{"id":"https://openalex.org/W4412857092","doi":"https://doi.org/10.1007/s10522-025-10296-x","title":"Deciphering the molecular clock: exploring molecular mechanisms and genetic influences on skin ageing","display_name":"Deciphering the molecular clock: exploring molecular mechanisms and genetic influences on skin ageing","publication_year":2025,"publication_date":"2025-08-01","ids":{"openalex":"https://openalex.org/W4412857092","doi":"https://doi.org/10.1007/s10522-025-10296-x","pmid":"https://pubmed.ncbi.nlm.nih.gov/40751759","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12317886"},"language":"en","primary_location":{"id":"doi:10.1007/s10522-025-10296-x","doi":"https://doi.org/10.1007/s10522-025-10296-x","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10522-025-10296-x","pdf_url":"https://link.springer.com/content/pdf/10.1007/s10522-025-10296-x.pdf","source":{"id":"https://openalex.org/S85312528","display_name":"Biogerontology","issn_l":"1389-5729","issn":["1389-5729","1573-6768"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biogerontology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s10522-025-10296-x.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Horng Yih Ng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33849332","display_name":"University of Malaya","ror":"https://ror.org/00rzspn62","country_code":"MY","type":"education","lineage":["https://openalex.org/I33849332"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Horng Yih Ng","raw_affiliation_strings":["Department of Pharmaceutical Life Sciences, Faculty of Pharmacy, Universiti Malaya, 50603, Kuala Lumpur, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Life Sciences, Faculty of Pharmacy, Universiti Malaya, 50603, Kuala Lumpur, Malaysia","institution_ids":["https://openalex.org/I33849332"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062667572","display_name":"Yuan Seng Wu","orcid":"https://orcid.org/0000-0001-5574-8049","observed_orcids":["https://orcid.org/0000-0001-5574-8049"]},"institutions":[{"id":"https://openalex.org/I84339108","display_name":"Sunway University","ror":"https://ror.org/04mjt7f73","country_code":"MY","type":"education","lineage":["https://openalex.org/I84339108"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Yuan Seng Wu","raw_affiliation_strings":["Department of Biomedical Sciences, Sir Jeffrey Cheah Sunway Medical School, Faculty of Medical and Life Sciences, Sunway University, Sunway City, Malaysia","Sunway Microbiome Centre, Faculty of Medical and Life Sciences, Sunway University, Sunway City, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, Sir Jeffrey Cheah Sunway Medical School, Faculty of Medical and Life Sciences, Sunway University, Sunway City, Malaysia","institution_ids":["https://openalex.org/I84339108"]},{"raw_affiliation_string":"Sunway Microbiome Centre, Faculty of Medical and Life Sciences, Sunway University, Sunway City, Malaysia","institution_ids":["https://openalex.org/I84339108"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031327164","display_name":"Mohitosh Biswas","orcid":"https://orcid.org/0000-0003-1432-7701","observed_orcids":["https://orcid.org/0000-0003-1432-7701"]},"institutions":[{"id":"https://openalex.org/I902853133","display_name":"University of Rajshahi","ror":"https://ror.org/05nnyr510","country_code":"BD","type":"education","lineage":["https://openalex.org/I902853133"]}],"countries":["BD"],"is_corresponding":false,"raw_author_name":"Mohitosh Biswas","raw_affiliation_strings":["Department of Pharmacy, Faculty of Science, University of Rajshahi, Rajshahi, Bangladesh"],"raw_orcid":"https://orcid.org/0000-0003-1432-7701","affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Faculty of Science, University of Rajshahi, Rajshahi, Bangladesh","institution_ids":["https://openalex.org/I902853133"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087101827","display_name":"Maw Shin Sim","orcid":"https://orcid.org/0000-0002-7848-0775","observed_orcids":["https://orcid.org/0000-0002-7848-0775"]},"institutions":[{"id":"https://openalex.org/I33849332","display_name":"University of Malaya","ror":"https://ror.org/00rzspn62","country_code":"MY","type":"education","lineage":["https://openalex.org/I33849332"]}],"countries":["MY"],"is_corresponding":true,"raw_author_name":"Maw Shin Sim","raw_affiliation_strings":["Department of Pharmaceutical Life Sciences, Faculty of Pharmacy, Universiti