{"id":"https://openalex.org/W4412568464","doi":"https://doi.org/10.1038/s41467-026-72641-z","title":"5\u2019tRNA-derived fragments modulate \u03b2-cell homeostasis and islet macrophage activation in type 2 diabetes","display_name":"5\u2019tRNA-derived fragments modulate \u03b2-cell homeostasis and islet macrophage activation in type 2 diabetes","publication_year":2026,"publication_date":"2026-05-04","ids":{"openalex":"https://openalex.org/W4412568464","doi":"https://doi.org/10.1038/s41467-026-72641-z","pmid":"https://pubmed.ncbi.nlm.nih.gov/42082525","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13346763"},"language":"en","primary_location":{"id":"doi:10.1038/s41467-026-72641-z","doi":"https://doi.org/10.1038/s41467-026-72641-z","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-026-72641-z","pdf_url":"https://www.nature.com/articles/s41467-026-72641-z_reference.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41467-026-72641-z_reference.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016441509","display_name":"Cristina Cosentino","orcid":"https://orcid.org/0000-0002-2876-3953","observed_orcids":["https://orcid.org/0000-0002-2876-3953"]},"institutions":[{"id":"https://openalex.org/I97565354","display_name":"University of Lausanne","ror":"https://ror.org/019whta54","country_code":"CH","type":"education","lineage":["https://openalex.org/I97565354"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Cristina Cosentino","raw_affiliation_strings":["Department of Fundamental Neuroscience, University of Lausanne, Lausanne, Switzerland. cristina.cosentino@unil.ch","Department of Fundamental Neuroscience, University of Lausanne, Lausanne, Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-2876-3953","affiliations":[{"raw_affiliation_string":"Department of Fundamental Neuroscience, University of Lausanne, Lausanne, Switzerland. cristina.cosentino@unil.ch","institution_ids":["https://openalex.org/I97565354"]},{"raw_affiliation_string":"Department of Fundamental Neuroscience, University of Lausanne, Lausanne, Switzerland","institution_ids":["https://openalex.org/I97565354"]}]},{"author_position":"middle","author":{"id":null,"display_name":"R\u00e9my Klein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I97565354","display_name":"University of Lausanne","ror":"https://ror.org/019whta54","country_code":"CH","type":"education","lineage":["https://openalex.org/I97565354"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"R\u00e9my Klein","raw_affiliation_strings":["Department of Fundamental Neuroscience, University of Lausanne, Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Fundamental Neuroscience, University of Lausanne, Lausanne, Switzerland","institution_ids":["https://openalex.org/I97565354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020330963","display_name":"V\u00e9ronique Menoud","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I97565354","display_name":"University of Lausanne","ror":"https://ror.org/019whta54","country_code":"CH","type":"education","lineage":["https://openalex.org/I97565354"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"V\u00e9ronique Menoud","raw_affiliation_strings":["Department of Fundamental Neuroscience, University of Lausanne, Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Fundamental Neuroscience, University of Lausanne, Lausanne, Switzerland","institution_ids":["https://openalex.org/I97565354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004685000","display_name":"Claudiane Guay","orcid":"https://orcid.org/0000-0002-6478-8744","observed_orcids":["https://orcid.org/0000-0002-6478-8744"]},"institutions":[{"id":"https://openalex.org/I97565354","display_name":"University of Lausanne","ror":"https://ror.org/019whta54","country_code":"CH","type":"education","lineage":["https://openalex.org/I97565354"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Claudiane Guay","raw_affiliation_strings":["Department of Fundamental Neuroscience, University of Lausanne, Lausanne, Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-6478-8744","affiliations":[{"raw_affiliation_string":"Department of Fundamental Neuroscience, University of Lausanne, Lausanne, Switzerland","institution_ids":["https://openalex.org/I97565354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017924398","display_name":"Elena Aiello","orcid":"https://orcid.org/0000-0002-2054-4369","observed_orcids":["https://orcid.org/0000-0002-2054-4369"]},"institutions":[{"id":"https://openalex.org/I102064193","display_name":"University of Siena","ror":"https://ror.org/01tevnk56","country_code":"IT","type":"education","lineage":["https://openalex.org/I102064193"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Elena Aiello","raw_affiliation_strings":["Dipartimento di Scienze Mediche, Chirurgiche e Neuroscienze, University of Siena, Siena, Italy","Dipartimento di Scienze Mediche, Chirurgiche e Neuroscienze, University of Siena, Italy"],"raw_orcid":"https://orcid.org/0000-0002-2054-4369","affiliations":[{"raw_affiliation_string":"Dipartimento di Scienze Mediche, Chirurgiche e Neuroscienze, University of Siena, Siena, Italy","institution_ids":["https://openalex.org/I102064193"]},{"raw_affiliation_string":"Dipartimento di Scienze Mediche, Chirurgiche e Neuroscienze, University of Siena, Italy","institution_ids":["https://openalex.org/I102064193"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069554598","display_name":"Stefano Auddino","orcid":"https://orcid.org/0000-0002-7919-5597","observed_orcids":["https://orcid.org/0000-0002-7919-5597"]},"institutions":[{"id":"https://openalex.org/I102064193","display_name":"University of