{"id":"https://openalex.org/W4412708317","doi":"https://doi.org/10.1186/s40478-025-02081-1","title":"Co-occurrence of multiple pathologies in a case of frontotemporal dementia with TBK1 mutation: first in vivo detection of alpha-synuclein and tau co-pathology","display_name":"Co-occurrence of multiple pathologies in a case of frontotemporal dementia with TBK1 mutation: first in vivo detection of alpha-synuclein and tau co-pathology","publication_year":2025,"publication_date":"2025-07-25","ids":{"openalex":"https://openalex.org/W4412708317","doi":"https://doi.org/10.1186/s40478-025-02081-1","pmid":"https://pubmed.ncbi.nlm.nih.gov/40713844","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12291237"},"language":"en","primary_location":{"id":"doi:10.1186/s40478-025-02081-1","doi":"https://doi.org/10.1186/s40478-025-02081-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s40478-025-02081-1","pdf_url":"https://link.springer.com/content/pdf/10.1186/s40478-025-02081-1.pdf","source":{"id":"https://openalex.org/S2764650462","display_name":"Acta Neuropathologica Communications","issn_l":"2051-5960","issn":["2051-5960"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Neuropathologica Communications","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://link.springer.com/content/pdf/10.1186/s40478-025-02081-1.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007852853","display_name":"Alexander Maximilian Bernhardt","orcid":"https://orcid.org/0000-0002-2572-5062","observed_orcids":["https://orcid.org/0000-0002-2572-5062"]},"institutions":[{"id":"https://openalex.org/I2801533059","display_name":"German Center for Neurodegenerative Diseases","ror":"https://ror.org/043j0f473","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I2801533059","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Alexander M. Bernhardt","raw_affiliation_strings":["Department of Neurology, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, M\u00fcnchen, Germany","German Center for Neurodegenerative Diseases (DZNE), site Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, M\u00fcnchen, Germany","institution_ids":["https://openalex.org/I8204097"]},{"raw_affiliation_string":"German Center for Neurodegenerative Diseases (DZNE), site Munich, Germany","institution_ids":["https://openalex.org/I2801533059"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058301976","display_name":"Sigrun Roeber","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405260960","display_name":"Institut f\u00fcr Neuropathologie","ror":"https://ror.org/04hhrpp03","country_code":"DE","type":"education","lineage":["https://openalex.org/I4405260960","https://openalex.org/I8204097"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sigrun Roeber","raw_affiliation_strings":["Center for Neuropathology and Prion Research, Faculty of Medicine, Ludwig-Maximilians- University Munich, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Neuropathology and Prion Research, Faculty of Medicine, Ludwig-Maximilians- University Munich, Munich, Germany","institution_ids":["https://openalex.org/I4405260960","https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072986945","display_name":"Viktoria Ruf","orcid":"https://orcid.org/0000-0002-3876-8854","observed_orcids":["https://orcid.org/0000-0002-3876-8854"]},"institutions":[{"id":"https://openalex.org/I4210113080","display_name":"Munich Cluster for Systems Neurology","ror":"https://ror.org/025z3z560","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210113080","https://openalex.org/I62916508","https://openalex.org/I8204097"]},{"id":"https://openalex.org/I4405260960","display_name":"Institut f\u00fcr Neuropathologie","ror":"https://ror.org/04hhrpp03","country_code":"DE","type":"education","lineage":["https://openalex.org/I4405260960","https://openalex.org/I8204097"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Viktoria Ruf","raw_affiliation_strings":["Center for Neuropathology and Prion Research, Faculty of Medicine, Ludwig-Maximilians- University Munich, Munich, Germany","Munich Cluster for Systems Neurology (SyNergy), Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Neuropathology and Prion Research, Faculty of Medicine, Ludwig-Maximilians- University Munich, Munich, Germany","institution_ids":["https://openalex.org/I4405260960","https://openalex.org/I8204097"]},{"raw_affiliation_string":"Munich Cluster for Systems Neurology (SyNergy), Munich, Germany","institution_ids":["https://openalex.org/I4210113080"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001789275","display_name":"Elisabeth