{"id":"https://openalex.org/W4412697447","doi":"https://doi.org/10.1242/bio.061904","title":"Phosphorylation deficient inducible cAMP early repressor (ICER) modulates tumorigenesis and survival in a transgenic zebrafish ( Danio rerio ) model of melanoma","display_name":"Phosphorylation deficient inducible cAMP early repressor (ICER) modulates tumorigenesis and survival in a transgenic zebrafish ( Danio rerio ) model of melanoma","publication_year":2025,"publication_date":"2025-07-28","ids":{"openalex":"https://openalex.org/W4412697447","doi":"https://doi.org/10.1242/bio.061904","pmid":"https://pubmed.ncbi.nlm.nih.gov/40719625","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12381921"},"language":"en","primary_location":{"id":"doi:10.1242/bio.061904","doi":"https://doi.org/10.1242/bio.061904","is_oa":true,"landing_page_url":"https://doi.org/10.1242/bio.061904","pdf_url":"https://journals.biologists.com/bio/article-pdf/doi/10.1242/bio.061904/3658708/bio061904.pdf","source":{"id":"https://openalex.org/S2738063279","display_name":"Biology Open","issn_l":"2046-6390","issn":["2046-6390"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology Open","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.biologists.com/bio/article-pdf/doi/10.1242/bio.061904/3658708/bio061904.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058080507","display_name":"Justin Wheelan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I166088655","display_name":"Montclair State University","ror":"https://ror.org/01nxc2t48","country_code":"US","type":"education","lineage":["https://openalex.org/I166088655"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Justin Wheelan","raw_affiliation_strings":["Montclair State University","Department of Biology, Montclair State University, Montclair, NJ 07043,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Montclair State University","institution_ids":["https://openalex.org/I166088655"]},{"raw_affiliation_string":"Department of Biology, Montclair State University, Montclair, NJ 07043,USA","institution_ids":["https://openalex.org/I166088655"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5116418751","display_name":"Melissa Spigelman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I166088655","display_name":"Montclair State University","ror":"https://ror.org/01nxc2t48","country_code":"US","type":"education","lineage":["https://openalex.org/I166088655"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melissa Spigelman","raw_affiliation_strings":["Montclair State University","Department of Biology, Montclair State University, Montclair, NJ 07043,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Montclair State University","institution_ids":["https://openalex.org/I166088655"]},{"raw_affiliation_string":"Department of Biology, Montclair State University, Montclair, NJ 07043,USA","institution_ids":["https://openalex.org/I166088655"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049426718","display_name":"Angelo Cirinelli","orcid":"https://orcid.org/0000-0002-5249-8782","observed_orcids":["https://orcid.org/0000-0002-5249-8782"]},"institutions":[{"id":"https://openalex.org/I166088655","display_name":"Montclair State University","ror":"https://ror.org/01nxc2t48","country_code":"US","type":"education","lineage":["https://openalex.org/I166088655"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Angelo Cirinelli","raw_affiliation_strings":["Montclair State University","Department of Biology, Montclair State University, Montclair, NJ 07043,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Montclair State University","institution_ids":["https://openalex.org/I166088655"]},{"raw_affiliation_string":"Department of Biology, Montclair State University, Montclair, NJ 07043,USA","institution_ids":["https://openalex.org/I166088655"]}]},{"author_position":"middle","author":{"id":null,"display_name":"James Reilly","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I166088655","display_name":"Montclair State University","ror":"https://ror.org/01nxc2t48","country_code":"US","type":"education","lineage":["https://openalex.org/I166088655"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Reilly","raw_affiliation_strings":["Montclair State University","Department of Biology, Montclair State University, Montclair, NJ 07043,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Montclair State University","institution_ids":["https://openalex.org/I166088655"]},{"raw_affiliation_string":"Department of Biology, Montclair State University, Montclair, NJ 07043,USA","institution_ids":["https://openalex.org/I166088655"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5116569162","display_name":"Carlos A. Molina","orcid":"https://orcid.org/0009-0000-3772-8319","observed_orcids":["https://orcid.org/0009-0000-3772-8319"]},"institutions":[{"id":"https://openalex.org/I166088655","display_name":"Montclair State University","ror":"https://ror.org/01nxc2t48","country_code":"US","type":"education","lineage":["https://openalex.org/I166088655"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Carlos A. Molina","raw_affiliation_strings":["Montclair State University","Department of Biology, Montclair State University, Montclair, NJ 07043,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Montclair State University","institution_ids":["https://openalex.org/I166088655"]},{"raw_affiliation_string":"Department of Biology, Montclair State University, Montclair, NJ 