{"id":"https://openalex.org/W4412645355","doi":"https://doi.org/10.3389/fimmu.2025.1643896","title":"The role of complement in normal pregnancy and preeclampsia","display_name":"The role of complement in normal pregnancy and preeclampsia","publication_year":2025,"publication_date":"2025-07-24","ids":{"openalex":"https://openalex.org/W4412645355","doi":"https://doi.org/10.3389/fimmu.2025.1643896","pmid":"https://pubmed.ncbi.nlm.nih.gov/40777009","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12328418"},"language":"en","primary_location":{"id":"doi:10.3389/fimmu.2025.1643896","doi":"https://doi.org/10.3389/fimmu.2025.1643896","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2025.1643896","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1643896/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1643896/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013884520","display_name":"Richard M. Burwick","orcid":"https://orcid.org/0000-0002-2340-3772","observed_orcids":["https://orcid.org/0000-0002-2340-3772"]},"institutions":[{"id":"https://openalex.org/I4210104294","display_name":"Pomona Valley Hospital Medical Center","ror":"https://ror.org/01a05a579","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210104294"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard M. Burwick","raw_affiliation_strings":["Maternal Fetal Medicine, San Gabriel Valley Perinatal Medical Group, Pomona Valley Hospital Medical Center, Pomona, CA,\u00a0United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Maternal Fetal Medicine, San Gabriel Valley Perinatal Medical Group, Pomona Valley Hospital Medical Center, Pomona, CA,\u00a0United States","institution_ids":["https://openalex.org/I4210104294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083115353","display_name":"Anuja Java","orcid":"https://orcid.org/0000-0003-0433-238X","observed_orcids":["https://orcid.org/0000-0003-0433-238X"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anuja Java","raw_affiliation_strings":["Division of Nephrology, Department of Medicine, Washington University School of Medicine, St. Louis, MO,\u00a0United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology, Department of Medicine, Washington University School of Medicine, St. Louis, MO,\u00a0United States","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091607844","display_name":"Jean F. Regal","orcid":"https://orcid.org/0000-0001-5713-0891","observed_orcids":["https://orcid.org/0000-0001-5713-0891"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I4210115145","display_name":"University of Minnesota, Duluth","ror":"https://ror.org/01hy4qx27","country_code":"US","type":"education","lineage":["https://openalex.org/I4210115145"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jean F. Regal","raw_affiliation_strings":["Department of Biomedical Sciences, University of Minnesota Medical School, Duluth, MN,\u00a0United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, University of Minnesota Medical School, Duluth, MN,\u00a0United States","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I4210115145"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5091607844"],"corresponding_institution_ids":["https://openalex.org/I130238516","https://openalex.org/I4210115145"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":4.0961,"has_fulltext":true,"cited_by_count":22,"citation_normalized_percentile":{"value":0.96487119,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":100},"biblio":{"volume":"16","issue":null,"first_page":"1643896","last_page":"1643896"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10290","display_name":"Pregnancy and preeclampsia studies","score":0.975600004196167,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10290","display_name":"Pregnancy and preeclampsia studies","score":0.975600004196167,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.02370000071823597,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/complement-system","display_name":"complement system","score":0.9769999980926514},{"id":"https://openalex.org/keywords/preeclampsia","display_name":"preeclampsia","score":0.9750000238418579},{"id":"https://openalex.org/keywords/normal-pregnancy","display_name":"normal pregnancy","score":0.8199999928474426},{"id":"https://openalex.org/keywords/complement-activation","display_name":"complement activation","score":0.8389999866485596},{"id":"https://openalex.org/keywords/complement-dysregulation","display_name":"complement dysregulation","score":0.7900000214576721},{"id":"https://openalex.org/keywords/hellp-syndrome","display_name":"HELLP syndrome","score":0.9380000233650208},{"id":"https://openalex.org/keywords/complement-biomarkers","display_name":"complement biomarkers","score":0.8450000286102295},{"id":"https://openalex.org/keywords/placental-development","display_name":"placental