Wlasich","orcid":"https://orcid.org/0009-0002-2733-7511","observed_orcids":["https://orcid.org/0009-0002-2733-7511"]},"institutions":[{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Elisabeth Wlasich","raw_affiliation_strings":["Department of Neurology, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, M\u00fcnchen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, M\u00fcnchen, Germany","institution_ids":["https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018438018","display_name":"Endy Weidinger","orcid":"https://orcid.org/0009-0003-6679-7788","observed_orcids":["https://orcid.org/0009-0003-6679-7788"]},"institutions":[{"id":"https://openalex.org/I2801533059","display_name":"German Center for Neurodegenerative Diseases","ror":"https://ror.org/043j0f473","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I2801533059","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Endy Weidinger","raw_affiliation_strings":["Department of Neurology, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, M\u00fcnchen, Germany","German Center for Neurodegenerative Diseases (DZNE), site Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, M\u00fcnchen, Germany","institution_ids":["https://openalex.org/I8204097"]},{"raw_affiliation_string":"German Center for Neurodegenerative Diseases (DZNE), site Munich, Germany","institution_ids":["https://openalex.org/I2801533059"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010091805","display_name":"Sebastian Longen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sebastian Longen","raw_affiliation_strings":["Aesku.Diagnostics GmbH, Wendelsheim, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aesku.Diagnostics GmbH, Wendelsheim, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005002446","display_name":"Svenja Verena Trossbach","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Svenja V. Trossbach","raw_affiliation_strings":["MODAG GmbH, Wendelsheim, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MODAG GmbH, Wendelsheim, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049725109","display_name":"Johannes S. Gn\u00f6rich","orcid":"https://orcid.org/0000-0003-1554-7765","observed_orcids":["https://orcid.org/0000-0003-1554-7765"]},"institutions":[{"id":"https://openalex.org/I3018771216","display_name":"LMU Klinikum","ror":"https://ror.org/02jet3w32","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I3018771216","https://openalex.org/I8204097"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Johannes Gn\u00f6rich","raw_affiliation_strings":["Department of Nuclear Medicine, LMU University Hospital, LMU Munich, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nuclear Medicine, LMU University Hospital, LMU Munich, Munich, Germany","institution_ids":["https://openalex.org/I3018771216","https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076330235","display_name":"Matthias Brendel","orcid":"https://orcid.org/0000-0002-6522-4895","observed_orcids":["https://orcid.org/0000-0002-6522-4895"]},"institutions":[{"id":"https://openalex.org/I3018771216","display_name":"LMU Klinikum","ror":"https://ror.org/02jet3w32","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I3018771216","https://openalex.org/I8204097"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Matthias Brendel","raw_affiliation_strings":["Department of Nuclear Medicine, LMU University Hospital, LMU Munich, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nuclear Medicine, LMU University Hospital, LMU Munich, Munich, Germany","institution_ids":["https://openalex.org/I3018771216","https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069184646","display_name":"Jochen Wolfgang Herms","orcid":"https://orcid.org/0000-0002-6201-1042","observed_orcids":["https://orcid.org/0000-0002-6201-1042"]},"institutions":[{"id":"https://openalex.org/I4210113080","display_name":"Munich Cluster for Systems Neurology","ror":"https://ror.org/025z3z560","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210113080","https://openalex.org/I62916508","https://openalex.org/I8204097"]},{"id":"https://openalex.org/I4405260960","display_name":"Institut f\u00fcr Neuropathologie","ror":"https://ror.org/04hhrpp03","country_code":"DE","type":"education","lineage":["https://openalex.org/I4405260960","https://openalex.org/I8204097"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jochen Herms","raw_affiliation_strings":["Center for Neuropathology and Prion Research, Faculty of Medicine, Ludwig-Maximilians- University Munich, Munich, Germany","Munich Cluster for Systems Neurology (SyNergy), Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Neuropathology