{"id":"https://openalex.org/W4412851014","doi":"https://doi.org/10.1016/j.ajt.2025.07.538","title":"Oral Tributyrate Promotes Treg-Mediated Immune Modulation and Prolongs Allograft Survival in Murine Transplant Models","display_name":"Oral Tributyrate Promotes Treg-Mediated Immune Modulation and Prolongs Allograft Survival in Murine Transplant Models","publication_year":2025,"publication_date":"2025-08-01","ids":{"openalex":"https://openalex.org/W4412851014","doi":"https://doi.org/10.1016/j.ajt.2025.07.538"},"language":"en","primary_location":{"id":"doi:10.1016/j.ajt.2025.07.538","doi":"https://doi.org/10.1016/j.ajt.2025.07.538","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ajt.2025.07.538","pdf_url":null,"source":{"id":"https://openalex.org/S182625382","display_name":"American Journal of Transplantation","issn_l":"1600-6135","issn":["1600-6135","1600-6143"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Transplantation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.ajt.2025.07.538","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"D. Marconi Mendes","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D. Marconi Mendes","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"T. Borges","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T. Borges","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5083826351","display_name":"Leonardo V. Riella","orcid":"https://orcid.org/0000-0002-7636-3196","observed_orcids":["https://orcid.org/0000-0002-7636-3196"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L. Riella","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4300,"currency":"USD","value_usd":4300},"apc_paid":{"value":4300,"currency":"USD","value_usd":4300},"fwci":0.3728,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.56030966,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"25","issue":"8","first_page":"S243","last_page":"S244"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9053000211715698,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9053000211715698,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.02329999953508377,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.015599999576807022,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tributyrin","display_name":"tributyrin","score":0.859000027179718},{"id":"https://openalex.org/keywords/butyrate","display_name":"butyrate","score":0.8360000252723694},{"id":"https://openalex.org/keywords/short-chain-fatty-acids","display_name":"short-chain fatty acids","score":0.9490000009536743},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.875},{"id":"https://openalex.org/keywords/immune-tolerance","display_name":"immune tolerance","score":0.7379999756813049},{"id":"https://openalex.org/keywords/allograft-survival","display_name":"allograft survival","score":0.9139999747276306},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.7749999761581421},{"id":"https://openalex.org/keywords/oral-immunomodulation","display_name":"oral immunomodulation","score":0.753000020980835},{"id":"https://openalex.org/keywords/graft-rejection","display_name":"graft rejection","score":0.42800000309944153}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8761997222900391},{"id":"https://openalex.org/C2991678113","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immune modulation","level":3,"score":0.8479294180870056},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6558116674423218},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6114302277565002},{"id":"https://openalex.org/C2780252810","wikidata":"https://www.wikidata.org/wiki/Q1455316","display_name":"Immunosuppression","level":2,"score":0.43646231293678284},{"id":"https://openalex.org/C3020684253","wikidata":"https://www.wikidata.org/wiki/Q1550619","display_name":"Treg cell","level":5,"score":0.4128977060317993},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3246030807495117},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.09999853372573853},{"id":"https://openalex.org/C79484868","wikidata":"https://www.wikidata.org/wiki/Q5971673","display_name":"IL-2 receptor","level":4,"score":0.06226283311843872}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.ajt.2025.07.538","doi":"https://doi.org/10.1016/j.ajt.2025.07.538","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ajt.2025.07.538","pdf_url":null,"source":{"id":"https://openalex.org/S182625382","display_name":"American Journal of Transplantation","issn_l":"1600-6135","issn":["1600-6135","1600-6143"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Transplantation","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.ajt.2025.07.538","doi":"https://doi.org/10.1016/j.ajt.2025.07.538","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ajt.2025.07.538","pdf_url":null,"source":{"id":"https://openalex.org/S182625382","display_name":"American Journal of Transplantation","issn_l":"1600-6135","issn":["1600-6135","1600-6143"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Transplantation","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7124714083","https://openalex.org/W4385687823","https://openalex.org/W4417327519","https://openalex.org/W4404499502","https://openalex.org/W1199473608","https://openalex.org/W4403440837","https://openalex.org/W4327957552","https://openalex.org/W2477377826","https://openalex.org/W4413119035","https://openalex.org/W4286870246"],"abstract_inverted_index":{"Purpose:":[0],"The":[1],"gut":[2],"microbiota":[3],"plays":[4],"a":[5,48],"critical":[6],"role":[7],"in":[8,74],"immune":[9,68],"tolerance,":[10],"partly":[11],"through":[12],"the":[13,44],"production":[14],"of":[15,50],"short-chain":[16],"fatty":[17],"acids":[18],"(SCFAs)":[19],"like":[20],"butyrate,":[21,51],"which":[22],"promotes":[23],"regulatory":[24],"T":[25],"cell":[26],"(Treg)":[27],"induction":[28],"and":[29,55,70],"suppresses":[30],"inflammation.":[31],"However,":[32],"due":[33],"to":[34,43],"poor":[35],"systemic":[36],"bioavailability,":[37],"butyrate\u2019s":[38],"effects":[39],"are":[40],"largely":[41],"restricted":[42],"gut.":[45],"Tributyrin":[46],"(Trib),":[47],"prodrug":[49],"enhances":[52],"its":[53,57],"absorption":[54],"extends":[56],"immunomodulatory":[58],"potential":[59],"systemically.":[60],"This":[61],"study":[62],"investigates":[63],"whether":[64],"oral":[65],"Trib":[66],"modulates":[67],"responses":[69],"improves":[71],"graft":[72],"survival":[73],"murine":[75],"transplant":[76],"models.":[77]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-22T09:42:04.148104","created_date":"2025-10-10T00:00:00"}