{"id":"https://openalex.org/W4412650545","doi":"https://doi.org/10.3390/arm93040024","title":"Pharmacological Immunomodulation via Collagen\u2013Polyvinylpyrrolidone or Pirfenidone Plays a Role in the Recovery of Patients with Severe COVID-19 Through Similar Mechanisms of Action Involving the JAK/STAT Signalling Pathway: A Pilot Study","display_name":"Pharmacological Immunomodulation via Collagen\u2013Polyvinylpyrrolidone or Pirfenidone Plays a Role in the Recovery of Patients with Severe COVID-19 Through Similar Mechanisms of Action Involving the JAK/STAT Signalling Pathway: A Pilot Study","publication_year":2025,"publication_date":"2025-07-18","ids":{"openalex":"https://openalex.org/W4412650545","doi":"https://doi.org/10.3390/arm93040024","pmid":"https://pubmed.ncbi.nlm.nih.gov/40700055","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12286056"},"language":"en","primary_location":{"id":"doi:10.3390/arm93040024","doi":"https://doi.org/10.3390/arm93040024","is_oa":true,"landing_page_url":"https://doi.org/10.3390/arm93040024","pdf_url":"https://www.mdpi.com/2543-6031/93/4/24/pdf?version=1752832940","source":{"id":"https://openalex.org/S2765076663","display_name":"Advances in respiratory medicine","issn_l":"2451-4934","issn":["2451-4934","2543-6031"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Respiratory Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2543-6031/93/4/24/pdf?version=1752832940","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067554990","display_name":"Hugo Mendieta Zer\u00f3n","orcid":"https://orcid.org/0000-0003-3492-8950","observed_orcids":["https://orcid.org/0000-0003-3492-8950"]},"institutions":[{"id":"https://openalex.org/I179647637","display_name":"Universidad Aut\u00f3noma del Estado de M\u00e9xico","ror":"https://ror.org/0079gpv38","country_code":"MX","type":"education","lineage":["https://openalex.org/I179647637"]},{"id":"https://openalex.org/I4210086292","display_name":"Maternal Perinatal Hospital M\u00f3nica Pretelini","ror":"https://ror.org/000pw2z54","country_code":"MX","type":"healthcare","lineage":["https://openalex.org/I4210086292"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Hugo Mendieta-Zer\u00f3n","raw_affiliation_strings":["Facultad de Medicina Universidad Aut\u00f3noma del Estado de M\u00e9xico. State of Mexico , Mexico","Hospital Materno-Perinatal ' M\u00f3nica Pretelini S\u00e1enz'. State of Mexico , Mexico","Facultad de Medicina, Universidad Aut\u00f3noma del Estado de M\u00e9xico, Toluca 50000, State of Mexico, Mexico","Hospital Materno-Perinatal 'M\u00f3nica Pretelini S\u00e1enz', Toluca 50140, State of Mexico, Mexico"],"raw_orcid":"https://orcid.org/0000-0003-3492-8950","affiliations":[{"raw_affiliation_string":"Facultad de Medicina Universidad Aut\u00f3noma del Estado de M\u00e9xico. State of Mexico , Mexico","institution_ids":["https://openalex.org/I179647637"]},{"raw_affiliation_string":"Hospital Materno-Perinatal ' M\u00f3nica Pretelini S\u00e1enz'. State of Mexico , Mexico","institution_ids":["https://openalex.org/I4210086292"]},{"raw_affiliation_string":"Facultad de Medicina, Universidad Aut\u00f3noma del Estado de M\u00e9xico, Toluca 50000, State of Mexico, Mexico","institution_ids":["https://openalex.org/I179647637"]},{"raw_affiliation_string":"Hospital Materno-Perinatal 'M\u00f3nica Pretelini S\u00e1enz', Toluca 50140, State of Mexico, Mexico","institution_ids":["https://openalex.org/I4210086292"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084625462","display_name":"Esteban Cruz-Arenas","orcid":"https://orcid.org/0000-0003-0238-9518","observed_orcids":["https://orcid.org/0000-0003-0238-9518"]},"institutions":[{"id":"https://openalex.org/I4210124243","display_name":"Instituto Nacional de Rehabilitaci\u00f3n","ror":"https://ror.org/03734cd59","country_code":"MX","type":"facility","lineage":["https://openalex.org/I4210124243"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Esteban