Siena","ror":"https://ror.org/01tevnk56","country_code":"IT","type":"education","lineage":["https://openalex.org/I102064193"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Stefano Auddino","raw_affiliation_strings":["Dipartimento di Scienze Mediche, Chirurgiche e Neuroscienze, University of Siena, Siena, Italy","Dipartimento di Scienze Mediche, Chirurgiche e Neuroscienze, University of Siena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Scienze Mediche, Chirurgiche e Neuroscienze, University of Siena, Siena, Italy","institution_ids":["https://openalex.org/I102064193"]},{"raw_affiliation_string":"Dipartimento di Scienze Mediche, Chirurgiche e Neuroscienze, University of Siena, Italy","institution_ids":["https://openalex.org/I102064193"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048228010","display_name":"Gianfranco Di Giuseppe","orcid":"https://orcid.org/0000-0003-4506-5193","observed_orcids":["https://orcid.org/0000-0003-4506-5193"]},"institutions":[{"id":"https://openalex.org/I103320735","display_name":"Universit\u00e0 Cattolica del Sacro Cuore","ror":"https://ror.org/03h7r5v07","country_code":"IT","type":"education","lineage":["https://openalex.org/I103320735"]},{"id":"https://openalex.org/I2802557943","display_name":"Agostino Gemelli University Polyclinic","ror":"https://ror.org/00rg70c39","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2802557943"]},{"id":"https://openalex.org/I4210153126","display_name":"Istituti di Ricovero e Cura a Carattere Scientifico","ror":"https://ror.org/04tfzc498","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Gianfranco Di Giuseppe","raw_affiliation_strings":["Department of Medical and Surgical Sciences, Internal medicine, Endocrinology and Diabetology Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy","Department of Translational Medicine and Surgery, Universit\u00e0 Cattolica del Sacro Cuore, Rome, Italy","Department of Translational Medicine and Surgery, Catholic University of Sacred Heart, Rome, Italy","Endocrinology and Diabetology Unit, University Hospital Agostino Gemelli, Rome, Italy"],"raw_orcid":"https://orcid.org/0000-0003-4506-5193","affiliations":[{"raw_affiliation_string":"Department of Medical and Surgical Sciences, Internal medicine, Endocrinology and Diabetology Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy","institution_ids":["https://openalex.org/I2802557943","https://openalex.org/I4210153126"]},{"raw_affiliation_string":"Department of Translational Medicine and Surgery, Universit\u00e0 Cattolica del Sacro Cuore, Rome, Italy","institution_ids":["https://openalex.org/I103320735"]},{"raw_affiliation_string":"Department of Translational Medicine and Surgery, Catholic University of Sacred Heart, Rome, Italy","institution_ids":["https://openalex.org/I103320735"]},{"raw_affiliation_string":"Endocrinology and Diabetology Unit, University Hospital Agostino Gemelli, Rome, Italy","institution_ids":["https://openalex.org/I2802557943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034871693","display_name":"Gea Ciccarelli","orcid":"https://orcid.org/0009-0001-3621-6298","observed_orcids":["https://orcid.org/0009-0001-3621-6298"]},"institutions":[{"id":"https://openalex.org/I103320735","display_name":"Universit\u00e0 Cattolica del Sacro Cuore","ror":"https://ror.org/03h7r5v07","country_code":"IT","type":"education","lineage":["https://openalex.org/I103320735"]},{"id":"https://openalex.org/I2802557943","display_name":"Agostino Gemelli University Polyclinic","ror":"https://ror.org/00rg70c39","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2802557943"]},{"id":"https://openalex.org/I4210153126","display_name":"Istituti di Ricovero e Cura a Carattere Scientifico","ror":"https://ror.org/04tfzc498","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Gea Ciccarelli","raw_affiliation_strings":["Department of Medical and Surgical Sciences, Internal medicine, Endocrinology and Diabetology Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy","Department of Translational Medicine and Surgery, Universit\u00e0 Cattolica del Sacro Cuore, Rome, Italy","Department of Translational Medicine and Surgery, Catholic University of Sacred Heart, Rome, Italy","Endocrinology and Diabetology Unit, University Hospital Agostino Gemelli, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical and Surgical Sciences, Internal medicine, Endocrinology and Diabetology Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy","institution_ids":["https://openalex.org/I2802557943","https://openalex.org/I4210153126"]},{"raw_affiliation_string":"Department of Translational Medicine and Surgery, Universit\u00e0 Cattolica del Sacro Cuore, Rome, Italy","institution_ids":["https://openalex.org/I103320735"]},{"raw_affiliation_string":"Department of Translational Medicine and Surgery, Catholic University of Sacred Heart, Rome, Italy","institution_ids":["https://openalex.org/I103320735"]},{"raw_affiliation_string":"Endocrinology and Diabetology Unit, University Hospital Agostino Gemelli, Rome, Italy","institution_ids":["https://openalex.org/I2802557943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012133663","display_name":"A. Galli","orcid":"https://orcid.org/0000-0001-9023-1571","observed_orcids":["https://orcid.org/0000-0001-9023-1571"]},"institutions":[{"id":"https://openalex.org/I97565354","display_name":"University of Lausanne","ror":"https://ror.org/019whta54","country_code":"CH","type":"education","lineage":["https://openalex.org/I97565354"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Alessandra Galli","raw_affiliation_strings":["Department of Fundamental Neuroscience, University of Lausanne, Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Fundamental Neuroscience, University of Lausanne, Lausanne, Switzerland","institution_ids":["https://openalex.org/I97565354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057171579","display_name":"Francesco