{"id":"https://openalex.org/W4412843370","doi":"https://doi.org/10.1158/1055-9965.c.7960528","title":"Data from The Interrelationship between Preconception Folate Nutritional Intake and Child Genetic Liability in the Risk of Childhood Acute Lymphoblastic Leukemia","display_name":"Data from The Interrelationship between Preconception Folate Nutritional Intake and Child Genetic Liability in the Risk of Childhood Acute Lymphoblastic Leukemia","publication_year":2025,"publication_date":"2025-08-01","ids":{"openalex":"https://openalex.org/W4412843370","doi":"https://doi.org/10.1158/1055-9965.c.7960528"},"language":"en","primary_location":{"id":"doi:10.1158/1055-9965.c.7960528","doi":"https://doi.org/10.1158/1055-9965.c.7960528","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1055-9965.c.7960528","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1055-9965.c.7960528","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049960359","display_name":"Yijin Xiang","orcid":"https://orcid.org/0000-0001-8926-0236","observed_orcids":["https://orcid.org/0000-0001-8926-0236"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yijin Xiang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8926-0236","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059955772","display_name":"Catherine Metayer","orcid":"https://orcid.org/0000-0003-3467-4145","observed_orcids":["https://orcid.org/0000-0003-3467-4145"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Catherine Metayer","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3467-4145","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035774267","display_name":"Scott C. Kogan","orcid":"https://orcid.org/0000-0002-2395-8479","observed_orcids":["https://orcid.org/0000-0002-2395-8479"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Scott C. Kogan","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2395-8479","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090259653","display_name":"Xiaomei Ma","orcid":"https://orcid.org/0000-0001-9472-8032","observed_orcids":["https://orcid.org/0000-0001-9472-8032"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiaomei Ma","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9472-8032","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021387807","display_name":"Eric M. Nickels","orcid":"https://orcid.org/0000-0001-5536-263X","observed_orcids":["https://orcid.org/0000-0001-5536-263X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eric Nickels","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5536-263X","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5043076766","display_name":"Joseph Leo Wiemels","orcid":"https://orcid.org/0000-0003-4838-9951","observed_orcids":["https://orcid.org/0000-0003-4838-9951"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joseph L. Wiemels","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4838-9951","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.006599999964237213,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13984","display_name":"Nutrition, Genetics, and Disease","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/childhood-acute-lymphoblastic-leukemia","display_name":"childhood acute lymphoblastic leukemia","score":0.9829999804496765},{"id":"https://openalex.org/keywords/maternal-folate-intake","display_name":"maternal folate intake","score":0.9100000262260437},{"id":"https://openalex.org/keywords/preconception-nutrition","display_name":"preconception nutrition","score":0.8759999871253967},{"id":"https://openalex.org/keywords/serum-folate","display_name":"serum folate","score":0.781000018119812},{"id":"https://openalex.org/keywords/total-homocysteine","display_name":"total homocysteine","score":0.9259999990463257},{"id":"https://openalex.org/keywords/b-vitamins","display_name":"B vitamins","score":0.9620000123977661},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.5519999861717224},{"id":"https://openalex.org/keywords/polygenic-risk-score","display_name":"polygenic risk score","score":0.9309999942779541},{"id":"https://openalex.org/keywords/methylenetetrahydrofolate-reductase","display_name":"methylenetetrahydrofolate reductase","score":0.9440000057220459},{"id":"https://openalex.org/keywords/mthfr-c677t-polymorphism","display_name":"MTHFR C677T polymorphism","score":0.972000002861023},{"id":"https://openalex.org/keywords/folate-deficiency","display_name":"folate deficiency","score":0.7559999823570251},{"id":"https://openalex.org/keywords/hispanic-americans","display_name":"Hispanic Americans","score":0.41100001335144043},{"id":"https://openalex.org/keywords/folic-acid-supplementation","display_name":"folic acid supplementation","score":0.7289999723434448},{"id":"https://openalex.org/keywords/mendelian-randomization","display_name":"Mendelian randomization","score":0.7770000100135803}],"concepts":[{"id":"https://openalex.org/C2909962599","wikidata":"https://www.wikidata.org/wiki/Q180664","display_name":"Lymphoblastic