Cruz-Arenas","raw_affiliation_strings":["Epidemiological Vigilance Unit . Instituto Nacional de Rehabilitaci\u00f3n 'Luis Guillermo Ibarra Ibarra' . Mexico City , Mexico","Epidemiological Vigilance Unit, Instituto Nacional de Rehabilitaci\u00f3n 'Luis Guillermo Ibarra Ibarra', Mexico City 14389, Mexico"],"raw_orcid":"https://orcid.org/0000-0003-0238-9518","affiliations":[{"raw_affiliation_string":"Epidemiological Vigilance Unit . Instituto Nacional de Rehabilitaci\u00f3n 'Luis Guillermo Ibarra Ibarra' . Mexico City , Mexico","institution_ids":["https://openalex.org/I4210124243"]},{"raw_affiliation_string":"Epidemiological Vigilance Unit, Instituto Nacional de Rehabilitaci\u00f3n 'Luis Guillermo Ibarra Ibarra', Mexico City 14389, Mexico","institution_ids":["https://openalex.org/I4210124243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5117824390","display_name":"Salvador D\u00edaz-Meza","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Salvador D\u00edaz-Meza","raw_affiliation_strings":["Hospital General 'Dr . Nicol\u00e1s San Juan'. State of Mexico , Mexico","Hospital General 'Dr. Nicol\u00e1s San Juan', Toluca 50010, State of Mexico, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital General 'Dr . Nicol\u00e1s San Juan'. State of Mexico , Mexico","institution_ids":[]},{"raw_affiliation_string":"Hospital General 'Dr. Nicol\u00e1s San Juan', Toluca 50010, State of Mexico, Mexico","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110692407","display_name":"Alejandro Cabrera\u2010Wrooman","orcid":"https://orcid.org/0000-0003-2178-9349","observed_orcids":["https://orcid.org/0000-0003-2178-9349"]},"institutions":[{"id":"https://openalex.org/I4210124243","display_name":"Instituto Nacional de Rehabilitaci\u00f3n","ror":"https://ror.org/03734cd59","country_code":"MX","type":"facility","lineage":["https://openalex.org/I4210124243"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Alejandro Cabrera-Wrooman","raw_affiliation_strings":["Laboratory of Connective Tissue. Centro Nacional de Investigaci\u00f3n y Atenci\u00f3n de Quemados , Instituto Nacional de Rehabilitaci\u00f3n 'Luis Guillermo Ibarra Ibarra'. Mexico City , Mexico","Laboratory of Connective Tissue, Centro Nacional de Investigaci\u00f3n y Atenci\u00f3n de Quemados, Instituto Nacional de Rehabilitaci\u00f3n 'Luis Guillermo Ibarra Ibarra', Mexico City 14389, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Connective Tissue. Centro Nacional de Investigaci\u00f3n y Atenci\u00f3n de Quemados , Instituto Nacional de Rehabilitaci\u00f3n 'Luis Guillermo Ibarra Ibarra'. Mexico City , Mexico","institution_ids":["https://openalex.org/I4210124243"]},{"raw_affiliation_string":"Laboratory of Connective Tissue, Centro Nacional de Investigaci\u00f3n y Atenci\u00f3n de Quemados, Instituto Nacional de Rehabilitaci\u00f3n 'Luis Guillermo Ibarra Ibarra', Mexico City 14389, Mexico","institution_ids":["https://openalex.org/I4210124243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036242375","display_name":"Edna Ayerim Mandujano-Tinoco","orcid":"https://orcid.org/0000-0002-0026-5880","observed_orcids":["https://orcid.org/0000-0002-0026-5880"]},"institutions":[{"id":"https://openalex.org/I4210124243","display_name":"Instituto Nacional de Rehabilitaci\u00f3n","ror":"https://ror.org/03734cd59","country_code":"MX","type":"facility","lineage":["https://openalex.org/I4210124243"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Edna Ayerim Mandujano-Tinoco","raw_affiliation_strings":["Laboratory of Connective Tissue. Centro Nacional de Investigaci\u00f3n y Atenci\u00f3n de Quemados , Instituto Nacional de Rehabilitaci\u00f3n 'Luis Guillermo Ibarra Ibarra'. Mexico City , Mexico","Laboratory of Connective Tissue, Centro Nacional de Investigaci\u00f3n y Atenci\u00f3n de Quemados, Instituto Nacional de Rehabilitaci\u00f3n 'Luis Guillermo Ibarra Ibarra', Mexico City 14389, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Connective