{"id":"https://openalex.org/W4412765751","doi":"https://doi.org/10.3389/fimmu.2025.1645019","title":"HPV infection and the immune microenvironment in cervical cancer","display_name":"HPV infection and the immune microenvironment in cervical cancer","publication_year":2025,"publication_date":"2025-07-30","ids":{"openalex":"https://openalex.org/W4412765751","doi":"https://doi.org/10.3389/fimmu.2025.1645019","pmid":"https://pubmed.ncbi.nlm.nih.gov/40808954","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12343561"},"language":"en","primary_location":{"id":"doi:10.3389/fimmu.2025.1645019","doi":"https://doi.org/10.3389/fimmu.2025.1645019","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2025.1645019","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1645019/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1645019/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100357554","display_name":"Yibo Li","orcid":"https://orcid.org/0000-0003-0434-7899","observed_orcids":["https://orcid.org/0000-0003-0434-7899"]},"institutions":[{"id":"https://openalex.org/I4210089320","display_name":"Central Hospital Affiliated to Shenyang Medical College","ror":"https://ror.org/006xrph64","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089320"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yibo Li","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Central Hospital Affiliated to Shenyang Medical College, Shenyang,\u00a0China","Department of Scientific Research, Central Hospital Affiliated to Shenyang Medical College, Shenyang,\u00a0China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Central Hospital Affiliated to Shenyang Medical College, Shenyang,\u00a0China","institution_ids":["https://openalex.org/I4210089320"]},{"raw_affiliation_string":"Department of Scientific Research, Central Hospital Affiliated to Shenyang Medical College, Shenyang,\u00a0China","institution_ids":["https://openalex.org/I4210089320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068265459","display_name":"Jingui Deng","orcid":"https://orcid.org/0000-0002-0461-2448","observed_orcids":["https://orcid.org/0000-0002-0461-2448"]},"institutions":[{"id":"https://openalex.org/I4210093430","display_name":"Shenyang Center for Disease Control and Prevention","ror":"https://ror.org/005mgvs97","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210093430"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingui Deng","raw_affiliation_strings":["Department of Microorganism Laboratory, Shenyang Center for Disease Control and Prevention, Shenyang,\u00a0China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microorganism Laboratory, Shenyang Center for Disease Control and Prevention, Shenyang,\u00a0China","institution_ids":["https://openalex.org/I4210093430"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yayong Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089320","display_name":"Central Hospital Affiliated to Shenyang Medical College","ror":"https://ror.org/006xrph64","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089320"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yayong Liu","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Central Hospital Affiliated to Shenyang Medical College, Shenyang,\u00a0China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Central Hospital Affiliated to Shenyang Medical College, Shenyang,\u00a0China","institution_ids":["https://openalex.org/I4210089320"]}]},{"author_position":"last","author":{"id":null,"display_name":"Shuangfeng Yu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089320","display_name":"Central Hospital Affiliated to Shenyang Medical College","ror":"https://ror.org/006xrph64","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089320"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuangfeng Yu","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Central Hospital Affiliated to Shenyang Medical College, Shenyang,\u00a0China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Central Hospital Affiliated to Shenyang Medical College, Shenyang,\u00a0China","institution_ids":["https://openalex.org/I4210089320"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100357554"],"corresponding_institution_ids":["https://openalex.org/I4210089320"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":4.7343,"has_fulltext":true,"cited_by_count":45,"citation_normalized_percentile":{"value":0.97056988,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"16","issue":null,"first_page":"1645019","last_page":"1645019"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.538100004196167,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.538100004196167,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":0.4408999979496002,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10668","display_name":"Endometrial