{"id":"https://openalex.org/W4412515170","doi":"https://doi.org/10.1111/bph.70135","title":"Anti\u2010nociceptive action of leonurine through TRPA1 and TRPV4 channels modulation","display_name":"Anti\u2010nociceptive action of leonurine through TRPA1 and TRPV4 channels modulation","publication_year":2025,"publication_date":"2025-07-21","ids":{"openalex":"https://openalex.org/W4412515170","doi":"https://doi.org/10.1111/bph.70135","pmid":"https://pubmed.ncbi.nlm.nih.gov/40686220"},"language":"en","primary_location":{"id":"doi:10.1111/bph.70135","doi":"https://doi.org/10.1111/bph.70135","is_oa":true,"landing_page_url":"https://doi.org/10.1111/bph.70135","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/bph.70135","source":{"id":"https://openalex.org/S55107261","display_name":"British Journal of Pharmacology","issn_l":"0007-1188","issn":["0007-1188","1476-5381"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/bph.70135","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014650498","display_name":"Matilde Marini","orcid":"https://orcid.org/0000-0002-2199-2905","observed_orcids":["https://orcid.org/0000-0002-2199-2905"]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Matilde Marini","raw_affiliation_strings":["Department of Health Science, Clinical Pharmacology and Oncology Section University of Florence  Florence Italy","Department of Health Science, Clinical Pharmacology and Oncology Section, University of Florence, Florence, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Science, Clinical Pharmacology and Oncology Section University of Florence  Florence Italy","institution_ids":["https://openalex.org/I45084792"]},{"raw_affiliation_string":"Department of Health Science, Clinical Pharmacology and Oncology Section, University of Florence, Florence, Italy","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046737240","display_name":"Lorenzo Landini","orcid":"https://orcid.org/0000-0002-3933-2497","observed_orcids":["https://orcid.org/0000-0002-3933-2497"]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Lorenzo Landini","raw_affiliation_strings":["Department of Health Science, Clinical Pharmacology and Oncology Section University of Florence  Florence Italy","Department of Health Science, Clinical Pharmacology and Oncology Section, University of Florence, Florence, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Science, Clinical Pharmacology and Oncology Section University of Florence  Florence Italy","institution_ids":["https://openalex.org/I45084792"]},{"raw_affiliation_string":"Department of Health Science, Clinical Pharmacology and Oncology Section, University of Florence, Florence, Italy","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041023972","display_name":"Elisabetta Coppi","orcid":"https://orcid.org/0000-0003-4434-5919","observed_orcids":["https://orcid.org/0000-0003-4434-5919"]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Elisabetta Coppi","raw_affiliation_strings":["Department of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), Section of Pharmacology and Toxicology University of Florence  Florence Italy","Department of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), Section of Pharmacology and Toxicology, University of Florence, Florence, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), Section of Pharmacology and Toxicology University of Florence  Florence Italy","institution_ids":["https://openalex.org/I45084792"]},{"raw_affiliation_string":"Department of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), Section of Pharmacology and Toxicology, University of Florence, Florence, Italy","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Martina Tesi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Martina Tesi","raw_affiliation_strings":["Department of Health Science, Clinical Pharmacology and Oncology Section University of Florence  Florence Italy","Department of Health Science, Clinical Pharmacology and Oncology Section, University of Florence, Florence, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Science, Clinical Pharmacology and Oncology Section University of Florence  Florence Italy","institution_ids":["https://openalex.org/I45084792"]},{"raw_affiliation_string":"Department of Health Science, Clinical Pharmacology and Oncology Section, University of Florence, Florence, Italy","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056794141","display_name":"Elisa Bellantoni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Elisa Bellantoni","raw_affiliation_strings":["Department of Health Science, Clinical Pharmacology and Oncology Section University of Florence  Florence Italy","Department of Health Science, Clinical Pharmacology and Oncology Section, University of Florence, Florence, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Science, Clinical