{"id":"https://openalex.org/W4412759233","doi":"https://doi.org/10.30574/gscbps.2025.32.1.0299","title":"Formulation of Lippi alba (Verbenaceae) leaves capsules for the treatment of high blood pressure","display_name":"Formulation of Lippi alba (Verbenaceae) leaves capsules for the treatment of high blood pressure","publication_year":2025,"publication_date":"2025-07-30","ids":{"openalex":"https://openalex.org/W4412759233","doi":"https://doi.org/10.30574/gscbps.2025.32.1.0299"},"language":"en","primary_location":{"id":"doi:10.30574/gscbps.2025.32.1.0299","doi":"https://doi.org/10.30574/gscbps.2025.32.1.0299","is_oa":true,"landing_page_url":"https://doi.org/10.30574/gscbps.2025.32.1.0299","pdf_url":"https://gscbps.gsconlinepress.com/sites/default/files/fulltext_pdf/GSCBPS-2025-0299.pdf","source":{"id":"https://openalex.org/S4210211081","display_name":"GSC Biological and Pharmaceutical Sciences","issn_l":"2581-3250","issn":["2581-3250"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4383735917","host_organization_name":"GSC Online Press","host_organization_lineage":["https://openalex.org/P4383735917"],"host_organization_lineage_names":["GSC Online Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"GSC Biological and Pharmaceutical Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://gscbps.gsconlinepress.com/sites/default/files/fulltext_pdf/GSCBPS-2025-0299.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051741572","display_name":"Ernest Djoko","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I279418767","display_name":"Universit\u00e9 des Montagnes","ror":"https://ror.org/027n9q071","country_code":"CM","type":"education","lineage":["https://openalex.org/I279418767"]}],"countries":["CM"],"is_corresponding":true,"raw_author_name":"Djoko Ernest","raw_affiliation_strings":["Laboratory of galenic pharmacy , Faculty of pharmacy \" Universit\u00e9 des Montagnes\". Bangangt\u00e9 Cameroon "],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of galenic pharmacy , Faculty of pharmacy \" Universit\u00e9 des Montagnes\". Bangangt\u00e9 Cameroon ","institution_ids":["https://openalex.org/I279418767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5119118407","display_name":"Nkobetchou Sephora","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I279418767","display_name":"Universit\u00e9 des Montagnes","ror":"https://ror.org/027n9q071","country_code":"CM","type":"education","lineage":["https://openalex.org/I279418767"]}],"countries":["CM"],"is_corresponding":false,"raw_author_name":"Nkobetchou Sephora","raw_affiliation_strings":["GSC Biological and Pharmaceutical Sciences , 2025 , 32","Laboratory of galenic pharmacy , Faculty of pharmacy \" Universit\u00e9 des Montagnes\". Bangangt\u00e9 Cameroon "],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GSC Biological and Pharmaceutical Sciences , 2025 , 32","institution_ids":[]},{"raw_affiliation_string":"Laboratory of galenic pharmacy , Faculty of pharmacy \" Universit\u00e9 des Montagnes\". Bangangt\u00e9 Cameroon ","institution_ids":["https://openalex.org/I279418767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048289051","display_name":"Foutse Yimta","orcid":"https://orcid.org/0009-0004-7297-6659","observed_orcids":["https://orcid.org/0009-0004-7297-6659"]},"institutions":[{"id":"https://openalex.org/I279418767","display_name":"Universit\u00e9 des Montagnes","ror":"https://ror.org/027n9q071","country_code":"CM","type":"education","lineage":["https://openalex.org/I279418767"]}],"countries":["CM"],"is_corresponding":false,"raw_author_name":"Foutse Yimta","raw_affiliation_strings":["Laboratory of Phytochemestry , Faculty of pharmacy \" Universit\u00e9 des Montagnes\". Bangangt\u00e9 Cameroon "],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Phytochemestry , Faculty of pharmacy \" Universit\u00e9 des Montagnes\". Bangangt\u00e9 Cameroon ","institution_ids":["https://openalex.org/I279418767"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010780802","display_name":"Denis Wouessidjewe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4387154850","display_name":"D\u00e9partement de Pharmacochimie Mol\u00e9culaire","ror":"https://ror.org/04fhvpc68","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4387154850","https://openalex.org/I899635006"]},{"id":"https://openalex.org/I899635006","display_name":"Universit\u00e9 Grenoble Alpes","ror":"https://ror.org/02rx3b187","country_code":"FR","type":"education","lineage":["https://openalex.org/I899635006"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Wouessidjewe Denis","raw_affiliation_strings":["Department of Molecular Pharmacochemistry , University of Grenoble Alpes-UFR de Pharmacy , UMR CNRS 5063 . France "],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Pharmacochemistry , University of Grenoble Alpes-UFR de Pharmacy , UMR CNRS 5063 . France ","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4387154850","https://openalex.org/I899635006"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5051741572"],"corresponding_institution_ids":["https://openalex.org/I279418767"],"apc_list":null,"apc_paid":null,"fwci":0.4326,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.53530168,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"32","issue":"1","first_page":"371","last_page":"381"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12657","display_name":"Phytochemistry Medicinal Plant Applications","score":0.7939000129699707,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12657","display_name":"Phytochemistry Medicinal Plant Applications","score":0.7939000129699707,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.1607999950647354,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13090","display_name":"Medicinal Plant Extracts Effects","score":0.00989999994635582,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lippia-alba","display_name":"Lippia alba","score":0.9959999918937683},{"id":"https://openalex.org/keywords/herbal-capsule-formulation","display_name":"herbal capsule formulation","score":0.6589999794960022},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.699999988079071},{"id":"https://openalex.org/keywords/antihypertensive-herbal-medicine","display_name":"antihypertensive herbal medicine","score":0.878000020980835},{"id":"https://openalex.org/keywords/aqueous-leaf-extract","display_name":"aqueous leaf extract","score":0.7979999780654907},{"id":"https://openalex.org/keywords/polyphenol-content","display_name":"polyphenol content","score":0.8130000233650208},{"id":"https://openalex.org/keywords/gallic-acid-equivalent","display_name":"gallic acid equivalent","score":0.7070000171661377},{"id":"https://openalex.org/keywords/microcrystalline-cellulose","display_name":"microcrystalline cellulose","score":0.8100000023841858},{"id":"https://openalex.org/keywords/dicalcium-phosphate","display_name":"dicalcium phosphate","score":0.7570000290870667},{"id":"https://openalex.org/keywords/herbal-medicine-development","display_name":"herbal drug development","score":0.4740000069141388}],"concepts":[{"id":"https://openalex.org/C2777512926","wikidata":"https://www.wikidata.org/wiki/Q156960","display_name":"Verbenaceae","level":2,"score":0.7456015348434448},{"id":"https://openalex.org/C2984729377","wikidata":"https://www.wikidata.org/wiki/Q5757669","display_name":"High pressure","level":2,"score":0.45698195695877075},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.42895251512527466},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33308807015419006},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.12122663855552673},{"id":"https://openalex.org/C57879066","wikidata":"https://www.wikidata.org/wiki/Q41217","display_name":"Mechanics","level":1,"score":0.053022027015686035}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.30574/gscbps.2025.32.1.0299","doi":"https://doi.org/10.30574/gscbps.2025.32.1.0299","is_oa":true,"landing_page_url":"https://doi.org/10.30574/gscbps.2025.32.1.0299","pdf_url":"https://gscbps.gsconlinepress.com/sites/default/files/fulltext_pdf/GSCBPS-2025-0299.pdf","source":{"id":"https://openalex.org/S4210211081","display_name":"GSC Biological and Pharmaceutical Sciences","issn_l":"2581-3250","issn":["2581-3250"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4383735917","host_organization_name":"GSC Online Press","host_organization_lineage":["https://openalex.org/P4383735917"],"host_organization_lineage_names":["GSC Online Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"GSC Biological and Pharmaceutical Sciences","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.30574/gscbps.2025.32.1.0299","doi":"https://doi.org/10.30574/gscbps.2025.32.1.0299","is_oa":true,"landing_page_url":"https://doi.org/10.30574/gscbps.2025.32.1.0299","pdf_url":"https://gscbps.gsconlinepress.com/sites/default/files/fulltext_pdf/GSCBPS-2025-0299.pdf","source":{"id":"https://openalex.org/S4210211081","display_name":"GSC Biological and Pharmaceutical Sciences","issn_l":"2581-3250","issn":["2581-3250"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4383735917","host_organization_name":"GSC Online Press","host_organization_lineage":["https://openalex.org/P4383735917"],"host_organization_lineage_names":["GSC Online Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"GSC Biological and Pharmaceutical Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4412759233.pdf","grobid_xml":"https://content.openalex.org/works/W4412759233.