Alabiso","orcid":"https://orcid.org/0000-0002-6101-062X","observed_orcids":["https://orcid.org/0000-0002-6101-062X"]},"institutions":[{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesco Alabiso","raw_affiliation_strings":["Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy"],"raw_orcid":"https://orcid.org/0000-0002-6101-062X","affiliations":[{"raw_affiliation_string":"Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy","institution_ids":["https://openalex.org/I9360294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038235367","display_name":"Eleonora Mangano","orcid":"https://orcid.org/0000-0002-4040-4654","observed_orcids":["https://orcid.org/0000-0002-4040-4654"]},"institutions":[{"id":"https://openalex.org/I4210154278","display_name":"Institute of Biomedical Technologies","ror":"https://ror.org/04ehykb85","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210154278","https://openalex.org/I4210155236"]},{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Eleonora Mangano","raw_affiliation_strings":["Institute for Biomedical Technologies, National Research Council, Milan, Italy","C.N.R. Institute for Biomedical Technologies, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Biomedical Technologies, National Research Council, Milan, Italy","institution_ids":["https://openalex.org/I4210155236"]},{"raw_affiliation_string":"C.N.R. Institute for Biomedical Technologies, Milan, Italy","institution_ids":["https://openalex.org/I4210154278"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059610808","display_name":"Flora Brozzi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I97565354","display_name":"University of Lausanne","ror":"https://ror.org/019whta54","country_code":"CH","type":"education","lineage":["https://openalex.org/I97565354"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Flora Brozzi","raw_affiliation_strings":["Department of Fundamental Neuroscience, University of Lausanne, Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Fundamental Neuroscience, University of Lausanne, Lausanne, Switzerland","institution_ids":["https://openalex.org/I97565354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025586948","display_name":"Karim Bouzakri","orcid":"https://orcid.org/0000-0002-0703-5105","observed_orcids":["https://orcid.org/0000-0002-0703-5105"]},"institutions":[{"id":"https://openalex.org/I4210155331","display_name":"Institut M\u00e9diterran\u00e9en d\u2019Oc\u00e9anologie","ror":"https://ror.org/05258q350","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I143002897","https://openalex.org/I21491767","https://openalex.org/I2802818602","https://openalex.org/I4210088668","https://openalex.org/I4210090127","https://openalex.org/I4210093025","https://openalex.org/I4210131494","https://openalex.org/I4210148025","https://openalex.org/I4210155331","https://openalex.org/I4210166444"]},{"id":"https://openalex.org/I4394709218","display_name":"Diab\u00e8te et th\u00e9rapie cellulaire","ror":"https://ror.org/02wj62e51","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4394709218","https://openalex.org/I68947357"]},{"id":"https://openalex.org/I68947357","display_name":"Universit\u00e9 de Strasbourg","ror":"https://ror.org/00pg6eq24","country_code":"FR","type":"education","lineage":["https://openalex.org/I68947357"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Karim Bouzakri","raw_affiliation_strings":["UMR DIATHEC, EA 7294, Centre Europ\u00e9en d'Etude du Diab\u00e8te, Universit\u00e9 de Strasbourg, F\u00e9d\u00e9ration de M\u00e9decine Translationnelle de Strasbourg, Strasbourg, France","UMR DIATHEC, EA 294, Centre Europ\u00e9en d'Etude du Diab\u00e8te, Universit\u00e9 de Strasbourg, F\u00e9d\u00e9ration de M\u00e9decine Translationnelle de Strasbourg, Strasbourg, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UMR DIATHEC, EA 7294, Centre Europ\u00e9en d'Etude du Diab\u00e8te, Universit\u00e9 de Strasbourg, F\u00e9d\u00e9ration de M\u00e9decine Translationnelle de Strasbourg, Strasbourg, France","institution_ids":["https://openalex.org/I4210155331","https://openalex.org/I4394709218","https://openalex.org/I68947357"]},{"raw_affiliation_string":"UMR DIATHEC, EA 294, Centre Europ\u00e9en d'Etude du Diab\u00e8te, Universit\u00e9 de Strasbourg, F\u00e9d\u00e9ration de M\u00e9decine Translationnelle de Strasbourg, Strasbourg, France","institution_ids":["https://openalex.org/I4394709218","https://openalex.org/I68947357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036820714","display_name":"Stefania D\u2019Adamo","orcid":"https://orcid.org/0000-0002-2209-9158","observed_orcids":["https://orcid.org/0000-0002-2209-9158"]},"institutions":[{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Stefania D\u2019Adamo","raw_affiliation_strings":["Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy"],"raw_orcid":"https://orcid.org/0000-0002-2209-9158","affiliations":[{"raw_affiliation_string":"Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy","institution_ids":["https://openalex.org/I9360294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091076723","display_name":"Silvia Cetrullo","orcid":"https://orcid.org/0000-0002-6900-4910","observed_orcids":["https://orcid.org/0000-0002-6900-4910"]},"institutions":[{"id":"https://openalex.org/I4210140019","display_name":"Istituto Nazionale per le Ricerche Cardiovascolari","ror":"https://ror.org/052q1fv39","country_code":"IT","type":"other","lineage":["https://openalex.org/I4210140019"]},{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Silvia Cetrullo","raw_affiliation_strings":["Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy","Health Sciences and