{"id":"https://openalex.org/W4412781007","doi":"https://doi.org/10.34172/ps.025.40914","title":"Phytosterol Glycosides from Olaxsubscorpioidea Oliv. Exhibit Cytotoxic Effects in InVitro and InSilico Studies","display_name":"Phytosterol Glycosides from Olaxsubscorpioidea Oliv. Exhibit Cytotoxic Effects in InVitro and InSilico Studies","publication_year":2025,"publication_date":"2025-06-17","ids":{"openalex":"https://openalex.org/W4412781007","doi":"https://doi.org/10.34172/ps.025.40914"},"language":"en","primary_location":{"id":"doi:10.34172/ps.025.40914","doi":"https://doi.org/10.34172/ps.025.40914","is_oa":true,"landing_page_url":"https://doi.org/10.34172/ps.025.40914","pdf_url":"https://ps.tbzmed.ac.ir/PDF/ps-31-294.pdf","source":{"id":"https://openalex.org/S4210185955","display_name":"Pharmaceutical Sciences","issn_l":"1735-403X","issn":["1735-403X","2383-2886"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319102","host_organization_name":"Tabriz University of Medical Sciences","host_organization_lineage":["https://openalex.org/P4310319102"],"host_organization_lineage_names":["Tabriz University of Medical Sciences"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutical Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://ps.tbzmed.ac.ir/PDF/ps-31-294.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014296207","display_name":"Yemi Adekola Adekunle","orcid":"https://orcid.org/0000-0002-9392-3925","observed_orcids":["https://orcid.org/0000-0002-9392-3925"]},"institutions":[{"id":"https://openalex.org/I181631907","display_name":"University of Ibadan","ror":"https://ror.org/03wx2rr30","country_code":"NG","type":"education","lineage":["https://openalex.org/I181631907"]},{"id":"https://openalex.org/I29787537","display_name":"Afe Babalola University","ror":"https://ror.org/03rsm0k65","country_code":"NG","type":"education","lineage":["https://openalex.org/I29787537"]},{"id":"https://openalex.org/I63098007","display_name":"Liverpool John Moores University","ror":"https://ror.org/04zfme737","country_code":"GB","type":"education","lineage":["https://openalex.org/I63098007"]}],"countries":["GB","NG"],"is_corresponding":true,"raw_author_name":"Yemi Adekola Adekunle","raw_affiliation_strings":["Centre for Natural Products Discovery, School of Pharmacy and Biomolecular Sciences, Faculty of Science, Liverpool John Moores University, Byrom Street, Liverpool L3 3AF, United Kingdom","Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Ibadan, Nigeria","Department of Pharmaceutical and Medicinal Chemistry, College of Pharmacy, Afe Babalola University, Ado-Ekiti, Nigeria"],"raw_orcid":"https://orcid.org/0000-0002-9392-3925","affiliations":[{"raw_affiliation_string":"Centre for Natural Products Discovery, School of Pharmacy and Biomolecular Sciences, Faculty of Science, Liverpool John Moores University, Byrom Street, Liverpool L3 3AF, United Kingdom","institution_ids":["https://openalex.org/I63098007"]},{"raw_affiliation_string":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Ibadan, Nigeria","institution_ids":["https://openalex.org/I181631907"]},{"raw_affiliation_string":"Department of Pharmaceutical and Medicinal Chemistry, College of Pharmacy, Afe Babalola University, Ado-Ekiti, Nigeria","institution_ids":["https://openalex.org/I29787537"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102769079","display_name":"Babatunde B. Samuel","orcid":"https://orcid.org/0000-0002-1834-9548","observed_orcids":["https://orcid.org/0000-0002-1834-9548","https://orcid.org/0000-0001-5553-4438"]},"institutions":[{"id":"https://openalex.org/I181631907","display_name":"University of Ibadan","ror":"https://ror.org/03wx2rr30","country_code":"NG","type":"education","lineage":["https://openalex.org/I181631907"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Babatunde B. Samuel","raw_affiliation_strings":["Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Ibadan, Nigeria"],"raw_orcid":"https://orcid.org/0000-0002-1834-9548","affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Ibadan, Nigeria","institution_ids":["https://openalex.org/I181631907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027734227","display_name":"Lutfun Nahar","orcid":"https://orcid.org/0000-0002-1157-2405","observed_orcids":["https://orcid.org/0000-0002-1157-2405","https://orcid.org/0009-0005-1873-2108"]},"institutions":[{"id":"https://openalex.org/I202391551","display_name":"Czech