{"id":"https://openalex.org/W4412688906","doi":"https://doi.org/10.1038/s41390-025-04300-w","title":"Low nephron number and high salt diet: the role of the \u201csecond hit\u201d in chronic kidney disease development","display_name":"Low nephron number and high salt diet: the role of the \u201csecond hit\u201d in chronic kidney disease development","publication_year":2025,"publication_date":"2025-07-28","ids":{"openalex":"https://openalex.org/W4412688906","doi":"https://doi.org/10.1038/s41390-025-04300-w","pmid":"https://pubmed.ncbi.nlm.nih.gov/40721526"},"language":"en","primary_location":{"id":"doi:10.1038/s41390-025-04300-w","doi":"https://doi.org/10.1038/s41390-025-04300-w","is_oa":false,"landing_page_url":"https://doi.org/10.1038/s41390-025-04300-w","pdf_url":null,"source":{"id":"https://openalex.org/S167664057","display_name":"Pediatric Research","issn_l":"0031-3998","issn":["0031-3998","1530-0447"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015491848","display_name":"Katherine Bernardo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katherine Bernardo","raw_affiliation_strings":["Cincinnati Children's Pediatric Residency Program, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cincinnati Children's Pediatric Residency Program, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA","institution_ids":["https://openalex.org/I1285204247"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014945172","display_name":"Meredith Posner Schuh","orcid":"https://orcid.org/0000-0001-7854-8138","observed_orcids":["https://orcid.org/0000-0001-7854-8138"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]},{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Meredith P. Schuh","raw_affiliation_strings":["Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA. Meredith.schuh@cchmc.org","Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. Meredith.schuh@cchmc.org","Division of Nephrology and Hypertension, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. Meredith.schuh@cchmc.org"],"raw_orcid":"https://orcid.org/0000-0001-7854-8138","affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA. Meredith.schuh@cchmc.org","institution_ids":["https://openalex.org/I63135867"]},{"raw_affiliation_string":"Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. Meredith.schuh@cchmc.org","institution_ids":["https://openalex.org/I1285204247"]},{"raw_affiliation_string":"Division of Nephrology and Hypertension, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. Meredith.schuh@cchmc.org","institution_ids":["https://openalex.org/I1285204247"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5014945172"],"corresponding_institution_ids":["https://openalex.org/I1285204247","https://openalex.org/I63135867"],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":null,"fwci":0.597,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.67411311,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"98","issue":"5","first_page":"1633","last_page":"1634"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.6869999766349792,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.6869999766349792,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12075","display_name":"Sodium Intake and Health","score":0.093299999833107,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11629","display_name":"Birth, Development, and Health","score":0.06260000169277191,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-kidney-disease","display_name":"chronic kidney disease","score":0.7379999756813049},{"id":"https://openalex.org/keywords/high-salt-diet","display_name":"high-salt diet","score":0.800000011920929},{"id":"https://openalex.org/keywords/second-hit","display_name":"second hit","score":0.7160000205039978},{"id":"https://openalex.org/keywords/glomerular-hyperfiltration","display_name":"glomerular hyperfiltration","score":0.7070000171661377},{"id":"https://openalex.org/keywords/glomerular-number","display_name":"glomerular number","score":0.4099999964237213},{"id":"https://openalex.org/keywords/kidney-development","display_name":"kidney development","score":0.5329999923706055},{"id":"https://openalex.org/keywords/preterm-birth","display_name":"preterm birth","score":0.7300000190734863},{"id":"https://openalex.org/keywords/neonatal-acute-kidney-injury","display_name":"neonatal acute kidney injury","score":0.871999979019165},{"id":"https://openalex.org/keywords/nephrotoxic-drugs","display_name":"nephrotoxic drugs","score":0.703000009059906},{"id":"https://openalex.org/keywords/salt-sensitive-hypertension","display_name":"salt-sensitive hypertension","score":0.40400001406669617},{"id":"https://openalex.org/keywords/glomerular-filtration-barrier","display_name":"glomerular filtration barrier","score":0.38199999928474426},{"id":"https://openalex.org/keywords/tubulointerstitial-fibrosis","display_name":"tubulointerstitial fibrosis","score":0.3630000054836273}],"concepts":[{"id":"https://openalex.org/C2781231759","wikidata":"https://www.wikidata.org/wiki/Q58184","display_name":"Nephron","level":3,"score":0.8798813819885254},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.6598560810089111},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.5135303139686584},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5026235580444336},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.49709680676460266},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.49627071619033813},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4409849941730499},{"id":"https://openalex.org/C2776371256","wikidata":"https://www.wikidata.org/wiki/Q12370","display_name":"Salt (chemistry)","level":2,"score":0.4387863874435425},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.3620292544364929},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3207666575908661},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.24437201023101807},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1038/s41390-025-04300-w","doi":"https://doi.org/10.1038/s41390-025-04300-w","is_oa":false,"landing_page_url":"https://doi.org/10.1038/s41390-025-04300-w","pdf_url":null,"source":{"id":"https://openalex.org/S167664057","display_name":"Pediatric Research","issn_l":"0031-3998","issn":["0031-3998","1530-0447"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric Research","raw_type":"journal-article"},{"id":"pmid:40721526","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40721526","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W1502534219","https://openalex.org/W1980020302","https://openalex.org/W2081523875","https://openalex.org/W2125296976","https://openalex.org/W2559824716","https://openalex.org/W2752404888","https://openalex.org/W2942751913","https://openalex.org/W3161180865","https://openalex.org/W4213240806","https://openalex.org/W4388366373"],"related_works":["https://openalex.org/W4316511401","https://openalex.org/W4310086836","https://openalex.org/W4318066987","https://openalex.org/W2789820562","https://openalex.org/W4247958731","https://openalex.org/W4413430838","https://openalex.org/W3083255126","https://openalex.org/W4410785290","https://openalex.org/W4393952213","https://openalex.org/W2735944743"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}
