{"id":"https://openalex.org/W4412852169","doi":"https://doi.org/10.1016/j.ajt.2025.07.677","title":"Changes in Immune Cell Markers: A Cross-Sectional Analysis of the Elderly Wait-Listed and Kidney Transplant Recipients","display_name":"Changes in Immune Cell Markers: A Cross-Sectional Analysis of the Elderly Wait-Listed and Kidney Transplant Recipients","publication_year":2025,"publication_date":"2025-08-01","ids":{"openalex":"https://openalex.org/W4412852169","doi":"https://doi.org/10.1016/j.ajt.2025.07.677"},"language":"en","primary_location":{"id":"doi:10.1016/j.ajt.2025.07.677","doi":"https://doi.org/10.1016/j.ajt.2025.07.677","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ajt.2025.07.677","pdf_url":null,"source":{"id":"https://openalex.org/S182625382","display_name":"American Journal of Transplantation","issn_l":"1600-6135","issn":["1600-6135","1600-6143"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Transplantation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.ajt.2025.07.677","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042866896","display_name":"Lavanya Kodali","orcid":"https://orcid.org/0000-0003-4141-7243","observed_orcids":["https://orcid.org/0000-0003-4141-7243"]},"institutions":[{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]},{"id":"https://openalex.org/I4210127938","display_name":"Mayo Clinic Hospital","ror":"https://ror.org/03660jn93","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099","https://openalex.org/I4210127938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L. Kodali","raw_affiliation_strings":["Transplant Nephrology, Mayo Clinic Arizona, Phoenix, AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Transplant Nephrology, Mayo Clinic Arizona, Phoenix, AZ","institution_ids":["https://openalex.org/I4210125099","https://openalex.org/I4210127938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041693914","display_name":"Anna N. Ligezka","orcid":"https://orcid.org/0000-0001-5183-3086","observed_orcids":["https://orcid.org/0000-0001-5183-3086"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]},{"id":"https://openalex.org/I4210127938","display_name":"Mayo Clinic Hospital","ror":"https://ror.org/03660jn93","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099","https://openalex.org/I4210127938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A.N. Ligezka","raw_affiliation_strings":["Immunology, Mayo Clinic, Phoenix, AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunology, Mayo Clinic, Phoenix, AZ","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210125099","https://openalex.org/I4210127938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100331228","display_name":"Nan Zhang","orcid":"https://orcid.org/0000-0001-7667-0615","observed_orcids":["https://orcid.org/0000-0001-7667-0615"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N. Zhang","raw_affiliation_strings":["Biostatistics, Mayo Clinic, Phoenix, AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biostatistics, Mayo Clinic, Phoenix, AZ","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044813155","display_name":"Payman L. Zamani","orcid":"https://orcid.org/0000-0002-9345-5834","observed_orcids":["https://orcid.org/0000-0002-9345-5834"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]},{"id":"https://openalex.org/I4210127938","display_name":"Mayo Clinic Hospital","ror":"https://ror.org/03660jn93","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099","https://openalex.org/I4210127938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P. Zamani","raw_affiliation_strings":["Immunology, Mayo Clinic, Phoenix, AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunology, Mayo Clinic, Phoenix, AZ","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210125099","https://openalex.org/I4210127938"]}]},{"author_position":"middle","author":{"id":null,"display_name":"T.M. Johnston","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]},{"id":"https://openalex.org/I4210127938","display_name":"Mayo Clinic Hospital","ror":"https://ror.org/03660jn93","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099","https://openalex.org/I4210127938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T.M. Johnston","raw_affiliation_strings":["Immunology, Mayo Clinic, Phoenix, AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunology, Mayo Clinic, Phoenix, AZ","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210125099","https://openalex.org/I4210127938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032584971","display_name":"Girish K. Mour","orcid":"https://orcid.org/0000-0003-3764-0047","observed_orcids":["https://orcid.org/0000-0003-3764-0047"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]},{"id":"https://openalex.org/I4210127938","display_name":"Mayo Clinic Hospital","ror":"https://ror.org/03660jn93","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099","https://openalex.org/I4210127938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G. Mour","raw_affiliation_strings":["Transplant Nephrology, Mayo Clinic, Phoenix, AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Transplant Nephrology, Mayo Clinic, Phoenix, AZ","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210125099","https://openalex.org/I4210127938"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018867812","display_name":"Mohsen