Tissue. Centro Nacional de Investigaci\u00f3n y Atenci\u00f3n de Quemados , Instituto Nacional de Rehabilitaci\u00f3n 'Luis Guillermo Ibarra Ibarra'. Mexico City , Mexico","institution_ids":["https://openalex.org/I4210124243"]},{"raw_affiliation_string":"Laboratory of Connective Tissue, Centro Nacional de Investigaci\u00f3n y Atenci\u00f3n de Quemados, Instituto Nacional de Rehabilitaci\u00f3n 'Luis Guillermo Ibarra Ibarra', Mexico City 14389, Mexico","institution_ids":["https://openalex.org/I4210124243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074021664","display_name":"Rosa M. Salgado","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210124243","display_name":"Instituto Nacional de Rehabilitaci\u00f3n","ror":"https://ror.org/03734cd59","country_code":"MX","type":"facility","lineage":["https://openalex.org/I4210124243"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Rosa Mar\u00eda Salgado","raw_affiliation_strings":["Laboratory of Connective Tissue. Centro Nacional de Investigaci\u00f3n y Atenci\u00f3n de Quemados , Instituto Nacional de Rehabilitaci\u00f3n 'Luis Guillermo Ibarra Ibarra'. Mexico City , Mexico","Laboratory of Connective Tissue, Centro Nacional de Investigaci\u00f3n y Atenci\u00f3n de Quemados, Instituto Nacional de Rehabilitaci\u00f3n 'Luis Guillermo Ibarra Ibarra', Mexico City 14389, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Connective Tissue. Centro Nacional de Investigaci\u00f3n y Atenci\u00f3n de Quemados , Instituto Nacional de Rehabilitaci\u00f3n 'Luis Guillermo Ibarra Ibarra'. Mexico City , Mexico","institution_ids":["https://openalex.org/I4210124243"]},{"raw_affiliation_string":"Laboratory of Connective Tissue, Centro Nacional de Investigaci\u00f3n y Atenci\u00f3n de Quemados, Instituto Nacional de Rehabilitaci\u00f3n 'Luis Guillermo Ibarra Ibarra', Mexico City 14389, Mexico","institution_ids":["https://openalex.org/I4210124243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003944080","display_name":"Hugo Tovar","orcid":"https://orcid.org/0000-0002-8360-6133","observed_orcids":["https://orcid.org/0000-0002-8360-6133"]},"institutions":[{"id":"https://openalex.org/I4210110970","display_name":"National Institute of Genomic Medicine","ror":"https://ror.org/01qjckx08","country_code":"MX","type":"government","lineage":["https://openalex.org/I4210095685","https://openalex.org/I4210110970"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Hugo Tovar","raw_affiliation_strings":["Computational Genomics Division , National Institute of Genomic Medicine , Mexico City , Mexico","Computational Genomics Division, National Institute of Genomic Medicine, Mexico City 14610, Mexico"],"raw_orcid":"https://orcid.org/0000-0002-8360-6133","affiliations":[{"raw_affiliation_string":"Computational Genomics Division , National Institute of Genomic Medicine , Mexico City , Mexico","institution_ids":["https://openalex.org/I4210110970"]},{"raw_affiliation_string":"Computational Genomics Division, National Institute of Genomic Medicine, Mexico City 14610, Mexico","institution_ids":["https://openalex.org/I4210110970"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5117824391","display_name":"Daniel Mu\u00f1iz-Garc\u00eda","orcid":"https://orcid.org/0009-0002-8242-7683","observed_orcids":["https://orcid.org/0009-0002-8242-7683"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniel Mu\u00f1iz-Garc\u00eda","raw_affiliation_strings":["Hospital General 'Dr . Nicol\u00e1s San Juan'. State of Mexico , Mexico","Hospital General 'Dr. Nicol\u00e1s San Juan', Toluca 50010, State of Mexico, Mexico"],"raw_orcid":"https://orcid.org/0009-0002-8242-7683","affiliations":[{"raw_affiliation_string":"Hospital General 'Dr . Nicol\u00e1s San Juan'. State of Mexico , Mexico","institution_ids":[]},{"raw_affiliation_string":"Hospital General 'Dr. Nicol\u00e1s San Juan', Toluca 50010, State of Mexico, Mexico","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5117824392","display_name":"Laura