and Cervical Cancer Treatments","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cervical-cancer","display_name":"cervical cancer","score":0.8960000276565552},{"id":"https://openalex.org/keywords/human-papillomavirus-infection","display_name":"HPV infection","score":0.8870000243186951},{"id":"https://openalex.org/keywords/tumor-immune-microenvironment","display_name":"tumor immune microenvironment","score":0.996999979019165},{"id":"https://openalex.org/keywords/immune-evasion","display_name":"immune evasion","score":0.9390000104904175},{"id":"https://openalex.org/keywords/pd-l1","display_name":"PD-L1","score":0.6309999823570251},{"id":"https://openalex.org/keywords/pembrolizumab","display_name":"pembrolizumab","score":0.9940000176429749},{"id":"https://openalex.org/keywords/tumor-associated-macrophages","display_name":"tumor-associated macrophages","score":0.890999972820282},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":1.0},{"id":"https://openalex.org/keywords/myeloid-derived-suppressor-cells","display_name":"myeloid-derived suppressor cells","score":1.0},{"id":"https://openalex.org/keywords/t-cell-exhaustion","display_name":"T cell exhaustion","score":0.7760000228881836},{"id":"https://openalex.org/keywords/immunotherapy-resistance","display_name":"immunotherapy resistance","score":0.8519999980926514},{"id":"https://openalex.org/keywords/immune-related-adverse-events","display_name":"immune-related adverse events","score":0.9179999828338623},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.8240000009536743}],"concepts":[{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.7548856735229492},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.691088080406189},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.6681251525878906},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6184532642364502},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5842090845108032},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5244826674461365},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5159772038459778},{"id":"https://openalex.org/C2778220009","wikidata":"https://www.wikidata.org/wiki/Q160105","display_name":"Cervical cancer","level":3,"score":0.5133592486381531},{"id":"https://openalex.org/C2780057760","wikidata":"https://www.wikidata.org/wiki/Q13896859","display_name":"Pembrolizumab","level":4,"score":0.49828004837036133},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.446757048368454},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.11866992712020874}],"mesh":[{"descriptor_ui":"D000072737","descriptor_name":"Myeloid-Derived Suppressor Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002583","descriptor_name":"Uterine Cervical Neoplasms","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D002583","descriptor_name":"Uterine Cervical Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D002583","descriptor_name":"Uterine Cervical Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002583","descriptor_name":"Uterine Cervical Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D002583","descriptor_name":"Uterine Cervical Neoplasms","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D027383","descriptor_name":"Papillomaviridae","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D030361","descriptor_name":"Papillomavirus Infections","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D030361","descriptor_name":"Papillomavirus Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D030361","descriptor_name":"Papillomavirus Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.3389/fimmu.2025.1645019","doi":"https://doi.org/10.3389/fimmu.2025.1645019","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2025.1645019","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1645019/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},{"id":"pmid:40808954","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40808954","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in immunology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12343561","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12343561/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Immunol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:c47f101a21814811a5baa94357b5f61b","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/c47f101a21814811a5baa94357b5f61b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, Vol 16 