{"id":"https://openalex.org/W4412699366","doi":"https://doi.org/10.18621/eurj.1661091","title":"Digital twins in personalized medicine: Insights from a systematic review","display_name":"Digital twins in personalized medicine: Insights from a systematic review","publication_year":2025,"publication_date":"2025-07-28","ids":{"openalex":"https://openalex.org/W4412699366","doi":"https://doi.org/10.18621/eurj.1661091"},"language":"en","primary_location":{"id":"doi:10.18621/eurj.1661091","doi":"https://doi.org/10.18621/eurj.1661091","is_oa":true,"landing_page_url":"https://doi.org/10.18621/eurj.1661091","pdf_url":"https://dergipark.org.tr/en/download/article-file/4705264","source":{"id":"https://openalex.org/S2764502452","display_name":"The European Research Journal","issn_l":"2149-3189","issn":["2149-3189"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["tr-dizin"],"host_organization":"https://openalex.org/P4310318383","host_organization_name":"Turkish Online Journal of Qualitative Inquiry (TOJQI)","host_organization_lineage":["https://openalex.org/P4310318383"],"host_organization_lineage_names":["Turkish Online Journal of Qualitative Inquiry (TOJQI)"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The European Research Journal","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://dergipark.org.tr/en/download/article-file/4705264","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070467074","display_name":"Ebru U\u011fra\u015f","orcid":"https://orcid.org/0000-0002-5618-5265","observed_orcids":["https://orcid.org/0000-0002-5618-5265"]},"institutions":[{"id":"https://openalex.org/I4210150808","display_name":"Ankara Y\u0131ld\u0131r\u0131m Beyaz\u0131t University","ror":"https://ror.org/05ryemn72","country_code":"TR","type":"education","lineage":["https://openalex.org/I4210150808"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Ebru U\u011fra\u015f","raw_affiliation_strings":["Department of Family Medicine, Ankara Y\u0131ld\u0131r\u0131m Beyaz\u0131t University School of Medicine, Ankara, T\u00fcrkiye"],"raw_orcid":"https://orcid.org/0000-0002-5618-5265","affiliations":[{"raw_affiliation_string":"Department of Family Medicine, Ankara Y\u0131ld\u0131r\u0131m Beyaz\u0131t University School of Medicine, Ankara, T\u00fcrkiye","institution_ids":["https://openalex.org/I4210150808"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5070467074"],"corresponding_institution_ids":["https://openalex.org/I4210150808"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.06386355,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"11","issue":"5","first_page":"1015","last_page":"1022"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14512","display_name":"Technology and Human Factors in Education and Health","score":0.5189999938011169,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T14512","display_name":"Technology and Human Factors in Education and Health","score":0.5189999938011169,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11636","display_name":"Artificial Intelligence in Healthcare and Education","score":0.4609000086784363,"subfield":{"id":"https://openalex.org/subfields/2718","display_name":"Health Informatics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10763","display_name":"Digital Transformation in Industry","score":0.006099999882280827,"subfield":{"id":"https://openalex.org/subfields/2209","display_name":"Industrial and Manufacturing Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/digital-twin","display_name":"digital twin","score":1.0},{"id":"https://openalex.org/keywords/personalized-medicine","display_name":"personalized medicine","score":1.0},{"id":"https://openalex.org/keywords/geriatrics","display_name":"geriatrics","score":0.9789999723434448},{"id":"https://openalex.org/keywords/radiology","display_name":"radiology","score":0.9559999704360962},{"id":"https://openalex.org/keywords/data-privacy","display_name":"data privacy","score":0.8560000061988831},{"id":"https://openalex.org/keywords/ethical-issues","display_name":"ethical considerations","score":0.7680000066757202},{"id":"https://openalex.org/keywords/technical-integration","display_name":"technical integration","score":0.7390000224113464},{"id":"https://openalex.org/keywords/interdisciplinary-collaboration","display_name":"interdisciplinary collaboration","score":0.8500000238418579},{"id":"https://openalex.org/keywords/treatment-precision","display_name":"treatment precision","score":0.625},{"id":"https://openalex.org/keywords/patient-outcomes","display_name":"patient outcomes","score":0.8389999866485596}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8443255424499512},{"id":"https://openalex.org/C32220436","wikidata":"https://www.wikidata.org/wiki/Q2072214","display_name":"Personalized medicine","level":2,"score":0.5128970146179199},{"id":"https://openalex.org/C163763905","wikidata":"https://www.wikidata.org/wiki/Q17075943","display_name":"Precision medicine","level":2,"score":0.4385698437690735},{"id":"https://openalex.org/C512399662","wikidata":"https://www.wikidata.org/wiki/Q3505712","display_name":"Family medicine","level":1,"score":0.34115517139434814},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.25463640689849854},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.19088482856750488},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.18621/eurj.1661091","doi":"https://doi.org/10.18621/eurj.1661091","is_oa":true,"landing_page_url":"https://doi.org/10.18621/eurj.1661091","pdf_url":"https://dergipark.org.tr/en/download/article-file/4705264","source":{"id":"https://openalex.org/S2764502452","display_name":"The European Research Journal","issn_l":"2149-3189","issn":["2149-3189"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["tr-dizin"],"host_organization":"https://openalex.org/P4310318383","host_organization_name":"Turkish