Pharmacology and Oncology Section University of Florence  Florence Italy","institution_ids":["https://openalex.org/I45084792"]},{"raw_affiliation_string":"Department of Health Science, Clinical Pharmacology and Oncology Section, University of Florence, Florence, Italy","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025238641","display_name":"Martina Chieca","orcid":"https://orcid.org/0000-0002-0247-9938","observed_orcids":["https://orcid.org/0000-0002-0247-9938"]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Martina Chieca","raw_affiliation_strings":["Department of Health Science, Clinical Pharmacology and Oncology Section University of Florence  Florence Italy","Department of Health Science, Clinical Pharmacology and Oncology Section, University of Florence, Florence, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Science, Clinical Pharmacology and Oncology Section University of Florence  Florence Italy","institution_ids":["https://openalex.org/I45084792"]},{"raw_affiliation_string":"Department of Health Science, Clinical Pharmacology and Oncology Section, University of Florence, Florence, Italy","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093705179","display_name":"Emma Beatrice Croce","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Emma Beatrice Croce","raw_affiliation_strings":["Department of Health Science, Forensic Toxicology Laboratory FT\u2010LAB University of Florence  Florence Italy","Department of Health Science, Forensic Toxicology Laboratory FT-LAB, University of Florence, Florence, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Science, Forensic Toxicology Laboratory FT\u2010LAB University of Florence  Florence Italy","institution_ids":["https://openalex.org/I45084792"]},{"raw_affiliation_string":"Department of Health Science, Forensic Toxicology Laboratory FT-LAB, University of Florence, Florence, Italy","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5119023095","display_name":"Lorenzo Bonacchi","orcid":"https://orcid.org/0009-0004-9083-6086","observed_orcids":["https://orcid.org/0009-0004-9083-6086"]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Lorenzo Bonacchi","raw_affiliation_strings":["Department of Information Engineering University of Florence  Florence Italy","Department of Information Engineering, University of Florence, Florence, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Information Engineering University of Florence  Florence Italy","institution_ids":["https://openalex.org/I45084792"]},{"raw_affiliation_string":"Department of Information Engineering, University of Florence, Florence, Italy","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5095694019","display_name":"Giulia Brancolini","orcid":"https://orcid.org/0009-0008-9269-8253","observed_orcids":["https://orcid.org/0009-0008-9269-8253"]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giulia Brancolini","raw_affiliation_strings":["Department of Health Science, Clinical Pharmacology and Oncology Section University of Florence  Florence Italy","FloNext Srl  Florence Italy","Department of Health Science, Clinical Pharmacology and Oncology Section, University of Florence, Florence, Italy","FloNext Srl, Florence, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Science, Clinical Pharmacology and Oncology Section University of Florence  Florence Italy","institution_ids":["https://openalex.org/I45084792"]},{"raw_affiliation_string":"FloNext Srl  Florence Italy","institution_ids":[]},{"raw_affiliation_string":"Department of Health Science, Clinical Pharmacology and Oncology Section, University of Florence, Florence, Italy","institution_ids":["https://openalex.org/I45084792"]},{"raw_affiliation_string":"FloNext Srl, Florence, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005632814","display_name":"Piero Bruschi","orcid":"https://orcid.org/0000-0003-1551-2626","observed_orcids":["https://orcid.org/0000-0003-1551-2626"]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Piero Bruschi","raw_affiliation_strings":["Department of Agricultural, Environmental, Food and Forestry Science and Technology University of Florence  Florence Italy","Department of Agricultural, Environmental, Food and Forestry Science and Technology, University of Florence, Florence, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Agricultural, Environmental, Food and Forestry Science and Technology University of Florence  Florence Italy","institution_ids":["https://openalex.org/I45084792"]},{"raw_affiliation_string":"Department of Agricultural, Environmental, Food and Forestry Science and Technology, University of Florence, Florence, Italy","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074430495","display_name":"Daniel Souza Monteiro de