{"id":"https://openalex.org/W4412856412","doi":"https://doi.org/10.3389/fphar.2025.1649837","title":"Editorial: Acute kidney injury: from pathology to phytotherapy","display_name":"Editorial: Acute kidney injury: from pathology to phytotherapy","publication_year":2025,"publication_date":"2025-07-17","ids":{"openalex":"https://openalex.org/W4412856412","doi":"https://doi.org/10.3389/fphar.2025.1649837","pmid":"https://pubmed.ncbi.nlm.nih.gov/40746729","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12311308"},"language":"en","primary_location":{"id":"doi:10.3389/fphar.2025.1649837","doi":"https://doi.org/10.3389/fphar.2025.1649837","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2025.1649837","pdf_url":"https://public-pages-files-2025.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1649837/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"volume":null,"type":"editorial","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://public-pages-files-2025.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1649837/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075079353","display_name":"Ya\u2010Long Feng","orcid":"https://orcid.org/0000-0001-5207-5010","observed_orcids":["https://orcid.org/0000-0001-5207-5010"]},"institutions":[{"id":"https://openalex.org/I4210118093","display_name":"Xianyang Normal University","ror":"https://ror.org/01r45yt97","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210118093"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ya-Long Feng","raw_affiliation_strings":["Department of Life Science, Xianyang Normal University, Xianyang, Shaanxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Life Science, Xianyang Normal University, Xianyang, Shaanxi, China","institution_ids":["https://openalex.org/I4210118093"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Wan-Ying Ma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210118093","display_name":"Xianyang Normal University","ror":"https://ror.org/01r45yt97","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210118093"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wan-Ying Ma","raw_affiliation_strings":["Department of Life Science, Xianyang Normal University, Xianyang, Shaanxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Life Science, Xianyang Normal University, Xianyang, Shaanxi, China","institution_ids":["https://openalex.org/I4210118093"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yin-Xuan Jiang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210118093","display_name":"Xianyang Normal University","ror":"https://ror.org/01r45yt97","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210118093"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yin-Xuan Jiang","raw_affiliation_strings":["Department of Life Science, Xianyang Normal University, Xianyang, Shaanxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Life Science, Xianyang Normal University, Xianyang, Shaanxi, China","institution_ids":["https://openalex.org/I4210118093"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088194738","display_name":"Le Shui","orcid":"https://orcid.org/0009-0001-6909-2383","observed_orcids":["https://orcid.org/0009-0001-6909-2383"]},"institutions":[{"id":"https://openalex.org/I4210118093","display_name":"Xianyang Normal University","ror":"https://ror.org/01r45yt97","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210118093"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Le Shui","raw_affiliation_strings":["Department of Life Science, Xianyang Normal University, Xianyang, Shaanxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Life Science, Xianyang Normal University, Xianyang, Shaanxi, China","institution_ids":["https://openalex.org/I4210118093"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100380200","display_name":"Hua