication_date":"2025-08-04","ids":{"openalex":"https://openalex.org/W4412902602","doi":"https://doi.org/10.1002/anie.202508562","pmid":"https://pubmed.ncbi.nlm.nih.gov/40757918","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12435433"},"language":"en","primary_location":{"id":"doi:10.1002/anie.202508562","doi":"https://doi.org/10.1002/anie.202508562","is_oa":true,"landing_page_url":"https://doi.org/10.1002/anie.202508562","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/anie.202508562","source":{"id":"https://openalex.org/S67393510","display_name":"Angewandte Chemie International Edition","issn_l":"1433-7851","issn":["1433-7851","1521-3773"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Angewandte Chemie International Edition","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/anie.202508562","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100205674","display_name":"Caroline Hiefinger","orcid":"https://orcid.org/0009-0000-4587-9248","observed_orcids":["https://orcid.org/0009-0000-4587-9248"]},"institutions":[{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Caroline Hiefinger","raw_affiliation_strings":["Institute of Biophysics and Physical Biochemistry and Regensburg Center for Biochemistry University of Regensburg, Universit\u00e4tsstra\u00dfe 31  D\u201093053 Regensburg Germany","Both authors contributed equally to this work"],"raw_orcid":"https://orcid.org/0009-0000-4587-9248","affiliations":[{"raw_affiliation_string":"Institute of Biophysics and Physical Biochemistry and Regensburg Center for Biochemistry University of Regensburg, Universit\u00e4tsstra\u00dfe 31  D\u201093053 Regensburg Germany","institution_ids":["https://openalex.org/I60668342"]},{"raw_affiliation_string":"Both authors contributed equally to this work","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Michela Marcon","orcid":"https://orcid.org/0000-0002-1201-1677","observed_orcids":["https://orcid.org/0000-0002-1201-1677"]},"institutions":[{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Michela Marcon","raw_affiliation_strings":["Institute of Organic Chemistry University of Regensburg, Universit\u00e4tsstra\u00dfe 31  D\u201093053 Regensburg Germany","Both authors contributed equally to this work"],"raw_orcid":"https://orcid.org/0000-0002-1201-1677","affiliations":[{"raw_affiliation_string":"Institute of Organic Chemistry University of Regensburg, Universit\u00e4tsstra\u00dfe 31  D\u201093053 Regensburg Germany","institution_ids":["https://openalex.org/I60668342"]},{"raw_affiliation_string":"Both authors contributed equally to this work","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5117275656","display_name":"Verena Pape","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Verena Pape","raw_affiliation_strings":["Institute of Biophysics and Physical Biochemistry and Regensburg Center for Biochemistry University of Regensburg, Universit\u00e4tsstra\u00dfe 31  D\u201093053 Regensburg Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biophysics and Physical Biochemistry and Regensburg Center for Biochemistry University of Regensburg, Universit\u00e4tsstra\u00dfe 31  D\u201093053 Regensburg Germany","institution_ids":["https://openalex.org/I60668342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022064979","display_name":"Guillem Casadevall","orcid":"https://orcid.org/0000-0003-4442-1600","observed_orcids":["https://orcid.org/0000-0003-4442-1600"]},"institutions":[{"id":"https://openalex.org/I251424209","display_name":"Universitat de Girona","ror":"https://ror.org/01xdxns91","country_code":"ES","type":"education","lineage":["https://openalex.org/I251424209"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Guillem Casadevall","raw_affiliation_strings":["Institut de Qu\u00edmica Computacional i Cat\u00e0lisi and Departament de Qu\u00edmica Universitat de Girona  c/ Maria Aur\u00e8lia Capmany 69 Girona 17003 Spain"],"raw_orcid":"https://orcid.org/0000-0003-4442-1600","affiliations":[{"raw_affiliation_string":"Institut de Qu\u00edmica Computacional i Cat\u00e0lisi and Departament de Qu\u00edmica Universitat de Girona  c/ Maria Aur\u00e8lia Capmany 69 Girona 17003 Spain","institution_ids":["https://openalex.org/I251424209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033519008","display_name":"Ranit Lahmy","orcid":"https://orcid.org/0000-0002-9432-7455","observed_orcids":["https://orcid.org/0000-0002-9432-7455"]},"institutions":[{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ranit Lahmy","raw_affiliation_strings":["Institute of Organic Chemistry University of Regensburg, Universit\u00e4tsstra\u00dfe 31  D\u201093053 Regensburg Germany"],"raw_orcid":"https://orcid.org/0000-0002-9432-7455","affiliations":[{"raw_affiliation_string":"Institute of Organic Chemistry University of