07043,USA","institution_ids":["https://openalex.org/I166088655"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5116569162"],"corresponding_institution_ids":["https://openalex.org/I166088655"],"apc_list":{"value":1995,"currency":"USD","value_usd":1995},"apc_paid":{"value":1995,"currency":"USD","value_usd":1995},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.11429573,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"14","issue":"8","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11685","display_name":"Zebrafish Biomedical Research Applications","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inducible-camp-early-repressor","display_name":"inducible cAMP early repressor","score":0.9380000233650208},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.8949999809265137},{"id":"https://openalex.org/keywords/braf-v600e-mutation","display_name":"BRAF V600E mutation","score":0.9760000109672546},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.5170000195503235},{"id":"https://openalex.org/keywords/treatment-resistance","display_name":"treatment resistance","score":0.6669999957084656},{"id":"https://openalex.org/keywords/ras-mapk-pathway","display_name":"RAS/MAPK pathway","score":0.8349999785423279},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.9150000214576721},{"id":"https://openalex.org/keywords/rap1","display_name":"Rap1","score":0.9039999842643738},{"id":"https://openalex.org/keywords/protein-kinase-a","display_name":"protein kinase A","score":0.7369999885559082},{"id":"https://openalex.org/keywords/tumor-suppression","display_name":"tumor suppression","score":0.49900001287460327},{"id":"https://openalex.org/keywords/transgenic-zebrafish","display_name":"transgenic zebrafish","score":0.7929999828338623},{"id":"https://openalex.org/keywords/p53-loss","display_name":"p53 deficiency","score":0.8629999756813049}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7978042364120483},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.668688178062439},{"id":"https://openalex.org/C2776878037","wikidata":"https://www.wikidata.org/wiki/Q169444","display_name":"Zebrafish","level":3,"score":0.6239420175552368},{"id":"https://openalex.org/C1629964","wikidata":"https://www.wikidata.org/wiki/Q106950729","display_name":"CREB","level":4,"score":0.5899930000305176},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.5406898856163025},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.49800705909729004},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.49113699793815613},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.46632105112075806},{"id":"https://openalex.org/C158448853","wikidata":"https://www.wikidata.org/wiki/Q425218","display_name":"Repressor","level":4,"score":0.45402178168296814},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.44649991393089294},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.3765445649623871},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.3568668067455292},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3157573938369751},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.25467872619628906},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16772711277008057},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1333291232585907}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015027","descriptor_name":"Zebrafish","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029961","descriptor_name":"Zebrafish Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D029961","descriptor_name":"Zebrafish Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D030801","descriptor_name":"Animals, Genetically Modified","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048493","descriptor_name":"Proto-Oncogene Proteins B-raf","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051786","descriptor_name":"Cyclic AMP Response Element Modulator","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051786","descriptor_name":"Cyclic AMP Response Element Modulator","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D063646","descriptor_name":"Carcinogenesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1242/bio.061904","doi":"https://doi.org/10.1242/bio.061904","is_oa":true,"landing_page_url":"https://doi.org/10.1242/bio.061904","pdf_url":"https://journals.biologists.com/bio/article-pdf/doi/10.1242/bio.061904/3658708/bio061904.pdf","source":{"id":"https://openalex.org/S2738063279","display_name":"Biology Open","issn_l":"2046-6390","issn":["2046-6390"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology Open","raw_type":"journal-article"},{"id":"doi:10.1101/2025.02.21.639575","doi":"https://doi.org/10.1101/2025.02.21.639575","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.02.21.639575","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:europepmc.org:11190377","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12381921","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:12381921","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12381921","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biol Open","raw_type":"Text"},{"id":"pmid:40719625","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40719625","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology open","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:a661ca398c4b4325a10115b2f89537a4","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/a661ca398c4b4325a10115b2f89537a4","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biology Open, Vol 14, Iss 8 