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fimmu.2025.1645019","doi":"https://doi.org/10.3389/fimmu.2025.1645019","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2025.1645019","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1645019/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4412765751.pdf","grobid_xml":"https://content.openalex.org/works/W4412765751.grobid-xml"},"referenced_works_count":60,"referenced_works":["https://openalex.org/W2159560463","https://openalex.org/W2189381691","https://openalex.org/W2344048868","https://openalex.org/W2766391538","https://openalex.org/W2767343890","https://openalex.org/W2784967823","https://openalex.org/W2802735541","https://openalex.org/W2889666043","https://openalex.org/W2902329477","https://openalex.org/W2906772792","https://openalex.org/W2913136068","https://openalex.org/W2942336783","https://openalex.org/W2947746385","https://openalex.org/W2950458958","https://openalex.org/W2952065098","https://openalex.org/W2955294253","https://openalex.org/W2968834401","https://openalex.org/W2988042652","https://openalex.org/W3011895923","https://openalex.org/W3014516696","https://openalex.org/W3027060564","https://openalex.org/W3036376773","https://openalex.org/W3040196641","https://openalex.org/W3040408059","https://openalex.org/W3048458628","https://openalex.org/W3062045183","https://openalex.org/W3084241168","https://openalex.org/W3094131523","https://openalex.org/W3097683670","https://openalex.org/W3107368663","https://openalex.org/W3110508356","https://openalex.org/W3128646645","https://openalex.org/W3130791700","https://openalex.org/W3146433121","https://openalex.org/W3161105228","https://openalex.org/W3162437281","https://openalex.org/W3164791653","https://openalex.org/W4200215773","https://openalex.org/W4205749782","https://openalex.org/W4206724375","https://openalex.org/W4210703727","https://openalex.org/W4212803055","https://openalex.org/W4226329559","https://openalex.org/W4283275383","https://openalex.org/W4296049926","https://openalex.org/W4302286539","https://openalex.org/W4306160500","https://openalex.org/W4306407186","https://openalex.org/W4307993363","https://openalex.org/W4313247192","https://openalex.org/W4366673085","https://openalex.org/W4378515638","https://openalex.org/W4385666674","https://openalex.org/W4386460994","https://openalex.org/W4388997799","https://openalex.org/W4389257832","https://openalex.org/W4390817262","https://openalex.org/W4394575396","https://openalex.org/W4403575722","https://openalex.org/W4404858369"],"related_works":["https://openalex.org/W4415924653","https://openalex.org/W2057488918","https://openalex.org/W7159933118","https://openalex.org/W7125590360","https://openalex.org/W4409276640","https://openalex.org/W4405887832","https://openalex.org/W4394768263","https://openalex.org/W2368571697","https://openalex.org/W7163034821","https://openalex.org/W3048458628"],"abstract_inverted_index":{"Cervical":[0],"cancer":[1,31],"remains":[2],"a":[3,26,128],"leading":[4],"cause":[5],"of":[6,53,75,95],"cancer-related":[7],"mortality":[8],"in":[9,12,17,29,55,64,111,122,138],"women,":[10],"particularly":[11],"low-resource":[13],"settings,":[14],"despite":[15],"advances":[16,121],"treatment":[18],"modalities.":[19],"The":[20],"tumor":[21,123],"immune":[22,45,87],"microenvironment":[23],"(TME)":[24],"plays":[25],"pivotal":[27],"role":[28],"cervical":[30,139],"pathogenesis,":[32],"progression,":[33],"and":[34,43,73,89,107,125],"therapeutic":[35],"response,":[36],"driven":[37],"largely":[38],"by":[39],"persistent":[40],"HPV":[41],"infection":[42],"subsequent":[44],"evasion":[46],"mechanisms.":[47],"Clinical":[48],"evidence":[49],"supports":[50],"the":[51,82,90,93],"efficacy":[52],"pembrolizumab":[54],"PD-L1-positive":[56],"recurrent/metastatic":[57],"disease,":[58],"while":[59],"combinatorial":[60],"strategies":[61,134],"show":[62],"promise":[63],"overcoming":[65],"resistance.":[66],"However,":[67],"challenges":[68],"persist,":[69],"including":[70],"biomarker":[71],"identification":[72],"management":[74],"immune-related":[76],"adverse":[77],"events.":[78],"This":[79],"review":[80,118],"elucidates":[81],"dynamic":[83],"interplay":[84],"between":[85],"HPV-mediated":[86],"suppression":[88],"TME,":[91],"highlighting":[92],"roles":[94],"tumor-associated":[96],"macrophages":[97],"(TAMs),":[98],"regulatory":[99],"T":[100],"cells":[101,105],"(Tregs),":[102],"myeloid-derived":[103],"suppressor":[104],"(MDSCs),":[106],"exhausted":[108],"lymphocyte":[109],"subsets":[110],"fostering":[112],"an":[113],"immunosuppressive":[114],"milieu.":[115],"Overall,":[116],"this":[117],"integrates":[119],"current":[120],"immunology":[124],"immunotherapy,":[126],"providing":[127],"comprehensive":[129],"framework":[130],"for":[131],"developing":[132],"precision-based":[133],"to":[135],"improve":[136],"outcomes":[137],"cancer.":[140]},"counts_by_year":[{"year":2026,"cited_by_count":39},{"year":2025,"cited_by_count":6}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2025-10-10T00:00:00"}