Technologies-Interdepartmental Center for Industrial Research (CIRI-SDV), University of Bologna, Bologna, Italy","Istituto Nazionale per le Ricerche Cardiovascolari, Bologna, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy","institution_ids":["https://openalex.org/I9360294"]},{"raw_affiliation_string":"Health Sciences and Technologies-Interdepartmental Center for Industrial Research (CIRI-SDV), University of Bologna, Bologna, Italy","institution_ids":["https://openalex.org/I9360294"]},{"raw_affiliation_string":"Istituto Nazionale per le Ricerche Cardiovascolari, Bologna, Italy","institution_ids":["https://openalex.org/I4210140019"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023823792","display_name":"Giuseppe Quero","orcid":"https://orcid.org/0000-0002-0001-9479","observed_orcids":["https://orcid.org/0000-0002-0001-9479"]},"institutions":[{"id":"https://openalex.org/I103320735","display_name":"Universit\u00e0 Cattolica del Sacro Cuore","ror":"https://ror.org/03h7r5v07","country_code":"IT","type":"education","lineage":["https://openalex.org/I103320735"]},{"id":"https://openalex.org/I2802557943","display_name":"Agostino Gemelli University Polyclinic","ror":"https://ror.org/00rg70c39","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2802557943"]},{"id":"https://openalex.org/I4210153126","display_name":"Istituti di Ricovero e Cura a Carattere Scientifico","ror":"https://ror.org/04tfzc498","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giuseppe Quero","raw_affiliation_strings":["Department of Medical and Surgical Sciences, Digestive Surgery Unit Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy","Department of Translational Medicine and Surgery, Universit\u00e0 Cattolica del Sacro Cuore, Rome, Italy","Department of Translational Medicine and Surgery, Catholic University of Sacred Heart, Rome, Italy","Digestive Surgery Unit, University Hospital Agostino Gemelli, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical and Surgical Sciences, Digestive Surgery Unit Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy","institution_ids":["https://openalex.org/I2802557943","https://openalex.org/I4210153126"]},{"raw_affiliation_string":"Department of Translational Medicine and Surgery, Universit\u00e0 Cattolica del Sacro Cuore, Rome, Italy","institution_ids":["https://openalex.org/I103320735"]},{"raw_affiliation_string":"Department of Translational Medicine and Surgery, Catholic University of Sacred Heart, Rome, Italy","institution_ids":["https://openalex.org/I103320735"]},{"raw_affiliation_string":"Digestive Surgery Unit, University Hospital Agostino Gemelli, Rome, Italy","institution_ids":["https://openalex.org/I2802557943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102028274","display_name":"Andrea Mari","orcid":"https://orcid.org/0000-0002-1436-5591","observed_orcids":["https://orcid.org/0000-0002-1436-5591"]},"institutions":[{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Andrea Mari","raw_affiliation_strings":["Institute of Neuroscience, National Research Council, Padua, Italy"],"raw_orcid":"https://orcid.org/0000-0002-1436-5591","affiliations":[{"raw_affiliation_string":"Institute of Neuroscience, National Research Council, Padua, Italy","institution_ids":["https://openalex.org/I4210155236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114930031","display_name":"Sergio Alfieri","orcid":"https://orcid.org/0000-0002-8057-0788","observed_orcids":["https://orcid.org/0000-0002-8057-0788"]},"institutions":[{"id":"https://openalex.org/I103320735","display_name":"Universit\u00e0 Cattolica del Sacro Cuore","ror":"https://ror.org/03h7r5v07","country_code":"IT","type":"education","lineage":["https://openalex.org/I103320735"]},{"id":"https://openalex.org/I2802557943","display_name":"Agostino Gemelli University Polyclinic","ror":"https://ror.org/00rg70c39","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2802557943"]},{"id":"https://openalex.org/I4210153126","display_name":"Istituti di Ricovero e Cura a Carattere Scientifico","ror":"https://ror.org/04tfzc498","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Sergio Alfieri","raw_affiliation_strings":["Department of Medical and Surgical Sciences, Digestive Surgery Unit Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy","Department of Translational Medicine and Surgery, Universit\u00e0 Cattolica del Sacro Cuore, Rome, Italy","Department of Translational Medicine and Surgery, Catholic University of Sacred Heart, Rome, Italy","Digestive Surgery Unit, University Hospital Agostino Gemelli, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical and Surgical Sciences, Digestive Surgery Unit Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy","institution_ids":["https://openalex.org/I2802557943","https://openalex.org/I4210153126"]},{"raw_affiliation_string":"Department of Translational Medicine and Surgery, Universit\u00e0 Cattolica del Sacro Cuore, Rome, Italy","institution_ids":["https://openalex.org/I103320735"]},{"raw_affiliation_string":"Department of Translational Medicine and Surgery, Catholic University of Sacred Heart, Rome, Italy","institution_ids":["https://openalex.org/I103320735"]},{"raw_affiliation_string":"Digestive Surgery Unit, University Hospital Agostino Gemelli, Rome, Italy","institution_ids":["https://openalex.org/I2802557943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081762535","display_name":"Andrea Giaccari","orcid":"https://orcid.org/0000-0002-7462-7792","observed_orcids":["https://orcid.org/0000-0002-7462-7792"]},"institutions":[{"id":"https://openalex.org/I103320735","display_name":"Universit\u00e0 Cattolica del Sacro Cuore","ror":"https://ror.org/03h7r5v07","country_code":"IT","type":"education","lineage":["https://openalex.org/I103320735"]},{"id":"https://openalex.org/I2802557943","display_name":"Agostino