{"id":"https://openalex.org/W4412725845","doi":"https://doi.org/10.5194/mr-6-157-2025","title":"3D-printed microcell for protein NMR at high ionic strengths and small sample volumes","display_name":"3D-printed microcell for protein NMR at high ionic strengths and small sample volumes","publication_year":2025,"publication_date":"2025-07-16","ids":{"openalex":"https://openalex.org/W4412725845","doi":"https://doi.org/10.5194/mr-6-157-2025","pmid":"https://pubmed.ncbi.nlm.nih.gov/40718365","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12296210"},"language":"en","primary_location":{"id":"doi:10.5194/mr-6-157-2025","doi":"https://doi.org/10.5194/mr-6-157-2025","is_oa":true,"landing_page_url":"https://doi.org/10.5194/mr-6-157-2025","pdf_url":"https://mr.copernicus.org/articles/6/157/2025/mr-6-157-2025.pdf","source":{"id":"https://openalex.org/S4210199904","display_name":"Magnetic Resonance","issn_l":"2699-0016","issn":["2699-0016"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Magnetic Resonance","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://mr.copernicus.org/articles/6/157/2025/mr-6-157-2025.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049427645","display_name":"Tayeb Kakeshpour","orcid":"https://orcid.org/0000-0002-4272-5558","observed_orcids":["https://orcid.org/0000-0002-4272-5558"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090567","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tayeb Kakeshpour","raw_affiliation_strings":["Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-0520, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-0520, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023052955","display_name":"Martin D. Gelenter","orcid":"https://orcid.org/0000-0002-6412-805X","observed_orcids":["https://orcid.org/0000-0002-6412-805X"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090567","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martin D. Gelenter","raw_affiliation_strings":["Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-0520, USA"],"raw_orcid":"https://orcid.org/0000-0002-6412-805X","affiliations":[{"raw_affiliation_string":"Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-0520, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024806540","display_name":"Jinfa Ying","orcid":"https://orcid.org/0009-0003-3101-0789","observed_orcids":["https://orcid.org/0009-0003-3101-0789"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090567","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jinfa Ying","raw_affiliation_strings":["Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-0520, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-0520, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082289559","display_name":"Ad Bax","orcid":"https://orcid.org/0000-0002-9809-5700","observed_orcids":["https://orcid.org/0000-0002-9809-5700"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090567","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ad Bax","raw_affiliation_strings":["Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-0520, USA"],"raw_orcid":"https://orcid.org/0000-0002-9809-5700","affiliations":[{"raw_affiliation_string":"Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-0520, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5082289559"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567"],"apc_list":{"value":920,"currency":"EUR","value_usd":992},"apc_paid":{"value":920,"currency":"EUR","value_usd":992},"fwci":0.7515,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.62483466,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"6","issue":"2","first_page":"157","last_page":"172"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11809","display_name":"Advanced NMR Techniques and Applications","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11809","display_name":"Advanced NMR Techniques and Applications","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12603","display_name":"NMR spectroscopy and applications","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/3106","display_name":"Nuclear and High Energy Physics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-nmr-spectroscopy","display_name":"protein