Online Journal of Qualitative Inquiry (TOJQI)","host_organization_lineage":["https://openalex.org/P4310318383"],"host_organization_lineage_names":["Turkish Online Journal of Qualitative Inquiry (TOJQI)"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The European Research Journal","raw_type":"journal-article"},{"id":"pmh:c9b8d134-ae50-4772-9a43-78cbcf5372fe","doi":null,"is_oa":true,"landing_page_url":"https://avesis.aybu.edu.tr/publication/details/c9b8d134-ae50-4772-9a43-78cbcf5372fe/oai","pdf_url":"https://avesis.aybu.edu.tr/publication/details/c9b8d134-ae50-4772-9a43-78cbcf5372fe/oai/document.pdf","source":{"id":"https://openalex.org/S7407055213","display_name":"AYBU AVESIS","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:dergipark.org.tr:article/1661091","doi":null,"is_oa":false,"landing_page_url":"https://dergipark.org.tr/en/pub/eurj/article/1661091","pdf_url":null,"source":{"id":"https://openalex.org/S4306401840","display_name":"DergiPark (Istanbul University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67581229","host_organization_name":"Istanbul University","host_organization_lineage":["https://openalex.org/I67581229"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.18621/eurj.1661091","doi":"https://doi.org/10.18621/eurj.1661091","is_oa":true,"landing_page_url":"https://doi.org/10.18621/eurj.1661091","pdf_url":"https://dergipark.org.tr/en/download/article-file/4705264","source":{"id":"https://openalex.org/S2764502452","display_name":"The European Research Journal","issn_l":"2149-3189","issn":["2149-3189"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["tr-dizin"],"host_organization":"https://openalex.org/P4310318383","host_organization_name":"Turkish Online Journal of Qualitative Inquiry (TOJQI)","host_organization_lineage":["https://openalex.org/P4310318383"],"host_organization_lineage_names":["Turkish Online Journal of Qualitative Inquiry (TOJQI)"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The European Research Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4412699366.pdf","grobid_xml":"https://content.openalex.org/works/W4412699366.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W2030966511","https://openalex.org/W2046074714","https://openalex.org/W2518147455","https://openalex.org/W2573209024","https://openalex.org/W2786689981","https://openalex.org/W2941876953","https://openalex.org/W2944832287","https://openalex.org/W2978281981","https://openalex.org/W2982277561","https://openalex.org/W3010152544","https://openalex.org/W3097205256","https://openalex.org/W3135755054","https://openalex.org/W3158919441","https://openalex.org/W3159064895","https://openalex.org/W3184746077","https://openalex.org/W3196127649","https://openalex.org/W3200915061","https://openalex.org/W3212148341","https://openalex.org/W3215822628","https://openalex.org/W4210811588","https://openalex.org/W4221063829","https://openalex.org/W4290755645","https://openalex.org/W4290773844","https://openalex.org/W4292236560","https://openalex.org/W4308131799","https://openalex.org/W4309162692","https://openalex.org/W4309658279","https://openalex.org/W4311504925","https://openalex.org/W4318049985","https://openalex.org/W4322619821","https://openalex.org/W4323568549","https://openalex.org/W4324087818","https://openalex.org/W4365513484","https://openalex.org/W4384933377","https://openalex.org/W4399862267","https://openalex.org/W4400449578","https://openalex.org/W4401221079"],"related_works":["https://openalex.org/W4410536475","https://openalex.org/W4415421293","https://openalex.org/W7117532817","https://openalex.org/W7165630072","https://openalex.org/W7161576850","https://openalex.org/W4417521058","https://openalex.org/W4416404949","https://openalex.org/W7220732122","https://openalex.org/W7204121099","https://openalex.org/W7166661896"],"abstract_inverted_index":{"Objectives:":[0],"Digital":[1],"twins":[2],"(DTs)":[3],"are":[4,71,122],"increasingly":[5],"recognized":[6],"as":[7,78],"valuable":[8],"tools":[9],"in":[10,59,74,86],"the":[11,22,106],"advancement":[12],"of":[13,25,119],"personalized":[14],"medicine":[15],"(PM).":[16],"Methods:":[17],"This":[18,112],"systematic":[19,113],"review":[20,114],"explores":[21],"current":[23],"landscape":[24],"DT":[26],"applications":[27],"across":[28],"medical":[29],"domains,":[30],"focusing":[31],"on":[32],"their":[33],"feasibility,":[34],"benefits,":[35],"challenges,":[36],"and":[37,49,55,82,91,105,127],"potential":[38],"future":[39],"roles.":[40],"Following":[41],"PRISMA":[42],"guidelines,":[43],"literature":[44],"was":[45],"sourced":[46],"from":[47],"PubMed":[48],"Scopus":[50],"using":[51],"clearly":[52],"defined":[53],"inclusion":[54],"exclusion":[56],"criteria,":[57],"resulting":[58],"14":[60],"studies":[61],"eligible":[62],"for":[63,108],"full-text":[64],"review.":[65],"Results:":[66],"Findings":[67],"show":[68],"that":[69],"DTs":[70,121],"being":[72,123],"utilized":[73],"various":[75],"specialties":[76],"such":[77],"cardiology,":[79],"geriatrics,":[80],"radiology,":[81],"oncology,":[83],"offering":[84],"advantages":[85],"cost":[87],"reduction,":[88],"treatment":[89],"precision,":[90],"patient":[92],"outcomes.":[93],"However,":[94],"key":[95],"challenges":[96],"remain,":[97],"including":[98],"data":[99],"privacy,":[100],"technical":[101],"integration,":[102],"ethical":[103],"considerations,":[104],"need":[107],"interdisciplinary":[109],"collaboration.":[110],"Conclusions:":[111],"offers":[115],"a":[116],"comprehensive":[117],"synthesis":[118],"how":[120],"integrated":[124],"into":[125],"PM":[126],"highlights":[128],"areas":[129],"requiring":[130],"further":[131],"empirical":[132],"research":[133],"to":[134],"support":[135],"wider":[136],"implementation.":[137]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2025-10-10T00:00:00"}