{"id":"https://openalex.org/W4412709646","doi":"https://doi.org/10.2139/ssrn.5368593","title":"Metabolic and Nutritional Mutation Signatures Drive Early Progression of Chronic Myeloid Leukemia: A Whole-Exome and AI-Guided Precision Framework","display_name":"Metabolic and Nutritional Mutation Signatures Drive Early Progression of Chronic Myeloid Leukemia: A Whole-Exome and AI-Guided Precision Framework","publication_year":2025,"publication_date":"2025-01-01","ids":{"openalex":"https://openalex.org/W4412709646","doi":"https://doi.org/10.2139/ssrn.5368593"},"language":"en","primary_location":{"id":"doi:10.2139/ssrn.5368593","doi":"https://doi.org/10.2139/ssrn.5368593","is_oa":true,"landing_page_url":"https://doi.org/10.2139/ssrn.5368593","pdf_url":null,"source":{"id":"https://openalex.org/S4210172589","display_name":"SSRN Electronic Journal","issn_l":"1556-5068","issn":["1556-5068"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1318003438","host_organization_name":"RELX Group (Netherlands)","host_organization_lineage":["https://openalex.org/I1318003438"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.2139/ssrn.5368593","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101740357","display_name":"Zafar Iqbal","orcid":"https://orcid.org/0000-0002-1334-6372","observed_orcids":["https://orcid.org/0000-0002-1334-6372","https://orcid.org/0000-0002-4195-2476"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Dr. Zafar Iqbal","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074297204","display_name":"Sarah AlMukhaylid","orcid":"https://orcid.org/0009-0000-0646-367X","observed_orcids":["https://orcid.org/0009-0000-0646-367X"]},"institutions":[{"id":"https://openalex.org/I185203018","display_name":"King Saud bin Abdulaziz University for Health Sciences","ror":"https://ror.org/0149jvn88","country_code":"SA","type":"education","lineage":["https://openalex.org/I185203018"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Sarah AlMukhaylid","raw_affiliation_strings":["King Saud Bin Abdulaziz University for Health Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"King Saud Bin Abdulaziz University for Health Sciences","institution_ids":["https://openalex.org/I185203018"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063099799","display_name":"Masood A. Shammas","orcid":"https://orcid.org/0000-0002-8932-6829","observed_orcids":["https://orcid.org/0000-0002-8932-6829"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4210134579","display_name":"Dana-Farber/Harvard Cancer Center","ror":"https://ror.org/03pvyf116","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210134579"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Masood Shammas","raw_affiliation_strings":["Department of Medical Oncology, Harvard (Dana Farber) Cancer Institute, Boston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Harvard (Dana Farber) Cancer Institute, Boston","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210134579"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088683743","display_name":"Sultan Al Qahtani","orcid":"https://orcid.org/0000-0001-7649-1457","observed_orcids":["https://orcid.org/0000-0001-7649-1457"]},"institutions":[{"id":"https://openalex.org/I4210134149","display_name":"King Abdulaziz Hospital","ror":"https://ror.org/04cjdzt83","country_code":"SA","type":"healthcare","lineage":["https://openalex.org/I4210134149"]},{"id":"https://openalex.org/I4405276535","display_name":"King Abdulaziz Hospital","ror":"https://ror.org/05mvv1442","country_code":"SA","type":"healthcare","lineage":["https://openalex.org/I4210127754","https://openalex.org/I4405269311","https://openalex.org/I4405276535"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Sultan Al Qahtani","raw_affiliation_strings":["King Abdulaziz Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"King Abdulaziz Hospital","institution_ids":["https://openalex.org/I4210134149","https://openalex.org/I4405276535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108970544","display_name":"Abdulkareem Al-Garni","orcid":"https://orcid.org/0009-0003-4708-4838","observed_orcids":["https://orcid.org/0009-0003-4708-4838"]},"institutions":[{"id":"https://openalex.org/I4210134149","display_name":"King Abdulaziz Hospital","ror":"https://ror.org/04cjdzt83","country_code":"SA","type":"healthcare","lineage":["https://openalex.org/I4210134149"]},{"id":"https://openalex.org/I4405276535","display_name":"King Abdulaziz Hospital","ror":"https://ror.org/05mvv1442","country_code":"SA","type":"healthcare","lineage":["https://openalex.org/I4210127754","https://openalex.org/I4405269311","https://openalex.org/I4405276535"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Abdulkareem Algarni","raw_affiliation_strings":["King Abdulaziz Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"King Abdulaziz