Gemelli University Polyclinic","ror":"https://ror.org/00rg70c39","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2802557943"]},{"id":"https://openalex.org/I4210153126","display_name":"Istituti di Ricovero e Cura a Carattere Scientifico","ror":"https://ror.org/04tfzc498","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Andrea Giaccari","raw_affiliation_strings":["Department of Medical and Surgical Sciences, Internal medicine, Endocrinology and Diabetology Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy","Department of Translational Medicine and Surgery, Universit\u00e0 Cattolica del Sacro Cuore, Rome, Italy","Department of Translational Medicine and Surgery, Catholic University of Sacred Heart, Rome, Italy","Endocrinology and Diabetology Unit, University Hospital Agostino Gemelli, Rome, Italy"],"raw_orcid":"https://orcid.org/0000-0002-7462-7792","affiliations":[{"raw_affiliation_string":"Department of Medical and Surgical Sciences, Internal medicine, Endocrinology and Diabetology Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy","institution_ids":["https://openalex.org/I2802557943","https://openalex.org/I4210153126"]},{"raw_affiliation_string":"Department of Translational Medicine and Surgery, Universit\u00e0 Cattolica del Sacro Cuore, Rome, Italy","institution_ids":["https://openalex.org/I103320735"]},{"raw_affiliation_string":"Department of Translational Medicine and Surgery, Catholic University of Sacred Heart, Rome, Italy","institution_ids":["https://openalex.org/I103320735"]},{"raw_affiliation_string":"Endocrinology and Diabetology Unit, University Hospital Agostino Gemelli, Rome, Italy","institution_ids":["https://openalex.org/I2802557943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071134404","display_name":"Teresa Mezza","orcid":"https://orcid.org/0000-0001-5407-9576","observed_orcids":["https://orcid.org/0000-0001-5407-9576"]},"institutions":[{"id":"https://openalex.org/I103320735","display_name":"Universit\u00e0 Cattolica del Sacro Cuore","ror":"https://ror.org/03h7r5v07","country_code":"IT","type":"education","lineage":["https://openalex.org/I103320735"]},{"id":"https://openalex.org/I2802557943","display_name":"Agostino Gemelli University Polyclinic","ror":"https://ror.org/00rg70c39","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2802557943"]},{"id":"https://openalex.org/I4210153126","display_name":"Istituti di Ricovero e Cura a Carattere Scientifico","ror":"https://ror.org/04tfzc498","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Teresa Mezza","raw_affiliation_strings":["Department of Medical and Surgical Sciences, Internal medicine, Endocrinology and Diabetology Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy","Department of Translational Medicine and Surgery, Universit\u00e0 Cattolica del Sacro Cuore, Rome, Italy","Department of Translational Medicine and Surgery, Catholic University of Sacred Heart, Rome, Italy","Endocrinology and Diabetology Unit, University Hospital Agostino Gemelli, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical and Surgical Sciences, Internal medicine, Endocrinology and Diabetology Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy","institution_ids":["https://openalex.org/I2802557943","https://openalex.org/I4210153126"]},{"raw_affiliation_string":"Department of Translational Medicine and Surgery, Universit\u00e0 Cattolica del Sacro Cuore, Rome, Italy","institution_ids":["https://openalex.org/I103320735"]},{"raw_affiliation_string":"Department of Translational Medicine and Surgery, Catholic University of Sacred Heart, Rome, Italy","institution_ids":["https://openalex.org/I103320735"]},{"raw_affiliation_string":"Endocrinology and Diabetology Unit, University Hospital Agostino Gemelli, Rome, Italy","institution_ids":["https://openalex.org/I2802557943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069364785","display_name":"Francesco Dotta","orcid":"https://orcid.org/0000-0003-4947-7478","observed_orcids":["https://orcid.org/0000-0003-4947-7478"]},"institutions":[{"id":"https://openalex.org/I102064193","display_name":"University of Siena","ror":"https://ror.org/01tevnk56","country_code":"IT","type":"education","lineage":["https://openalex.org/I102064193"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesco Dotta","raw_affiliation_strings":["Dipartimento di Scienze Mediche, Chirurgiche e Neuroscienze, University of Siena, Siena, Italy","Dipartimento di Scienze Mediche, Chirurgiche e Neuroscienze, University of Siena, Italy"],"raw_orcid":"https://orcid.org/0000-0003-4947-7478","affiliations":[{"raw_affiliation_string":"Dipartimento di Scienze Mediche, Chirurgiche e Neuroscienze, University of Siena, Siena, Italy","institution_ids":["https://openalex.org/I102064193"]},{"raw_affiliation_string":"Dipartimento di Scienze Mediche, Chirurgiche e Neuroscienze, University of Siena, Italy","institution_ids":["https://openalex.org/I102064193"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040035539","display_name":"Guido Sebastiani","orcid":"https://orcid.org/0000-0003-4374-8564","observed_orcids":["https://orcid.org/0000-0003-4374-8564"]},"institutions":[{"id":"https://openalex.org/I102064193","display_name":"University of Siena","ror":"https://ror.org/01tevnk56","country_code":"IT","type":"education","lineage":["https://openalex.org/I102064193"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Guido Sebastiani","raw_affiliation_strings":["Dipartimento di Scienze Mediche, Chirurgiche e Neuroscienze, University of Siena, Siena, Italy","Dipartimento di Scienze Mediche, Chirurgiche e Neuroscienze, University of