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W6977457513","https://openalex.org/W1639988354","https://openalex.org/W7158058043","https://openalex.org/W3136727574","https://openalex.org/W4401844796","https://openalex.org/W7052605125","https://openalex.org/W2374246517","https://openalex.org/W3204494282","https://openalex.org/W4402446261","https://openalex.org/W2180754495"],"abstract_inverted_index":{"High":[0],"blood":[1,29,126,151],"pressure":[2,30,152],"is":[3,69,75],"a":[4,71,103,221,281,287,339,403],"real":[5],"public":[6],"health":[7],"issue,":[8],"affecting":[9],"around":[10],"1.13":[11],"billion":[12],"people":[13,26],"worldwide.":[14],"The":[15,35,143,184,203,225,238,267,292,334,368,396],"World":[16],"Health":[17],"Organization":[18],"(WHO)":[19],"reports":[20],"that":[21],"less":[22],"than":[23],"20%":[24],"of":[25,44,61,92,98,124,145,157,161,166,177,199,223,236,279,284,290,310,320,324,331,346,355,370,388,392,398],"with":[27,181,191,220,385],"high":[28,59,125,150],"are":[31,39],"properly":[32],"managed":[33],"medically.":[34],"most":[36],"common":[37],"treatments":[38],"based":[40],"on":[41,378],"the":[42,57,64,89,93,96,122,131,174,192,196,200,245,371,379,386,389,393],"use":[43,91],"diuretics,":[45],"calcium":[46],"channel":[47],"blockers,":[48,50],"beta":[49],"and":[51,83,88,137,212,286,296,328,373],"alpha":[52],"blockers.":[53],"However,":[54],"due":[55],"to":[56,108,113,120,148,243,314,349,383],"relatively":[58],"cost":[60],"antihypertensive":[62,84],"drugs,":[63],"search":[65],"for":[66,77,277,338,365,406],"new":[67],"alternatives":[68],"becoming":[70],"necessity.":[72],"Lippia":[73,117,132,178],"alba":[74,118,133,179],"known":[76],"its":[78],"antispasmodic,":[79],"analgesic,":[80],"sedative,":[81],"anxiolytic,":[82],"properties.":[85],"These":[86],"properties":[87,274],"empirical":[90],"plant":[94],"in":[95,140,155,189,195,208],"form":[97],"an":[99,214,409],"infusion":[100],"make":[101,401],"it":[102,217],"potentially":[104],"interesting":[105],"herbal":[106],"drug":[107],"develop.":[109],"This":[110],"study":[111],"aimed":[112],"formulate":[114,244],"capsules":[115,185,364,380,400],"from":[116],"leaves":[119,134,180],"improve":[121],"management":[123],"pressure.":[127],"To":[128],"do":[129],"this,":[130],"were":[135,170,186,241,381],"crushed":[136],"then":[138],"infused":[139],"drinking":[141],"water.":[142],"amount":[144],"extract":[146,176,204,312],"needed":[147],"manage":[149],"was":[153,205,218,228,294,343],"determined":[154,337],"milligrams":[156],"gallic":[158,231,317,352],"acid":[159,232,318,353],"equivalent":[160,233,319,354],"total":[162,356],"polyphenols":[163],"per":[164,234],"gram":[165,235],"extract.":[167,237],"Several":[168],"formulas":[169],"prepared":[171],"by":[172],"mixing":[173],"aqueous":[175],"suitable":[182],"excipients.":[183],"also":[187],"tested":[188],"accordance":[190],"techniques":[193],"described":[194],"11th":[197,390],"edition":[198,391],"European":[201,394],"Pharmacopoeia.":[202,395],"dark":[206],"brown":[207],"color,":[209],"very":[210],"bitter,":[211],"had":[213,271],"aromatic":[215],"odor;":[216],"obtained":[219],"yield":[222],"18.60%.":[224],"polyphenol":[226],"content":[227],"175":[229],"mg":[230,309,316,323,330,345,351],"following":[239],"excipients":[240],"used":[242],"capsules:":[246],"colloidal":[247],"anhydrous":[248],"silica":[249],"(Aerosol*":[250],"300),":[251],"microcrystalline":[252],"cellulose":[253],"(Avicel*PH-102,":[254],"PH-101),":[255],"dicalcium":[256],"phosphate":[257],"(Fuji":[258],"Calin*),":[259],"ready-to-use":[260],"lactose-polyvinylpyrrolidone":[261],"K30-crospovidone":[262],"(Ludi":[263],"press*)":[264],"LCE":[265],"mixture.":[266],"chosen":[268],"unit":[269],"formula":[270],"good":[272,404],"flow":[273],"(3":[275],"seconds":[276],"100g":[278],"powder),":[280],"Carr":[282],"index":[283,289],"14.80%":[285],"Hausner":[288],"1.17.":[291],"powder":[293],"homogeneous":[295],"moderately":[297],"fine":[298],"(d50":[299],"<":[300],"300":[301],"am).":[302],"Each":[303],"size":[304],"0":[305],"capsule":[306],"contains":[307],"364.5":[308],"crude":[311],"corresponding":[313,348],"63.8":[315],"polyphenols,":[321,357],"73":[322],"Ludi":[325],"press*":[326],"LCE,":[327],"48.5":[329],"Fuji":[332],"Calin*.":[333],"daily":[335],"dose":[336],"60":[340],"kg":[341],"adult":[342],"729":[344],"extract,":[347],"127.6":[350],"which":[358],"can":[359],"be":[360],"divided":[361],"into":[362,408],"2":[363],"one":[366],"day.":[367],"results":[369],"physicochemical":[372],"pharmaceutical":[374],"tests":[375],"carried":[376],"out":[377],"found":[382],"comply":[384],"specifications":[387],"characteristics":[397],"these":[399],"them":[402],"candidate":[405],"development":[407],"improved":[410],"traditional":[411],"medicine":[412],"(ITM).":[413]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2025-10-10T00:00:00"}