Julieta Orozco-Casta\u00f1eda","orcid":"https://orcid.org/0009-0007-6205-496X","observed_orcids":["https://orcid.org/0009-0007-6205-496X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Laura Julieta Orozco-Casta\u00f1eda","raw_affiliation_strings":["Hospital General 'Dr . Nicol\u00e1s San Juan'. State of Mexico , Mexico","Hospital General 'Dr. Nicol\u00e1s San Juan', Toluca 50010, State of Mexico, Mexico"],"raw_orcid":"https://orcid.org/0009-0007-6205-496X","affiliations":[{"raw_affiliation_string":"Hospital General 'Dr . Nicol\u00e1s San Juan'. State of Mexico , Mexico","institution_ids":[]},{"raw_affiliation_string":"Hospital General 'Dr. Nicol\u00e1s San Juan', Toluca 50010, State of Mexico, Mexico","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5117824387","display_name":"Sonia Hern\u00e1ndez-Enr\u00edquez","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sonia Hern\u00e1ndez-Enr\u00edquez","raw_affiliation_strings":["Hospital General 'Dr . Nicol\u00e1s San Juan'. State of Mexico , Mexico","Hospital General 'Dr. Nicol\u00e1s San Juan', Toluca 50010, State of Mexico, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital General 'Dr . Nicol\u00e1s San Juan'. State of Mexico , Mexico","institution_ids":[]},{"raw_affiliation_string":"Hospital General 'Dr. Nicol\u00e1s San Juan', Toluca 50010, State of Mexico, Mexico","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5117824388","display_name":"Miriam Deyanira Rodr\u00edguez-Pi\u00f1a","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I179647637","display_name":"Universidad Aut\u00f3noma del Estado de M\u00e9xico","ror":"https://ror.org/0079gpv38","country_code":"MX","type":"education","lineage":["https://openalex.org/I179647637"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Miriam Deyanira Rodr\u00edguez-Pi\u00f1a","raw_affiliation_strings":["Facultad de Medicina Universidad Aut\u00f3noma del Estado de M\u00e9xico. State of Mexico , Mexico","Facultad de Medicina, Universidad Aut\u00f3noma del Estado de M\u00e9xico, Toluca 50000, State of Mexico, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Facultad de Medicina Universidad Aut\u00f3noma del Estado de M\u00e9xico. State of Mexico , Mexico","institution_ids":["https://openalex.org/I179647637"]},{"raw_affiliation_string":"Facultad de Medicina, Universidad Aut\u00f3noma del Estado de M\u00e9xico, Toluca 50000, State of Mexico, Mexico","institution_ids":["https://openalex.org/I179647637"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5117824389","display_name":"Ana Sarah\u00ed Mulia-Soto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I179647637","display_name":"Universidad Aut\u00f3noma del Estado de M\u00e9xico","ror":"https://ror.org/0079gpv38","country_code":"MX","type":"education","lineage":["https://openalex.org/I179647637"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Ana Sarah\u00ed Mulia-Soto","raw_affiliation_strings":["Facultad de Medicina Universidad Aut\u00f3noma del Estado de M\u00e9xico. State of Mexico , Mexico","Facultad de Medicina, Universidad Aut\u00f3noma del Estado de M\u00e9xico, Toluca 50000, State of Mexico, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Facultad de Medicina Universidad Aut\u00f3noma del Estado de M\u00e9xico. State of Mexico , Mexico","institution_ids":["https://openalex.org/I179647637"]},{"raw_affiliation_string":"Facultad de Medicina, Universidad Aut\u00f3noma del Estado de M\u00e9xico, Toluca 50000, State of Mexico, Mexico","institution_ids":["https://openalex.org/I179647637"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086906149","display_name":"Jos\u00e9 Meneses-Calder\u00f3n","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I179647637","display_name":"Universidad Aut\u00f3noma del Estado de M\u00e9xico","ror":"https://ror.org/0079gpv38","country_code":"MX","type":"education","lineage":["https://openalex.org/I179647637"]},{"id":"https://openalex.org/I4210086292","display_name":"Maternal