Regensburg, Universit\u00e4tsstra\u00dfe 31  D\u201093053 Regensburg Germany","institution_ids":["https://openalex.org/I60668342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080940574","display_name":"Christoph Haag","orcid":"https://orcid.org/0009-0008-4292-9869","observed_orcids":["https://orcid.org/0009-0008-4292-9869"]},"institutions":[{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christoph Haag","raw_affiliation_strings":["Institute of Organic Chemistry University of Regensburg, Universit\u00e4tsstra\u00dfe 31  D\u201093053 Regensburg Germany"],"raw_orcid":"https://orcid.org/0009-0008-4292-9869","affiliations":[{"raw_affiliation_string":"Institute of Organic Chemistry University of Regensburg, Universit\u00e4tsstra\u00dfe 31  D\u201093053 Regensburg Germany","institution_ids":["https://openalex.org/I60668342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009283691","display_name":"Julian Nazet","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Julian Nazet","raw_affiliation_strings":["Institute of Biophysics and Physical Biochemistry and Regensburg Center for Biochemistry University of Regensburg, Universit\u00e4tsstra\u00dfe 31  D\u201093053 Regensburg Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biophysics and Physical Biochemistry and Regensburg Center for Biochemistry University of Regensburg, Universit\u00e4tsstra\u00dfe 31  D\u201093053 Regensburg Germany","institution_ids":["https://openalex.org/I60668342"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Michael Bartl","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Michael Bartl","raw_affiliation_strings":["Institute of Biophysics and Physical Biochemistry and Regensburg Center for Biochemistry University of Regensburg, Universit\u00e4tsstra\u00dfe 31  D\u201093053 Regensburg Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biophysics and Physical Biochemistry and Regensburg Center for Biochemistry University of Regensburg, Universit\u00e4tsstra\u00dfe 31  D\u201093053 Regensburg Germany","institution_ids":["https://openalex.org/I60668342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062249535","display_name":"Astrid Bruckmann","orcid":"https://orcid.org/0000-0001-6082-2944","observed_orcids":["https://orcid.org/0000-0001-6082-2944"]},"institutions":[{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Astrid Bruckmann","raw_affiliation_strings":["Institute of Biochemistry, Genetics and Microbiology, University of Regensburg, Universitatsstrasse 31, D-93053 Regensburg, Germany"],"raw_orcid":"https://orcid.org/0000-0001-6082-2944","affiliations":[{"raw_affiliation_string":"Institute of Biochemistry, Genetics and Microbiology, University of Regensburg, Universitatsstrasse 31, D-93053 Regensburg, Germany","institution_ids":["https://openalex.org/I60668342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009140704","display_name":"S\u00edlvia Osuna","orcid":"https://orcid.org/0000-0003-3657-6469","observed_orcids":["https://orcid.org/0000-0003-3657-6469"]},"institutions":[{"id":"https://openalex.org/I11932220","display_name":"Instituci\u00f3 Catalana de Recerca i Estudis Avan\u00e7ats","ror":"https://ror.org/0371hy230","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I11932220"]},{"id":"https://openalex.org/I251424209","display_name":"Universitat de Girona","ror":"https://ror.org/01xdxns91","country_code":"ES","type":"education","lineage":["https://openalex.org/I251424209"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"S\u00edlvia Osuna","raw_affiliation_strings":["ICREA, Pg. Llu\u00eds Companys 23  Barcelona 08010 Spain","Institut de Qu\u00edmica Computacional i Cat\u00e0lisi and Departament de Qu\u00edmica Universitat de Girona  c/ Maria Aur\u00e8lia Capmany 69 Girona 17003 Spain"],"raw_orcid":"https://orcid.org/0000-0003-3657-6469","affiliations":[{"raw_affiliation_string":"ICREA, Pg. Llu\u00eds Companys 23  Barcelona 08010 Spain","institution_ids":["https://openalex.org/I11932220"]},{"raw_affiliation_string":"Institut de Qu\u00edmica Computacional i Cat\u00e0lisi and Departament de Qu\u00edmica Universitat de Girona  c/ Maria Aur\u00e8lia Capmany 69 Girona 17003 Spain","institution_ids":["https://openalex.org/I251424209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108080809","display_name":"Burkhard K\u00f6nig","orcid":"https://orcid.org/0000-0002-6131-4850","observed_orcids":["https://orcid.org/0000-0002-6131-4850"]},"institutions":[{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Burkhard K\u00f6nig","raw_affiliation_strings":["Institute of Organic Chemistry University of Regensburg, Universit\u00e4tsstra\u00dfe 31  D\u201093053 Regensburg Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Organic Chemistry University of Regensburg, Universit\u00e4tsstra\u00dfe 31  D\u201093053 Regensburg