Malaya, 50603, Kuala Lumpur, Malaysia. garethsim@um.edu.my","Precision Medicine & Omics Centre (PrOmiC), Faculty of Pharmacy, Universiti Malaya, 50603, Kuala Lumpur, Malaysia. garethsim@um.edu.my"],"raw_orcid":"https://orcid.org/0000-0002-7848-0775","affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Life Sciences, Faculty of Pharmacy, Universiti Malaya, 50603, Kuala Lumpur, Malaysia. garethsim@um.edu.my","institution_ids":["https://openalex.org/I33849332"]},{"raw_affiliation_string":"Precision Medicine & Omics Centre (PrOmiC), Faculty of Pharmacy, Universiti Malaya, 50603, Kuala Lumpur, Malaysia. garethsim@um.edu.my","institution_ids":["https://openalex.org/I33849332"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5087101827"],"corresponding_institution_ids":["https://openalex.org/I33849332"],"apc_list":{"value":4790,"currency":"USD","value_usd":4790},"apc_paid":{"value":4790,"currency":"USD","value_usd":4790},"fwci":0.8562,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.65819722,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":98},"biblio":{"volume":"26","issue":"4","first_page":"153","last_page":"153"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11013","display_name":"Skin Protection and Aging","score":0.899399995803833,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11013","display_name":"Skin Protection and Aging","score":0.899399995803833,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11144","display_name":"melanin and skin pigmentation","score":0.04430000111460686,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.028200000524520874,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/skin-aging","display_name":"skin aging","score":1.0},{"id":"https://openalex.org/keywords/genetic-association","display_name":"genetic association","score":0.5619999766349792},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.9990000128746033},{"id":"https://openalex.org/keywords/oca2","display_name":"OCA2","score":0.8980000019073486},{"id":"https://openalex.org/keywords/hyperpigmentation","display_name":"hyperpigmentation","score":0.8830000162124634},{"id":"https://openalex.org/keywords/collagen-metabolism","display_name":"collagen metabolism","score":0.7870000004768372},{"id":"https://openalex.org/keywords/melanin-synthesis","display_name":"melanogenesis","score":0.996999979019165},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9900000095367432},{"id":"https://openalex.org/keywords/skin-mechanics","display_name":"skin biomechanics","score":0.6380000114440918},{"id":"https://openalex.org/keywords/irf4","display_name":"IRF4","score":0.9990000128746033},{"id":"https://openalex.org/keywords/sptlc1","display_name":"SPTLC1","score":0.9549999833106995},{"id":"https://openalex.org/keywords/smyd3","display_name":"SMYD3","score":0.9760000109672546},{"id":"https://openalex.org/keywords/cyp1a1","display_name":"CYP1A1","score":0.9819999933242798},{"id":"https://openalex.org/keywords/extracellular-matrix-degradation","display_name":"extracellular matrix degradation","score":0.8489999771118164},{"id":"https://openalex.org/keywords/col1a2","display_name":"COL1A2","score":0.949999988079071},{"id":"https://openalex.org/keywords/col13a1","display_name":"COL13A1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/skin-sagging","display_name":"skin sagging","score":0.8330000042915344},{"id":"https://openalex.org/keywords/wrinkling","display_name":"wrinkling","score":0.6859999895095825},{"id":"https://openalex.org/keywords/pleiotropy","display_name":"pleiotropy","score":0.6669999957084656},{"id":"https://openalex.org/keywords/environmental-contaminants","display_name":"environmental pollutants","score":0.7020000219345093}],"concepts":[{"id":"https://openalex.org/C500499127","wikidata":"https://www.wikidata.org/wiki/Q332154","display_name":"Ageing","level":2,"score":0.8132573962211609},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5719856023788452},{"id":"https://openalex.org/C2909910311","wikidata":"https://www.wikidata.org/wiki/Q5259911","display_name":"Skin Aging","level":2,"score":0.4877486824989319},{"id":"https://openalex.org/C183074962","wikidata":"https://www.wikidata.org/wiki/Q213713","display_name":"Developmental biology","level":2,"score":0.48066389560699463},{"id":"https://openalex.org/C196662502","wikidata":"https://www.wikidata.org/wiki/Q827541","display_name":"Molecular