Siena, Italy"],"raw_orcid":"https://orcid.org/0000-0003-4374-8564","affiliations":[{"raw_affiliation_string":"Dipartimento di Scienze Mediche, Chirurgiche e Neuroscienze, University of Siena, Siena, Italy","institution_ids":["https://openalex.org/I102064193"]},{"raw_affiliation_string":"Dipartimento di Scienze Mediche, Chirurgiche e Neuroscienze, University of Siena, Italy","institution_ids":["https://openalex.org/I102064193"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018790360","display_name":"Romano Regazzi","orcid":"https://orcid.org/0000-0002-9773-2915","observed_orcids":["https://orcid.org/0000-0002-9773-2915"]},"institutions":[{"id":"https://openalex.org/I97565354","display_name":"University of Lausanne","ror":"https://ror.org/019whta54","country_code":"CH","type":"education","lineage":["https://openalex.org/I97565354"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Romano Regazzi","raw_affiliation_strings":["Department of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland","Department of Fundamental Neuroscience, University of Lausanne, Lausanne, Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-9773-2915","affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland","institution_ids":["https://openalex.org/I97565354"]},{"raw_affiliation_string":"Department of Fundamental Neuroscience, University of Lausanne, Lausanne, Switzerland","institution_ids":["https://openalex.org/I97565354"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":12,"corresponding_author_ids":["https://openalex.org/A5016441509"],"corresponding_institution_ids":["https://openalex.org/I97565354"],"apc_list":{"value":6990,"currency":"USD","value_usd":6990},"apc_paid":{"value":6990,"currency":"USD","value_usd":6990},"fwci":23.2264,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.99412881,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"17","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trna-derived-fragments","display_name":"tRNA-derived fragments","score":0.968999981880188},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.8169999718666077},{"id":"https://openalex.org/keywords/pancreatic-beta-cells","display_name":"pancreatic beta cells","score":0.7670000195503235},{"id":"https://openalex.org/keywords/islet-macrophages","display_name":"islet macrophages","score":0.9459999799728394},{"id":"https://openalex.org/keywords/insulin-secretion","display_name":"insulin secretion","score":0.6499999761581421},{"id":"https://openalex.org/keywords/palmitate","display_name":"palmitate","score":0.8029999732971191},{"id":"https://openalex.org/keywords/angiogenin","display_name":"angiogenin","score":0.8619999885559082},{"id":"https://openalex.org/keywords/beta-cell-apoptosis","display_name":"beta-cell apoptosis","score":0.8220000267028809},{"id":"https://openalex.org/keywords/macrophage-activation","display_name":"macrophage activation","score":0.722000002861023},{"id":"https://openalex.org/keywords/islet-microenvironment","display_name":"islet microenvironment","score":0.7730000019073486},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.4399999976158142},{"id":"https://openalex.org/keywords/prediabetes","display_name":"prediabetes","score":0.7250000238418579},{"id":"https://openalex.org/keywords/rna-binding-proteins","display_name":"RNA-binding proteins","score":0.7710000276565552},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.6869999766349792},{"id":"https://openalex.org/keywords/extracellular-matrix-remodeling","display_name":"extracellular matrix remodeling","score":0.8849999904632568}],"concepts":[{"id":"https://openalex.org/C165220095","wikidata":"https://www.wikidata.org/wiki/Q207524","display_name":"Islet","level":3,"score":0.791035532951355},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.6636114716529846},{"id":"https://openalex.org/C153957851","wikidata":"https://www.wikidata.org/wiki/Q201448","display_name":"Transfer RNA","level":4,"score":0.6083745956420898},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.5819658637046814},{"id":"https://openalex.org/C3018667095","wikidata":"https://www.wikidata.org/wiki/Q3455903","display_name":"Glucose homeostasis","level":4,"score":0.554327666759491},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.5358079671859741},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4961265027523041},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.41468751430511475},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3777692914009094},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.35583677887916565},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32932454347610474},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2956922948360443},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1984194815158844},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.18422913551330566},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.15883058309555054},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12101128697395325},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000078790","descriptor_name":"Insulin Secretion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007515","descriptor_name":"Islets of Langerhans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008262","descriptor_name":"Macrophage Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012343","descriptor_name":"RNA, Transfer","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012343","descriptor_name":"RNA, Transfer","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018920","descriptor_name":"Coculture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050417","descriptor_name":"Insulin-Secreting Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1038/s41467-026-72641-z","doi":"https://doi.org/10.1038/s41467-026-72641-z","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-026-72641-z","pdf_url":"https://www.nature.com/articles/s41467-026-72641-z_reference.