development","score":0.8209999799728394},{"id":"https://openalex.org/keywords/complement-therapeutics","display_name":"complement therapeutics","score":0.7239999771118164},{"id":"https://openalex.org/keywords/adverse-pregnancy-outcomes","display_name":"adverse pregnancy outcomes","score":0.6000000238418579}],"concepts":[{"id":"https://openalex.org/C2777218350","wikidata":"https://www.wikidata.org/wiki/Q61335","display_name":"Preeclampsia","level":3,"score":0.8297136425971985},{"id":"https://openalex.org/C111684460","wikidata":"https://www.wikidata.org/wiki/Q334848","display_name":"Complement system","level":3,"score":0.8267947435379028},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.7170159220695496},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5984847545623779},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5503541231155396},{"id":"https://openalex.org/C112313634","wikidata":"https://www.wikidata.org/wiki/Q7886648","display_name":"Complement (music)","level":5,"score":0.5466249585151672},{"id":"https://openalex.org/C2779902561","wikidata":"https://www.wikidata.org/wiki/Q471706","display_name":"Hemolysis","level":2,"score":0.517403244972229},{"id":"https://openalex.org/C2777637130","wikidata":"https://www.wikidata.org/wiki/Q17165460","display_name":"Atypical hemolytic uremic syndrome","level":4,"score":0.5172244310379028},{"id":"https://openalex.org/C2777991916","wikidata":"https://www.wikidata.org/wiki/Q421617","display_name":"Eculizumab","level":4,"score":0.5014665126800537},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.45620888471603394},{"id":"https://openalex.org/C2777327493","wikidata":"https://www.wikidata.org/wiki/Q5156409","display_name":"Complement deficiency","level":4,"score":0.42654597759246826},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3218820095062256},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15963390469551086},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.060389310121536255},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.05886995792388916},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.05789989233016968},{"id":"https://openalex.org/C188082640","wikidata":"https://www.wikidata.org/wiki/Q1780899","display_name":"Complementation","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003165","descriptor_name":"Complement System Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003165","descriptor_name":"Complement System Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003167","descriptor_name":"Complement Activation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011225","descriptor_name":"Pre-Eclampsia","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D011225","descriptor_name":"Pre-Eclampsia","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.3389/fimmu.2025.1643896","doi":"https://doi.org/10.3389/fimmu.2025.1643896","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2025.1643896","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1643896/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12328418","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12328418","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Immunol","raw_type":"Text"},{"id":"pmid:40777009","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40777009","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in immunology","raw_type":"Journal Article"},{"id":"pmh:oai:digitalcommons.wustl.edu:oa_4-8518","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.wustl.edu/oa_4/7537","pdf_url":"https://digitalcommons.wustl.edu/context/oa_4/article/8518/viewcontent/fimmu_16_1643896.pdf","source":{"id":"https://openalex.org/S4306400764","display_name":"Digital Commons@Becker (Washington University School of Medicine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I204465549","host_organization_name":"Washington University in St. Louis","host_organization_lineage":["https://openalex.org/I204465549"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"2020-Current year OA Pubs","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:99f73d3925a045e592ef19215dd9dfd8","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/99f73d3925a045e592ef19215dd9dfd8","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, Vol 16 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fimmu.2025.1643896","doi":"https://doi.org/10.3389/fimmu.2025.1643896","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2025.1643896","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1643896/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309636","display_name":"University of