NMR","score":0.7590000033378601},{"id":"https://openalex.org/keywords/high-ionic-strength","display_name":"high ionic strength","score":0.9259999990463257},{"id":"https://openalex.org/keywords/small-sample-volumes","display_name":"small sample volumes","score":0.8709999918937683},{"id":"https://openalex.org/keywords/magnetic-field-homogeneity","display_name":"magnetic field homogeneity","score":0.875},{"id":"https://openalex.org/keywords/sodium-chloride","display_name":"sodium chloride","score":0.4909999966621399}],"concepts":[{"id":"https://openalex.org/C158314712","wikidata":"https://www.wikidata.org/wiki/Q1177092","display_name":"Microcell","level":2,"score":0.9018841981887817},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.6093325614929199},{"id":"https://openalex.org/C2780471494","wikidata":"https://www.wikidata.org/wiki/Q146505","display_name":"Solvent","level":2,"score":0.558875322341919},{"id":"https://openalex.org/C113196181","wikidata":"https://www.wikidata.org/wiki/Q485223","display_name":"Analytical Chemistry (journal)","level":2,"score":0.5355937480926514},{"id":"https://openalex.org/C187428577","wikidata":"https://www.wikidata.org/wiki/Q898396","display_name":"Ionic strength","level":3,"score":0.48715659976005554},{"id":"https://openalex.org/C160671074","wikidata":"https://www.wikidata.org/wiki/Q267131","display_name":"Wafer","level":2,"score":0.4348357915878296},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3870640993118286},{"id":"https://openalex.org/C46141821","wikidata":"https://www.wikidata.org/wiki/Q209402","display_name":"Nuclear magnetic resonance","level":1,"score":0.35814082622528076},{"id":"https://openalex.org/C184651966","wikidata":"https://www.wikidata.org/wiki/Q906356","display_name":"Aqueous solution","level":2,"score":0.34789618849754333},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.24046999216079712},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.1485171616077423},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.5194/mr-6-157-2025","doi":"https://doi.org/10.5194/mr-6-157-2025","is_oa":true,"landing_page_url":"https://doi.org/10.5194/mr-6-157-2025","pdf_url":"https://mr.copernicus.org/articles/6/157/2025/mr-6-157-2025.pdf","source":{"id":"https://openalex.org/S4210199904","display_name":"Magnetic Resonance","issn_l":"2699-0016","issn":["2699-0016"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Magnetic Resonance","raw_type":"journal-article"},{"id":"doi:10.5194/mr-2025-5","doi":"https://doi.org/10.5194/mr-2025-5","is_oa":true,"landing_page_url":"https://doi.org/10.5194/mr-2025-5","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},{"id":"pmid:40718365","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40718365","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Magnetic resonance (Gottingen, Germany)","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:2c95bc399de846959d3b5a3f373d0526","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/2c95bc399de846959d3b5a3f373d0526","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Magnetic Resonance, Vol 6, Pp 157-172 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.5194/mr-6-157-2025","doi":"https://doi.org/10.5194/mr-6-157-2025","is_oa":true,"landing_page_url":"https://doi.org/10.5194/mr-6-157-2025","pdf_url":"https://mr.copernicus.org/articles/6/157/2025/mr-6-157-2025.pdf","source":{"id":"https://openalex.org/S4210199904","display_name":"Magnetic Resonance","issn_l":"2699-0016","issn":["2699-0016"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Magnetic Resonance","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G6288077373","display_name":null,"funder_award_id":"DK029046","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4412725845.pdf","grobid_xml":"https://content.openalex.org/works/W4412725845.