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},{"id":"doi:10.1101/2025.07.22.665911","doi":"https://doi.org/10.1101/2025.07.22.665911","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.07.22.665911","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:13346763","doi":null,"is_oa":true,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42082525/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13346763/pdf/41467_2026_Article_72641.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nat Commun","raw_type":"Text"},{"id":"pmid:42082525","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42082525","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature communications","raw_type":"Journal Article"},{"id":"pmh:oai:air.unimi.it:2434/1258239","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2434/1258239","pdf_url":"https://air.unimi.it/bitstream/2434/1258239/3/s41467-026-72641-z.pdf","source":{"id":"https://openalex.org/S4306400516","display_name":"Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I189158943","host_organization_name":"University of Milan","host_organization_lineage":["https://openalex.org/I189158943"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:cris.unibo.it:11585/1023919","doi":null,"is_oa":true,"landing_page_url":"https://www.biorxiv.org/content/10.1101/2025.07.22.665911v1","pdf_url":null,"source":{"id":"https://openalex.org/S4306402579","display_name":"Archivio istituzionale della ricerca (Alma Mater Studiorum Universit\u00e0 di Bologna)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210117483","host_organization_name":"Istituto di Ematologia di Bologna","host_organization_lineage":["https://openalex.org/I4210117483"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:fdbb11c308c741bfa03f4c48ccca868c","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/fdbb11c308c741bfa03f4c48ccca868c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, Vol 17, Iss 1 (2026)","raw_type":"article"},{"id":"pmh:oai:iris.unil.ch:iris/281813","doi":null,"is_oa":false,"landing_page_url":"https://iris.unil.ch/handle/iris/281813","pdf_url":null,"source":{"id":"https://openalex.org/S7407055444","display_name":"IRIS","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"research article"}],"best_oa_location":{"id":"doi:10.1038/s41467-026-72641-z","doi":"https://doi.org/10.1038/s41467-026-72641-z","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-026-72641-z","pdf_url":"https://www.nature.com/articles/s41467-026-72641-z_reference.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1799975854","display_name":null,"funder_award_id":"GR-2018-12365577","funder_id":"https://openalex.org/F4320321781","funder_display_name":"Ministero della Salute"},{"id":"https://openalex.org/G2076520454","display_name":null,"funder_award_id":"2018-","funder_id":"https://openalex.org/F4320321781","funder_display_name":"Ministero della Salute"},{"id":"https://openalex.org/G2246204914","display_name":null,"funder_award_id":"PNRR-MCNT2-2023-12378096","funder_id":"https://openalex.org/F4320321873","funder_display_name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca"},{"id":"https://openalex.org/G3697406614","display_name":null,"funder_award_id":"PRIN Prot. 2022TJWNLL","funder_id":"https://openalex.org/F4320321873","funder_display_name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca"},{"id":"https://openalex.org/G3835342081","display_name":null,"funder_award_id":"PNRR-PRIN2022 Prot. P2022445ES","funder_id":"https://openalex.org/F4320321873","funder_display_name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca"},{"id":"https://openalex.org/G4592710318","display_name":null,"funder_award_id":"PNRR-PRIN2022 No. P2022EB5B8","funder_id":"https://openalex.org/F4320321873","funder_display_name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca"},{"id":"https://openalex.org/G4804289599","display_name":null,"funder_award_id":"PRIN2022 No.2022FRBXHY","funder_id":"https://openalex.org/F4320321873","funder_display_name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca"},{"id":"https://openalex.org/G4955095694","display_name":null,"funder_award_id":"FBM-Transition Grant 2023","funder_id":"https://openalex.org/F4320323831","funder_display_name":"Universit\u00e9 de Lausanne"},{"id":"https://openalex.org/G5327906233","display_name":null,"funder_award_id":"101029421","funder_id":"https://openalex.org/F4320332999","funder_display_name":"Horizon 2020 Framework Programme"},{"id":"https://openalex.org/G5911110335","display_name":null,"funder_award_id":"PRIN2022","funder_id":"https://openalex.org/F4320321781","funder_display_name":"Ministero della Salute"},{"id":"https://openalex.org/G5927810603","display_name":"Role of tRNA-derived fragments in the control of pancreatic beta-cell functions and in diabetes development","funder_award_id":"219252","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"},{"id":"https://openalex.org/G7241874831","display_name":"Modulation of tRNA pool and tRNA fragments in obesity and diabetes; focus on their role in macrophage activation and exosome-mediated crosstalk with pancreatic beta cells","funder_award_id":"101029421","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G972786147","display_name":null,"funder_award_id":"PRIN-2022","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320320915","display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","ror":"https://ror.org/02s376052"},{"id":"https://openalex.org/F4320320924","display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","ror":"https://ror.org/00yjd3n13"},{"id":"https://openalex.org/F4320321781","display_name":"Ministero