Ara\u00fajo","orcid":"https://orcid.org/0000-0003-1115-725X","observed_orcids":["https://orcid.org/0000-0003-1115-725X"]},"institutions":[{"id":"https://openalex.org/I161127581","display_name":"Universidade Federal Fluminense","ror":"https://ror.org/02rjhbb08","country_code":"BR","type":"education","lineage":["https://openalex.org/I161127581"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Daniel Souza Monteiro de Ara\u00fajo","raw_affiliation_strings":["Graduate Program in Neurosciences, Neurobiology Department, Biology Institute Fluminense Federal University  Niteroi Brazil","Graduate Program in Neurosciences, Neurobiology Department, Biology Institute, Fluminense Federal University, Niteroi, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate Program in Neurosciences, Neurobiology Department, Biology Institute Fluminense Federal University  Niteroi Brazil","institution_ids":["https://openalex.org/I161127581"]},{"raw_affiliation_string":"Graduate Program in Neurosciences, Neurobiology Department, Biology Institute, Fluminense Federal University, Niteroi, Brazil","institution_ids":["https://openalex.org/I161127581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037861075","display_name":"Gaetano De Siena","orcid":"https://orcid.org/0000-0003-3600-9130","observed_orcids":["https://orcid.org/0000-0003-3600-9130"]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Gaetano De Siena","raw_affiliation_strings":["Department of Health Science, Clinical Pharmacology and Oncology Section University of Florence  Florence Italy","Department of Health Science, Clinical Pharmacology and Oncology Section, University of Florence, Florence, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Science, Clinical Pharmacology and Oncology Section University of Florence  Florence Italy","institution_ids":["https://openalex.org/I45084792"]},{"raw_affiliation_string":"Department of Health Science, Clinical Pharmacology and Oncology Section, University of Florence, Florence, Italy","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114877162","display_name":"Alexandra Dimitrova","orcid":"https://orcid.org/0009-0001-4166-8010","observed_orcids":["https://orcid.org/0009-0001-4166-8010"]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alexandra Dimitrova","raw_affiliation_strings":["Department of Health Science, Forensic Toxicology Laboratory FT\u2010LAB University of Florence  Florence Italy","Department of Health Science, Forensic Toxicology Laboratory FT-LAB, University of Florence, Florence, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Science, Forensic Toxicology Laboratory FT\u2010LAB University of Florence  Florence Italy","institution_ids":["https://openalex.org/I45084792"]},{"raw_affiliation_string":"Department of Health Science, Forensic Toxicology Laboratory FT-LAB, University of Florence, Florence, Italy","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5095694021","display_name":"Alessandra Mastricci","orcid":"https://orcid.org/0009-0009-3755-8802","observed_orcids":["https://orcid.org/0009-0009-3755-8802"]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alessandra Mastricci","raw_affiliation_strings":["Department of Health Science, Clinical Pharmacology and Oncology Section University of Florence  Florence Italy","Department of Health Science, Clinical Pharmacology and Oncology Section, University of Florence, Florence, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Science, Clinical Pharmacology and Oncology Section University of Florence  Florence Italy","institution_ids":["https://openalex.org/I45084792"]},{"raw_affiliation_string":"Department of Health Science, Clinical Pharmacology and Oncology Section, University of Florence, Florence, Italy","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047000436","display_name":"Henrique Rocha Mendon\u00e7a","orcid":"https://orcid.org/0000-0002-0940-5675","observed_orcids":["https://orcid.org/0000-0002-0940-5675"]},"institutions":[{"id":"https://openalex.org/I122140584","display_name":"Universidade Federal do Rio de Janeiro","ror":"https://ror.org/03490as77","country_code":"BR","type":"education","lineage":["https://openalex.org/I122140584"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Henrique Rocha Mendon\u00e7a","raw_affiliation_strings":["Integrated Lab of Morphology Institute of Biodiversity and Sustainability NUPEM, Federal University of Rio de Janeiro  Maca\u00e9 Brazil","Neurodegeneration and Repair Lab, Department of Pathology, Postgraduate Program in Anatomical Pathology, Faculty of Medicine Federal University of Rio de Janeiro  Rio de Janeiro Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Integrated Lab of Morphology Institute of Biodiversity and Sustainability NUPEM, Federal University of Rio de Janeiro  Maca\u00e9 Brazil","institution_ids":["https://openalex.org/I122140584"]},{"raw_affiliation_string":"Neurodegeneration