Germany","institution_ids":["https://openalex.org/I60668342"]}]},{"author_position":"last","author":{"id":null,"display_name":"Andrea Hupfeld","orcid":"https://orcid.org/0000-0002-4341-1593","observed_orcids":["https://orcid.org/0000-0002-4341-1593"]},"institutions":[{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Andrea Hupfeld","raw_affiliation_strings":["Institute of Biophysics and Physical Biochemistry and Regensburg Center for Biochemistry University of Regensburg, Universit\u00e4tsstra\u00dfe 31  D\u201093053 Regensburg Germany"],"raw_orcid":"https://orcid.org/0000-0002-4341-1593","affiliations":[{"raw_affiliation_string":"Institute of Biophysics and Physical Biochemistry and Regensburg Center for Biochemistry University of Regensburg, Universit\u00e4tsstra\u00dfe 31  D\u201093053 Regensburg Germany","institution_ids":["https://openalex.org/I60668342"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I60668342"],"apc_list":{"value":5510,"currency":"USD","value_usd":5510},"apc_paid":{"value":5510,"currency":"USD","value_usd":5510},"fwci":1.311,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.78300393,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":98},"biblio":{"volume":"64","issue":"38","first_page":"e202508562","last_page":"e202508562"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11708","display_name":"Photochromic and Fluorescence Chemistry","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11708","display_name":"Photochromic and Fluorescence Chemistry","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10404","display_name":"Enzyme Catalysis and Immobilization","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/enzyme-engineering","display_name":"enzyme engineering","score":0.8349999785423279},{"id":"https://openalex.org/keywords/azobenzene","display_name":"azobenzene","score":0.8769999742507935},{"id":"https://openalex.org/keywords/arylazopyrazole","display_name":"arylazopyrazole","score":0.984000027179718},{"id":"https://openalex.org/keywords/hemithioindigo","display_name":"hemithioindigo","score":0.9929999709129333},{"id":"https://openalex.org/keywords/spiropyran","display_name":"spiropyran","score":0.996999979019165},{"id":"https://openalex.org/keywords/aminoacyl-trna-synthetase","display_name":"aminoacyl-tRNA synthetase","score":0.8880000114440918},{"id":"https://openalex.org/keywords/photoconversion","display_name":"photoconversion","score":0.527999997138977},{"id":"https://openalex.org/keywords/visible-light-photoisomerization","display_name":"visible-light photoisomerization","score":0.7129999995231628},{"id":"https://openalex.org/keywords/hydrogen-bonding","display_name":"hydrogen bonding","score":0.5730000138282776},{"id":"https://openalex.org/keywords/metal-coordination","display_name":"metal coordination","score":0.9419999718666077}],"concepts":[{"id":"https://openalex.org/C2778150588","wikidata":"https://www.wikidata.org/wiki/Q8884513","display_name":"Azobenzene","level":3,"score":0.7592962980270386},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.5813822150230408},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5631053447723389},{"id":"https://openalex.org/C147816474","wikidata":"https://www.wikidata.org/wiki/Q169525","display_name":"Protein engineering","level":3,"score":0.5356734395027161},{"id":"https://openalex.org/C191503008","wikidata":"https://www.wikidata.org/wiki/Q16007026","display_name":"Biocatalysis","level":4,"score":0.5088334679603577},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.4646894931793213},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.3881053924560547},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.2973625361919403},{"id":"https://openalex.org/C154881586","wikidata":"https://www.wikidata.org/wiki/Q898579","display_name":"Ionic liquid","level":3,"score":0.19640949368476868},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1635478138923645},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.13556590676307678},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000604","descriptor_name":"Amino Acyl-tRNA Synthetases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000604","descriptor_name":"Amino Acyl-tRNA Synthetases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001391","descriptor_name":"Azo Compounds","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008027","descriptor_name":"Light","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015202","descriptor_name":"Protein Engineering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055668","descriptor_name":"Photochemical Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1002/anie.202508562","doi":"https://doi.org/10.1002/anie.202508562","is_oa":true,"landing_page_url":"https://doi.org/10.1002/anie.202508562","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/anie.202508562","source":{"id":"https://openalex.org/S67393510","display_name":"Angewandte Chemie International Edition","issn_l":"1433-7851","issn":["1433-7851","1521-3773"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Angewandte Chemie International Edition","raw_type":"journal-article"},{"id":"doi:10.1101/2025.04.17.649278","doi":"https://doi.org/10.1101/2025.04.17.649278","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.04.17.649278","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2025/04/17/2025.04.17.649278.