Chen","orcid":"https://orcid.org/0009-0001-1241-4978","observed_orcids":["https://orcid.org/0009-0001-1241-4978","https://orcid.org/0000-0001-5564-4610"]},"institutions":[{"id":"https://openalex.org/I4210127460","display_name":"Ningxia Medical University","ror":"https://ror.org/02h8a1848","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210127460"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Hua Chen","raw_affiliation_strings":["College of Pharmacy, Ningxia Medical University, Yinchuan, Ningxia, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Ningxia Medical University, Yinchuan, Ningxia, China","institution_ids":["https://openalex.org/I4210127460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072983863","display_name":"Xuezhong Gong","orcid":"https://orcid.org/0000-0002-4496-7972","observed_orcids":["https://orcid.org/0000-0002-4496-7972"]},"institutions":[{"id":"https://openalex.org/I4210098460","display_name":"Shanghai University of Traditional Chinese Medicine","ror":"https://ror.org/00z27jk27","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210098460"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xue-Zhong Gong","raw_affiliation_strings":["Department of Nephrology, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China","institution_ids":["https://openalex.org/I4210098460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5072983863","https://openalex.org/A5075079353","https://openalex.org/A5100380200"],"corresponding_institution_ids":["https://openalex.org/I4210098460","https://openalex.org/I4210118093","https://openalex.org/I4210127460"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":null,"first_page":"1649837","last_page":"1649837"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.9761000275611877,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.9761000275611877,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12962","display_name":"Nephrotoxicity and Medicinal Plants","score":0.010200000368058681,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12429","display_name":"Chemotherapy-induced organ toxicity mitigation","score":0.0044999998062849045,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-kidney-injury","display_name":"acute kidney injury","score":0.9990000128746033},{"id":"https://openalex.org/keywords/traditional-chinese-medicine","display_name":"traditional Chinese medicine","score":0.7009999752044678},{"id":"https://openalex.org/keywords/herbal-compounds","display_name":"herbal compounds","score":0.8880000114440918},{"id":"https://openalex.org/keywords/aki-pathophysiology","display_name":"AKI pathophysiology","score":0.843999981880188},{"id":"https://openalex.org/keywords/liver-fatty-acid-binding-protein","display_name":"liver fatty acid binding protein","score":0.6019999980926514},{"id":"https://openalex.org/keywords/he4","display_name":"HE4","score":0.777999997138977},{"id":"https://openalex.org/keywords/nt-probnp","display_name":"NT-proBNP","score":0.9980000257492065},{"id":"https://openalex.org/keywords/anisodamine","display_name":"anisodamine","score":0.8029999732971191},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.5109999775886536},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9959999918937683},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9850000143051147},{"id":"https://openalex.org/keywords/chronic-kidney-disease","display_name":"chronic kidney disease","score":0.6919999718666077},{"id":"https://openalex.org/keywords/kidney-injury-biomarkers","display_name":"kidney injury biomarkers","score":0.7440000176429749},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"drug discovery","score":0.5339999794960022},{"id":"https://openalex.org/keywords/covid-19","display_name":"COVID-19 