and Repair Lab, Department of Pathology, Postgraduate Program in Anatomical Pathology, Faculty of Medicine Federal University of Rio de Janeiro  Rio de Janeiro Brazil","institution_ids":["https://openalex.org/I122140584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5095694020","display_name":"Irene Scuffi","orcid":"https://orcid.org/0009-0008-2312-3325","observed_orcids":["https://orcid.org/0009-0008-2312-3325"]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Irene Scuffi","raw_affiliation_strings":["Department of Health Science, Clinical Pharmacology and Oncology Section University of Florence  Florence Italy","Department of Health Science, Clinical Pharmacology and Oncology Section, University of Florence, Florence, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Science, Clinical Pharmacology and Oncology Section University of Florence  Florence Italy","institution_ids":["https://openalex.org/I45084792"]},{"raw_affiliation_string":"Department of Health Science, Clinical Pharmacology and Oncology Section, University of Florence, Florence, Italy","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088921361","display_name":"Martina Venturini","orcid":"https://orcid.org/0000-0002-8198-4683","observed_orcids":["https://orcid.org/0000-0002-8198-4683"]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Martina Venturini","raw_affiliation_strings":["Department of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), Section of Pharmacology and Toxicology University of Florence  Florence Italy","Department of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), Section of Pharmacology and Toxicology, University of Florence, Florence, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), Section of Pharmacology and Toxicology University of Florence  Florence Italy","institution_ids":["https://openalex.org/I45084792"]},{"raw_affiliation_string":"Department of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), Section of Pharmacology and Toxicology, University of Florence, Florence, Italy","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020298497","display_name":"Luiza dos Santos Heringer","orcid":"https://orcid.org/0000-0003-3375-9550","observed_orcids":["https://orcid.org/0000-0003-3375-9550"]},"institutions":[{"id":"https://openalex.org/I122140584","display_name":"Universidade Federal do Rio de Janeiro","ror":"https://ror.org/03490as77","country_code":"BR","type":"education","lineage":["https://openalex.org/I122140584"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Luiza Dos Santos Heringer","raw_affiliation_strings":["Neurodegeneration and Repair Lab, Department of Pathology, Postgraduate Program in Anatomical Pathology, Faculty of Medicine Federal University of Rio de Janeiro  Rio de Janeiro Brazil","Neurodegeneration and Repair Lab, Department of Pathology, Postgraduate Program in Anatomical Pathology, Faculty of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurodegeneration and Repair Lab, Department of Pathology, Postgraduate Program in Anatomical Pathology, Faculty of Medicine Federal University of Rio de Janeiro  Rio de Janeiro Brazil","institution_ids":["https://openalex.org/I122140584"]},{"raw_affiliation_string":"Neurodegeneration and Repair Lab, Department of Pathology, Postgraduate Program in Anatomical Pathology, Faculty of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil","institution_ids":["https://openalex.org/I122140584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083460461","display_name":"Fabio Vaiano","orcid":"https://orcid.org/0000-0002-9256-4326","observed_orcids":["https://orcid.org/0000-0002-9256-4326"]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Fabio Vaiano","raw_affiliation_strings":["Department of Health Science, Forensic Toxicology Laboratory FT\u2010LAB University of Florence  Florence Italy","Department of Health Science, Forensic Toxicology Laboratory FT-LAB, University of Florence, Florence, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Science, Forensic Toxicology Laboratory FT\u2010LAB University of Florence  Florence Italy","institution_ids":["https://openalex.org/I45084792"]},{"raw_affiliation_string":"Department of Health Science, Forensic Toxicology Laboratory FT-LAB, University of Florence, Florence, Italy","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063715630","display_name":"Romina Nassini","orcid":"https://orcid.org/0000-0002-9223-8395","observed_orcids":["https://orcid.org/0000-0002-9223-8395"]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Romina Nassini","raw_affiliation_strings":["Department of Health Science, Clinical Pharmacology and Oncology Section University of Florence  Florence Italy","Department of Health Science, Clinical Pharmacology and Oncology Section, University of