and Prion Research, Faculty of Medicine, Ludwig-Maximilians- University Munich, Munich, Germany","institution_ids":["https://openalex.org/I4405260960","https://openalex.org/I8204097"]},{"raw_affiliation_string":"Munich Cluster for Systems Neurology (SyNergy), Munich, Germany","institution_ids":["https://openalex.org/I4210113080"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009231408","display_name":"Armin Giese","orcid":"https://orcid.org/0000-0002-8238-4102","observed_orcids":["https://orcid.org/0000-0002-8238-4102"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Armin Giese","raw_affiliation_strings":["MODAG GmbH, Wendelsheim, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MODAG GmbH, Wendelsheim, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068749612","display_name":"G\u00fcnter U. H\u00f6glinger","orcid":"https://orcid.org/0000-0001-7587-6187","observed_orcids":["https://orcid.org/0000-0001-7587-6187"]},"institutions":[{"id":"https://openalex.org/I2801533059","display_name":"German Center for Neurodegenerative Diseases","ror":"https://ror.org/043j0f473","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I2801533059","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I4210113080","display_name":"Munich Cluster for Systems Neurology","ror":"https://ror.org/025z3z560","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210113080","https://openalex.org/I62916508","https://openalex.org/I8204097"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"G\u00fcnter U. H\u00f6glinger","raw_affiliation_strings":["Department of Neurology, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, M\u00fcnchen, Germany","German Center for Neurodegenerative Diseases (DZNE), site Munich, Germany","Munich Cluster for Systems Neurology (SyNergy), Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, M\u00fcnchen, Germany","institution_ids":["https://openalex.org/I8204097"]},{"raw_affiliation_string":"German Center for Neurodegenerative Diseases (DZNE), site Munich, Germany","institution_ids":["https://openalex.org/I2801533059"]},{"raw_affiliation_string":"Munich Cluster for Systems Neurology (SyNergy), Munich, Germany","institution_ids":["https://openalex.org/I4210113080"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035514608","display_name":"Johannes Levin","orcid":"https://orcid.org/0000-0001-5092-4306","observed_orcids":["https://orcid.org/0000-0001-5092-4306"]},"institutions":[{"id":"https://openalex.org/I2801533059","display_name":"German Center for Neurodegenerative Diseases","ror":"https://ror.org/043j0f473","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I2801533059","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I4210113080","display_name":"Munich Cluster for Systems Neurology","ror":"https://ror.org/025z3z560","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210113080","https://openalex.org/I62916508","https://openalex.org/I8204097"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Johannes Levin","raw_affiliation_strings":["Department of Neurology, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, M\u00fcnchen, Germany. jlevin@med.uni-muenchen.de","German Center for Neurodegenerative Diseases (DZNE), site Munich, Germany. jlevin@med.uni-muenchen.de","Munich Cluster for Systems Neurology (SyNergy), Munich, Germany. jlevin@med.uni-muenchen.de"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, M\u00fcnchen, Germany. jlevin@med.uni-muenchen.de","institution_ids":["https://openalex.org/I8204097"]},{"raw_affiliation_string":"German Center for Neurodegenerative Diseases (DZNE), site Munich, Germany. jlevin@med.uni-muenchen.de","institution_ids":["https://openalex.org/I2801533059"]},{"raw_affiliation_string":"Munich Cluster for Systems Neurology (SyNergy), Munich, Germany. jlevin@med.uni-muenchen.de","institution_ids":["https://openalex.org/I4210113080"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5035514608"],"corresponding_institution_ids":["https://openalex.org/I2801533059","https://openalex.org/I4210113080","https://openalex.org/I8204097"],"apc_list":{"value":3790,"currency":"USD","value_usd":3790},"apc_paid":{"value":3790,"currency":"USD","value_usd":3790},"fwci":1.2869,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.79238985,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":97},"biblio":{"volume":"13","issue":"1","first_page":"163","last_page":"163"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.5938000082969666,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.5938000082969666,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.2102999985218048,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.11190000176429749,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/frontotemporal-dementia","display_name":"frontotemporal