{"id":"https://openalex.org/W4412866017","doi":"https://doi.org/10.1016/j.ajt.2025.07.1809","title":"Assessment of De Novo Extended-Release Tacrolimus Weight-Based Dosing Compared to Immediate-Release Tacrolimus in Kidney Transplant Recipients Leads to Improved Outcomes","display_name":"Assessment of De Novo Extended-Release Tacrolimus Weight-Based Dosing Compared to Immediate-Release Tacrolimus in Kidney Transplant Recipients Leads to Improved Outcomes","publication_year":2025,"publication_date":"2025-08-01","ids":{"openalex":"https://openalex.org/W4412866017","doi":"https://doi.org/10.1016/j.ajt.2025.07.1809"},"language":"en","primary_location":{"id":"doi:10.1016/j.ajt.2025.07.1809","doi":"https://doi.org/10.1016/j.ajt.2025.07.1809","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ajt.2025.07.1809","pdf_url":null,"source":{"id":"https://openalex.org/S182625382","display_name":"American Journal of Transplantation","issn_l":"1600-6135","issn":["1600-6135","1600-6143"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Transplantation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.ajt.2025.07.1809","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5119170300","display_name":"J. Quenzer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117083","display_name":"Temple University Hospital","ror":"https://ror.org/028rvnd71","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210117083","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Quenzer","raw_affiliation_strings":["Temple University Hospital, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Temple University Hospital, PA","institution_ids":["https://openalex.org/I4210117083"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078262925","display_name":"Kenneth D. Chavin","orcid":"https://orcid.org/0000-0003-0818-4847","observed_orcids":["https://orcid.org/0000-0003-0818-4847"]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. Chavin","raw_affiliation_strings":["Temple University School of Medicine, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Temple University School of Medicine, PA","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088542956","display_name":"K. Ly","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117083","display_name":"Temple University Hospital","ror":"https://ror.org/028rvnd71","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210117083","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. Ly","raw_affiliation_strings":["Temple University Hospital, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Temple University Hospital, PA","institution_ids":["https://openalex.org/I4210117083"]}]},{"author_position":"middle","author":{"id":null,"display_name":"I. Shah","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117083","display_name":"Temple University Hospital","ror":"https://ror.org/028rvnd71","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210117083","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"I. Shah","raw_affiliation_strings":["Temple University Hospital, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Temple University Hospital, PA","institution_ids":["https://openalex.org/I4210117083"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019853283","display_name":"Christina Ruggia-Check","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117083","display_name":"Temple University Hospital","ror":"https://ror.org/028rvnd71","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210117083","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. Ruggia-Check","raw_affiliation_strings":["Temple University Hospital, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Temple University Hospital, PA","institution_ids":["https://openalex.org/I4210117083"]}]},{"author_position":"middle","author":{"id":null,"display_name":"J. Au","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117083","display_name":"Temple University Hospital","ror":"https://ror.org/028rvnd71","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210117083","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Au","raw_affiliation_strings":["Temple University Hospital, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Temple University Hospital, PA","institution_ids":["https://openalex.org/I4210117083"]}]},{"author_position":"last","author":{"id":null,"display_name":"A. Diamond","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117083","display_name":"Temple University Hospital","ror":"https://ror.org/028rvnd71","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210117083","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Diamond","raw_affiliation_strings":["Temple University Hospital, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Temple University