Perinatal Hospital M\u00f3nica Pretelini","ror":"https://ror.org/000pw2z54","country_code":"MX","type":"healthcare","lineage":["https://openalex.org/I4210086292"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Jos\u00e9 Meneses-Calder\u00f3n","raw_affiliation_strings":["Facultad de Medicina Universidad Aut\u00f3noma del Estado de M\u00e9xico. State of Mexico , Mexico","Hospital Materno-Perinatal ' M\u00f3nica Pretelini S\u00e1enz'. State of Mexico , Mexico","Facultad de Medicina, Universidad Aut\u00f3noma del Estado de M\u00e9xico, Toluca 50000, State of Mexico, Mexico","Hospital Materno-Perinatal 'M\u00f3nica Pretelini S\u00e1enz', Toluca 50140, State of Mexico, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Facultad de Medicina Universidad Aut\u00f3noma del Estado de M\u00e9xico. State of Mexico , Mexico","institution_ids":["https://openalex.org/I179647637"]},{"raw_affiliation_string":"Hospital Materno-Perinatal ' M\u00f3nica Pretelini S\u00e1enz'. State of Mexico , Mexico","institution_ids":["https://openalex.org/I4210086292"]},{"raw_affiliation_string":"Facultad de Medicina, Universidad Aut\u00f3noma del Estado de M\u00e9xico, Toluca 50000, State of Mexico, Mexico","institution_ids":["https://openalex.org/I179647637"]},{"raw_affiliation_string":"Hospital Materno-Perinatal 'M\u00f3nica Pretelini S\u00e1enz', Toluca 50140, State of Mexico, Mexico","institution_ids":["https://openalex.org/I4210086292"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078086228","display_name":"Paul Mondrag\u00f3n\u2010Ter\u00e1n","orcid":"https://orcid.org/0000-0003-0940-3626","observed_orcids":["https://orcid.org/0000-0003-0940-3626"]},"institutions":[{"id":"https://openalex.org/I59361560","display_name":"Instituto Polit\u00e9cnico Nacional","ror":"https://ror.org/059sp8j34","country_code":"MX","type":"education","lineage":["https://openalex.org/I59361560"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Paul Mondrag\u00f3n-Ter\u00e1n","raw_affiliation_strings":["CICATA Unidad Morelos , Instituto Polit\u00e9cnico Nacional","CICATA Unidad Morelos, Instituto Polit\u00e9cnico Nacional, Xochitepec 62790, Morelos, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CICATA Unidad Morelos , Instituto Polit\u00e9cnico Nacional","institution_ids":["https://openalex.org/I59361560"]},{"raw_affiliation_string":"CICATA Unidad Morelos, Instituto Polit\u00e9cnico Nacional, Xochitepec 62790, Morelos, Mexico","institution_ids":["https://openalex.org/I59361560"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023587491","display_name":"Edgar Kr\u00f6tzsch","orcid":"https://orcid.org/0000-0002-0696-0147","observed_orcids":["https://orcid.org/0000-0002-0696-0147"]},"institutions":[{"id":"https://openalex.org/I4210124243","display_name":"Instituto Nacional de Rehabilitaci\u00f3n","ror":"https://ror.org/03734cd59","country_code":"MX","type":"facility","lineage":["https://openalex.org/I4210124243"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Edgar Kr\u00f6tzsch","raw_affiliation_strings":["Laboratory of Connective Tissue. Centro Nacional de Investigaci\u00f3n y Atenci\u00f3n de Quemados , Instituto Nacional de Rehabilitaci\u00f3n 'Luis Guillermo Ibarra Ibarra'. Mexico City , Mexico","Laboratory of Connective Tissue, Centro Nacional de Investigaci\u00f3n y Atenci\u00f3n de Quemados, Instituto Nacional de Rehabilitaci\u00f3n 'Luis Guillermo Ibarra Ibarra', Mexico City 14389, Mexico"],"raw_orcid":"https://orcid.org/0000-0002-0696-0147","affiliations":[{"raw_affiliation_string":"Laboratory of Connective Tissue. Centro Nacional de Investigaci\u00f3n y Atenci\u00f3n de Quemados , Instituto Nacional de Rehabilitaci\u00f3n 'Luis Guillermo Ibarra Ibarra'. Mexico City , Mexico","institution_ids":["https://openalex.org/I4210124243"]},{"raw_affiliation_string":"Laboratory of Connective Tissue, Centro Nacional de Investigaci\u00f3n y Atenci\u00f3n de