dementia","score":0.890999972820282},{"id":"https://openalex.org/keywords/behavioral-variant-frontotemporal-dementia","display_name":"behavioral variant frontotemporal dementia","score":0.9300000071525574},{"id":"https://openalex.org/keywords/alpha-synuclein","display_name":"alpha-synuclein","score":0.8880000114440918},{"id":"https://openalex.org/keywords/tau-pathology","display_name":"tau pathology","score":0.7110000252723694},{"id":"https://openalex.org/keywords/lewy-body-disease","display_name":"Lewy body disease","score":0.8330000042915344},{"id":"https://openalex.org/keywords/argyrophilic-grain-disease","display_name":"argyrophilic grain disease","score":0.8809999823570251},{"id":"https://openalex.org/keywords/primary-age-related-tauopathy","display_name":"primary age-related tauopathy","score":0.8619999885559082},{"id":"https://openalex.org/keywords/seed-amplification-assay","display_name":"seed amplification assay","score":0.6549999713897705},{"id":"https://openalex.org/keywords/tau-pet","display_name":"tau PET","score":0.8999999761581421},{"id":"https://openalex.org/keywords/18f-pi-2620","display_name":"[18F]PI-2620","score":0.9279999732971191},{"id":"https://openalex.org/keywords/co-pathology","display_name":"co-pathology","score":0.5329999923706055}],"concepts":[{"id":"https://openalex.org/C2778641062","wikidata":"https://www.wikidata.org/wiki/Q18592","display_name":"Frontotemporal dementia","level":4,"score":0.7788791656494141},{"id":"https://openalex.org/C2781449126","wikidata":"https://www.wikidata.org/wiki/Q288591","display_name":"Alpha-synuclein","level":4,"score":0.654065728187561},{"id":"https://openalex.org/C3017833866","wikidata":"https://www.wikidata.org/wiki/Q2397106","display_name":"Tau pathology","level":4,"score":0.5885161757469177},{"id":"https://openalex.org/C16568411","wikidata":"https://www.wikidata.org/wiki/Q83042","display_name":"Neurology","level":2,"score":0.5474718809127808},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.5054171085357666},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5018796920776367},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.4980027675628662},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4681219160556793},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4292915165424347},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.41316521167755127},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.25326263904571533},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2376825511455536},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.2272786796092987},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.20934399962425232},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17970633506774902},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.14059990644454956},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08656367659568787}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016875","descriptor_name":"tau Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016875","descriptor_name":"tau Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016875","descriptor_name":"tau Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016875","descriptor_name":"tau Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016875","descriptor_name":"tau Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D049268","descriptor_name":"Positron-Emission Tomography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049268","descriptor_name":"Positron-Emission Tomography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049268","descriptor_name":"Positron-Emission Tomography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049268","descriptor_name":"Positron-Emission Tomography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049268","descriptor_name":"Positron-Emission Tomography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051844","descriptor_name":"alpha-Synuclein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051844","descriptor_name":"alpha-Synuclein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051844","descriptor_name":"alpha-Synuclein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051844","descriptor_name":"alpha-Synuclein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051844","descriptor_name":"alpha-Synuclein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D057180","descriptor_name":"Frontotemporal