Leukemia","level":3,"score":0.68288254737854},{"id":"https://openalex.org/C2777834853","wikidata":"https://www.wikidata.org/wiki/Q96776939","display_name":"Liability","level":2,"score":0.6222001910209656},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5980533957481384},{"id":"https://openalex.org/C2779401946","wikidata":"https://www.wikidata.org/wiki/Q5097982","display_name":"Childhood leukemia","level":4,"score":0.4739551544189453},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.449547678232193},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.3839681148529053},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.3446226418018341},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20963695645332336},{"id":"https://openalex.org/C144133560","wikidata":"https://www.wikidata.org/wiki/Q4830453","display_name":"Business","level":0,"score":0.19270026683807373},{"id":"https://openalex.org/C10138342","wikidata":"https://www.wikidata.org/wiki/Q43015","display_name":"Finance","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1055-9965.c.7960528","doi":"https://doi.org/10.1158/1055-9965.c.7960528","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1055-9965.c.7960528","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1055-9965.c.7960528","doi":"https://doi.org/10.1158/1055-9965.c.7960528","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1055-9965.c.7960528","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"},{"score":0.40450000762939453,"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4410857494","https://openalex.org/W4409629612","https://openalex.org/W4399888466","https://openalex.org/W4412843350","https://openalex.org/W2158091821","https://openalex.org/W2169647489","https://openalex.org/W2890898952","https://openalex.org/W4412843397","https://openalex.org/W4412843268","https://openalex.org/W1997208998"],"abstract_inverted_index":{"AbstractBackground:":[0],"Prenatal":[1],"maternal":[2,92],"folate":[3,26,96,117,136,149,159,181,218],"intake":[4,137,160,219],"is":[5],"associated":[6,119,146],"with":[7,21,80,120,147],"a":[8],"reduced":[9,121],"risk":[10,99,123,145],"of":[11,164,248],"childhood":[12,60],"acute":[13],"lymphoblastic":[14],"leukemia":[15],"(ALL),":[16],"but":[17],"how":[18],"this":[19],"interacts":[20],"children\u2019s":[22,95],"genetic":[23,52,221,229],"predisposition":[24],"to":[25,35,172,189,244],"deficiency":[27],"remains":[28],"unclear.":[29],"Methods:":[30],"We":[31],"used":[32],"Mendelian":[33,108],"randomization":[34,109],"investigate":[36],"the":[37,65,73,78,89,143,152,157,162,202,239,246],"causal":[38],"link":[39],"among":[40,199],"serum":[41,116],"folate,":[42],"total":[43,158],"homocysteine,":[44],"and":[45,72,94,102,141,151,183,211],"B":[46],"vitamins":[47],"on":[48],"ALL":[49,61,122,165,224],"using":[50],"independent":[51,59],"instruments.":[53],"These":[54],"were":[55],"evaluated":[56],"in":[57,180,225,232],"two":[58],"genome-wide":[62],"association":[63],"studies:":[64],"California":[66,74],"Childhood":[67,75],"Cancer":[68],"Record":[69],"Linkage":[70],"Project":[71],"Leukemia":[76],"Study,":[77],"latter":[79],"available":[81],"self-reported":[82],"periconceptional":[83,135],"nutrition":[84,93],"data.":[85],"Logistic":[86],"regressions":[87],"assessed":[88],"interrelationship":[90],"between":[91],"metabolism\u2013related":[97],"polygenic":[98],"score":[100],"(PRS)":[101],"methylenetetrahydrofolate":[103],"reductase":[104],"rs1801133":[105,153],"genotype.":[106],"Results:":[107],"analyses":[110],"showed":[111],"that":[112],"higher":[113,134],"genetically":[114],"predicted":[115],"was":[118],"[meta-analysis":[124],"OR,":[125],"0.58;":[126],"95%":[127],"confidence":[128],"interval":[129],"(CI),":[130],"0.34\u20130.97].":[131],"In":[132,197],"Latinos,":[133],"from":[138,167,184],"food":[139],"mitigated":[140,220],"reversed":[142],"elevated":[144],"low":[148],"PRS":[150,182],"T":[154,195],"allele.":[155,196],"As":[156],"increased,":[161],"odds":[163],"shifted":[166],"1.31":[168],"(95%":[169,174,186,191,208,213],"CI,":[170,175,187,192,209,214],"1.01\u20131.69)":[171],"0.53":[173],"0.30\u20130.91)":[176],"per":[177,194],"0.05-unit":[178],"decrease":[179],"1.71":[185],"1.02\u20132.88)":[188],"0.24":[190],"0.07\u20130.79)":[193],"contrast,":[198],"non-Latino":[200,233],"Whites,":[201],"corresponding":[203],"ORs":[204],"remained":[205],"at":[206],"1.24":[207],"1.07\u20131.43)":[210],"1.40":[212],"1.04\u20131.91).":[215],"Conclusions:":[216],"Maternal":[217],"liability":[222,230],"against":[223],"Latinos":[226],"only,":[227],"whereas":[228],"persisted":[231],"Whites.":[234],"Impact:":[235],"This":[236],"study":[237],"highlights":[238],"need":[240],"for":[241],"personalized":[242],"approaches":[243],"maximize":[245],"benefits":[247],"folic":[249],"acid":[250],"supplementation":[251],"programs.":[252]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2025-10-10T00:00:00"}