pandemic","score":0.5580000281333923},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.9570000171661377},{"id":"https://openalex.org/keywords/regulated-necrosis","display_name":"regulated necrosis","score":0.871999979019165}],"concepts":[{"id":"https://openalex.org/C2779969877","wikidata":"https://www.wikidata.org/wiki/Q861699","display_name":"Phytotherapy","level":3,"score":0.7103762030601501},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6635556817054749},{"id":"https://openalex.org/C2780472472","wikidata":"https://www.wikidata.org/wiki/Q424337","display_name":"Acute kidney injury","level":2,"score":0.552091658115387},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.42604944109916687},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3195708096027374},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.2984462380409241},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.26889175176620483}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3389/fphar.2025.1649837","doi":"https://doi.org/10.3389/fphar.2025.1649837","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2025.1649837","pdf_url":"https://public-pages-files-2025.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1649837/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:11124053","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12311308","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:40746729","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40746729","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in pharmacology","raw_type":"Editorial"},{"id":"pmh:oai:pubmedcentral.nih.gov:12311308","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12311308/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Pharmacol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:1f81e7c987664ca7947b5226d03eecd3","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/1f81e7c987664ca7947b5226d03eecd3","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Pharmacology, Vol 16 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fphar.2025.1649837","doi":"https://doi.org/10.3389/fphar.2025.1649837","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2025.1649837","pdf_url":"https://public-pages-files-2025.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1649837/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4412856412.pdf","grobid_xml":"https://content.openalex.org/works/W4412856412.grobid-xml"},"referenced_works_count":2,"referenced_works":["https://openalex.org/W2146081758","https://openalex.org/W4211157472"],"related_works":["https://openalex.org/W4415471850","https://openalex.org/W7134955667","https://openalex.org/W2283725907","https://openalex.org/W2937652823","https://openalex.org/W4280503935","https://openalex.org/W2728754842","https://openalex.org/W4220762944","https://openalex.org/W4407756783","https://openalex.org/W3092031097","https://openalex.org/W4413870480"],"abstract_inverted_index":{"Acute":[0],"kidney":[1,243,288,448,578,767,800,920,1137],"injury":[2,244,449,886,907,1138],"(AKI),":[3],"defined":[4],"by":[5,101,551,644,831,1025,1058,1125,1139],"an":[6,123],"abrupt":[7],"rise":[8],"in":[9,15,117,130,163,284,377,392,452,462,492,523,539,590,630,678,693,717,728,733,756,765,799,859,901,922,1070],"serum":[10,268,330,872],"creatinine":[11,873],"and":[12,22,46,84,106,139,169,195,239,276,291,312,319,334,352,369,394,412,420,525,574,592,602,616,654,700,708,775,779,791,817,835,857,874,882,888,899,905,942,948,975,998,1004,1021,1030,1090,1109,1156,1177,1192],"a":[13,19,186,217,253,346,406,468,520,543,567,663,675,723,753,796,812,819,915,1043,1078],"decrease":[14,871],"urinary":[16,209],"output,":[17],"causes":[18],"high":[20],"morbidity":[21],"mortality":[23],"worldwide":[24],"(Ronco":[25],"et":[26,204,224,263,299,343,381,439,474,529,558,581,607,620,634,