Academy of Sciences","ror":"https://ror.org/053avzc18","country_code":"CZ","type":"government","lineage":["https://openalex.org/I202391551"]},{"id":"https://openalex.org/I4210156025","display_name":"Czech Academy of Sciences, Institute of Experimental Botany","ror":"https://ror.org/057br4398","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210156025"]},{"id":"https://openalex.org/I70703428","display_name":"Palack\u00fd University Olomouc","ror":"https://ror.org/04qxnmv42","country_code":"CZ","type":"education","lineage":["https://openalex.org/I70703428"]}],"countries":["CZ"],"is_corresponding":true,"raw_author_name":"Lutfun Nahar","raw_affiliation_strings":["Laboratory of Growth Regulators, Palack\u00fd University and Institute of Experimental Botany, The Czech Academy of Sciences, \u0160lechtitel\u016f 27, 78371 Olomouc, Czech Republic"],"raw_orcid":"https://orcid.org/0000-0002-1157-2405","affiliations":[{"raw_affiliation_string":"Laboratory of Growth Regulators, Palack\u00fd University and Institute of Experimental Botany, The Czech Academy of Sciences, \u0160lechtitel\u016f 27, 78371 Olomouc, Czech Republic","institution_ids":["https://openalex.org/I202391551","https://openalex.org/I4210156025","https://openalex.org/I70703428"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042492055","display_name":"Amos A. Fatokun","orcid":"https://orcid.org/0000-0001-5183-7589","observed_orcids":["https://orcid.org/0000-0001-5183-7589"]},"institutions":[{"id":"https://openalex.org/I63098007","display_name":"Liverpool John Moores University","ror":"https://ror.org/04zfme737","country_code":"GB","type":"education","lineage":["https://openalex.org/I63098007"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Amos A. Fatokun","raw_affiliation_strings":["Centre for Natural Products Discovery, School of Pharmacy and Biomolecular Sciences, Faculty of Science, Liverpool John Moores University, Byrom Street, Liverpool L3 3AF, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0001-5183-7589","affiliations":[{"raw_affiliation_string":"Centre for Natural Products Discovery, School of Pharmacy and Biomolecular Sciences, Faculty of Science, Liverpool John Moores University, Byrom Street, Liverpool L3 3AF, United Kingdom","institution_ids":["https://openalex.org/I63098007"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012769245","display_name":"Satyajit Dey Sarker","orcid":"https://orcid.org/0000-0003-4038-0514","observed_orcids":["https://orcid.org/0000-0003-4038-0514"]},"institutions":[{"id":"https://openalex.org/I63098007","display_name":"Liverpool John Moores University","ror":"https://ror.org/04zfme737","country_code":"GB","type":"education","lineage":["https://openalex.org/I63098007"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Satyajit D. Sarker","raw_affiliation_strings":["Centre for Natural Products Discovery, School of Pharmacy and Biomolecular Sciences, Faculty of Science, Liverpool John Moores University, Byrom Street, Liverpool L3 3AF, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0003-4038-0514","affiliations":[{"raw_affiliation_string":"Centre for Natural Products Discovery, School of Pharmacy and Biomolecular Sciences, Faculty of Science, Liverpool John Moores University, Byrom Street, Liverpool L3 3AF, United Kingdom","institution_ids":["https://openalex.org/I63098007"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5014296207","https://openalex.org/A5027734227"],"corresponding_institution_ids":["https://openalex.org/I181631907","https://openalex.org/I202391551","https://openalex.org/I29787537","https://openalex.org/I4210156025","https://openalex.org/I63098007","https://openalex.org/I70703428"],"apc_list":null,"apc_paid":null,"fwci":0.2566,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.45953622,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"31","issue":"3","first_page":"294","last_page":"303"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12215","display_name":"Phytochemical Studies and Bioactivities","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12215","display_name":"Phytochemical Studies and Bioactivities","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11385","display_name":"Natural product bioactivities and synthesis","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/olax-subscorpioidea","display_name":"Olax