Khosravi Maharlooei","orcid":"https://orcid.org/0009-0001-2385-3714","observed_orcids":["https://orcid.org/0009-0001-2385-3714","https://orcid.org/0000-0002-1394-9245"]},"institutions":[{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Khosravi Maharlooei","raw_affiliation_strings":["Immunology, Mayo Clinic Arizona, Phoenix, AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunology, Mayo Clinic Arizona, Phoenix, AZ","institution_ids":["https://openalex.org/I4210125099"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4300,"currency":"USD","value_usd":4300},"apc_paid":{"value":4300,"currency":"USD","value_usd":4300},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.33426652,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"25","issue":"8","first_page":"S301","last_page":"S301"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.9692000150680542,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.9692000150680542,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.008200000040233135,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.004399999976158142,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/immunosenescence","display_name":"immunosenescence","score":0.8460000157356262},{"id":"https://openalex.org/keywords/kidney-transplant-recipients","display_name":"kidney transplant recipients","score":0.7860000133514404},{"id":"https://openalex.org/keywords/elderly-patients","display_name":"elderly patients","score":0.902999997138977},{"id":"https://openalex.org/keywords/immune-cell-markers","display_name":"immune cell markers","score":0.7910000085830688},{"id":"https://openalex.org/keywords/mitochondrial-function","display_name":"mitochondrial function","score":0.7549999952316284},{"id":"https://openalex.org/keywords/immune-regulation","display_name":"immune regulation","score":0.5419999957084656},{"id":"https://openalex.org/keywords/acute-rejection","display_name":"acute rejection","score":0.859000027179718},{"id":"https://openalex.org/keywords/6-minute-walk-test","display_name":"6-minute walk test","score":0.890999972820282}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9212415218353271},{"id":"https://openalex.org/C2994498544","wikidata":"https://www.wikidata.org/wiki/Q740909","display_name":"Kidney transplant","level":4,"score":0.6662548780441284},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5461391806602478},{"id":"https://openalex.org/C142052008","wikidata":"https://www.wikidata.org/wiki/Q954027","display_name":"Cross-sectional study","level":2,"score":0.5042387247085571},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.43218883872032166},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4036008417606354},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.3967397212982178},{"id":"https://openalex.org/C2780303639","wikidata":"https://www.wikidata.org/wiki/Q740909","display_name":"Kidney transplantation","level":3,"score":0.37887823581695557},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.25078195333480835}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.ajt.2025.07.677","doi":"https://doi.org/10.1016/j.ajt.2025.07.677","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ajt.2025.07.677","pdf_url":null,"source":{"id":"https://openalex.org/S182625382","display_name":"American Journal of Transplantation","issn_l":"1600-6135","issn":["1600-6135","1600-6143"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Transplantation","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.ajt.2025.07.677","doi":"https://doi.org/10.1016/j.ajt.2025.07.677","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ajt.2025.07.677","pdf_url":null,"source":{"id":"https://openalex.org/S182625382","display_name":"American Journal of Transplantation","issn_l":"1600-6135","issn":["1600-6135","1600-6143"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Transplantation","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2808208013","https://openalex.org/W4415425383","https://openalex.org/W4220795325","https://openalex.org/W2059073244","https://openalex.org/W4392058350","https://openalex.org/W7057140293","https://openalex.org/W4403271243","https://openalex.org/W2748501592","https://openalex.org/W4412379227","https://openalex.org/W2892409381"],"abstract_inverted_index":{"Purpose:":[0],"Infections,":[1],"cardiovascular":[2],"disease,":[3],"and":[4,32,51,63,75],"malignancy":[5],"are":[6],"the":[7,55,70],"leading":[8],"causes":[9],"of":[10,37,47],"mortality":[11],"in":[12,24,44,54],"elderly":[13,25,56,59],"kidney":[14],"transplant":[15],"recipients":[16],"(KTRs).":[17],"While":[18],"acute":[19],"rejection":[20,76],"is":[21,40],"less":[22],"frequent":[23],"KTRs,":[26],"immunosenescence":[27],"may":[28],"lead":[29],"to":[30,41],"infections":[31],"cancer":[33],".":[34],"The":[35],"aim":[36],"this":[38],"study":[39],"assess":[42],"changes":[43],"immune":[45],"markers":[46],"senescence,":[48],"regulation,":[49],"metabolism,":[50],"mitochondrial":[52],"function":[53],"KTRs":[57],"versus":[58],"wait-listed":[60],"(WL)":[61],"patients":[62],"correlate":[64],"them":[65],"with":[66],"clinical":[67],"metrics,":[68],"including":[69],"six-minute":[71],"walk":[72],"test,":[73],"infections,":[74],"episodes.":[77]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-10-10T00:00:00"}