Hospital","institution_ids":["https://openalex.org/I4210134149","https://openalex.org/I4405276535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031714547","display_name":"Aamer Aleem","orcid":"https://orcid.org/0000-0001-5774-0358","observed_orcids":["https://orcid.org/0000-0001-5774-0358"]},"institutions":[{"id":"https://openalex.org/I28022161","display_name":"King Saud University","ror":"https://ror.org/02f81g417","country_code":"SA","type":"education","lineage":["https://openalex.org/I28022161"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Aamer Aleem","raw_affiliation_strings":["King Saud University Medical City"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"King Saud University Medical City","institution_ids":["https://openalex.org/I28022161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093106786","display_name":"Nawaf Alanzazi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210134149","display_name":"King Abdulaziz Hospital","ror":"https://ror.org/04cjdzt83","country_code":"SA","type":"healthcare","lineage":["https://openalex.org/I4210134149"]},{"id":"https://openalex.org/I4405276535","display_name":"King Abdulaziz Hospital","ror":"https://ror.org/05mvv1442","country_code":"SA","type":"healthcare","lineage":["https://openalex.org/I4210127754","https://openalex.org/I4405269311","https://openalex.org/I4405276535"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Nawaf Alanzazi","raw_affiliation_strings":["King Abdulaziz Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"King Abdulaziz Hospital","institution_ids":["https://openalex.org/I4210134149","https://openalex.org/I4405276535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106538239","display_name":"Yaqob Samir Taleb","orcid":"https://orcid.org/0009-0002-0751-6643","observed_orcids":["https://orcid.org/0009-0002-0751-6643"]},"institutions":[{"id":"https://openalex.org/I185203018","display_name":"King Saud bin Abdulaziz University for Health Sciences","ror":"https://ror.org/0149jvn88","country_code":"SA","type":"education","lineage":["https://openalex.org/I185203018"]},{"id":"https://openalex.org/I2802517405","display_name":"King Abdulaziz Medical City","ror":"https://ror.org/009djsq06","country_code":"SA","type":"healthcare","lineage":["https://openalex.org/I2802517405"]},{"id":"https://openalex.org/I4517696","display_name":"National Guard Health Affairs","ror":"https://ror.org/02pecpe58","country_code":"SA","type":"healthcare","lineage":["https://openalex.org/I4517696"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Yaqob Taleb","raw_affiliation_strings":["King Saud Bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City, National Guard Health Affairs"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"King Saud Bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City, National Guard Health Affairs","institution_ids":["https://openalex.org/I185203018","https://openalex.org/I2802517405","https://openalex.org/I4517696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110508991","display_name":"Rizwan C. Naeem","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rizwan Naeem","raw_affiliation_strings":["Albert Einstein College of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Albert Einstein College of Medicine","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003104026","display_name":"Amer Mahmood","orcid":"https://orcid.org/0000-0002-9199-0120","observed_orcids":["https://orcid.org/0000-0002-9199-0120"]},"institutions":[{"id":"https://openalex.org/I28022161","display_name":"King Saud University","ror":"https://ror.org/02f81g417","country_code":"SA","type":"education","lineage":["https://openalex.org/I28022161"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Amer Mahmood","raw_affiliation_strings":["King Saud University - Cancer Stem Cell Group, Riyadh, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"King Saud University - Cancer Stem Cell Group, Riyadh, Saudi Arabia","institution_ids":["https://openalex.org/I28022161"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019949455","display_name":"Giuseppe Nicola Saglio","orcid":"https://orcid.org/0000-0002-1046-3514","observed_orcids":["https://orcid.org/0000-0002-1046-3514"]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giuseppe Saglio","raw_affiliation_strings":["University of Turin, Via Po 53, Torino, 10100, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Turin, Via Po 53, Torino, 10100, Italy","institution_ids":["https://openalex.org/I55143463"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":11,"corresponding_author_ids":["https://openalex.org/A5101740357"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":0.948199987411499,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":0.948199987411499,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.01889999955892563,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.015699999406933784,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-myeloid-leukemia","display_name":"chronic