{"id":"https://openalex.org/W4412844293","doi":"https://doi.org/10.1158/0008-5472.29759903","title":"Supplementary Video 4 from Tobacco Smoking Rewires Cell Metabolism by Inducing GAPDH Succinylation to Promote Lung Cancer Progression","display_name":"Supplementary Video 4 from Tobacco Smoking Rewires Cell Metabolism by Inducing GAPDH Succinylation to Promote Lung Cancer Progression","publication_year":2025,"publication_date":"2025-08-01","ids":{"openalex":"https://openalex.org/W4412844293","doi":"https://doi.org/10.1158/0008-5472.29759903"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.29759903","doi":"https://doi.org/10.1158/0008-5472.29759903","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.29759903","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/0008-5472.29759903","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086596778","display_name":"Kun Wang","orcid":"https://orcid.org/0009-0007-7374-0041","observed_orcids":["https://orcid.org/0009-0007-7374-0041"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kun Wang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0007-7374-0041","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104229119","display_name":"Jingzhuo Li","orcid":"https://orcid.org/0009-0007-9971-7202","observed_orcids":["https://orcid.org/0009-0007-9971-7202"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jingzhuo Li","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0007-9971-7202","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101893099","display_name":"Hai Zhang","orcid":"https://orcid.org/0000-0002-7999-0208","observed_orcids":["https://orcid.org/0000-0002-7999-0208"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hai Zhang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7999-0208","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100826737","display_name":"Hongyan Ma","orcid":"https://orcid.org/0009-0000-6093-5340","observed_orcids":["https://orcid.org/0009-0000-6093-5340"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hongyan Ma","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0000-6093-5340","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070334057","display_name":"Hong\u2010Yong Cui","orcid":"https://orcid.org/0000-0003-0051-2666","observed_orcids":["https://orcid.org/0000-0003-0051-2666"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hong-Yong Cui","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0051-2666","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050581018","display_name":"Huai\u2010Qiang Ju","orcid":"https://orcid.org/0000-0003-1713-5465","observed_orcids":["https://orcid.org/0000-0003-1713-5465"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Huai-Qiang Ju","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1713-5465","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005030510","display_name":"Jing Zhang","orcid":"https://orcid.org/0000-0001-7719-6943","observed_orcids":["https://orcid.org/0000-0001-7719-6943"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jing Zhang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7719-6943","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018531049","display_name":"Qing-zhi Ma","orcid":"https://orcid.org/0009-0005-8813-4621","observed_orcids":["https://orcid.org/0009-0005-8813-4621"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Qing-zhi Ma","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0005-8813-4621","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044914538","display_name":"Ming Zhao","orcid":"https://orcid.org/0000-0003-1093-6817","observed_orcids":["https://orcid.org/0000-0003-1093-6817"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ming Zhao","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1093-6817","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026757462","display_name":"Qing-mei Zeng","orcid":"https://orcid.org/0000-0002-6276-9603","observed_orcids":["https://orcid.org/0000-0002-6276-9603"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Qing-mei Zeng","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6276-9603","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108716805","display_name":"Jie Zou","orcid":"https://orcid.org/0009-0001-7594-5864","observed_orcids":["https://orcid.org/0009-0001-7594-5864"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jie Zou","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0001-7594-5864","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108633854","display_name":"Xiuxuan Sun","orcid":"https://orcid.org/0009-0006-8735-2851","observed_orcids":["https://orcid.org/0009-0006-8735-2851"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiu-Xuan Sun","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0006-8735-2851","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010696053","display_name":"Gang Nan","orcid":"https://orcid.org/0000-0002-7926-4572","observed_orcids":["https://orcid.org/0000-0002-7926-4572"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gang Nan","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7926-4572","affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Meirui Qian","orcid":"https://orcid.org/0009-0009-7852-5732","observed_orcids":["https://orcid.org/0009-0009-7852-5732"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Meirui Qian","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0009-7852-5732","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101338016","display_name":"Lin Jing","orcid":"https://orcid.org/0009-0001-5925-0253","observed_orcids":["https://orcid.org/0009-0001-5925-0253"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lin Jing","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0001-5925-0253","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100346359","display_name":"Yiming Li","orcid":"https://orcid.org/0000-0003-3251-0104","observed_orcids":["https://orcid.org/0000-0003-3251-0104"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yiming