Florence, Florence, Italy"],"raw_orcid":"https://orcid.org/0000-0002-9223-8395","affiliations":[{"raw_affiliation_string":"Department of Health Science, Clinical Pharmacology and Oncology Section University of Florence  Florence Italy","institution_ids":["https://openalex.org/I45084792"]},{"raw_affiliation_string":"Department of Health Science, Clinical Pharmacology and Oncology Section, University of Florence, Florence, Italy","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065992201","display_name":"Francesco De Logu","orcid":"https://orcid.org/0000-0001-8360-6929","observed_orcids":["https://orcid.org/0000-0001-8360-6929"]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Francesco De Logu","raw_affiliation_strings":["Department of Health Science, Clinical Pharmacology and Oncology Section University of Florence  Florence Italy","Department of Health Science, Clinical Pharmacology and Oncology Section, University of Florence, Florence, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Science, Clinical Pharmacology and Oncology Section University of Florence  Florence Italy","institution_ids":["https://openalex.org/I45084792"]},{"raw_affiliation_string":"Department of Health Science, Clinical Pharmacology and Oncology Section, University of Florence, Florence, Italy","institution_ids":["https://openalex.org/I45084792"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5063715630","https://openalex.org/A5065992201"],"corresponding_institution_ids":["https://openalex.org/I45084792"],"apc_list":{"value":4780,"currency":"USD","value_usd":4780},"apc_paid":{"value":4780,"currency":"USD","value_usd":4780},"fwci":2.9339,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.90602837,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"182","issue":"22","first_page":"5469","last_page":"5488"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.9355000257492065,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.9355000257492065,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.06289999932050705,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11840","display_name":"Pain Management and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/leonurine","display_name":"leonurine","score":1.0},{"id":"https://openalex.org/keywords/leonotis-leonurus","display_name":"Leonotis leonurus","score":0.9259999990463257},{"id":"https://openalex.org/keywords/trpa1","display_name":"TRPA1","score":0.9309999942779541},{"id":"https://openalex.org/keywords/trpv4","display_name":"TRPV4","score":1.0},{"id":"https://openalex.org/keywords/antinociceptive-effect","display_name":"antinociceptive effect","score":0.6570000052452087},{"id":"https://openalex.org/keywords/intracellular-calcium","display_name":"intracellular calcium","score":0.7269999980926514},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.8230000138282776},{"id":"https://openalex.org/keywords/mechanical-allodynia","display_name":"mechanical allodynia","score":0.796999990940094},{"id":"https://openalex.org/keywords/chemotherapy-induced-peripheral-neuropathy","display_name":"chemotherapy-induced peripheral neuropathy","score":0.9480000138282776},{"id":"https://openalex.org/keywords/thalidomide","display_name":"thalidomide","score":0.902999997138977},{"id":"https://openalex.org/keywords/dorsal-root-ganglion-neurons","display_name":"dorsal root ganglion neurons","score":0.9120000004768372},{"id":"https://openalex.org/keywords/pain-modulation","display_name":"pain modulation","score":0.6290000081062317}],"concepts":[{"id":"https://openalex.org/C2780791683","wikidata":"https://www.wikidata.org/wiki/Q846785","display_name":"Action (physics)","level":2,"score":0.5083257555961609},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5043932199478149},{"id":"https://openalex.org/C15490471","wikidata":"https://www.wikidata.org/wiki/Q2734305","display_name":"Nociception","level":3,"score":0.4794130027294159},{"id":"https://openalex.org/C155164980","wikidata":"https://www.wikidata.org/wiki/Q304043","display_name":"Transient receptor potential channel","level":3,"score":0.4436710476875305},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38173216581344604},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.28360602259635925},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16831821203231812},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.1550024151802063},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.09787559509277344},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000074025","descriptor_name":"TRPA1 Cation Channel","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000074025","descriptor_name":"TRPA1 Cation