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1242/bio.061904","doi":"https://doi.org/10.1242/bio.061904","is_oa":true,"landing_page_url":"https://doi.org/10.1242/bio.061904","pdf_url":"https://journals.biologists.com/bio/article-pdf/doi/10.1242/bio.061904/3658708/bio061904.pdf","source":{"id":"https://openalex.org/S2738063279","display_name":"Biology Open","issn_l":"2046-6390","issn":["2046-6390"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology Open","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G215186302","display_name":null,"funder_award_id":"5SC1GM125583","funder_id":"https://openalex.org/F4320306080","funder_display_name":"Foundation for the National Institutes of Health"},{"id":"https://openalex.org/G4317861257","display_name":"Post-translational Regulation of Inducible cAMP Early Repressor and its Implications in Cancer","funder_award_id":"SC1GM125583","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320306080","display_name":"Foundation for the National Institutes of Health","ror":"https://ror.org/00k86s890"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4412697447.pdf","grobid_xml":"https://content.openalex.org/works/W4412697447.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W1974227241","https://openalex.org/W1982393730","https://openalex.org/W1984105227","https://openalex.org/W1994830544","https://openalex.org/W2006254842","https://openalex.org/W2013605664","https://openalex.org/W2039236418","https://openalex.org/W2079261364","https://openalex.org/W2081497545","https://openalex.org/W2082282329","https://openalex.org/W2086579453","https://openalex.org/W2098820114","https://openalex.org/W2100877370","https://openalex.org/W2108939654","https://openalex.org/W2124662474","https://openalex.org/W2140952049","https://openalex.org/W2153409210","https://openalex.org/W2155420645","https://openalex.org/W2159220884","https://openalex.org/W2163027927","https://openalex.org/W2163188200","https://openalex.org/W2168804371","https://openalex.org/W2177518191","https://openalex.org/W2535510152","https://openalex.org/W2594072445","https://openalex.org/W2724990555","https://openalex.org/W2735863468","https://openalex.org/W2757021412","https://openalex.org/W2773070885","https://openalex.org/W2903808414","https://openalex.org/W2955675297","https://openalex.org/W2970347002","https://openalex.org/W2997022986","https://openalex.org/W3098882801","https://openalex.org/W3197265554","https://openalex.org/W3215682729","https://openalex.org/W4214689496","https://openalex.org/W4214845413","https://openalex.org/W4220831425","https://openalex.org/W4220908892","https://openalex.org/W4285005569","https://openalex.org/W4311673453","https://openalex.org/W4388043892","https://openalex.org/W4388615740","https://openalex.org/W4390511258","https://openalex.org/W4393305611","https://openalex.org/W4411021766"],"related_works":["https://openalex.org/W1993646859","https://openalex.org/W2768771874","https://openalex.org/W2800964090","https://openalex.org/W2030459426","https://openalex.org/W2563090889","https://openalex.org/W2490799769","https://openalex.org/W7009802647","https://openalex.org/W1987086100","https://openalex.org/W7155782689","https://openalex.org/W1541710662"],"abstract_inverted_index":{"Melanoma,":[0],"the":[1,14,24,43,48,100,151],"most":[2],"lethal":[3],"form":[4],"of":[5,91,102,130,147],"skin":[6],"cancer,":[7],"is":[8,78],"commonly":[9],"associated":[10],"with":[11],"mutations":[12],"in":[13,62,80,108,173],"BRAF":[15,29],"gene,":[16],"particularly":[17,47],"BRAFV600E,":[18],"which":[19],"drives":[20],"tumor":[21,109,120],"proliferation":[22],"via":[23,73],"ERK1/2":[25],"signaling":[26,45],"cascade.":[27],"While":[28],"inhibitors":[30],"initially":[31],"demonstrate":[32],"efficacy,":[33],"therapeutic":[34],"resistance":[35],"remains":[36],"a":[37,69,87,103,162,174],"significant":[38],"challenge.":[39],"Emerging":[40],"evidence":[41],"implicates":[42],"cAMP":[44,49,58],"pathway,":[46],"response":[50],"element-binding":[51],"protein":[52,152],"(CREB)":[53],"and":[54,65,76,118,133,138,169],"its":[55,83],"repressor,":[56],"inducible":[57],"early":[59],"repressor":[60,71],"(ICER),":[61],"melanoma":[63,167,176],"progression":[64,168],"drug":[66],"resistance.":[67],"ICER,":[68],"transcriptional":[70],"regulated":[72],"Ras/MAPK-mediated":[74],"phosphorylation":[75],"ubiquitination,":[77],"degraded":[79],"melanoma,":[81],"undermining":[82],"tumor-suppressive":[84],"role.":[85],"In":[86],"brafV600E;":[88],"p53":[89],"(loss":[90],"function)":[92],"transgenic":[93],"zebrafish":[94],"(Danio":[95],"rerio)":[96],"model,":[97],"we":[98],"investigated":[99],"role":[101],"ubiquitin-resistant":[104],"ICER":[105,148,165],"mutant":[106],"(S35-41A-ICER)":[107],"progression.":[110],"Transgenic":[111],"fish":[112],"expressing":[113],"S35-41A-ICER":[114],"exhibited":[115],"extended":[116],"survival":[117],"reduced":[119],"invasiveness":[121],"compared":[122],"to":[123],"wild-type":[124],"ICER.":[125],"RNA":[126],"sequencing":[127],"revealed":[128],"dysregulation":[129],"CREB/CREM":[131],"targets":[132,146],"compensatory":[134],"pathways,":[135],"including":[136,150],"Rap1":[137],"PI3K/AKT":[139],"signaling,":[140],"as":[141,143],"well":[142],"candidate":[144],"gene":[145],"regulation,":[149],"kinase":[153],"A":[154],"catalytic":[155],"subunit":[156],"prkacaa.":[157],"Our":[158],"findings":[159],"suggest":[160],"that":[161],"ubiquitin":[163],"resistant":[164],"mitigates":[166],"represses":[170],"oncogenic":[171],"pathways":[172],"brafV600E":[175],"context.":[177]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2025-07-28T00:00:00"}