686,736,759,784,823,845,862,909,925,953,977,988,1012,1051,1074,1094,1114],"al.,":[27,225,300,382,475,559,608,635,737,785,846,910,954,1013,1075,1115],"2019).":[28],"Due":[29],"to":[30,70,546,703,852,1047,1150],"the":[31,44,136,157,160,164,170,208,231,267,309,329,356,410,423,443,481,490,505,532,547,553,584,596,624,679,683,705,740,789,840,894,929,945,964,992,1036,1065,1098,1126,1159,1164,1180,1187,1193],"poor":[32],"understanding":[33],"of":[34,49,79,95,126,141,167,173,188,270,303,317,332,339,350,445,483,507,535,549,570,588,598,682,695,726,742,766,793,896,933,958,967,996,1100,1120,1128,1161,1168,1196],"AKI":[35,40,50,72,100,116,146,168,201,221,294,340,351,430,550,631,806,830,938,1018,1024,1191],"pathophysiology,":[36],"effective":[37],"drugs":[38,62],"for":[39,59,73,133,200,258,513,613,666,918,1190],"treatment":[41,424,548,807],"remain":[42],"lacking.Therefore,":[43],"cellular":[45],"molecular":[47,949],"mechanisms":[48,140],"should":[51,234],"be":[52,57,235,963,1123],"deeply":[53],"studied,":[54],"which":[55,541,658,1131,1183],"will":[56,1184],"beneficial":[58,512],"developing":[60],"therapy":[61,499],"against":[63,145,180,747,829,936,970],"AKI.Traditional":[64],"medical":[65,88,128,143,178,1170,1198],"herb":[66],"has":[67,914,1152],"been":[68,82],"used":[69,851,1046],"treat":[71,853,1048],"many":[74],"years.":[75],"A":[76],"large":[77,469],"number":[78],"compounds":[80,97,110,174],"have":[81,322],"isolated":[83],"identified":[85],"from":[86,176,355,712,731,1106,1179],"traditional":[87,127,142,177,984,1044,1169,1197],"herbs.":[89],"Recent":[90],"studies":[91,354,1155],"reveal":[92],"that":[93,207,230,266,328,422,442,480,623,660,689,826,865,928,991,1054,1097,1134,1174],"some":[94,109],"these":[96],"can":[98],"alleviate":[99],"inhibiting":[102,645,1035],"inflammation,":[103,651,1027],"oxidative":[104,526,593,836],"stress,":[105],"apoptosis.":[107],"Noteworthily,":[108],"exhibited":[111],"their":[112,803],"therapeutic":[113,664,797,1166],"efficacy":[114],"on":[115,295,341,1158],"clinics,":[118],"such":[119,1086],"as":[120,373,805,1087],"anisodamine,":[121],"indicating":[122],"important":[124,199,533],"source":[125],"herbs":[129,144,179],"drug":[131,1188],"discovery":[132],"AKI.":[134,181,259,508,668,971],"However,":[135,739],"active":[137],"ingredients":[138,932,995],"are":[147,197,336,401,511,981],"still":[148],"poorly":[149],"understood.The":[150],"present":[151],"Research":[152,1143,1181],"Topic":[153,1144],"aims":[154],"at":[155,237,249],"collecting":[156],"manuscripts":[158,190],"demonstrating":[159],"novel":[161],"findings":[162],"pathological":[165],"process":[166],"protective":[171,1118],"effects":[172],"derived":[175],"After":[182],"rigorous":[183],"peer":[184],"reviews,":[185],"total":[187],"16":[189],"were":[191,282,939],"published.The":[192],"early":[193],"diagnosis":[194],"intervention":[196],"very":[198],"treatment.":[202],"Ryu":[203],"al":[205,264,344,440,530,582,621,687,760,824,863,926,989,1052,1095],"found":[206,265,421,441,622,688,825,864,927,990,1053,1096],"L-liver-type":[210],"fatty":[211],"acid-binding":[212],"protein":[213,273],"(L-FABP)":[214],"level":[215,233,302],"had":[216,435],"close":[218],"relationship":[219],"with":[220,286,293,308,314,425,454,485,494,577,903,1082],"progression":[222],"(Yasuda":[223],"2024).":[226,738,1116],"Further":[227],"study":[228,472],"revealed":[229],"L-FABP":[232],"measured":[236],"6":[238,250],"12":[240],"hours":[241],"after":[242],"than":[245,461,501],"only":[246],"one":[247],"time":[248],"hours,":[251],"suggesting":[252,722],"more":[254],"precise":[255],"diagnose":[256],"method":[257,1010],"In":[260,496,561,669,1015],"addition,":[261,433,497,562,670],"Gong":[262],"levels":[269,316,331],"human":[271,697,720],"epididymis":[272],"4":[274],"(HE4)":[275],"N-terminal":[277],"pro-B-type":[278],