Channel","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000700","descriptor_name":"Analgesics","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000700","descriptor_name":"Analgesics","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000700","descriptor_name":"Analgesics","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000700","descriptor_name":"Analgesics","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005707","descriptor_name":"Gallic Acid","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D005707","descriptor_name":"Gallic Acid","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D005707","descriptor_name":"Gallic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005707","descriptor_name":"Gallic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005707","descriptor_name":"Gallic Acid","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005707","descriptor_name":"Gallic Acid","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005727","descriptor_name":"Ganglia, Spinal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005727","descriptor_name":"Ganglia, Spinal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005727","descriptor_name":"Ganglia, Spinal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005727","descriptor_name":"Ganglia, Spinal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050916","descriptor_name":"TRPV Cation Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050916","descriptor_name":"TRPV Cation Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/bph.70135","doi":"https://doi.org/10.1111/bph.70135","is_oa":true,"landing_page_url":"https://doi.org/10.1111/bph.70135","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/bph.70135","source":{"id":"https://openalex.org/S55107261","display_name":"British Journal of Pharmacology","issn_l":"0007-1188","issn":["0007-1188","1476-5381"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Pharmacology","raw_type":"journal-article"},{"id":"pmid:40686220","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40686220","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:flore.unifi.it:2158/1454132","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2158/1454132","pdf_url":"https://flore.unifi.it/bitstream/2158/1454132/2/British%20J%20Pharmacology%20-%202025%20-%20Marini%20-%20Anti%e2%80%90nociceptive%20action%20of%20leonurine%20through%20TRPA1%20and%20TRPV4%20channels%20modulation.pdf","source":{"id":"https://openalex.org/S4306402033","display_name":"Florence Research (University of Florence)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45084792","host_organization_name":"University of Florence","host_organization_lineage":["https://openalex.org/I45084792"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1111/bph.70135","doi":"https://doi.org/10.1111/bph.70135","is_oa":true,"landing_page_url":"https://doi.org/10.1111/bph.70135","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/bph.70135","source":{"id":"https://openalex.org/S55107261","display_name":"British Journal of Pharmacology","issn_l":"0007-1188","issn":["0007-1188","1476-5381"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8560000061988831,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2306727999","display_name":null,"funder_award_id":"11-10-2022","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G3323308467","display_name":null,"funder_award_id":"PE0000006","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"}],"funders":[{"id":"https://openalex.org/F4320307773","display_name":"GlaxoSmithKline","ror":"https://ror.org/01xsqw823"},{"id":"https://openalex.org/F4320311314","display_name":"University of Hull","ror":"https://ror.org/04nkhwh30"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F7311471023","display_name":"NextGenerationEU","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4412515170.pdf","grobid_xml":"https://content.openalex.org/works/W4412515170.grobid-xml"},"referenced_works_count":73,"referenced_works":["https://openalex.org/W833208189","https://openalex.org/W1495617953","https://openalex.org/W1593555249","https://openalex.org/W1713016576","https://openalex.org/W1888470382","https://openalex.org/W1966919173","https://openalex.org/W1970073314","https://openalex.org/W1976471139","https://openalex.org/W1980764414","https://openalex.org/W1980798939","https://openalex.org/W2003380041","https://openalex.org/W2009763296","https://openalex.org/W2011557706","https://openalex.org/W2014707225","https://openalex.org/W2021370268","https://openalex.org/W2026983868","https://openalex.org/W2027587746","https://openalex.org/W2035257142","https://openalex.org/W2040501484","https://openalex.org/W2041546619","https://openalex.org/W2047539024","https://openalex.org/W2053627692","https://openalex.org/W2056794468","https://openalex.org/W2060772141","https://openalex.org/W2075100277","https://openalex.org/W2079719679","https://openalex.org/W2087454739","https://openalex.org/W2087484885","https://openalex.org/W2090592412","