clock","level":4,"score":0.4738070070743561},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4078952670097351},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.4047291576862335},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3703174591064453},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22951346635818481},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.20059069991111755},{"id":"https://openalex.org/C90132467","wikidata":"https://www.wikidata.org/wiki/Q171184","display_name":"Phylogenetics","level":3,"score":0.12489181756973267},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.07579755783081055}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015595","descriptor_name":"Skin Aging","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1007/s10522-025-10296-x","doi":"https://doi.org/10.1007/s10522-025-10296-x","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10522-025-10296-x","pdf_url":"https://link.springer.com/content/pdf/10.1007/s10522-025-10296-x.pdf","source":{"id":"https://openalex.org/S85312528","display_name":"Biogerontology","issn_l":"1389-5729","issn":["1389-5729","1573-6768"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biogerontology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12317886","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12317886","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12317886/pdf/10522_2025_Article_10296.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biogerontology","raw_type":"Text"},{"id":"pmid:40751759","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40751759","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biogerontology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1007/s10522-025-10296-x","doi":"https://doi.org/10.1007/s10522-025-10296-x","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10522-025-10296-x","pdf_url":"https://link.springer.com/content/pdf/10.1007/s10522-025-10296-x.pdf","source":{"id":"https://openalex.org/S85312528","display_name":"Biogerontology","issn_l":"1389-5729","issn":["1389-5729","1573-6768"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biogerontology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8560000061988831,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320322604","display_name":"Universiti Malaya","ror":"https://ror.org/00rzspn62"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4412857092.pdf","grobid_xml":"https://content.openalex.org/works/W4412857092.grobid-xml"},"referenced_works_count":79,"referenced_works":["https://openalex.org/W1480167191","https://openalex.org/W1893000945","https://openalex.org/W1938542587","https://openalex.org/W1964418802","https://openalex.org/W1971782825","https://openalex.org/W1980051172","https://openalex.org/W1987557823","https://openalex.org/W1997183853","https://openalex.org/W2002052058","https://openalex.org/W2005516232","https://openalex.org/W2009238217","https://openalex.org/W2011693952","https://openalex.org/W2017779665","https://openalex.org/W2025963025","https://openalex.org/W2040903642","https://openalex.org/W2052101576","https://openalex.org/W2063209097","https://openalex.org/W2064516354","https://openalex.org/W2072443346","https://openalex.org/W2086824544","https://openalex.org/W2088658436","https://openalex.org/W2089161677","https://openalex.org/W2090554202","https://openalex.org/W2101892858","https://openalex.org/W2122732537","https://openalex.org/W2129424926","https://openalex.org/W2131602910","https://openalex.org/W2148026003","https://openalex.org/W2148923431","https://openalex.org/W2149280464","https://openalex.org/W2162058188","https://openalex.org/W2165645002","https://openalex.org/W2192616992","https://openalex.org/W2240037263","https://openalex.org/W2342822247","https://openalex.org/W2467318665","https://openalex.org/W2507940711","https://openalex.org/W2524760488","https://openalex.org/W2560438049","https://openalex.org/W2562513815","https://openalex.org/W2613074263","https://openalex.org/W2615975691","https://openalex.org/W2620450752","https://openalex.org/W2796878204","https://openalex.org/W2800114115","https://openalex.org/W2800438504","https://openalex.org/W2806309723","https://openalex.org/W2874545088","https://openalex.org/W2905916527","https://openalex.org/W2932503900","https://openalex.org/W2940564657","https://openalex.org/W2953620536","https://openalex.org/W2959409237","https://openalex.org/W2966008106","https://openalex.org/W2972205941","