Quemados, Instituto Nacional de Rehabilitaci\u00f3n 'Luis Guillermo Ibarra Ibarra', Mexico City 14389, Mexico","institution_ids":["https://openalex.org/I4210124243"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":1300,"currency":"CHF","value_usd":1568},"apc_paid":{"value":1300,"currency":"CHF","value_usd":1568},"fwci":1.2372,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.73440213,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":95},"biblio":{"volume":"93","issue":"4","first_page":"24","last_page":"24"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/severe-covid-19","display_name":"severe COVID-19","score":0.9380000233650208},{"id":"https://openalex.org/keywords/pirfenidone","display_name":"pirfenidone","score":0.9980000257492065},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.9490000009536743},{"id":"https://openalex.org/keywords/jak-stat-signaling","display_name":"JAK/STAT signaling","score":0.8610000014305115},{"id":"https://openalex.org/keywords/cytokine-storm","display_name":"cytokine storm","score":0.9440000057220459},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.5799999833106995},{"id":"https://openalex.org/keywords/fibrosis","display_name":"fibrosis","score":0.8080000281333923},{"id":"https://openalex.org/keywords/dexamethasone","display_name":"dexamethasone","score":0.9179999828338623},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.7739999890327454},{"id":"https://openalex.org/keywords/th2-response","display_name":"Th2 immune response","score":0.824999988079071},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.9169999957084656},{"id":"https://openalex.org/keywords/interferon-gamma-pathway","display_name":"interferon-gamma pathway","score":0.8019999861717224},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.7089999914169312},{"id":"https://openalex.org/keywords/fibroblasts","display_name":"fibroblasts","score":0.8410000205039978},{"id":"https://openalex.org/keywords/monocytes","display_name":"monocytes","score":0.9369999766349792},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.574999988079071}],"concepts":[{"id":"https://openalex.org/C2779832356","wikidata":"https://www.wikidata.org/wiki/Q2060696","display_name":"Pirfenidone","level":4,"score":0.9000623822212219},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6405238509178162},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.612492561340332},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.5343904495239258},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.4878733158111572},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.40514853596687317},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3551653027534485},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3270832300186157},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21946880221366882},{"id":"https://openalex.org/C2778341716","wikidata":"https://www.wikidata.org/wiki/Q2290446","display_name":"Idiopathic pulmonary fibrosis","level":3,"score":0.20094236731529236},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.18411868810653687},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10521170496940613},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.09683337807655334},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000093485","descriptor_name":"COVID-19 Drug Treatment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010865","descriptor_name":"Pilot Projects","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011728","descriptor_name":"Pyridones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011728","descriptor_name":"Pyridones","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D050791","descriptor_name":"STAT Transcription Factors","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D050791","descriptor_name":"STAT Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053612","descriptor_name":"Janus