Minnesota","ror":"https://ror.org/03grvy078"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4412645355.pdf","grobid_xml":"https://content.openalex.org/works/W4412645355.grobid-xml"},"referenced_works_count":203,"referenced_works":["https://openalex.org/W70905589","https://openalex.org/W980642183","https://openalex.org/W1054691025","https://openalex.org/W1484753378","https://openalex.org/W1594129922","https://openalex.org/W1659820601","https://openalex.org/W1700743858","https://openalex.org/W1922557247","https://openalex.org/W1926780910","https://openalex.org/W1960544894","https://openalex.org/W1964354023","https://openalex.org/W1968137581","https://openalex.org/W1968384491","https://openalex.org/W1968774836","https://openalex.org/W1972521538","https://openalex.org/W1975922104","https://openalex.org/W1981692914","https://openalex.org/W1983186128","https://openalex.org/W1984051494","https://openalex.org/W1984433766","https://openalex.org/W1986469266","https://openalex.org/W1989739763","https://openalex.org/W1993495768","https://openalex.org/W1998774111","https://openalex.org/W2002201877","https://openalex.org/W2004265876","https://openalex.org/W2009820767","https://openalex.org/W2013062338","https://openalex.org/W2013710242","https://openalex.org/W2016907215","https://openalex.org/W2022777558","https://openalex.org/W2023195146","https://openalex.org/W2023377972","https://openalex.org/W2023929943","https://openalex.org/W2026194321","https://openalex.org/W2028212842","https://openalex.org/W2029220893","https://openalex.org/W2032665278","https://openalex.org/W2033871878","https://openalex.org/W2035432263","https://openalex.org/W2038885399","https://openalex.org/W2043893206","https://openalex.org/W2050522333","https://openalex.org/W2054765980","https://openalex.org/W2058344851","https://openalex.org/W2058441905","https://openalex.org/W2063271953","https://openalex.org/W2063795565","https://openalex.org/W2064143839","https://openalex.org/W2065381864","https://openalex.org/W2067078910","https://openalex.org/W2067795707","https://openalex.org/W2070415724","https://openalex.org/W2070729260","https://openalex.org/W2070758022","https://openalex.org/W2071004236","https://openalex.org/W2074202650","https://openalex.org/W2074367236","https://openalex.org/W2074747030","https://openalex.org/W2076378943","https://openalex.org/W2080088844","https://openalex.org/W2081255404","https://openalex.org/W2082002688","https://openalex.org/W2084198005","https://openalex.org/W2085796361","https://openalex.org/W2089109813","https://openalex.org/W2089221056","https://openalex.org/W2089481411","https://openalex.org/W2090669293","https://openalex.org/W2095687105","https://openalex.org/W2096582474","https://openalex.org/W2098307091","https://openalex.org/W2101494871","https://openalex.org/W2102336650","https://openalex.org/W2107839246","https://openalex.org/W2113181839","https://openalex.org/W2115547580","https://openalex.org/W2117431149","https://openalex.org/W2118510193","https://openalex.org/W2122037893","https://openalex.org/W2122918206","https://openalex.org/W2123022047","https://openalex.org/W2124641948","https://openalex.org/W2127425255","https://openalex.org/W2135266046","https://openalex.org/W2138775203","https://openalex.org/W2140537006","https://openalex.org/W2143180984","https://openalex.org/W2145782275","https://openalex.org/W2146371213","https://openalex.org/W2150087846","https://openalex.org/W2154315551","https://openalex.org/W2155807513","https://openalex.org/W2157991535","https://openalex.org/W2158551074","https://openalex.org/W2163268391","https://openalex.org/W2242104128","https://openalex.org/W2261223866","https://openalex.org/W2280809848","https://openalex.org/W2286386131","https://openalex.org/W2316383122","https://openalex.org/W2335653426","https://openalex.org/W2412863605","https://openalex.org/W2413185477","https://openalex.org/W2414645876","https://openalex.org/W2505085952","https://openalex.org/W2507792628","https://openalex.org/W2519080135","https://openalex.org/W2524166045","https://openalex.org/W2557184605","https://openalex.org/W2575188224","https://openalex.org/W2580867287","https://openalex.org/W2586795610","https://openalex.org/W2610299824","https://openalex.org/W2625214851","https://openalex.org/W2754122438","https://openalex.org/W2765467770","https://openalex.org/W2776122260","https://openalex.org/W2790023857","https://openalex.org/W2790690444","https://openalex.org/W2792448726","https://openalex.org/W2793920749","https://openalex.org/W2797057269","https://openalex.org/W2802029328","https://openalex.org/W2885540420","https://openalex.org/W2889840463","https://openalex.org/W2892281512","https://openalex.org/W2894626084","https://openalex.org/W2895608067","https://openalex.org/W2900362322","https://openalex.org/W2906273745","https://openalex.org/W2911471292","https://openalex.org/W2923578927","https://openalex.org/W2945507784","https://openalex.org/W2952343158","https://openalex.org/W2960118783","https://openalex.org/W2965276188","https://openalex.org/W2967019693","https://openalex.org/W2971704573","https://openalex.org/W2973774575","https://openalex.org/W2979834394","https://openalex.org/W2984285298","https://openalex.org/W2984924244","https://openalex.org/W2993877501","https://openalex.org/W2996763848","https://openalex.org/W3000403208","https://openalex.org/W3009326009","https://openalex.org/W3009359759","https://openalex.org/W3014509888","https://openalex.org/W3016390864","https://openalex.org/W3023204402","https://openalex.org/W3026834368","https://openalex.org/W3047066849","https://openalex.org/W3071414872","https://openalex.org/W3088115488","https://openalex.org/W3092038024","https://openalex.org/W3093017290","https://openalex.org/W3093086557","https://openalex.org/W3118979249","https://openalex.org/W3124426521","https://openalex.org/W3126859454","https://openalex.org/W3128095006","https://openalex.org/W3131889816","https://openalex.org/W3138193346","https://openalex.org/W3142113446","https://openalex.org/W3155945056","https://openalex.org/W3183088136","https://openalex.org/W3183634783","https://openalex.org/W3200015660","https://openalex.org/W3202478085","https://openalex.org/W3202672013","https://openalex.org/W4207016536","https://openalex.org/W4211032164","https://openalex.org/W4225909379","https://openalex.org/W4281889037","https://openalex.org/W4289550710","https://openalex.org/W4295754773","https://openalex.org/W4308726186","https://openalex.org/W4309094833","https://openalex.org/W4309827641","https://openalex.org/W4321003437","https://openalex.org/W4375955192","https://openalex.org/W4386462271","https://openalex.org/W4392791092","https://openalex.org/W4393946559","https://openalex.org/W4394686719","https://openalex.org/W4394692169","https://openalex.org/W4398223947","https://openalex.org/W4399983519","https://openalex.org/W4400354779","https://openalex.org/W4403054010","https://openalex.org/W4405050178","https://openalex.org/W4405109158","https://openalex.org/W4405463679","https://openalex.org/W4406978199","https://openalex.org/W4408474552","https://openalex.org/W4408520391","https://openalex.org/W4409085286","https://openalex.org/W4409415983","https://openalex.org/W4409916127","https://openalex.org/W4410041331","https://openalex.org/W6602901078","https://openalex.org/W6715484327"],"related_works":["https://openalex.org/W3000403208","https://openalex.org/W3088860676","https://openalex.org/W2083133044","https://openalex.org/W3016390864","https://openalex.org/W1971154967","https://openalex.org/W2008831874","https://openalex.org/W2058441905","https://openalex.org/W4399983519","https://openalex.org/W2765467770","https://openalex.org/W2800806937"],"abstract_inverted_index":{"Preeclampsia":[0],"affects":[1],"3-4%":[2],"of":[3,57,89,99,120,128,141,143,161,174,182,196,200],"pregnancies":[4],"with":[5,54,71,97,126,170],"adverse":[6,81],"effects":[7],"for":[8,108],"both":[9],"mother":[10],"and":[11,18,36,69,116,133,151],"child.":[12],"Minimal":[13],"therapeutic":[14],"options":[15],"are":[16,20,40],"available,":[17],"biomarkers":[19,130],"urgently":[21],"needed":[22],"to":[23,80,118],"identify":[24],"those":[25],"at":[26],"greatest":[27],"risk":[28],"early":[29],"in":[30,61,103,111,131,138,164,194,203,205],"the":[31,34,47,90,100,139,159,197],"pregnancy.":[32],"Both":[33],"innate":[35],"adaptive":[37],"immune":[38,207],"systems":[39],"well":[41],"regulated":[42],"during":[43,189],"normal":[44,114],"pregnancy":[45,68,82,115,190,204],"including":[46,145],"complement":[48,52,58,76,91,109,129,136,162,177,184,188,201],"system.":[49],"A":[50],"functioning":[51],"system":[53,92],"some":[55],"degree":[56],"activation":[59,77,185],"participates":[60],"proper":[62],"placental":[63],"development,":[64],"ensuring":[65],"a":[66,113],"healthy":[67],"assisting":[70],"host":[72],"defense.":[73],"However,":[74],"aberrant":[75],"can":[78],"lead":[79],"outcomes":[83],"such":[84],"as":[85],"preeclampsia.":[86,121],"An":[87],"overview":[88],"will":[93,166,191],"be":[94,167,192],"presented,":[95],"along":[96,169],"review":[98],"pre-clinical":[101],"literature":[102],"animal":[104],"models":[105],"providing":[106],"evidence":[107],"involvement":[110],"maintaining":[112],"contributing":[117],"symptoms":[119],"In":[122],"addition,":[123],"clinical":[124],"studies":[125,157],"evaluation":[127],"plasma":[132],"urine":[134],"implicate":[135],"dysregulation":[137,163],"pathophysiology":[140],"subtypes":[142],"preeclampsia":[144,165],"HELLP":[146],"(hemolysis,":[147],"elevated":[148],"liver":[149],"enzymes":[150],"low":[152],"platelet":[153],"count)":[154],"syndrome.":[155],"Recent":[156],"on":[158,172],"genetics":[160],"reviewed,":[168],"updates":[171],"use":[173,199],"recently":[175],"developed":[176],"therapeutics.":[178],"The":[179],"potential":[180],"utility":[181],"evaluating":[183],"or":[186],"manipulating":[187],"discussed":[193],"view":[195],"successful":[198],"therapeutics":[202],"other":[206],"diseases.":[208]},"counts_by_year":[{"year":2026,"cited_by_count":21},{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-10-10T00:00:00"}