Li","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3251-0104","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108897172","display_name":"Cai-feng Xiong","orcid":"https://orcid.org/0009-0006-9221-8876","observed_orcids":["https://orcid.org/0009-0006-9221-8876"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cai-feng Xiong","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0006-9221-8876","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077947586","display_name":"Qiu-zi Yang","orcid":"https://orcid.org/0009-0007-9326-9955","observed_orcids":["https://orcid.org/0009-0007-9326-9955"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Qiu-zi Yang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0007-9326-9955","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072483113","display_name":"Hao Wang","orcid":"https://orcid.org/0000-0003-1086-5182","observed_orcids":["https://orcid.org/0000-0003-1086-5182"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hao Wang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1086-5182","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018051539","display_name":"Jian\u2010Li Jiang","orcid":"https://orcid.org/0000-0001-7952-5667","observed_orcids":["https://orcid.org/0000-0001-7952-5667"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jian-Li Jiang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7952-5667","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027880821","display_name":"Zhi\u2010Nan Chen","orcid":"https://orcid.org/0000-0001-5512-4623","observed_orcids":["https://orcid.org/0000-0001-5512-4623"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhi-Nan Chen","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5512-4623","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034842740","display_name":"Liang Chen","orcid":"https://orcid.org/0000-0002-0440-0306","observed_orcids":["https://orcid.org/0000-0002-0440-0306"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Liang Chen","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0440-0306","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5073268931","display_name":"Wan Huang","orcid":"https://orcid.org/0000-0002-6326-9838","observed_orcids":["https://orcid.org/0000-0002-6326-9838"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wan Huang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6326-9838","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.9711999893188477,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.9711999893188477,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.00930000003427267,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/smoking","display_name":"smoking","score":0.8379999995231628},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.6420000195503235},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.8980000019073486},{"id":"https://openalex.org/keywords/cellular-metabolism","display_name":"cellular metabolism","score":0.8240000009536743},{"id":"https://openalex.org/keywords/kras-g12d","display_name":"KRAS G12D","score":0.8759999871253967},{"id":"https://openalex.org/keywords/pet-ct-imaging","display_name":"PET/CT imaging","score":0.734000027179718},{"id":"https://openalex.org/keywords/18f-flt","display_name":"18F-FLT","score":0.9419999718666077},{"id":"https://openalex.org/keywords/tumor-glucose-metabolism","display_name":"tumor glucose metabolism","score":0.5210000276565552},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.6100000143051147}],"concepts":[{"id":"https://openalex.org/C12290205","wikidata":"https://www.wikidata.org/wiki/Q22284030","display_name":"Succinylation","level":4,"score":0.8760753273963928},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.5051644444465637},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.48843613266944885},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.4524485170841217},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.42649537324905396},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.406083881855011},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34900498390197754},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.270841121673584},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1291496753692627},{"id":"https://openalex.org/C119157956","wikidata":"https://www.wikidata.org/wiki/Q796604","display_name":"Acetylation","level":3,"score":0.07047480344772339},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.059911102056503296}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/0008-5472.29759903","doi":"https://doi.org/10.1158/0008-5472.29759903","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.29759903","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"pmh:oai:figshare.com:article/29759903","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/media/Supplementary_Video_4_from_Tobacco_Smoking_Rewires_Cell_Metabolism_by_Inducing_GAPDH_Succinylation_to_Promote_Lung_Cancer_Progression/29759903","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.29759903","doi":"https://doi.org/10.1158/0008-5472.29759903","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.29759903","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4412844048","https://openalex.org/W4412844097","https://openalex.org/W4412844081","https://openalex.org/W4412844023","https://openalex.org/W4412844139","https://openalex.org/W4412844189","https://openalex.org/W4412844001","https://openalex.org/W4412844074","https://openalex.org/W4410361372","https://openalex.org/W4412843963"],"abstract_inverted_index":{"The":[0,13],"video":[1],"of":[2,21],"lung":[3],"PET-CT":[4],"scanning":[5],"in":[6],"a":[7],"KrasG12D-driven":[8],"NSCLC":[9],"GAPDH":[10],"K251R":[11],"mouse.":[12],"green":[14],"fluorescence":[15],"is":[16],"the":[17],"isotope":[18],"absorption":[19],"signal":[20],"18F-FLT.":[22]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2025-10-10T00:00:00"}