Kinases","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D053612","descriptor_name":"Janus Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.3390/arm93040024","doi":"https://doi.org/10.3390/arm93040024","is_oa":true,"landing_page_url":"https://doi.org/10.3390/arm93040024","pdf_url":"https://www.mdpi.com/2543-6031/93/4/24/pdf?version=1752832940","source":{"id":"https://openalex.org/S2765076663","display_name":"Advances in respiratory medicine","issn_l":"2451-4934","issn":["2451-4934","2543-6031"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Respiratory Medicine","raw_type":"journal-article"},{"id":"doi:10.20944/preprints202506.0007.v1","doi":"https://doi.org/10.20944/preprints202506.0007.v1","is_oa":true,"landing_page_url":"https://doi.org/10.20944/preprints202506.0007.v1","pdf_url":"https://www.preprints.org/frontend/manuscript/ab7d55300f357ca20b2ba9966300751c/download_pub","source":{"id":"https://openalex.org/S6309402219","display_name":"Preprints.org","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},{"id":"pmid:40700055","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40700055","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in respiratory medicine","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12286056","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12286056/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Adv Respir Med","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:673eaf8f1f9f42b5a2300e91e12ba10b","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/673eaf8f1f9f42b5a2300e91e12ba10b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Advances in Respiratory Medicine, Vol 93, Iss 4, p 24 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/arm93040024","doi":"https://doi.org/10.3390/arm93040024","is_oa":true,"landing_page_url":"https://doi.org/10.3390/arm93040024","pdf_url":"https://www.mdpi.com/2543-6031/93/4/24/pdf?version=1752832940","source":{"id":"https://openalex.org/S2765076663","display_name":"Advances in respiratory medicine","issn_l":"2451-4934","issn":["2451-4934","2543-6031"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Respiratory Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320337011","display_name":"Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico","ror":"https://ror.org/02zz52s52"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4412650545.pdf","grobid_xml":"https://content.openalex.org/works/W4412650545.grobid-xml"},"referenced_works_count":58,"referenced_works":["https://openalex.org/W1965854265","https://openalex.org/W1967201035","https://openalex.org/W1988985090","https://openalex.org/W2000433942","https://openalex.org/W2106839470","https://openalex.org/W2129122223","https://openalex.org/W2152237318","https://openalex.org/W2155681713","https://openalex.org/W2162143298","https://openalex.org/W2170143283","https://openalex.org/W2283090762","https://openalex.org/W2335545691","https://openalex.org/W2396288232","https://openalex.org/W2613880790","https://openalex.org/W2752164271","https://openalex.org/W3004412595","https://openalex.org/W3005838342","https://openalex.org/W3008644093","https://openalex.org/W3008874180","https://openalex.org/W3009820633","https://openalex.org/W3010556122","https://openalex.org/W3010890049","https://openalex.org/W3011610993","https://openalex.org/W3012559827","https://openalex.org/W3015228903","https://openalex.org/W3021560285","https://openalex.org/W3022970339","https://openalex.org/W3024848265","https://openalex.org/W3026032531","https://openalex.org/W3031365196","https://openalex.org/W3033694833","https://openalex.org/W3035304779","https://openalex.org/W3035765027","https://openalex.org/W3037185429","https://openalex.org/W3041803180","https://openalex.org/W3046473329","https://openalex.org/W3047795214","https://openalex.org/W3062249604","https://openalex.org/W3078290162","https://openalex.org/W3082749806","https://openalex.org/W3089936348","https://openalex.org/W3096383810","https://openalex.org