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W1501032637","https://openalex.org/W1529209589","https://openalex.org/W1579101720","https://openalex.org/W1964318214","https://openalex.org/W1965732458","https://openalex.org/W1999892194","https://openalex.org/W2002744092","https://openalex.org/W2017093898","https://openalex.org/W2017845112","https://openalex.org/W2026717532","https://openalex.org/W2043147713","https://openalex.org/W2059111747","https://openalex.org/W2068056075","https://openalex.org/W2068227670","https://openalex.org/W2084751239","https://openalex.org/W2092205516","https://openalex.org/W2092701914","https://openalex.org/W2094876597","https://openalex.org/W2099037802","https://openalex.org/W2136956472","https://openalex.org/W2160942335","https://openalex.org/W2168965440","https://openalex.org/W2169120093","https://openalex.org/W2169821755","https://openalex.org/W2622700352","https://openalex.org/W2729638236","https://openalex.org/W2768348132","https://openalex.org/W2888401974","https://openalex.org/W3003413233","https://openalex.org/W3137222452","https://openalex.org/W3212357304","https://openalex.org/W4242798901","https://openalex.org/W4319457912","https://openalex.org/W4382344658","https://openalex.org/W4384025559","https://openalex.org/W4388665666","https://openalex.org/W4391743466","https://openalex.org/W4406411674"],"related_works":["https://openalex.org/W2736970943","https://openalex.org/W2080299357","https://openalex.org/W1992125081","https://openalex.org/W1985062696","https://openalex.org/W2101573912","https://openalex.org/W2009868143","https://openalex.org/W1977192267","https://openalex.org/W2141812499","https://openalex.org/W3137222452","https://openalex.org/W2622700352"],"abstract_inverted_index":{"Abstract.":[0],"Standard":[1],"solution":[2,225],"NMR":[3,98,179],"measurements":[4],"use":[5],"5-mm":[6,96,229],"outer":[7],"diameter":[8],"(OD)":[9],"sample":[10,80,209,230],"tubes":[11],"that":[12,92,117,186],"require":[13],"ca":[14,41],"0.5":[15,219],"mL":[16,84,220],"of":[17,31,88,104,120,141,166,221,246],"solvent":[18,38],"to":[19,40,58,82,130,135,145,189],"minimize":[20],"\u201cend":[21],"effects\u201d":[22],"on":[23],"magnetic":[24,51,101],"field":[25],"homogeneity":[26],"in":[27,61,210,226,239],"the":[28,32,37,78,118,153,167,207,222],"active":[29,79],"volume":[30,81],"sample.":[33],"Shigemi":[34],"cells":[35,91,185],"reduce":[36],"requirement":[39],"0.29":[42],"mL.":[43],"At":[44],"high":[45,176],"ionic":[46],"strength,":[47],"or":[48],"at":[49,248],"ultrahigh":[50],"fields,":[52],"smaller":[53],"OD":[54,97],"samples":[55,60],"are":[56,93,187],"needed":[57],"study":[59],"conductive,":[62],"radiofrequency":[63],"absorbing":[64],"solvents":[65],"such":[66],"as":[67],"water.":[68],"We":[69,115],"demonstrate":[70],"an":[71],"effective":[72],"and":[73,158,197,242],"inexpensive":[74],"alternative":[75],"for":[76,133,174,206,218,236,243],"reducing":[77],"0.13":[83],"by":[85,163],"3D":[86],"printing":[87],"ellipsoidal":[89,183],"shaped":[90,184],"inserted":[94],"into":[95],"tubes.":[99],"Static":[100],"susceptibility,":[102],"\u03c7,":[103],"printer":[105],"resin":[106,154],"was":[107,143,171],"measured":[108,144],"using":[109,182],"a":[110,227],"simple":[111],"slice-selection":[112],"pulse":[113],"sequence.":[114],"found":[116,172],"\u03c7":[119,140],"water":[121,159],"increases":[122],"linearly":[123],"with":[124],"NaCl":[125],"concentration,":[126],"from":[127],"-9.05":[128],"ppm":[129,132],"-8.65":[131],"0":[134],"2":[136,249],"M":[137,250],"NaCl.":[138,251],"The":[139,149,192,232],"D2O":[142],"be":[146,161],"-9.01":[147],"ppm.":[148],"susceptibility":[150,190],"difference":[151],"between":[152],"(\u03c7=":[155],"-9.40":[156],"ppm)":[157],"can":[160],"minimized":[162],"paramagnetic":[164],"doping":[165,170],"resin.":[168],"Such":[169],"unnecessary":[173],"obtaining":[175],"quality":[177],"protein":[178,224],"spectra":[180],"when":[181],"insensitive":[188],"mismatching.":[191],"microcells":[193],"offer":[194],"outstanding":[195],"RF":[196],"good":[198],"Bo":[199],"homogeneities.":[200],"Integrated":[201],"600-MHz":[202],"HSQC":[203],"signal":[204],"intensities":[205],"microcell":[208],"PBS":[211,240],"buffer":[212],"were":[213],"6.5\u00b14":[214],"%":[215],"lower":[216],"than":[217],"same":[223],"regular":[228],"tube.":[231],"cell":[233],"is":[234],"demonstrated":[235],"N-acetylated":[237],"\u03b1-synuclein":[238],"buffer,":[241],"observing":[244],"tetramerization":[245],"melittin":[247]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2025-10-10T00:00:00"}