subscorpioidea","score":0.9850000143051147},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.8519999980926514},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.8240000009536743},{"id":"https://openalex.org/keywords/hela-cells","display_name":"HeLa cells","score":0.777999997138977},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.9900000095367432},{"id":"https://openalex.org/keywords/caco-2-cells","display_name":"Caco-2 cells","score":0.9459999799728394},{"id":"https://openalex.org/keywords/epidermal-growth-factor-receptor","display_name":"epidermal growth factor receptor","score":0.8840000033378601},{"id":"https://openalex.org/keywords/parp-1","display_name":"PARP1","score":0.9240000247955322},{"id":"https://openalex.org/keywords/17beta-hydroxysteroid-dehydrogenase-type-1","display_name":"17\u03b2-hydroxysteroid dehydrogenase type 1","score":0.9649999737739563},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.7590000033378601},{"id":"https://openalex.org/keywords/phytochemical-isolation","display_name":"phytochemical isolation","score":0.7770000100135803},{"id":"https://openalex.org/keywords/medicinal-plants","display_name":"medicinal plants","score":0.6990000009536743},{"id":"https://openalex.org/keywords/root-extract","display_name":"root extract","score":0.6930000185966492},{"id":"https://openalex.org/keywords/natural-product-isolation","display_name":"natural product isolation","score":0.3160000145435333},{"id":"https://openalex.org/keywords/structure-elucidation","display_name":"structure elucidation","score":0.722000002861023},{"id":"https://openalex.org/keywords/cancer-therapy-targets","display_name":"cancer therapy targets","score":0.33799999952316284}],"concepts":[{"id":"https://openalex.org/C2779718769","wikidata":"https://www.wikidata.org/wiki/Q412457","display_name":"Phytosterol","level":2,"score":0.8099062442779541},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.6997032165527344},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5943746566772461},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.5505684018135071},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5031072497367859},{"id":"https://openalex.org/C194671627","wikidata":"https://www.wikidata.org/wiki/Q192639","display_name":"Glycoside","level":2,"score":0.4340529441833496},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4303797483444214},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.37230661511421204},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.33362388610839844},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28652843832969666},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2369873821735382},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17792242765426636},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.34172/ps.025.40914","doi":"https://doi.org/10.34172/ps.025.40914","is_oa":true,"landing_page_url":"https://doi.org/10.34172/ps.025.40914","pdf_url":"https://ps.tbzmed.ac.ir/PDF/ps-31-294.pdf","source":{"id":"https://openalex.org/S4210185955","display_name":"Pharmaceutical Sciences","issn_l":"1735-403X","issn":["1735-403X","2383-2886"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319102","host_organization_name":"Tabriz University of Medical Sciences","host_organization_lineage":["https://openalex.org/P4310319102"],"host_organization_lineage_names":["Tabriz University of Medical Sciences"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutical Sciences","raw_type":"journal-article"},{"id":"pmh:oai:researchonline.ljmu.ac.uk:26927","doi":null,"is_oa":false,"landing_page_url":"https://orcid.org/0000-0002-1157-2405","pdf_url":null,"source":{"id":"https://openalex.org/S4306401246","display_name":"Liverpool John Moores University","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I63098007","host_organization_name":"Liverpool John Moores University","host_organization_lineage":["https://openalex.org/I63098007"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:doaj.org/article:788f7201478c4050aa3137465da04082","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/788f7201478c4050aa3137465da04082","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pharmaceutical Sciences, Vol 31, Iss 3, Pp 294-303 