/W3112032086","https://openalex.org/W3119858919","https://openalex.org/W3152558084","https://openalex.org/W3160535978","https://openalex.org/W3183966385","https://openalex.org/W3192002558","https://openalex.org/W3201938605","https://openalex.org/W4200583142","https://openalex.org/W4206428633","https://openalex.org/W4220985845","https://openalex.org/W4281491649","https://openalex.org/W4293802328","https://openalex.org/W4296612182","https://openalex.org/W4302287640","https://openalex.org/W4406847868","https://openalex.org/W6780496054"],"related_works":["https://openalex.org/W4245982512","https://openalex.org/W3035304779","https://openalex.org/W4327979153","https://openalex.org/W3122070002","https://openalex.org/W3217038280","https://openalex.org/W4406847868","https://openalex.org/W3035802734","https://openalex.org/W3037867966","https://openalex.org/W4310186707","https://openalex.org/W4322584267"],"abstract_inverted_index":{"The":[0],"therapeutic":[1],"target":[2],"of":[3,42,46,114,119,193,207,209,231],"COVID-19":[4,131],"is":[5],"focused":[6],"on":[7],"controlling":[8,232],"inflammation":[9,233],"and":[10,15,29,62,74,79,104,135,162,180,244],"preventing":[11],"fibrosis.":[12],"Collagen\u2013polyvinylpyrrolidone":[13],"(collagen-PVP)":[14],"pirfenidone":[16,70,87,155,243],"both":[17],"have":[18],"the":[19,23,40,77,109,112,138,159,176,191,205,210,224,229,235],"ability":[20],"to":[21,38,137],"control":[22,160,220],"cytokine":[24],"storm":[25],"observed":[26,241],"in":[27,49,149,213,223],"rheumatic":[28],"fibrotic":[30],"disorders.":[31],"In":[32,54],"this":[33],"work,":[34],"our":[35],"aim":[36,113],"was":[37],"understand":[39],"benefits":[41],"treatment":[43],"with":[44,51,60,108,111,152,158,188],"each":[45],"these":[47],"drugs":[48],"patients":[50,57,150],"severe":[52],"COVID-19.":[53],"total,":[55],"36":[56],"were":[58,66,82,142],"treated":[59,107,151],"dexamethasone":[61],"enoxaparin,":[63],"but":[64],"26":[65],"allocated":[67],"collagen-PVP":[68,153,165,189],"or":[69,154],"(n":[71],"=":[72],"15":[73],"11,":[75],"respectively);":[76],"clinical":[78],"metabolic":[80],"effects":[81],"compared":[83,157],"among":[84],"them.":[85],"Since":[86],"works":[88],"via":[89,190],"transcriptional":[90],"mechanisms,":[91],"we":[92],"performed":[93],"a":[94,116,218],"human":[95],"genome":[96],"microarray":[97],"assay":[98],"using":[99],"RNA":[100],"isolated":[101],"from":[102],"fibroblast":[103],"monocyte":[105],"cultures":[106],"biodrug,":[110],"hypothesising":[115],"possible":[117,219],"mechanism":[118],"action":[120],"for":[121,221,228,242],"collagen-PVP.":[122],"Our":[123],"results":[124],"showed":[125,174,217],"that":[126,163,175],"hospital":[127],"stay":[128],"duration,":[129],"quick":[130],"severity":[132],"index":[133],"(qCSI),":[134],"admission":[136],"intensive":[139],"care":[140],"unit":[141],"statistically":[143],"significantly":[144],"lower":[145],"(p":[146],"<":[147],"0.02)":[148],"when":[156],"group,":[161],"only":[164],"normalised":[166],"serum":[167],"glucose":[168],"at":[169],"discharge.":[170],"Ingenuity":[171],"Pathway":[172],"Analysis":[173],"cell":[177,181],"cycle,":[178],"inflammation,":[179],"surface\u2013extracellular":[182],"matrix":[183],"interactions":[184],"could":[185,201],"be":[186,202],"regulated":[187],"downmodulation":[192],"proinflammatory":[194],"cytokines,":[195],"while":[196],"Th2":[197],"anti-inflammatory":[198],"response":[199],"signalling":[200],"upregulated.":[203],"Furthermore,":[204],"downregulation":[206],"some":[208],"genes":[211],"involved":[212],"nitric":[214],"oxide":[215],"production":[216],"JAK":[222],"IFN-\u03b3":[225],"pathway,":[226,237],"allowing":[227],"possibility":[230],"through":[234],"JAK/STAT":[236],"as":[238,248],"has":[239],"been":[240],"other":[245],"immunomodulators,":[246],"such":[247],"ruxolitinib.":[249]},"counts_by_year":[{"year":2025,"cited_by_count":2}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2025-10-10T00:00:00"}