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:europepmc.org:11245277","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12435433","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:40757918","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40757918","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Angewandte Chemie (International ed. in English)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12435433","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12435433/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Angew Chem Int Ed Engl","raw_type":"Text"},{"id":"pmh:doi:10.5283/epub.77502","doi":null,"is_oa":true,"landing_page_url":"https://epub.uni-regensburg.de/77502/","pdf_url":"https://epub.uni-regensburg.de/77502/1/Angew%20Chem%20Int%20Ed%20-%202025%20-%20Hiefinger%20-%20Expanding%20the%20Repertoire%20of%20Photoswitchable%20Unnatural%20Amino%20Acids%20for%20Enzyme.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:epub.uni-regensburg.de:77502","doi":null,"is_oa":false,"landing_page_url":"http://orcid.org/0009-0000-4587-9248>,","pdf_url":null,"source":{"id":"https://openalex.org/S4306401229","display_name":"University of Regensburg Publication Server (University of Regensburg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I60668342","host_organization_name":"University of Regensburg","host_organization_lineage":["https://openalex.org/I60668342"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"doi:10.5283/epub.77502","doi":"https://doi.org/10.5283/epub.77502","is_oa":true,"landing_page_url":"https://doi.org/10.5283/epub.77502","pdf_url":null,"source":{"id":"https://openalex.org/S4306401229","display_name":"University of Regensburg Publication Server (University of Regensburg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I60668342","host_organization_name":"University of Regensburg","host_organization_lineage":["https://openalex.org/I60668342"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1002/anie.202508562","doi":"https://doi.org/10.1002/anie.202508562","is_oa":true,"landing_page_url":"https://doi.org/10.1002/anie.202508562","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/anie.202508562","source":{"id":"https://openalex.org/S67393510","display_name":"Angewandte Chemie International Edition","issn_l":"1433-7851","issn":["1433-7851","1521-3773"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Angewandte Chemie International Edition","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1418621114","display_name":null,"funder_award_id":"STE 891/12-2","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4412902602.pdf","grobid_xml":"https://content.openalex.org/works/W4412902602.grobid-xml"},"referenced_works_count":96,"referenced_works":["https://openalex.org/W48878885","https://openalex.org/W148764549","https://openalex.org/W617079929","https://openalex.org/W1970743827","https://openalex.org/W1976880774","https://openalex.org/W1986826865","https://openalex.org/W2012537676","https://openalex.org/W2013723044","https://openalex.org/W2016667239","https://openalex.org/W2016893951","https://openalex.org/W2026554647","https://openalex.org/W2031757629","https://openalex.org/W2034144975","https://openalex.org/W2042995756","https://openalex.org/W2043137541","https://openalex.org/W2045194875","https://openalex.org/W2050265985","https://openalex.org/W2056870506","https://openalex.org/W2058223635","https://openalex.org/W2067864327","https://openalex.org/W2090333491","https://openalex.org/W2104571730","https://openalex.org/W2108821634","https://openalex.org/W2109606373","https://openalex.org/W2112111333","https://openalex.org/W2116906170","https://openalex.org/W2121397110","https://openalex.org/W2132266602","https://openalex.org/W2140315661","https://openalex.org/W2146390768","https://openalex.org/W2152148732","https://openalex.org/W2155478020","https://openalex.org/W2164618483","https://openalex.org/W2201713963","https://openalex.org/W2261688117","https://openalex.org/W2315586721","https://openalex.org/W2326558292","https://openalex.org/W2332604836","https://openalex.org/W2415206900","https://openalex.org/W2418946054","https://openalex.org/W2470087878","https://openalex.org/W2562071635","https://openalex.org/W2601081289","https://openalex.org/W2605818344","https://openalex.org/W2616139473","https://openalex.org/W2761662691","https://openalex.org/W2763278454","https://openalex.org/W2767073975","https://openalex.org/W2789149182","https://openalex.org/W2790620957","https://openalex.org/W2807134300","https://openalex.org/W2886726581","https://openalex.org/W2891494391","https://openalex.org/W2895396755","https://openalex.org/W2924847629","https://openalex.org/W2936378241","https://openalex.org/W2944014204","https://openalex.org/W2947049443","https://openalex.org/W2951386692","https://openalex.org/W2952434583","https://openalex.org/W2952893814","https://openalex.org/W2972077284","https://openalex.org/W2985855765","https://openalex.org/W2995172366","https://openalex.org/W3004134978","https://openalex.org/W3040862332","https://openalex.org/W3041397808","https://openalex.org/W3115774164","https://openalex.org/W3157645956","https://openalex.org/W3174881694","https://openalex.org/W3177828909","https://openalex.org/W3193795232","https://openalex.org/W3203838281","https://openalex.org/W4211112687","https://openalex.org/W4214666672","https://openalex.org/W4220722692","https://openalex.org/W4221120440","https://openalex.org/W4225995052","https://openalex.org/W4281708787","https://openalex.org/W4313528104","https://openalex.org/W4317390896","https://openalex.org/W4365135703","https://openalex.org/W4379162128","https://openalex.org/W4384296512","https://openalex.org/W4384924359","https://openalex.org/W4386760878","https://openalex.org/W4400520823","https://openalex.org/W4401386744","https://openalex.org/W4401615082","https://openalex.org/W4407165242","https://openalex.org/W4407304958","https://openalex.org/W4409919879","https://openalex.org/W4410120519","https://openalex.org/W6601106914","https://openalex.org/W6602124240","https://openalex.org/W6607014420"],"related_works":["https://openalex.org/W4412902559","https://openalex.org/W7106701004","https://openalex.org/W2895396755","https://openalex.org/W4386760878","https://openalex.org/W4410120519","https://openalex.org/W2146390768","https://openalex.org/W2991099601","https://openalex.org/W4384296784","https://openalex.org/W7204277594","https://openalex.org/W2046062552"],"abstract_inverted_index":{"Photoswitchable":[0],"unnatural":[1],"amino":[2],"acids":[3],"(psUAAs)":[4],"play":[5],"a":[6,36,39],"crucial":[7],"role":[8],"in":[9,14,64],"the":[10,31,49,65,115,124,138,143,150,156,160,169,181],"engineering":[11,191],"of":[12,35,58,119,140,142,159,171,183],"light-sensitivity":[13],"enzymes,":[15],"which":[16],"holds":[17],"significant":[18],"promise":[19],"for":[20,38,99,189],"diverse":[21,111],"applications":[22],"such":[23],"as":[24],"biotherapy":[25],"and":[26,33,54,71,81,104,147,167,185],"biocatalysis.":[27],"Besides":[28],"near-quantitative":[29],"photoconversion,":[30],"success":[32],"expediency":[34],"psUAA":[37],"certain":[40],"application":[41],"is":[42],"defined":[43],"by":[44],"its":[45,51,55],"interaction":[46,90],"potential":[47,91],"with":[48,117,126],"enzyme,":[50],"thermal":[52],"stability":[53],"effective":[56],"wavelength":[57],"irradiation.":[59],"To":[60],"establish":[61],"high":[62],"versatility":[63],"current":[66],"repertoire,":[67],"we":[68,109,131,154],"have":[69],"designed":[70],"synthesized":[72],"six":[73,144],"psUAAs":[74,86,145,162,184],"based":[75],"on":[76],"azobenzene,":[77],"arylazopyrazole,":[78],"arylazothiazole,":[79],"hemithioindigo":[80],"spiropyran":[82],"photoswitches.":[83],"The":[84],"resulting":[85],"exhibit":[87],"an":[88,93,164],"enhanced":[89],"within":[92,163],"enzyme":[94,190],"owing":[95],"to":[96],"their":[97,174,187],"capacity":[98],"hydrogen":[100],"bonding,":[101],"ionic":[102],"interactions":[103],"metal":[105],"ion":[106],"coordination.":[107],"Moreover,":[108],"observed":[110],"photochemical":[112,157],"behaviors":[113],"among":[114],"psUAAs,":[116],"four":[118],"them":[120],"reversibly":[121],"switching":[122],"between":[123],"isomers":[125],"purely":[127],"visible":[128],"light.":[129],"Notably,":[130],"identified":[132],"orthogonal":[133],"aminoacyl-tRNA":[134],"synthetases":[135],"that":[136],"facilitate":[137],"incorporation":[139],"five":[141,161],"co-translationally":[146],"computationally":[148],"analyzed":[149],"synthetase-psUAA":[151],"interactions.":[152],"Finally,":[153],"evaluated":[155],"behavior":[158],"enzymatic":[165],"model":[166],"tested":[168],"photocontrol":[170],"catalysis":[172],"confirming":[173],"diversity.":[175],"Ultimately,":[176],"our":[177],"findings":[178],"significantly":[179],"expanded":[180],"repertoire":[182],"demonstrated":[186],"feasibility":[188],"studies.":[192]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":3}],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2025-10-10T00:00:00"}