"natriuretic":[279],"peptide":[280],"(NT-proBNP)":[281],"increased":[283,489,504,628],"patients":[285,292,313,453,465,493],"chronic":[287],"diseases":[289,921],"(CKD)":[290],"CKD":[296],"(Song":[297],"J":[298],"2023).The":[301,636],"HE4":[304,318,333],"is":[305,389,566,575,611,752,811,850,1042,1077],"positively":[306],"correlated":[307],"disease":[310,768],"severity,":[311],"higher":[315,460],"NT-proBNP":[320,335],"usually":[321],"poorer":[323],"prognosis.":[324],"These":[325,509],"results":[326,510],"suggest":[327,1133],"impactful":[337],"predictors":[338],"CKD.Chen":[342],"conducted":[345,405],"comprehensive":[347],"bibliometric":[348],"analysis":[349,408,951],"immune-related":[353],"past":[357],"two":[358],"decades,":[359],"identifying":[360],"COVID-19,":[361],"immune":[362],"checkpoint":[363],"inhibitors,":[364],"regulated":[365],"necrosis,":[366],"cirrhosis-related":[367],"AKI,":[368,540,599,1162],"other":[370],"emerging":[371],"topics":[372],"key":[374,521,676,965],"research":[375],"foci":[376],"recent":[378],"years":[379],"(Chen":[380,783],"2024b).Proprotein":[383],"convertase":[384],"subtilisin/kexin":[385],"type":[386],"9":[387],"(PCSK9)":[388],"mainly":[390],"expressed":[391],"liver":[393],"regulates":[395],"cholesterol":[396],"metabolism.":[397],"The":[398,956,1117],"PCSK9":[399,426],"inhibitors":[400,427,792],"lipid-lowering":[402],"drugs.":[403],"Liu":[404,822],"disproportionality":[407],"through":[409,466,944],"Food":[411],"Drug":[413],"Administration":[414],"Adverse":[415],"Event":[416],"Reporting":[417],"System":[418],"database":[419],"might":[428,962,1132],"induce":[429],"(Liu,":[431],"2024).In":[432],"vancomycin":[434,484,498],"significant":[436],"nephrotoxicity.":[437],"Pan":[438],"incidence":[444],"vancomycin-associated":[446],"acute":[447],"(VA":[450],"-AKI)":[451],"infective":[455],"endocarditis":[456],"(IE)":[457],"was":[458,627,662,691,701],"slightly":[459],"general":[463],"adult":[464],"conducting":[467],"retrospective":[470],"cohort":[471],"(Kunming":[473],"2023).":[476,560,847,955],"It's":[477],"worth":[478],"noting":[479],"combination":[482],"contrast":[486,1016],"agents":[487],"significantly":[488,640,1102],"nephrotoxic":[491],"IE.":[495],"longer":[500],"10.75":[502],"days":[503],"risk":[506],"preventing":[514],"AKI.The":[515],"NF-\u03baB":[516,536,554,959],"signaling":[517,537,555,960,1038,1068],"pathway":[518,538,556,961,1069],"plays":[519,674],"role":[522,534,677,725],"inflammation":[524,591,834],"stress.":[527],"Ren":[528],"reviewed":[531,583],"provided":[542],"new":[544],"insight":[545],"targeting":[552],"(Ren":[557],"arachidonic":[563],"acid":[564,1006],"(AA)":[565],"main":[568,585,930],"component":[569],"cell":[571,604,649,781,885,891,1028,1031,1107],"membrane":[572],"lipids":[573],"associated":[576],"function.":[579],"Li":[580,861,987,1050],"metabolic":[586],"pathways":[587],"AA":[589],"stress":[594,837],"during":[595],"processes":[597,1033],"diabetic":[600],"nephropathy":[601],"renal":[603,642,646,879,883,890,1060],"carcinoma":[605],"(Li":[606,908,1011,1073],"2024).Calprotectin":[609],"(S100A8/A9)":[610],"crucial":[612,724],"leukocyte":[614],"recruitment":[615],"inflammatory":[617],"response.":[618],"Shi":[619],"S100A9":[625,637,661],"expression":[626],"continuously":[629],"mice":[632,699,902],"(Shi":[633],"inhibitor,":[638],"paquinimod,":[639],"improved":[641],"function":[643,681],"tubular":[647,714,884],"epithelial":[648,715],"apoptosis,":[650,833],"superoxide":[652],"production,":[653],"mitochondrial":[655],"dynamic":[656],"imbalance,":[657],"suggested":[659],"target":[665],"treating":[667,919],"apolipoprotein":[671],"M":[672],"(apoM)":[673],"reabsorption":[680],"kidney.":[684],"Bisgaard":[685],"apoM":[690,727,743],"detectable":[692],"plasma":[694],"kidney-specific":[696],"transgenic":[698],"secreted":[702],"both":[704,788],"apical":[706],"(urine)":[707],"basolateral":[709],"(blood)":[710],"compartment":[711],"proximal":[713],"cells":[716,1105],"HK-2":[718,1104],"cells-overexpressed":[719],"apoM,":[721],"sequestering":[729],"molecules":[730],"excretion":[732],"urine":[734],"(Bisgaard":[735],"overexpression":[741],"did":[744],"not":[745],"protect":[746],"AKI.Pyruvate":[748],"kinase":[749],"M2":[750],"(PKM2)":[751],"rate-limiting":[754],"enzyme":[755],"glycolysis.":[757],"Chen":[758],"highlighted":[761],"its":[762],"critical":[763],"roles":[764],"progression,":[769],"including":[770],"podocyte":[771],"injury,":[772],"fibroblast":[773],"activation":[774],"proliferation,":[776],"macrophage":[777],"polarization,":[778],"T":[780],"regulation":[782],"2024a).":[786],"Notably,":[787],"activators":[790],"PKM2":[794],"showed":[795],"effect":[798,1119],"diseases,":[801],"underscoring":[802],"potential":[804],"strategies.Huangqi-Danshen":[808],"decoction":[809],"(HDD)":[810],"well-known":[813],"Chinese":[814,985],"herbal":[815],"preparation":[816],"shows":[818],"reno-protective":[820],"effect.":[821],"HDD":[827],"protected":[828],"suppressing":[832,1064],"via":[838,893,1034,1063],"modulating":[839],"NAD":[841],"+":[842],"biosynthesis":[843],"(Liu":[844],"Panax":[848,866],"notoginseng":[849,867],"haemorrhage,":[854],"blood-stasis,":[855],"swelling":[856],"pain":[858],"China.":[860,923],"rhizomes":[868],"(PNR)":[869],"could":[870,1122],"urea":[875],"nitrogen":[876],"levels,":[877],"reduce":[878],"infarct":[880],"areas":[881],"areas,":[887],"inhibit":[889],"apoptosis":[892],"downregulation":[895],"MMP9,":[897],"TP53":[898],"IL-6":[900],"ischemia":[904],"reperfusion":[906],"2023a).":[911],"Prunella":[912,934,968],"vulgaris":[913,935,969],"long":[916],"history":[917],"Yang":[924],"bio-active":[931,994],"COVID-19-associated":[937],"quercetin,":[940],"luteolin":[941],"kaempferol":[943],"network":[946,1008],"pharmacology":[947,1009],"docking":[950],"(Yang":[952],"inhibition":[957],"mechanism":[966],"Rhizoma":[972,978],"Chuanxiong":[973],"(CX)":[974],"Radix":[976],"Rhei":[979],"(DH)":[980],"well":[982],"known":[983],"medicines.":[986],"core":[993],"CX":[997,1020],"DH":[999,1022],"included":[1000],"aloe-emodin,":[1001],"(-)-catechin,":[1002],"\u03b2-sitosterol":[1003],"folic":[1005],"though":[1007],"2023b).":[1014],"media-induced":[1017],"rats,":[1019],"alleviated":[1023,1056],"regulating":[1026],"death":[1029,1108],"cycle":[1032],"p38-MAPK/p53":[1037],"pathway.":[1039],"Yue-bi-tang":[1040],"(YBT)":[1041],"formula":[1045],"edema.":[1049],"YBT":[1055],"edema":[1057],"decreasing":[1059],"microvascular":[1061],"permeability":[1062],"Cav-1/":[1066],"eNOS":[1067],"Adriamycin-treated":[1071],"rats":[1072],"2023c).Myricitrin":[1076],"natural":[1079],"flavonoid":[1080],"compound":[1081],"diverse":[1083],"pharmacological":[1084],"properties,":[1085],"anti-oxidant,":[1088],"anti-inflammation":[1089],"anti-cancer":[1091],"activities.":[1092],"Huang":[1093],"pretreatment":[1099],"myricitrin":[1101,1121,1135],"rescued":[1103],"reduced":[1110],"iron":[1111],"overload":[1112],"(Lin":[1113],"reserved":[1124],"inducer":[1127],"ferritinophagy":[1129],"rapamycin,":[1130],"ameliorated":[1136],"attenuating":[1140],"ferritinophagy-mediated":[1141],"ferroptosis.The":[1142],"\"Acute":[1145],"Kidney":[1146],"Injury:":[1147],"From":[1148],"Pathology":[1149],"Phytotherapy\"":[1151],"collected":[1153],"worthy":[1154],"contributions":[1157],"subject":[1160],"highlighting":[1163],"promising":[1165],"property":[1167],"herb.":[1171,1199],"We":[1172],"hope":[1173],"you":[1175],"enjoy":[1176],"gain":[1178],"Topic,":[1182],"surely":[1185],"promote":[1186],"development":[1189],"further":[1194],"application":[1195]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2025-10-10T00:00:00"}