Dementia","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D057180","descriptor_name":"Frontotemporal Dementia","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D057180","descriptor_name":"Frontotemporal Dementia","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D057180","descriptor_name":"Frontotemporal Dementia","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D057180","descriptor_name":"Frontotemporal Dementia","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D057180","descriptor_name":"Frontotemporal Dementia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D057180","descriptor_name":"Frontotemporal Dementia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D057180","descriptor_name":"Frontotemporal Dementia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D057180","descriptor_name":"Frontotemporal Dementia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D057180","descriptor_name":"Frontotemporal Dementia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D057180","descriptor_name":"Frontotemporal Dementia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D057180","descriptor_name":"Frontotemporal Dementia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D057180","descriptor_name":"Frontotemporal Dementia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D057180","descriptor_name":"Frontotemporal Dementia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D057180","descriptor_name":"Frontotemporal Dementia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D057180","descriptor_name":"Frontotemporal Dementia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D057180","descriptor_name":"Frontotemporal Dementia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D057180","descriptor_name":"Frontotemporal Dementia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D057180","descriptor_name":"Frontotemporal Dementia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D057180","descriptor_name":"Frontotemporal Dementia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1186/s40478-025-02081-1","doi":"https://doi.org/10.1186/s40478-025-02081-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s40478-025-02081-1","pdf_url":"https://link.springer.com/content/pdf/10.1186/s40478-025-02081-1.pdf","source":{"id":"https://openalex.org/S2764650462","display_name":"Acta Neuropathologica Communications","issn_l":"2051-5960","issn":["2051-5960"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Neuropathologica Communications","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12291237","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12291237","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Neuropathol Commun","raw_type":"Text"},{"id":"pmid:40713844","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40713844","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta neuropathologica communications","raw_type":"Journal Article"},{"id":"pmh:oai:epub.ub.uni-muenchen.de:129932","doi":null,"is_oa":true,"landing_page_url":"http://nbn-resolving.de/urn:nbn:de:bvb:19-epub-129932-8","pdf_url":"https://epub.ub.uni-muenchen.de/129932/1/s40478-025-02081-1.pdf","source":{"id":"https://openalex.org/S4306401845","display_name":"Open access LMU (Ludwid Maxmilian's Universitat Munchen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I8204097","host_organization_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","host_organization_lineage":["https://openalex.org/I8204097"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Acta Neuropathologica Communications","raw_type":"doc-type:article"},{"id":"pmh:oai:pub.dzne.de:280252","doi":null,"is_oa":true,"landing_page_url":"https://pub.dzne.de/search?p=id:%22DZNE-2025-00930%22","pdf_url":"https://pub.dzne.de/record/280252/files/DZNE-2025-00930.pdf","source":{"id":"https://openalex.org/S7407051172","display_name":"DZNE Pub","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801533059","host_organization_name":"German Center for Neurodegenerative Diseases","host_organization_lineage":["https://openalex.org/I2801533059"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Acta Neuropathologica Communications 13(1), 163 (2025). doi:10.1186/s40478-025-02081-1","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:40db96c6bc9241a39eaccddc40986cd2","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/40db96c6bc9241a39eaccddc40986cd2","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Acta Neuropathologica Communications, Vol 13, Iss 1, Pp 1-6 