https://openalex.org/W2972920443","https://openalex.org/W2988451010","https://openalex.org/W3047106040","https://openalex.org/W3088358085","https://openalex.org/W3101513431","https://openalex.org/W3115483941","https://openalex.org/W3118615836","https://openalex.org/W3127893968","https://openalex.org/W3132482446","https://openalex.org/W3150104960","https://openalex.org/W3158396215","https://openalex.org/W3165119206","https://openalex.org/W3205442095","https://openalex.org/W3209250650","https://openalex.org/W4205533183","https://openalex.org/W4210563361","https://openalex.org/W4225616506","https://openalex.org/W4283017800","https://openalex.org/W4287409590","https://openalex.org/W4292491962","https://openalex.org/W4307828247","https://openalex.org/W4312203940","https://openalex.org/W4313831009","https://openalex.org/W4402229801"],"related_works":["https://openalex.org/W6902640556","https://openalex.org/W4283459522","https://openalex.org/W6958752242","https://openalex.org/W6958770129","https://openalex.org/W4288758334","https://openalex.org/W2972205941","https://openalex.org/W4411006634","https://openalex.org/W6958723593","https://openalex.org/W6939934447","https://openalex.org/W6958883209"],"abstract_inverted_index":{"Skin":[0],"ageing":[1,27,126],"is":[2],"a":[3,59],"multifaceted":[4],"process":[5],"influenced":[6],"by":[7],"both":[8,157],"intrinsic":[9],"genetic":[10,20,63,179,230,246],"factors":[11],"and":[12,22,45,66,139,148,159,169,191,212,218,240],"extrinsic":[13],"environmental":[14,195],"exposures.":[15],"This":[16],"review":[17],"explores":[18],"the":[19,43,72,89,95,113,143,176,241],"variants":[21,206],"molecular":[23],"mechanisms":[24],"underlying":[25],"skin":[26,125,203,219,249],"phenotypes,":[28],"while":[29],"identifying":[30],"gaps":[31,237],"in":[32,68,133,183,207,238],"current":[33],"research":[34,247],"to":[35,119,156,194,223],"inform":[36],"future":[37],"studies.":[38],"A":[39],"systematic":[40],"search":[41],"of":[42,47,79,83,142,178],"Scopus":[44,70],"Web":[46,78],"Science":[48],"databases":[49],"was":[50,86],"conducted,":[51],"with":[52,130,201],"articles":[53],"screened":[54],"based":[55],"on":[56,61],"criteria":[57],"including":[58],"focus":[60],"human":[62],"association":[64],"studies":[65,85,93],"indexing":[67],"either":[69],"or":[71],"Institute":[73],"for":[74,243],"Scientific":[75],"Information":[76],"(ISI)":[77],"Science.":[80],"The":[81,108],"quality":[82],"included":[84],"assessed":[87],"using":[88],"Q-Genie":[90],"tool.":[91],"Thirteen":[92],"met":[94],"inclusion":[96],"criteria,":[97],"collectively":[98],"analysing":[99],"115":[100],"single":[101],"nucleotide":[102],"polymorphisms":[103,151],"(SNPs)":[104],"across":[105],"99":[106],"genes.":[107],"OCA2":[109],"gene":[110],"emerged":[111],"as":[112,166,189,210],"most":[114],"frequently":[115],"investigated,":[116],"consistently":[117],"linked":[118,222],"hyperpigmentation.":[120],"Overall,":[121],"findings":[122],"indicate":[123],"that":[124],"phenotypes":[127],"are":[128],"associated":[129,200],"genes":[131,208],"involved":[132],"collagen":[134],"metabolism,":[135],"melanogenesis,":[136],"oxidative":[137],"stress,":[138],"mechanical":[140],"properties":[141],"skin.":[144],"Notably,":[145],"SPATA33":[146],"rs35063026":[147],"IRF4":[149],"rs12203592":[150],"exhibit":[152],"pleiotropic":[153],"effects,":[154,174],"contributing":[155],"wrinkling":[158],"pigmentation":[160],"changes.":[161],"Interestingly,":[162],"some":[163],"variants,":[164],"such":[165,188,209],"SPTLC1":[167],"rs7042102":[168],"REEP3":[170],"rs11961184,":[171],"display":[172],"paradoxical":[173],"underscoring":[175],"complexity":[177],"modulation.":[180],"Genes":[181],"implicated":[182],"extracellular":[184],"matrix":[185],"(ECM)":[186],"degradation,":[187],"SMYD3,":[190],"those":[192],"responsive":[193],"pollutants,":[196],"like":[197],"CYP1A1,":[198],"were":[199,221],"increased":[202],"sagging.":[204],"Conversely,":[205],"COL1A2":[211],"COL13A1,":[213],"which":[214],"support":[215],"ECM":[216],"integrity":[217],"resilience,":[220],"protective":[224],"effects.":[225],"Despite":[226],"these":[227],"insights,":[228],"many":[229],"associations":[231],"remain":[232],"poorly":[233],"understood,":[234],"highlighting":[235],"substantial":[236],"knowledge":[239],"need":[242],"more":[244],"comprehensive":[245],"into":[248],"ageing.":[250]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2025-10-10T00:00:00"}