Hospital, PA","institution_ids":["https://openalex.org/I4210117083"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4300,"currency":"USD","value_usd":4300},"apc_paid":{"value":4300,"currency":"USD","value_usd":4300},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.37648031,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"25","issue":"8","first_page":"S767","last_page":"S768"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tacrolimus","display_name":"tacrolimus","score":0.9900000095367432},{"id":"https://openalex.org/keywords/extended-release-formulation","display_name":"sustained-release formulation","score":0.878000020980835},{"id":"https://openalex.org/keywords/weight-based-dosing","display_name":"weight-based dosing","score":0.8420000076293945},{"id":"https://openalex.org/keywords/immediate-release-tacrolimus","display_name":"immediate-release tacrolimus","score":0.8870000243186951},{"id":"https://openalex.org/keywords/kidney-transplantation","display_name":"kidney transplantation","score":0.9480000138282776},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.8410000205039978},{"id":"https://openalex.org/keywords/maintenance-immunosuppression","display_name":"maintenance immunosuppression","score":0.7689999938011169},{"id":"https://openalex.org/keywords/bioavailability","display_name":"bioavailability","score":0.875},{"id":"https://openalex.org/keywords/delayed-graft-function","display_name":"delayed graft function","score":0.6610000133514404},{"id":"https://openalex.org/keywords/graft-rejection","display_name":"graft rejection","score":0.7549999952316284},{"id":"https://openalex.org/keywords/renal-vasoconstriction","display_name":"renal vasoconstriction","score":0.7319999933242798},{"id":"https://openalex.org/keywords/pharmacokinetic-variability","display_name":"pharmacokinetic variability","score":0.7950000166893005}],"concepts":[{"id":"https://openalex.org/C2909675724","wikidata":"https://www.wikidata.org/wiki/Q411648","display_name":"Tacrolimus","level":3,"score":0.9610180854797363},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9457122683525085},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.826775848865509},{"id":"https://openalex.org/C2994498544","wikidata":"https://www.wikidata.org/wiki/Q740909","display_name":"Kidney transplant","level":4,"score":0.6701819896697998},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.4897637367248535},{"id":"https://openalex.org/C2780303639","wikidata":"https://www.wikidata.org/wiki/Q740909","display_name":"Kidney transplantation","level":3,"score":0.4854605793952942},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.36776483058929443},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.30320465564727783},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.29667478799819946}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.ajt.2025.07.1809","doi":"https://doi.org/10.1016/j.ajt.2025.07.1809","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ajt.2025.07.1809","pdf_url":null,"source":{"id":"https://openalex.org/S182625382","display_name":"American Journal of Transplantation","issn_l":"1600-6135","issn":["1600-6135","1600-6143"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Transplantation","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.ajt.2025.07.1809","doi":"https://doi.org/10.1016/j.ajt.2025.07.1809","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ajt.2025.07.1809","pdf_url":null,"source":{"id":"https://openalex.org/S182625382","display_name":"American Journal of Transplantation","issn_l":"1600-6135","issn":["1600-6135","1600-6143"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Transplantation","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.4399999976158142,"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4412865586","https://openalex.org/W7166419772","https://openalex.org/W3169481037","https://openalex.org/W2042729726","https://openalex.org/W4210924433","https://openalex.org/W2904327346","https://openalex.org/W3000454810","https://openalex.org/W4280573510","https://openalex.org/W2996037968","https://openalex.org/W4396243076"],"abstract_inverted_index":{"Purpose:":[0],"Tacrolimus":[1,13,47],"is":[2],"commonly":[3],"utilized":[4],"as":[5],"maintenance":[6],"immunosuppression":[7],"in":[8],"solid":[9],"organ":[10],"transplant":[11],"recipients.":[12],"has":[14],"a":[15],"narrow":[16],"therapeutic":[17,60],"index":[18],"and":[19,22,44],"exhibits":[20],"pharmacokinetic":[21],"pharmacodynamic":[23],"variability.":[24],"Dosing":[25],"strategies":[26],"remain":[27],"inconsistent":[28],"due":[29],"to":[30,34,39],"various":[31],"formulations,":[32],"desire":[33],"minimize":[35],"renal":[36],"vasoconstrictive":[37],"effects,":[38],"avoid":[40],"delayed":[41],"graft":[42],"function,":[43],"limit":[45],"rejection.":[46],"XR":[48],"uses":[49],"MeltDose":[50],"technology,":[51],"improving":[52],"bioavailability.":[53],"This":[54],"formulation":[55],"provides":[56],"rapid":[57],"attainment":[58],"of":[59],"levels":[61],"with":[62],"less":[63],"fluctuation.":[64]},"counts_by_year":[],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2025-10-10T00:00:00"}