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s40478-025-02081-1","doi":"https://doi.org/10.1186/s40478-025-02081-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s40478-025-02081-1","pdf_url":"https://link.springer.com/content/pdf/10.1186/s40478-025-02081-1.pdf","source":{"id":"https://openalex.org/S2764650462","display_name":"Acta Neuropathologica Communications","issn_l":"2051-5960","issn":["2051-5960"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Neuropathologica Communications","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"sustainable_development_goals_aurora":[],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4412708317.pdf","grobid_xml":"https://content.openalex.org/works/W4412708317.grobid-xml"},"referenced_works_count":12,"referenced_works":["https://openalex.org/W2128030851","https://openalex.org/W2156054547","https://openalex.org/W2548717269","https://openalex.org/W2561589481","https://openalex.org/W2619097621","https://openalex.org/W2765194278","https://openalex.org/W2941204550","https://openalex.org/W3038832112","https://openalex.org/W3162078396","https://openalex.org/W4388210741","https://openalex.org/W4404655653","https://openalex.org/W4407800149"],"related_works":["https://openalex.org/W2548717269","https://openalex.org/W2948535196","https://openalex.org/W7133860018","https://openalex.org/W2336677669","https://openalex.org/W2513974003","https://openalex.org/W2901366012","https://openalex.org/W2210071362","https://openalex.org/W4409222434","https://openalex.org/W2593979508","https://openalex.org/W2561589481"],"abstract_inverted_index":{"Abstract":[0],"We":[1],"present":[2],"the":[3,29,60,77,92,100,137,161,180,198,217,223],"case":[4,141,159,195],"of":[5,102,146,155,166,175,182,200],"a":[6,17,172],"74-year-old":[7],"woman":[8],"with":[9,95,142],"behavioral":[10],"variant":[11],"frontotemporal":[12],"dementia":[13],"(bvFTD)":[14],"linked":[15],"to":[16],"pathogenic":[18],"TANK-binding":[19],"kinase":[20],"1":[21],"(TBK1)":[22],"mutation":[23],"(c.1349_1352del;":[24],"p.Ile450Lysfs*15).":[25],"During":[26],"clinical":[27,162],"workup,":[28],"patient":[30],"underwent":[31],"comprehensive":[32],"biomarker":[33],"analysis,":[34],"including":[35],"tau":[36,127,156,204],"positron":[37],"emission":[38],"tomography":[39],"(PET)":[40],"and":[41,99,130,151,163,178,191,203,215,229],"cerebrospinal":[42],"fluid":[43],"(CSF)":[44],"seed":[45],"amplification":[46],"assay":[47],"(SAA)":[48],"for":[49,55,219],"\u03b1-synuclein":[50],"(\u03b1Syn).":[51],"While":[52],"CSF":[53],"biomarkers":[54],"Alzheimer\u2019s":[56],"disease":[57,116,124],"were":[58],"normal,":[59],"\u03b1Syn":[61,68,147,201,230],"SAA":[62,150,202],"was":[63],"clearly":[64],"positive,":[65],"indicating":[66],"misfolded":[67],"aggregates.":[69],"Tau":[70],"PET":[71,205],"revealed":[72],"increased":[73],"[18F]PI-2620":[74],"uptake":[75],"in":[76,143,152,206],"basal":[78],"ganglia.":[79],"Genetic":[80],"testing":[81],"confirmed":[82,108],"autosomal":[83],"dominant":[84],"TBK1-associated":[85,167,176],"FTD.":[86,168],"The":[87,158],"patient\u2019s":[88],"condition":[89],"deteriorated":[90],"over":[91],"following":[93],"year,":[94],"rapid":[96],"cognitive":[97],"decline":[98],"emergence":[101],"cortical":[103],"signs.":[104],"Post-mortem":[105],"neuropathological":[106,164,192],"analysis":[107],"multiple":[109],"proteinopathies:":[110],"FTLD-TDP43":[111],"(subtype":[112],"A),":[113],"Lewy":[114],"body":[115],"(limbic":[117],"type,":[118],"Braak":[119],"stage":[120],"5),":[121],"argyrophilic":[122],"grain":[123],"(AGD),":[125],"aging-related":[126],"astrogliopathy":[128],"(ARTAG),":[129],"primary":[131],"age-related":[132],"tauopathy":[133],"(PART).":[134],"This":[135,194],"is":[136],"first":[138],"reported":[139],"TBK1-FTD":[140],"vivo":[144,153],"detection":[145],"pathology":[148],"via":[149],"monitoring":[154],"pathology.":[157],"expands":[160],"spectrum":[165],"Our":[169],"findings":[170],"support":[171],"broader":[173],"interpretation":[174],"neurodegeneration":[177],"highlight":[179],"importance":[181],"multimodal":[183],"diagnostic":[184],"approaches":[185],"that":[186,209],"integrate":[187],"molecular,":[188],"genetic,":[189],"imaging,":[190],"tools.":[193],"also":[196],"underscores":[197],"utility":[199],"detecting":[207],"co-pathologies":[208],"may":[210],"otherwise":[211],"remain":[212],"clinically":[213],"silent":[214],"illustrates":[216],"need":[218],"further":[220],"studies":[221],"exploring":[222],"molecular":[224],"cross-talk":[225],"between":[226],"TBK1,":[227],"tau,":[228],"pathologies.":[231]},"counts_by_year":[{"year":2026,"cited_by_count":2}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2025-10-10T00:00:00"}