myeloid leukemia","score":0.996999979019165},{"id":"https://openalex.org/keywords/accelerated-phase-cml","display_name":"accelerated phase CML","score":0.9210000038146973},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.6830000281333923},{"id":"https://openalex.org/keywords/idh1","display_name":"IDH1","score":0.7799999713897705},{"id":"https://openalex.org/keywords/idh2","display_name":"IDH2","score":0.949999988079071},{"id":"https://openalex.org/keywords/dnmt3a","display_name":"DNMT3A","score":0.9929999709129333},{"id":"https://openalex.org/keywords/tet2","display_name":"TET2","score":0.9929999709129333},{"id":"https://openalex.org/keywords/asxl1","display_name":"ASXL1","score":0.9869999885559082},{"id":"https://openalex.org/keywords/wt1","display_name":"WT1","score":0.9810000061988831},{"id":"https://openalex.org/keywords/u2af1","display_name":"U2AF1","score":0.9940000176429749},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":0.9049999713897705},{"id":"https://openalex.org/keywords/early-biomarkers","display_name":"early biomarkers","score":0.6809999942779541},{"id":"https://openalex.org/keywords/precision-oncology","display_name":"precision oncology","score":0.8519999980926514},{"id":"https://openalex.org/keywords/personalized-nutrition","display_name":"personalized nutrition","score":0.8100000023841858},{"id":"https://openalex.org/keywords/machine-learning-prediction","display_name":"machine learning prediction","score":0.5659999847412109}],"concepts":[{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.7438240051269531},{"id":"https://openalex.org/C16671776","wikidata":"https://www.wikidata.org/wiki/Q5420592","display_name":"Exome sequencing","level":4,"score":0.5373339653015137},{"id":"https://openalex.org/C10590036","wikidata":"https://www.wikidata.org/wiki/Q417664","display_name":"Exome","level":5,"score":0.5164996981620789},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.49529972672462463},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3916492760181427},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3693644106388092},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3521491289138794},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33643388748168945},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2798703908920288},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16382566094398499}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.2139/ssrn.5368593","doi":"https://doi.org/10.2139/ssrn.5368593","is_oa":true,"landing_page_url":"https://doi.org/10.2139/ssrn.5368593","pdf_url":null,"source":{"id":"https://openalex.org/S4210172589","display_name":"SSRN Electronic Journal","issn_l":"1556-5068","issn":["1556-5068"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1318003438","host_organization_name":"RELX Group (Netherlands)","host_organization_lineage":["https://openalex.org/I1318003438"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.2139/ssrn.5368593","doi":"https://doi.org/10.2139/ssrn.5368593","is_oa":true,"landing_page_url":"https://doi.org/10.2139/ssrn.5368593","pdf_url":null,"source":{"id":"https://openalex.org/S4210172589","display_name":"SSRN Electronic Journal","issn_l":"1556-5068","issn":["1556-5068"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1318003438","host_organization_name":"RELX Group (Netherlands)","host_organization_lineage":["https://openalex.org/I1318003438"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1605230984","https://openalex.org/W1984068087","https://openalex.org/W2074986801","https://openalex.org/W2101234009","https://openalex.org/W2131072337","https://openalex.org/W2154313451","https://openalex.org/W2160995259","https://openalex.org/W2168133698","https://openalex.org/W2234115940","https://openalex.org/W2295598076","https://openalex.org/W2298232809","https://openalex.org/W2559588208","https://openalex.org/W2804822363","https://openalex.org/W2806682325","https://openalex.org/W2809646241","https://openalex.org/W2997591727","https://openalex.org/W3003257820","https://openalex.org/W3175752499","https://openalex.org/W3177828909","https://openalex.org/W4283447987","https://openalex.org/W4284884567","https://openalex.org/W4292528167","https://openalex.org/W4301730562","https://openalex.org/W4394666350"],"related_works":["https://openalex.org/W4253687050","https://openalex.org/W2322134621","https://openalex.org/W4416441513","https://openalex.org/W4412627085","https://openalex.org/W2953230895","https://openalex.org/W2569478684","https://openalex.org/W2556041488","https://openalex.org/W2546708148","https://openalex.org/W4391487498","https://openalex.org/W3195343023"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}