della Salute","ror":"https://ror.org/00789fa95"},{"id":"https://openalex.org/F4320321873","display_name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","ror":"https://ror.org/0166hxq48"},{"id":"https://openalex.org/F4320323831","display_name":"Universit\u00e9 de Lausanne","ror":"https://ror.org/019whta54"},{"id":"https://openalex.org/F4320332999","display_name":"Horizon 2020 Framework Programme","ror":"https://ror.org/00k4n6c32"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4412568464.pdf","grobid_xml":"https://content.openalex.org/works/W4412568464.grobid-xml"},"referenced_works_count":59,"referenced_works":["https://openalex.org/W1979793615","https://openalex.org/W1979855720","https://openalex.org/W1995065078","https://openalex.org/W1995319214","https://openalex.org/W2032294094","https://openalex.org/W2036321220","https://openalex.org/W2053492654","https://openalex.org/W2054777152","https://openalex.org/W2080752012","https://openalex.org/W2109140791","https://openalex.org/W2124091237","https://openalex.org/W2128551987","https://openalex.org/W2141707748","https://openalex.org/W2463195069","https://openalex.org/W2566820606","https://openalex.org/W2624373429","https://openalex.org/W2708333767","https://openalex.org/W2763718005","https://openalex.org/W2891388080","https://openalex.org/W2896348655","https://openalex.org/W2896349650","https://openalex.org/W2900884817","https://openalex.org/W2906826986","https://openalex.org/W2918642428","https://openalex.org/W2938897352","https://openalex.org/W2939643004","https://openalex.org/W2952907530","https://openalex.org/W2978006966","https://openalex.org/W2980342819","https://openalex.org/W2990158924","https://openalex.org/W2995142178","https://openalex.org/W2996329482","https://openalex.org/W2997022986","https://openalex.org/W3080129453","https://openalex.org/W3081932558","https://openalex.org/W3108232640","https://openalex.org/W3130759679","https://openalex.org/W3133557863","https://openalex.org/W3158076751","https://openalex.org/W3181421854","https://openalex.org/W4200566690","https://openalex.org/W4206799195","https://openalex.org/W4213115908","https://openalex.org/W4213230613","https://openalex.org/W4284882692","https://openalex.org/W4285099111","https://openalex.org/W4285728636","https://openalex.org/W4307229478","https://openalex.org/W4318307972","https://openalex.org/W4386579580","https://openalex.org/W4389563588","https://openalex.org/W4390615336","https://openalex.org/W4392561676","https://openalex.org/W4396621957","https://openalex.org/W4403381392","https://openalex.org/W4404893371","https://openalex.org/W4405187673","https://openalex.org/W4410137804","https://openalex.org/W4410604099"],"related_works":["https://openalex.org/W4400369554","https://openalex.org/W3020913978","https://openalex.org/W2918642428","https://openalex.org/W4285099111","https://openalex.org/W7171801993","https://openalex.org/W7161397511","https://openalex.org/W2944421432","https://openalex.org/W7207742399","https://openalex.org/W4416395493","https://openalex.org/W7117138763"],"abstract_inverted_index":{"ABSTRACT":[0],"During":[1],"obesity":[2],"and":[3,50,55,60,77,100,144,158,169],"type":[4,64],"2":[5,65],"diabetes,":[6,184],"pancreatic":[7],"\u03b2-cells":[8,54],"face":[9],"chronic":[10],"environmental":[11],"stress,":[12,143],"while":[13],"islet-resident":[14],"macrophages":[15],"(iMACs)":[16],"undergo":[17],"metabolic":[18,193],"reprogramming":[19],"that":[20,114,123],"exacerbates":[21],"\u03b2-cell":[22,98,115,142],"dysfunction.":[23],"Stress-induced":[24],"cleavage":[25],"of":[26,47,179],"transfer":[27],"RNAs":[28],"(tRNAs)":[29],"generates":[30],"tRNA-derived":[31],"fragments":[32],"(tRFs),":[33],"whose":[34],"role":[35],"in":[36,53,61,94,128,134,183,192],"this":[37,138],"context":[38],"is":[39,71],"not":[40],"fully":[41],"understood.":[42],"We":[43],"identify":[44],"elevated":[45],"levels":[46],"5\u2019tRF":[48,51,69,92,132,149],"Glu(CTC)":[49,70,93,133,150],"Gly(GCC)":[52],"iMACs":[56],"from":[57,63],"db/db":[58],"mice":[59],"islets":[62,95],"diabetic":[66],"patients.":[67],"Notably,":[68],"also":[72],"induced":[73],"under":[74,104],"prediabetic":[75],"conditions":[76],"inversely":[78],"correlates":[79],"with":[80,152],"insulin":[81,102,146],"secretion.":[82,147],"Lipotoxic":[83],"stress":[84,190],"triggers":[85],"their":[86],"production":[87],"via":[88],"Angiogenin-mediated":[89],"cleavage.":[90],"Blocking":[91],"protects":[96],"against":[97],"apoptosis":[99],"restores":[101],"secretion":[103],"palmitate":[105,126],"stress.":[106,171],"Using":[107],"a":[108,118],"\u03b2-cell/macrophage":[109],"co-culture":[110],"system,":[111],"we":[112],"show":[113],"contact":[116],"shapes":[117],"unique":[119],"macrophage":[120],"phenotype":[121],"(iMAC-like)":[122],"shifts":[124],"upon":[125],"exposure\u2014recapitulating":[127],"vivo":[129],"observations.":[130],"Inhibiting":[131],"iMAC-like":[135],"cells":[136],"prevents":[137],"activation":[139],"switch,":[140],"reduces":[141],"improves":[145],"Mechanistically,":[148],"interacts":[151],"RNA-binding":[153],"proteins":[154],"to":[155,162],"regulate":[156],"transcriptional":[157],"post-transcriptional":[159],"pathways":[160],"linked":[161],"immune":[163],"activation,":[164],"extracellular":[165],"matrex":[166],"remodeling,":[167],"neurogenesis,":[168],"oxidative":[170],"Our":[172],"study":[173],"identifies":[174],"5\u2019tRFs":[175],"as":[176],"key":[177],"mediators":[178],"islet":[180],"microenvironment":[181],"remodeling":[182],"offering":[185],"new":[186],"insights":[187],"into":[188],"intercellular":[189],"signaling":[191],"disease.":[194]},"counts_by_year":[{"year":2026,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-10-10T00:00:00"}