https://openalex.org/W2097157824","https://openalex.org/W2104637582","https://openalex.org/W2105565132","https://openalex.org/W2113737911","https://openalex.org/W2118622904","https://openalex.org/W2129155568","https://openalex.org/W2150070295","https://openalex.org/W2165499151","https://openalex.org/W2167960858","https://openalex.org/W2172201406","https://openalex.org/W2477421433","https://openalex.org/W2508720811","https://openalex.org/W2528111863","https://openalex.org/W2626091793","https://openalex.org/W2765919408","https://openalex.org/W2770446525","https://openalex.org/W2791419854","https://openalex.org/W2791891546","https://openalex.org/W2905113504","https://openalex.org/W2921561810","https://openalex.org/W2936355305","https://openalex.org/W2971406123","https://openalex.org/W3042519295","https://openalex.org/W3043803513","https://openalex.org/W3110796948","https://openalex.org/W3112024367","https://openalex.org/W3136278209","https://openalex.org/W4210809802","https://openalex.org/W4224223616","https://openalex.org/W4236357753","https://openalex.org/W4283018542","https://openalex.org/W4294733197","https://openalex.org/W4301610446","https://openalex.org/W4307931636","https://openalex.org/W4313414933","https://openalex.org/W4316039107","https://openalex.org/W4327919075","https://openalex.org/W4367055253","https://openalex.org/W4390030366","https://openalex.org/W4393509411","https://openalex.org/W4400427377","https://openalex.org/W4400838912","https://openalex.org/W4402321568","https://openalex.org/W4404699579"],"related_works":["https://openalex.org/W4387497383","https://openalex.org/W2948807893","https://openalex.org/W2899084033","https://openalex.org/W2778153218","https://openalex.org/W2748952813","https://openalex.org/W1531601525","https://openalex.org/W4391375266","https://openalex.org/W2078814861","https://openalex.org/W2527526854","https://openalex.org/W1976181487"],"abstract_inverted_index":{"BACKGROUND":[0],"AND":[1,188],"PURPOSE:":[2],"Leonurine,":[3],"a":[4,102,140,195],"pseudoalkaloid":[5],"derived":[6],"from":[7,92],"Leonotis":[8],"leonurus,":[9],"has":[10],"been":[11,121],"traditionally":[12],"used":[13,139],"in":[14,106,123,184],"herbal":[15],"medicine":[16],"to":[17,32,67,144,150],"alleviate":[18],"conditions":[19],"such":[20],"as":[21,54,194],"headaches":[22],"and":[23,51,79,85,87,118,126,153,181,208],"abdominal":[24],"discomfort.":[25],"Its":[26],"therapeutic":[27,206],"effects":[28],"are":[29],"often":[30],"attributed":[31],"potential":[33,209],"antioxidant":[34],"properties;":[35],"however,":[36],"the":[37,124,146,176],"precise":[38],"molecular":[39],"mechanisms":[40],"remain":[41],"poorly":[42],"understood.":[43],"Transient":[44],"Receptor":[45],"Potential":[46],"(TRP)":[47],"channels,":[48],"particularly":[49],"TRPA1":[50,84,117,180],"TRPV4,":[52,86],"serve":[53],"critical":[55],"sensors":[56],"of":[57,113,128,133,148,168,179],"reactive":[58],"oxygen":[59],"species":[60],"(ROS).":[61],"Persistent":[62],"ROS":[63],"elevation":[64],"can":[65],"contribute":[66],"pain":[68,185,199],"by":[69,111],"activating":[70],"these":[71],"channels.":[72,115],"EXPERIMENTAL":[73],"APPROACH:":[74],")":[75],"agonists.":[76],"Employing":[77],"human":[78],"murine":[80],"cell":[81],"lines":[82],"expressing":[83],"mouse":[88],"primary":[89],"sensory":[90],"neurons":[91],"dorsal":[93],"root":[94],"ganglia":[95],"(DRG),":[96],"we":[97],"observed":[98],"that":[99,162],"leonurine":[100,149,169,193],"elicited":[101],"selective,":[103],"concentration-dependent":[104],"increase":[105],"intracellular":[107],"calcium":[108],"levels,":[109],"followed":[110],"desensitisation":[112,183],"both":[114],"Notably,":[116],"TRPV4":[119,182],"have":[120],"implicated":[122],"development":[125],"maintenance":[127],"mechanical":[129,155,173],"allodynia":[130],"within":[131],"models":[132],"chemotherapy-induced":[134],"peripheral":[135],"neuropathy":[136],"(CIPN).":[137],"We":[138],"thalidomide":[141],"CIPN":[142],"model":[143],"assess":[145],"efficacy":[147],"reduce":[151],"TRPA1-":[152],"TRPV4-dependent":[154],"allodynia.":[156],"KEY":[157],"RESULTS:":[158],"Our":[159],"findings":[160],"indicate":[161],"repeated,":[163],"but":[164],"not":[165],"acute,":[166],"administration":[167],"significantly":[170],"reduced":[171],"thalidomide-induced":[172],"allodynia,":[174],"highlighting":[175],"crucial":[177],"role":[178],"modulation.":[186],"CONCLUSIONS":[187],"IMPLICATIONS:":[189],"These":[190],"results":[191],"position":[192],"promising":[196],"candidate":[197],"for":[198],"management,":[200],"warranting":[201],"further":[202],"investigation":[203],"into":[204],"long-term":[205],"strategies":[207],"clinical":[210],"applications.":[211]},"counts_by_year":[{"year":2026,"cited_by_count":5}],"updated_date":"2026-10-02T10:15:12.560889","created_date":"2025-10-10T00:00:00"}