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.34172/ps.025.40914","doi":"https://doi.org/10.34172/ps.025.40914","is_oa":true,"landing_page_url":"https://doi.org/10.34172/ps.025.40914","pdf_url":"https://ps.tbzmed.ac.ir/PDF/ps-31-294.pdf","source":{"id":"https://openalex.org/S4210185955","display_name":"Pharmaceutical Sciences","issn_l":"1735-403X","issn":["1735-403X","2383-2886"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319102","host_organization_name":"Tabriz University of Medical Sciences","host_organization_lineage":["https://openalex.org/P4310319102"],"host_organization_lineage_names":["Tabriz University of Medical Sciences"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutical Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G176604203","display_name":null,"funder_award_id":"02.1.01/0.0/0.0","funder_id":"https://openalex.org/F4320335322","funder_display_name":"European Regional Development Fund"},{"id":"https://openalex.org/G2039240949","display_name":null,"funder_award_id":".02.1.01/0.0/0.0/16_019/0000868","funder_id":"https://openalex.org/F4320335322","funder_display_name":"European Regional Development Fund"},{"id":"https://openalex.org/G291036901","display_name":null,"funder_award_id":"CZ.02","funder_id":"https://openalex.org/F4320335322","funder_display_name":"European Regional Development Fund"},{"id":"https://openalex.org/G310317919","display_name":null,"funder_award_id":"CZ.02.1.01/0.0/0.0/16_019 /0000868","funder_id":"https://openalex.org/F4320335322","funder_display_name":"European Regional Development Fund"},{"id":"https://openalex.org/G3490171961","display_name":null,"funder_award_id":"CZ.02.1.01","funder_id":"https://openalex.org/F4320335322","funder_display_name":"European Regional Development Fund"},{"id":"https://openalex.org/G5916014575","display_name":null,"funder_award_id":"CZ.02.1.01/0.0/0.0","funder_id":"https://openalex.org/F4320335322","funder_display_name":"European Regional Development Fund"},{"id":"https://openalex.org/G7363506711","display_name":null,"funder_award_id":"/16_019","funder_id":"https://openalex.org/F4320335322","funder_display_name":"European Regional Development Fund"}],"funders":[{"id":"https://openalex.org/F4320314707","display_name":"Government of the United Kingdom","ror":"https://ror.org/05wnh3t63"},{"id":"https://openalex.org/F4320322390","display_name":"Liverpool John Moores University","ror":"https://ror.org/04zfme737"},{"id":"https://openalex.org/F4320335322","display_name":"European Regional Development Fund","ror":"https://ror.org/00k4n6c32"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4412781007.pdf","grobid_xml":"https://content.openalex.org/works/W4412781007.grobid-xml"},"referenced_works_count":58,"referenced_works":["https://openalex.org/W1524091002","https://openalex.org/W1973266090","https://openalex.org/W1990133984","https://openalex.org/W2010298595","https://openalex.org/W2037504970","https://openalex.org/W2050619096","https://openalex.org/W2058997498","https://openalex.org/W2062166596","https://openalex.org/W2064571598","https://openalex.org/W2069506489","https://openalex.org/W2082869199","https://openalex.org/W2107614388","https://openalex.org/W2111650618","https://openalex.org/W2114918609","https://openalex.org/W2124965465","https://openalex.org/W2130479394","https://openalex.org/W2132629607","https://openalex.org/W2133051701","https://openalex.org/W2134967712","https://openalex.org/W2166167940","https://openalex.org/W2167831982","https://openalex.org/W2177419974","https://openalex.org/W2185221896","https://openalex.org/W2261018698","https://openalex.org/W2415785512","https://openalex.org/W2481730204","https://openalex.org/W2559136621","https://openalex.org/W2585294008","https://openalex.org/W2593436234","https://openalex.org/W2614063047","https://openalex.org/W2621216894","https://openalex.org/W2801849960","https://openalex.org/W2919334769","https://openalex.org/W2922388086","https://openalex.org/W2940517953","https://openalex.org/W2953346319","https://openalex.org/W3011366455","https://openalex.org/W3014618858","https://openalex.org/W3022804102","https://openalex.org/W3031602758","https://openalex.org/W3039687229","https://openalex.org/W3119067383","https://openalex.org/W3128646645","https://openalex.org/W3135560452","https://openalex.org/W3147142721","https://openalex.org/W3167631869","https://openalex.org/W3186027501","https://openalex.org/W3186223962","https://openalex.org/W3196232603","https://openalex.org/W4205730316","https://openalex.org/W4291033596","https://openalex.org/W4309773420","https://openalex.org/W4317521135","https://openalex.org/W4365503300","https://openalex.org/W4385781745","https://openalex.org/W4386520664","https://openalex.org/W4387163087","https://openalex.org/W6926111724"],"related_works":["https://openalex.org/W2019260035","https://openalex.org/W1970164168","https://openalex.org/W2333694901","https://openalex.org/W3148746591","https://openalex.org/W2376070423","https://openalex.org/W2353411784","https://openalex.org/W4390503553","https://openalex.org/W2067462858","https://openalex.org/W2322593884","https://openalex.org/W4404170249"],"abstract_inverted_index":{"Background:":[0],"Olax":[1],"subscorpioidea":[2,38,156,288],"is":[3,270],"traditionally":[4],"used":[5,98,125],"to":[6,60,99,126,173,295],"treat":[7],"arthritis,":[8],"cancer,":[9],"diabetes,":[10],"neurodegenerative":[11],"disorders,":[12],"and":[13,23,54,67,75,82,117,134,163,181,210,218,222,226,229,231,259,297],"oxidative":[14],"stress.":[15],"This":[16],"study":[17],"carried":[18],"out":[19],"chromatographic":[20],"isolation,":[21],"cytotoxicity,":[22],"molecular":[24],"docking":[25,123],"studies":[26],"of":[27,36,104,136,151,154,199,242,253,266,274,277,286],"bioactive":[28],"compounds":[29,64,106,138,170,188,247,279],"from":[30,280],"O.":[31,37,155,287],"subscorpioidea.":[32],"Methods:":[33],"The":[34,47,148,169,187,246,283],"root":[35,289],"was":[39,49,58,97,124,236],"extracted":[40],"with":[41,88,141,192],"methanol":[42],"using":[43],"Soxhlet":[44],"extraction":[45],"method.":[46],"extract":[48,153,290],"partitioned":[50],"into":[51,129],"n-hexane,":[52],"dichloromethane,":[53],"methanol/water.":[55],"Dichloromethane":[56],"fraction":[57],"subjected":[59],"column":[61],"chromatography.":[62],"Bioactive":[63],"were":[65,71,171],"isolated":[66],"their":[68,85],"chemical":[69],"structures":[70],"established":[72],"by":[73,83],"1D":[74],"2D":[76],"nuclear":[77],"magnetic":[78],"resonance":[79],"(NMR)":[80],"spectroscopy,":[81],"comparing":[84],"NMR":[86],"data":[87],"those":[89],"previously":[90],"reported":[91],"in":[92,240,249],"the":[93,101,130,137,152,193,197,243,250,254,264,271,275],"literature.":[94],"MTT":[95],"assay":[96],"evaluate":[100],"cytotoxic":[102,284],"activity":[103],"these":[105,278],"against":[107,176],"three":[108],"human":[109],"cancer":[110],"cell":[111,120,185],"lines:":[112],"breast":[113],"(MCF-7),":[114],"cervical":[115],"(HeLa),":[116],"colorectal":[118],"(Caco-2)":[119],"lines.":[121,186],"Molecular":[122],"gain":[127],"insights":[128],"favourable":[131],"binding":[132,251],"conformations":[133],"energies":[135],"when":[139],"interacting":[140],"ten":[142],"selected":[143],"cancer-related":[144],"protein":[145],"targets.":[146],"Results:":[147],"phytochemical":[149],"investigation":[150],"afforded":[157],"two":[158],"sterol":[159],"glycosides,":[160],"stigmast-5,22-dien-3-O-\u03b2-D-glucoside":[161,296],"(1a)":[162],"sitosterol-3-O-\u03b2-D-glucoside":[164],"(1b),":[165],"as":[166],"a":[167],"mixture.":[168],"found":[172],"be":[174,292],"active":[175],"HeLa":[177],"(IC50:":[178],"37.0\u00b14.51":[179],"\u00b5g/mL)":[180,184],"MCF-7":[182],"(137.07\u00b119.43":[183],"showed":[189],"strong":[190],"interactions":[191],"colchicine-binding":[194],"site":[195],"on":[196],"\u03b2-subunit":[198],"tubulin":[200],"protein,":[201],"epidermal":[202],"growth":[203],"factor":[204],"receptor":[205],"kinase":[206],"domain,":[207],"poly(ADP-ribose)":[208],"polymerase-1,":[209],"17\u03b2-hydroxysteroid":[211],"dehydrogenase":[212],"type":[213],"1":[214],"(binding":[215],"energies:":[216],"\u201310.3":[217],"\u201310.0":[219],"kcal/mol;":[220,224,228],"\u20139.3":[221,223,230],"\u20139.2":[225,227],"\u20139.1":[232],"kcal/mol,":[233],"respectively).":[234],"Stigmast-5,22-dien-3-O-\u03b2-D-glucoside":[235],"consistently":[237],"ranked":[238],"higher":[239],"some":[241],"proteins":[244,255],"tested.":[245],"stabilised":[248],"sites":[252],"via":[256],"hydrogen":[257],"bonds":[258],"hydrophobic":[260],"interactions.":[261],"Conclusion:":[262],"To":[263],"best":[265],"our":[267],"knowledge,":[268],"this":[269,281],"first":[272],"report":[273],"isolation":[276],"plant.":[282],"effects":[285],"could":[291],"partly":[293],"attributed":[294],"sitosterol-3-O-\u03b2-D-glucoside.":[298]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-11T09:32:39.932853","created_date":"2025-10-10T00:00:00"}